Estrogen metabolism (Homo sapiens)

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314212122HSD17B3CYP1A2STS2-Methoxyestradiol4-HydroxyestradiolCYP2C19COMTEstradiolglucuronateCYP2C8CYP3A42-MethoxyestroneEstradiol4-MethoxyestradiolEstroneHSD17B14-HydroxyestroneCYP3A5CYP1A116alpha-Hydroxyestrone 16-glucuronideCYP2C9Testosterone16alpha-hydroxyestrone2-HydroxyestradiolHSD17B7HSD17B2HSD17B1Estriol4-MethoxyestroneEstrone sulfateUGT2B7SULT1E1HSD17B84-methoxy-17beta-estradiol3-glucuronide2-Methoxyestrone3-glucuronideHSD17B14UGT2A2Estrone3-glucuronideAndrostenedione16alpha-Hydroxyestrone3-glucuronideHSD17B4HSD17B12CYP3A7AKR1C3HSD17B2HSD17B44-methoxyestrone 3-glucuronideUGT1A10CYP19A12-methoxy-17beta-estradiol3-glucuronide2-hydroxyestroneHSD17B10CYP1B1AKR1C3COMTCYP1B1CYP3A5CYP2C9CYP3A4CYP1A2CYP1A1CYP2C19CYP1B1CYP3A5CYP2C8CYP3A4CYP1A2CYP1A1UGT1A10UGT1A8UGT1A8


Description

Estrogen synthesis and metabolism. Data from W. Griffiths. All metabolic reactions in this pathway model have been annotated with a Rhea identifier.

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Ontology Terms

 

