Retinol metabolism (Homo sapiens)
From WikiPathways
Description
This pathway describes the metabolism of retinol. Retinol, more common known as vitamin A, is involved in various physiological processes in the human body.
Vitamin A must acquired from the diet. When taken up, retinol metabolism is important to create all the different retinoid forms, such as retinoic acid and retinyl esters. All these types have their own function.
There are many carries proteins and enzymes specific to retinoid metabolism involved in the processes.Quality Tags
Ontology Terms
Bibliography
- Blaner WS, Prystowsky JH, Smith JE, Goodman DS; ''Rat liver retinyl palmitate hydrolase activity. Relationship to cholesteryl oleate and triolein hydrolase activities.''; Biochim Biophys Acta, 1984 PubMed Europe PMC Scholia
- Blaner WS, Das SR, Gouras P, Flood MT; ''Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells.''; J Biol Chem, 1987 PubMed Europe PMC Scholia
- Travis GH, Golczak M, Moise AR, Palczewski K; ''Retinol Metabolism''; Kegg,
- Li Y, Wongsiriroj N, Blaner WS; ''The multifaceted nature of retinoid transport and metabolism.''; Hepatobiliary Surg Nutr, 2014 PubMed Europe PMC Scholia
- Arne JM, Widjaja-Adhi MAK, Hughes T, Huynh KW, Silvaroli JA, Chelstowska S, Moiseenkova-Bell VY, Golczak M; ''Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2.''; J Lipid Res, 2017 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
11-cis retinal | Metabolite | Q17002962 (Wikidata) | |
11-cis-retinol | Metabolite | CHEBI:16302 (ChEBI) | |
11-cis-retinyl palmitate | Metabolite | CHEBI:16254 (ChEBI) | |
11-cis-retinyl tetradecanoate | Metabolite | CHEBI:138676 (ChEBI) | |
11-cis-retinyl-palmitate hydrolase | Protein | 3.1.1.63 (BRENDA) | |
18-hydroxy RA | Metabolite | HMDB0012452 (HMDB) | |
4-hydroxy RA | Metabolite | Q27132808 (Wikidata) | |
4-oxo RA | Metabolite | CHEBI:80656 (ChEBI) | |
9-cis-retinal | Metabolite | CHEBI:78273 (ChEBI) | |
9-cis-retinoate | Metabolite | CHEBI:78630 (ChEBI) | |
9-cis-retinol | Metabolite | CHEBI:78272 (ChEBI) | |
ADH1A | Protein | P07327 (Uniprot-TrEMBL) | |
AWAT2 | Protein | Q6E213 (Uniprot-TrEMBL) | |
Aldehyde oxidase | Protein | Q06278 (Uniprot-TrEMBL) | |
BCDO1 | Protein | Q9HAY6 (Uniprot-TrEMBL) | |
CP1A1 | Protein | P04798 (Uniprot-TrEMBL) | |
CP26A | Protein | 043174 (Uniprot-TrEMBL) | |
CP2A6 | Protein | P11509 (Uniprot-TrEMBL) | |
CP2W1 | Protein | Q8TAV3 (Uniprot-TrEMBL) | |
CP3A7 | Protein | P24462 (Uniprot-TrEMBL) | |
DHRS4 | Protein | Q9BTZ2 (Uniprot-TrEMBL) | |
DHRS9 | Protein | Q9BPW9 (Uniprot-TrEMBL) | |
Iodopsin | Metabolite | CHEBI:5949 (ChEBI) | |
LRAT | Protein | O95237 (Uniprot-TrEMBL) | |
PNPL4 | Protein | P41247 (Uniprot-TrEMBL) | |
RDH12 | Protein | Q96NR8 (Uniprot-TrEMBL) | |
RDH13 | Protein | Q8NBN7 (Uniprot-TrEMBL) | |
RDH13 | Protein | Q8NBN7 (Uniprot-TrEMBL) | |
RPE65 | Protein | Q16518 (Uniprot-TrEMBL) | |
Retinal dehydrogenase 1 | Protein | P00352 (Uniprot-TrEMBL) | |
SDR16C5 | Protein | Q8N3Y7 (Uniprot-TrEMBL) | |
Vitamin A and carotenoid metabolism (Homo sapiens) | Pathway | WP716 (WikiPathways) | |
Vitamins A and D - action mechanisms (Homo Sapiens) | Pathway | WP4342 (WikiPathways) | |
all-trans-retinal | Metabolite | CHEBI:17898 (ChEBI) | |
all-trans-retinoate | Metabolite | CHEBI:35291 (ChEBI) | |
all-trans-retinol | Metabolite | CHEBI:17336 (ChEBI) | |
all-trans-retinyl esters | Metabolite | CHEBI:63410 (ChEBI) | |
beta-Carotene | Metabolite | HMDB0000561 (HMDB) |
Annotated Interactions
No annotated interactions