COVID-19 and endothelial cell senescence (Homo sapiens)

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Bibliography

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1. Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY; ''Evasion of Type I Interferon by SARS-CoV-2.''; Cell Rep, 2020 PubMed Europe PMC Scholia
2. Xia H, Shi PY; ''Antagonism of Type I Interferon by Severe Acute Respiratory Syndrome Coronavirus 2.''; J Interferon Cytokine Res, 2020 PubMed Europe PMC Scholia
3. Yamauchi K, Shibata Y, Kimura T, Abe S, Inoue S, Osaka D, Sato M, Igarashi A, Kubota I; ''Azithromycin suppresses interleukin-12p40 expression in lipopolysaccharideand interferon-gamma stimulated macrophages.''; Int J Biol Sci, 2009 PubMed Europe PMC Scholia
4. Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD; ''A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
5. Aghai ZH, Kode A, Saslow JG, Nakhla T, Farhath S, Stahl GE, Eydelman R, Strande L, Leone P, Rahman I; ''Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants.''; Pediatr Res, 2007 PubMed Europe PMC Scholia
6. Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF 3rd, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK; ''The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.''; Nat Immunol, 2015 PubMed Europe PMC Scholia
7. Sa Ribero M, Jouvenet N, Dreux M, Nisole S; ''''; , PubMed Europe PMC Scholia
8. Baines KJ, Wright TK, Gibson PG, Powell H, Hansbro PM, Simpson JL; ''Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD.''; ERJ Open Res, 2018 PubMed Europe PMC Scholia
9. Baines KJ, Wright TK, Gibson PG, Powell H, Hansbro PM, Simpson JL; ''Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD.''; ERJ Open Res, 2018 PubMed Europe PMC Scholia
10. Khanmohammadi S, Rezaei N; ''Role of Toll-like receptors in the pathogenesis of COVID-19.''; J Med Virol, 2021 PubMed Europe PMC Scholia
11. Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z, Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z, Xiang Z, Wang J; ''Activation and evasion of type I interferon responses by SARS-CoV-2.''; Nat Commun, 2020 PubMed Europe PMC Scholia
12. Edelmann MJ, Nicholson B, Kessler BM; ''Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.''; Expert Rev Mol Med, 2011 PubMed Europe PMC Scholia
13. Wu X, Xia T, Shin WJ, Yu KM, Jung W, Herrmann A, Foo SS, Chen W, Zhang P, Lee JS, Poo H, Comhair SAA, Jehi L, Choi YK, Ensser A, Jung JU; ''Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8.''; mBio, 2022 PubMed Europe PMC Scholia
14. Carter-Timofte ME, Jørgensen SE, Freytag MR, Thomsen MM, Brinck Andersen NS, Al-Mousawi A, Hait AS, Mogensen TH; ''Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19.''; Front Immunol, 2020 PubMed Europe PMC Scholia
15. Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, Doudier B, Courjon J, Giordanengo V, Vieira VE, Dupont HT, Honoré S, Colson P, Chabrière E, La Scola B, Rolain JM, Brouqui P, Raoult D; ''Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.''; Int J Antimicrob Agents, 2020 PubMed Europe PMC Scholia
16. Yamauchi K, Shibata Y, Kimura T, Abe S, Inoue S, Osaka D, Sato M, Igarashi A, Kubota I; ''Azithromycin suppresses interleukin-12p40 expression in lipopolysaccharide and interferon-gamma stimulated macrophages.''; Int J Biol Sci, 2009 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	124640	view	12:48, 18 November 2022	Jfigueirahasbun	updated viral protein labels, shapes and identifiers
	124554	view	12:38, 8 November 2022	Eweitz	Reduce negative space at top and left of pathway graphic
	124553	view	12:32, 8 November 2022	Eweitz	Use name instead of ID as pathway label, fix typos, refine virus dimensions
	124552	view	12:25, 8 November 2022	Eweitz	Modified title
	124041	view	15:07, 14 September 2022	DeSl	Update ID for NSP4
	124040	view	15:05, 14 September 2022	DeSl	Chnaged MIM-conversion to Arrows
	124039	view	15:04, 14 September 2022	DeSl	Converted SARS-COV2 drawing to graphical lines
	123978	view	10:43, 9 September 2022	Eweitz	Modified title
	123678	view	09:52, 9 August 2022	Egonw	Not a mim-conversion
	123532	view	06:33, 2 August 2022	Egonw	Made a pathway clickable
	123236	view	14:51, 5 July 2022	LaureAlix
	123235	view	14:48, 5 July 2022	LaureAlix
	123222	view	14:21, 5 July 2022	LaureAlix	Modified description
	123221	view	14:20, 5 July 2022	LaureAlix
	123220	view	14:10, 5 July 2022	LaureAlix
	123217	view	14:06, 5 July 2022	LaureAlix
	123215	view	14:03, 5 July 2022	LaureAlix	changes
	123209	view	13:39, 5 July 2022	LaureAlix
	123208	view	13:38, 5 July 2022	LaureAlix	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ANO6	GeneProduct	ENSG00000177119 (Ensembl)
IL17A	GeneProduct	ENSG00000112115 (Ensembl)
IL17RA	GeneProduct	ENSG00000177663 (Ensembl)
IL17RC	GeneProduct	ENSG00000163702 (Ensembl)
STING pathway in Kawasaki-like disease and COVID-19	Pathway	WP4961 (WikiPathways)
TLR4	Protein	O00206 (Uniprot-TrEMBL)
nsp4	Protein	PRO_0000449622 (Uniprot-TrEMBL)	PDB structure for SARS-CoV strain: 6JYT; PRO_0000449622
orf3a	Protein	P0DTC3 (Uniprot-TrEMBL)	PDB structure for SARS-CoV strain: 6JYT
orf8	Protein	P0DTC8 (Uniprot-TrEMBL)	PDB structure for SARS-CoV strain: 6JYT

Annotated Interactions

No annotated interactions