Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists (Homo sapiens)
From WikiPathways
Description
A hypothetical pathway showing the interactions of metabolites produced by the intestinal microbiome, which can affects the anticoagulant response of vitamin K antagonists (VKAs).
Quality Tags
Ontology Terms
Bibliography
- Han Yan, Yi Chen, Hong Zhu, Wei-Hua Huang, Xin-He Cai, Dan Li, Ya-Juan Lv, Si-Zhao, Hong-Hao Zhou, Fan-Yan Luo, Wei Zhang, Xi Li; ''The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism''; Front Med (Lausanne), 2022 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
1-butyrate | Metabolite | CHEBI:17968 (ChEBI) |
|
Acenocoumarol | Metabolite | CHEBI:53766 (ChEBI) | |
Anisindione | Metabolite | CHEBI:133809 (ChEBI) | |
Apaxiban | Metabolite | CHEBI:72296 (ChEBI) | AKA Eliquis, alternative to warfarin |
Brodifacoum | Metabolite | Q421203 (Wikidata) | |
CD36 | GeneProduct | P16671 (Uniprot-TrEMBL) | |
CYP2C9 | GeneProduct | P11712 (Uniprot-TrEMBL) | AKA cytochrome P450 Family 2 Subfamily C Member 9. |
Chlorophacinone | Metabolite | Q413488 (Wikidata) | |
Coumatetralyl | Metabolite | Q415772 (Wikidata) | |
Diphacinone | Metabolite | CHEBI:81896 (ChEBI) | |
Fluindione | Metabolite | Q3074488 (Wikidata) | |
Lithocholic acid | Metabolite | CHEBI:16325 (ChEBI) |
|
NPC1L1 | GeneProduct | Q9UHC9 (Uniprot-TrEMBL) | AKA NPC1like intracellular cholesterol transporter 1; |
PPAR alpha | Protein | Q07869 (Uniprot-TrEMBL) |
|
PPAR beta | Protein | Q03181 (Uniprot-TrEMBL) |
|
PXR | Protein | O75469 (Uniprot-TrEMBL) |
|
Phenindione | Metabolite | CHEBI:8066 (ChEBI) | |
Phenprocoumon | Metabolite | CHEBI:50438 (ChEBI) | |
Pindone | Metabolite | HMDB0256560 (HMDB) | |
SR-BI | Protein | Q8WTV0 (Uniprot-TrEMBL) | AKA Scavenger receptor class B member 1 |
Tioclomarol | Metabolite | CHEBI:135730 (ChEBI) | |
VDR | GeneProduct | P11473 (Uniprot-TrEMBL) |
|
Vitamin K absorption | Pathway | ||
Warfarin | Metabolite | CHEBI:10033 (ChEBI) | AKA Coumadin |
dicoumarol | Metabolite | CHEBI:4513 (ChEBI) | |
menaquinone | Metabolite | CHEBI:16374 (ChEBI) | Figure in paper describes menaquinone, text mentiones: "MK-4 has been found as the most common menaquinone in humans, as well as the only menaquinone converted by phylloquinone. The other menaquinone is synthesized by some obligate and facultative anaerobic bacteria. Except for MK-4, the other menaquinone in humans is mostly synthesized by intestinal bacteria. [PMID:35510250]. Therefore, annotated with overarching Vit.K2 ID from chebi (which should constitute all subforms) |
phylloquinone | Metabolite | CHEBI:28433 (ChEBI) |
|
Annotated Interactions
No annotated interactions