Fluoroacetic acid toxicity (Homo sapiens)

Description

Pathway on fluoroacetic acid toxicity describing how it ultimately leads to disturbance of the Krebs cycle.

View approved pathways at the new wikipathways.org.

Johnson BM, Shu YZ, Zhuo X, Meanwell NA; ''Metabolic and Pharmaceutical Aspects of Fluorinated Compounds.''; J Med Chem, 2020 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
134720	view	21:30, 26 July 2024	Eweitz	Fix typo
123489	view	04:48, 29 July 2022	Egonw	Made a pathway clickable
112070	view	10:14, 18 September 2020	Marvin M2	Ontology Term : 'altered metabolic pathway' added !
112069	view	10:14, 18 September 2020	Marvin M2	Ontology Term : 'altered citric acid cycle pathway' added !
112068	view	10:13, 18 September 2020	DeSl	Ontology Term : 'disease pathway' added !
112067	view	10:09, 18 September 2020	Marvin M2	Added reference and minor layout edit
111923	view	06:49, 11 September 2020	Egonw	Added the missing compound identifier.
111922	view	06:22, 11 September 2020	Egonw	Modified description
111816	view	19:16, 8 September 2020	Marvin M2	changed secondary chebi IDs to primary chebi IDs.
111786	view	14:17, 7 September 2020	Marvin M2	New pathway

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Name	Type	Database reference
4-Hydroxy-trans-aconitate	Metabolite	Q76106265 (Wikidata)
ALDH2	GeneProduct	ENSG00000111275 (Ensembl)
ALDH3A2	GeneProduct	ENSG00000072210 (Ensembl)
ALDH9A1	GeneProduct	ENSG00000143149 (Ensembl)
Acetate	Metabolite	71-50-1 (CAS)
Acetyl-CoA synthetase	GeneProduct	ENSG00000131069 (Ensembl)
Aconitase	GeneProduct	ENSG00000100412 (Ensembl)
Citrate synthase	GeneProduct	1431 (Entrez Gene)
Citric acid cycle (Krebs cycle)	Pathway	WP78 (WikiPathways)
Citric acid	Metabolite	CHEBI:30769 (ChEBI)
Fluoroacetaldehyde	Metabolite	CHEBI:14272 (ChEBI)
Fluoroacetic acid	Metabolite	CHEBI:30775 (ChEBI)
Fluoroacetyl-CoA	Metabolite	49859653 (PubChem-compound)
Fluorocitric acid	Metabolite	357-89-1 (CAS)
Isocitric acid	Metabolite	CHEBI:30887 (ChEBI)

No annotated interactions