Bibliography

  1. Kallionpää RA, Järvinen E, Finel M; ''Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.''; J Steroid Biochem Mol Biol, 2015 PubMed Europe PMC Scholia
  2. Lépine J, Bernard O, Plante M, Têtu B, Pelletier G, Labrie F, Bélanger A, Guillemette C; ''Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.''; J Clin Endocrinol Metab, 2004 PubMed Europe PMC Scholia
  3. Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, Shackleton CHL, Storbeck KH; ''Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.''; J Steroid Biochem Mol Biol, 2019 PubMed Europe PMC Scholia
  4. Sneitz N, Vahermo M, Mosorin J, Laakkonen L, Poirier D, Finel M; ''Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.''; Drug Metab Dispos, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126877view14:56, 29 June 2023DeSlAdded info on Rhea IDs in description
126876view14:51, 29 June 2023WilliamJGriffiths
126875view14:45, 29 June 2023DeSlConnected unconnected line
125492view10:21, 20 February 2023LinaSchifferModified description
125451view14:35, 14 February 2023Conroy lipidsfix typos, box sizes
125449view14:14, 14 February 2023Conroy lipidsexpert corrections
124302view11:29, 12 October 2022Conroy lipidsadded a couple of missing rhea IDs
123930view09:06, 2 September 2022Conroy lipids
123929view08:26, 2 September 2022Conroy lipids
123928view06:50, 2 September 2022Conroy lipidsadd glucuronides, refs, rhea
123923view16:04, 31 August 2022Conroy lipidsadded refs, new glucuronid metabolites
123922view12:32, 31 August 2022Conroy lipidsadd glucuroniate, rheas, refs
123921view12:18, 31 August 2022Conroy lipidsadd overall ref and some Rhea IDs
123723view14:44, 11 August 2022Conroy lipids
123721view14:35, 11 August 2022Conroy lipidsmssing anchor
123719view14:29, 11 August 2022Conroy lipidsmissing anchor fixed
123712view13:46, 11 August 2022Conroy lipidsadd anchors to conversions
123708view09:29, 11 August 2022Conroy lipidsOntology Term : 'steroid biosynthetic pathway' added !
123707view09:28, 11 August 2022Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
123706view09:28, 11 August 2022Conroy lipidsOntology Term : 'classic metabolic pathway' added !
123683view14:14, 9 August 2022EgonwFixed a datasource
123681view11:34, 9 August 2022Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
16alpha-Hydroxyestrone 3-glucuronideMetaboliteLMST05010070 (LIPID MAPS)
16alpha-Hydroxyestrone 16-glucuronideMetaboliteLMST05010069 (LIPID MAPS)
16alpha-hydroxyestroneMetaboliteLMST02010041 (LIPID MAPS)
2-HydroxyestradiolMetaboliteLMST02010027 (LIPID MAPS)
2-MethoxyestradiolMetaboliteLMST02010035 (LIPID MAPS)
2-Methoxyestrone 3-glucuronideMetaboliteLMST05010010 (LIPID MAPS)
2-MethoxyestroneMetaboliteLMST02010033 (LIPID MAPS)
2-hydroxyestroneMetaboliteLMST02010032 (LIPID MAPS)
2-methoxy-17beta-estradiol 3-glucuronideMetaboliteLMST05010009 (LIPID MAPS)
4-HydroxyestradiolMetaboliteLMST02010028 (LIPID MAPS)
4-HydroxyestroneMetaboliteLMST02010056 (LIPID MAPS)
4-MethoxyestradiolMetaboliteLMST02010055 (LIPID MAPS)
4-MethoxyestroneMetaboliteLMST02010057 (LIPID MAPS)
4-methoxy-17beta-estradiol 3-glucuronideMetaboliteLMST05010072 (LIPID MAPS)
4-methoxyestrone 3-glucuronideMetaboliteLMST05010071 (LIPID MAPS)
AKR1C3GeneProductP42330 (Uniprot-TrEMBL)
AndrostenedioneMetaboliteLMST02020007 (LIPID MAPS)
COMTGeneProductP21964 (Uniprot-TrEMBL)
CYP19A1GeneProductP11511 (Uniprot-TrEMBL)
CYP1A1GeneProductQ0VHD5 (Uniprot-TrEMBL)
CYP1A2GeneProductP05177 (Uniprot-TrEMBL)
CYP1B1GeneProductQ16678 (Uniprot-TrEMBL)
CYP2C19GeneProductP33261 (Uniprot-TrEMBL)
CYP2C8GeneProductP10632 (Uniprot-TrEMBL)
CYP2C9GeneProductP11712 (Uniprot-TrEMBL)
CYP3A4GeneProductP08684 (Uniprot-TrEMBL)
CYP3A5GeneProductP20815 (Uniprot-TrEMBL)
CYP3A7GeneProductP24462 (Uniprot-TrEMBL)
Estradiol glucuronateMetaboliteLMST05010007 (LIPID MAPS)
EstradiolMetaboliteLMST02010001 (LIPID MAPS)
EstriolMetaboliteLMST02010003 (LIPID MAPS)
Estrone 3-glucuronideMetaboliteLMST05010011 (LIPID MAPS)
Estrone sulfateMetaboliteLMST02010043 (LIPID MAPS)
EstroneMetaboliteLMST02010004 (LIPID MAPS)
HSD17B10GeneProductQ99714 (Uniprot-TrEMBL)
HSD17B12GeneProductD3DR22 (Uniprot-TrEMBL)
HSD17B14GeneProductQ9BPX1 (Uniprot-TrEMBL)
HSD17B1GeneProductP14061 (Uniprot-TrEMBL)
HSD17B2GeneProductP37059 (Uniprot-TrEMBL)
HSD17B3GeneProductP37058 (Uniprot-TrEMBL)
HSD17B4GeneProductP51659 (Uniprot-TrEMBL)
HSD17B7GeneProductP56937 (Uniprot-TrEMBL)
HSD17B8GeneProductQ92506 (Uniprot-TrEMBL)
STSGeneProductP08842 (Uniprot-TrEMBL)
SULT1E1GeneProductP49888 (Uniprot-TrEMBL)
TestosteroneMetaboliteLMST02020002 (LIPID MAPS)
UGT1A10GeneProductQ9HAW8 (Uniprot-TrEMBL)
UGT1A8GeneProductQ9HAW9 (Uniprot-TrEMBL)
UGT2A2GeneProductP0DTE5 (Uniprot-TrEMBL)
UGT2B7GeneProductP16662 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
16alpha-hydroxyestrone16alpha-Hydroxyestrone 3-glucuronidemim-conversion52449 (Rhea) EC:2.4.1.17
16alpha-hydroxyestrone16alpha-Hydroxyestrone 16-glucuronidemim-conversion52453 (Rhea) EC:2.4.1.17
2-Hydroxyestradiol2-Methoxyestradiolmim-conversion53089 (Rhea) EC:2.1.1.6
2-Methoxyestradiol2-methoxy-17beta-estradiol 3-glucuronidemim-conversion53081 (Rhea) EC:2.4.1.17
2-Methoxyestrone2-Methoxyestrone 3-glucuronidemim-conversion53065 (Rhea) EC:2.4.1.17
2-hydroxyestrone2-Methoxyestronemim-conversion53101 (Rhea) EC:2.1.1.6
4-Hydroxyestradiol4-Methoxyestradiolmim-conversion53097 (Rhea) EC:2.1.1.6
4-Hydroxyestrone4-Methoxyestronemim-conversion53105 (Rhea) EC:2.1.1.6
4-Methoxyestradiol4-methoxy-17beta-estradiol 3-glucuronidemim-conversion53073 (Rhea) EC:2.4.1.17
4-Methoxyestrone4-methoxyestrone 3-glucuronidemim-conversion53069 (Rhea) EC:2.4.1.17
AndrostenedioneEstronemim-conversion38196 (Rhea) EC:1.14.14.14
AndrostenedioneTestosteronemim-conversion14931 (Rhea)
Estradiol2-Hydroxyestradiolmim-conversion47213 (Rhea) EC:1.14.14.1
Estradiol4-Hydroxyestradiolmim-conversion47281 (Rhea) EC:1.14.14.1
EstradiolEstradiol glucuronatemim-conversion52461 (Rhea) EC:2.4.1.17
EstradiolEstriolmim-conversion47333 (Rhea) EC:1.14.14.1
EstradiolEstronemim-conversion24612 (Rhea)
Estrone sulfateEstronemim-conversion31056 (Rhea) EC:3.1.6.2
Estrone16alpha-hydroxyestronemim-conversion47205 (Rhea) EC:1.14.14.1
Estrone2-hydroxyestronemim-conversion47209 (Rhea) EC:1.14.13
Estrone4-Hydroxyestronemim-conversion47293 (Rhea) EC:1.14.14.1
EstroneEstradiolmim-conversion24618 (Rhea)
EstroneEstrone 3-glucuronidemim-conversion52477 (Rhea) EC:2.4.1.17
EstroneEstrone sulfatemim-conversion15974 (Rhea) EC:2.8.2.4
TestosteroneAndrostenedionemim-conversion14930 (Rhea) EC:1.1.1.51
TestosteroneEstradiolmim-conversion38192 (Rhea) EC:1.14.14.14
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