Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids (Homo sapiens)

Description

Modulation of the PI3K-Akt-mTOR signaling by bioactive sphinoglipids

View approved pathways at the new wikipathways.org.

Jęśko H, Stępień A, Lukiw WJ, Strosznajder RP; ''The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration.''; Mol Neurobiol, 2019 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
135482	view	05:20, 16 September 2024	Egonw	It seems to me the ChEBI ID was wrong, and for a different kinase
134496	view	05:30, 22 July 2024	Egonw	Removed a template comment
128742	view	04:54, 21 February 2024	Eweitz	Standardize case
122557	view	02:15, 16 April 2022	Eweitz	Modified title
122178	view	10:06, 15 March 2022	Jesper	visual changes
122177	view	09:56, 15 March 2022	Jesper	Ontology Term : 'senile degeneration of brain' added !
122176	view	09:52, 15 March 2022	Jesper	Changed databases
122175	view	09:45, 15 March 2022	Jesper	Added and changed identifiers and added text labels
121872	view	22:32, 7 March 2022	DeSl	More layout and condensation of pathway
121871	view	22:02, 7 March 2022	DeSl	More layout changes for readability
121870	view	21:58, 7 March 2022	DeSl	Layout top of page
121869	view	21:56, 7 March 2022	DeSl	Connected last unconnected line
121596	view	18:04, 21 February 2022	AnnaVanWersch	Added pathway reference
121594	view	17:58, 21 February 2022	AnnaVanWersch	changed some interactions, hoping to fix the unconnected interactions
121593	view	17:49, 21 February 2022	AnnaVanWersch	Changed activation arrow to inhibition interaction
121588	view	17:39, 21 February 2022	AnnaVanWersch	Fixed some interactions and aligned some boxes
121434	view	12:55, 17 February 2022	Jesper	Title change
121432	view	12:53, 17 February 2022	Jesper	Addition of new data nodes
121351	view	09:47, 16 February 2022	Jesper	New pathway

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Name	Type	Database reference
AKT1	GeneProduct	ENSG00000142208 (Ensembl)
Amino acids	Metabolite	CHEBI:33704 (ChEBI)
Ceramide 1-phosphates	Metabolite	CHEBI:16197 (ChEBI)
Ceramide kinase	Protein	Q8TCT0 (Uniprot-TrEMBL)
Ceramide synthase 1	Protein	ENSG00000223802 (Ensembl)
Ceramide	Metabolite	CHEBI:52639 (ChEBI)
Hypoxia-inducible factor-1 alpha	GeneProduct	ENSG00000100644 (Ensembl)
Inhibitor of NF-kB kinase	Metabolite	Q130305247 (Wikidata)
Insulin-like growth factor 1 receptor	Protein	ENSG00000140443 (Ensembl)
NF-kB	GeneProduct	ENSG00000109320 (Ensembl)
Neutral ceramidase	Protein	Q9NR71 (Uniprot-TrEMBL)
PI3K	Protein	ENSG00000121879 (Ensembl)
Phospholipase D1	Protein	ENSG00000075651 (Ensembl)
Protein associated with Myc	Protein
RNS	Metabolite	62764 (ChEBI)
ROS	Metabolite	26523 (ChEBI)
Ras homolog enriched in the brain	Protein
Sphingosine kinase 2	Protein	ENSG00000063176 (Ensembl)
Sphingosine 1-phosphate receptor 1	Protein	ENSG00000170989 (Ensembl)
Sphingosine 1-phosphate receptor 3	Protein	Q99500 (Uniprot-TrEMBL)
Sphingosine 1-phosphate	Metabolite	HMDB0000277 (HMDB)
Sphingosine	Metabolite	CHEBI:45719 (ChEBI)
Tuberous sclerosis protein	Protein	Q92574 (Uniprot-TrEMBL)
arginine	Metabolite	CHEBI:29016 (ChEBI)
glucose	Metabolite	CHEBI:17234 (ChEBI)
mTORC1	Protein	ENSG00000198793 (Ensembl)

No annotated interactions