Estrogen metabolism (Homo sapiens)
From WikiPathways
Description
Estrogen synthesis and metabolism. Data from W. Griffiths.
All metabolic reactions in this pathway model have been annotated with a Rhea identifier.
Quality Tags
Ontology Terms
Bibliography
- Kallionpää RA, Järvinen E, Finel M; ''Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.''; J Steroid Biochem Mol Biol, 2015 PubMed Europe PMC Scholia
- Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, Shackleton CHL, Storbeck KH; ''Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.''; J Steroid Biochem Mol Biol, 2019 PubMed Europe PMC Scholia
- Sneitz N, Vahermo M, Mosorin J, Laakkonen L, Poirier D, Finel M; ''Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.''; Drug Metab Dispos, 2013 PubMed Europe PMC Scholia
- Lépine J, Bernard O, Plante M, Têtu B, Pelletier G, Labrie F, Bélanger A, Guillemette C; ''Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.''; J Clin Endocrinol Metab, 2004 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
16alpha-Hydroxyestrone 3-glucuronide | Metabolite | LMST05010070 (LIPID MAPS) | |
16alpha-Hydroxyestrone 16-glucuronide | Metabolite | LMST05010069 (LIPID MAPS) | |
16alpha-Hydroxyestrone | Metabolite | LMST02010041 (LIPID MAPS) | |
2-Hydroxyestradiol | Metabolite | LMST02010027 (LIPID MAPS) | |
2-Hydroxyestrone | Metabolite | LMST02010032 (LIPID MAPS) | |
2-Methoxy-17beta-estradiol 3-glucuronide | Metabolite | LMST05010009 (LIPID MAPS) | |
2-Methoxyestradiol | Metabolite | LMST02010035 (LIPID MAPS) | |
2-Methoxyestrone 3-glucuronide | Metabolite | LMST05010010 (LIPID MAPS) | |
2-Methoxyestrone | Metabolite | LMST02010033 (LIPID MAPS) | |
4-Hydroxyestradiol | Metabolite | LMST02010028 (LIPID MAPS) | |
4-Hydroxyestrone | Metabolite | LMST02010056 (LIPID MAPS) | |
4-Methoxy-17beta-estradiol 3-glucuronide | Metabolite | LMST05010072 (LIPID MAPS) | |
4-Methoxyestradiol | Metabolite | LMST02010055 (LIPID MAPS) | |
4-Methoxyestrone 3-glucuronide | Metabolite | LMST05010071 (LIPID MAPS) | |
4-Methoxyestrone | Metabolite | LMST02010057 (LIPID MAPS) | |
AKR1C3 | GeneProduct | P42330 (Uniprot-TrEMBL) | |
Androstenedione | Metabolite | LMST02020007 (LIPID MAPS) | |
COMT | GeneProduct | P21964 (Uniprot-TrEMBL) | |
CYP19A1 | GeneProduct | P11511 (Uniprot-TrEMBL) | |
CYP1A1 | GeneProduct | Q0VHD5 (Uniprot-TrEMBL) | |
CYP1A2 | GeneProduct | P05177 (Uniprot-TrEMBL) | |
CYP1B1 | GeneProduct | Q16678 (Uniprot-TrEMBL) | |
CYP2C19 | GeneProduct | P33261 (Uniprot-TrEMBL) | |
CYP2C8 | GeneProduct | P10632 (Uniprot-TrEMBL) | |
CYP2C9 | GeneProduct | P11712 (Uniprot-TrEMBL) | |
CYP3A4 | GeneProduct | P08684 (Uniprot-TrEMBL) | |
CYP3A5 | GeneProduct | P20815 (Uniprot-TrEMBL) | |
CYP3A7 | GeneProduct | P24462 (Uniprot-TrEMBL) | |
Estradiol glucuronate | Metabolite | LMST05010007 (LIPID MAPS) | |
Estradiol | Metabolite | LMST02010001 (LIPID MAPS) | |
Estriol | Metabolite | LMST02010003 (LIPID MAPS) | |
Estrone 3-glucuronide | Metabolite | LMST05010011 (LIPID MAPS) | |
Estrone sulfate | Metabolite | LMST02010043 (LIPID MAPS) | |
Estrone | Metabolite | LMST02010004 (LIPID MAPS) | |
