Signal transducer and activator of transcription (STAT) constitutes a family of universal transcription factors. STAT5 refers to two highly related proteins, STAT5A and STAT5B, with critical function in cell survival and proliferation. Several upstream signals including cytokines and growth factors can trigger STAT5 activation.
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Signal transducer and activator of transcription (STAT5A/STAT5B) is a key component in several cell signaling and gene transcription process and regulated cell survival and proliferation. STAT5 is activated by multiple upstream activators including cytokines and growth factors. The process begins when an active upstream regulator binds STAT5 to initiate its phosphorylation (Nabinger et al, 2013).
Signal transducer and activator of transcription (STAT5A/STAT5B) is activated by a range of upstream signals including cytokines and growth factors. Activators bind and phosphorylate STAT5 following which STAT5 is released from the complex and translocates to the nucleus to regulate gene transcription (Nabinger et al, 2013).
Signal transducer and activator of transcription (STAT5A/STAT5B) is regulated by extracellular factors including cytokines and growth factors. Activators bind and phosphorylate STAT5 which results in its activation (Nabinger et al, 2013).
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