HSD17B10 | GeneProduct | Q99714 (Uniprot-TrEMBL) | |
HSD17B12 | GeneProduct | D3DR22 (Uniprot-TrEMBL) | |
HSD17B14 | GeneProduct | Q9BPX1 (Uniprot-TrEMBL) | |
HSD17B1 | GeneProduct | P14061 (Uniprot-TrEMBL) | |
HSD17B2 | GeneProduct | P37059 (Uniprot-TrEMBL) | |
HSD17B3 | GeneProduct | P37058 (Uniprot-TrEMBL) | |
HSD17B4 | GeneProduct | P51659 (Uniprot-TrEMBL) | |
HSD17B7 | GeneProduct | P56937 (Uniprot-TrEMBL) | |
HSD17B8 | GeneProduct | Q92506 (Uniprot-TrEMBL) | |
STS | GeneProduct | P08842 (Uniprot-TrEMBL) | |
SULT1E1 | GeneProduct | P49888 (Uniprot-TrEMBL) | |
Testosterone | Metabolite | LMST02020002 (LIPID MAPS) | |
UGT1A10 | GeneProduct | Q9HAW8 (Uniprot-TrEMBL) | |
UGT1A8 | GeneProduct | Q9HAW9 (Uniprot-TrEMBL) | |
UGT2A2 | GeneProduct | P0DTE5 (Uniprot-TrEMBL) | |
UGT2B7 | GeneProduct | P16662 (Uniprot-TrEMBL) |
Annotated Interactions
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Source | Target | Type | Database reference | Comment |
---|---|---|---|---|
16alpha-Hydroxyestrone | 16alpha-Hydroxyestrone 3-glucuronide | mim-conversion | 52449 (Rhea) | EC:2.4.1.17 |
16alpha-Hydroxyestrone | 16alpha-Hydroxyestrone 16-glucuronide | mim-conversion | 52453 (Rhea) | EC:2.4.1.17 |
2-Hydroxyestradiol | 2-Methoxyestradiol | mim-conversion | 53089 (Rhea) | EC:2.1.1.6 |
2-Hydroxyestrone | 2-Methoxyestrone | mim-conversion | 53101 (Rhea) | EC:2.1.1.6 |
2-Methoxyestradiol | 2-Methoxy-17beta-estradiol 3-glucuronide | mim-conversion | 53081 (Rhea) | EC:2.4.1.17 |
2-Methoxyestrone | 2-Methoxyestrone 3-glucuronide | mim-conversion | 53065 (Rhea) | EC:2.4.1.17 |
4-Hydroxyestradiol | 4-Methoxyestradiol | mim-conversion | 53097 (Rhea) | EC:2.1.1.6 |
4-Hydroxyestrone | 4-Methoxyestrone | mim-conversion | 53105 (Rhea) | EC:2.1.1.6 |
4-Methoxyestradiol | 4-Methoxy-17beta-estradiol 3-glucuronide | mim-conversion | 53073 (Rhea) | EC:2.4.1.17 |
4-Methoxyestrone | 4-Methoxyestrone 3-glucuronide | mim-conversion | 53069 (Rhea) | EC:2.4.1.17 |
Androstenedione | Estrone | mim-conversion | 38196 (Rhea) | EC:1.14.14.14 |
Androstenedione | Testosterone | mim-conversion | 14931 (Rhea) | |
Estradiol | 2-Hydroxyestradiol | mim-conversion | 47213 (Rhea) | EC:1.14.14.1 |
Estradiol | 4-Hydroxyestradiol | mim-conversion | 47281 (Rhea) | EC:1.14.14.1 |
Estradiol | Estradiol glucuronate | mim-conversion | 52461 (Rhea) | EC:2.4.1.17 |
Estradiol | Estriol | mim-conversion | 47333 (Rhea) | EC:1.14.14.1 |
Estradiol | Estrone | mim-conversion | 24612 (Rhea) | |
Estrone sulfate | Estrone | mim-conversion | 31056 (Rhea) | EC:3.1.6.2 |
Estrone | 16alpha-Hydroxyestrone | mim-conversion | 47205 (Rhea) | EC:1.14.14.1 |
Estrone | 2-Hydroxyestrone | mim-conversion | 47209 (Rhea) | EC:1.14.13 |
Estrone | 4-Hydroxyestrone | mim-conversion | 47293 (Rhea) | EC:1.14.14.1 |
Estrone | Estradiol | mim-conversion | 24618 (Rhea) | |
Estrone | Estrone 3-glucuronide | mim-conversion | 52477 (Rhea) | EC:2.4.1.17 |
Estrone | Estrone sulfate | mim-conversion | 15974 (Rhea) | EC:2.8.2.4 |
Testosterone | Androstenedione | mim-conversion | 14930 (Rhea) | EC:1.1.1.51 |
Testosterone | Estradiol | mim-conversion | 38192 (Rhea) | EC:1.14.14.14 |