Mineralocorticoid biosynthesis (Homo sapiens)

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21HSD11B2AKR1C45beta-dihydrodeoxycorticosteroneCYP21A2AKR1C1Steroid hormone precursor biosynthesis3alpha,11beta,18,21-tetrahydroxy-5beta-pregnan-20-oneAldosterone 18-glucuronideAllotetrahydrocorticosterone11-DehydrocorticosteroneUGT2B7SRD5A2Alfadolone5alpha-pregnan-21-ol-3,11,20-trioneHSD11B1SRD5A1AKR1D1CorticosteroneTetrahydroaldosterone18-Hydroxycorticosterone18-Hydroxy-11-dehydrotetrahydrocorticosteroneTetrahydrocorticosterone3alpha,21-dihydroxy-5beta-pregnane-11,20-dioneHSD11B25alpha-DihydrocorticosteroneAKR1C3Aldosterone5beta-Dihydrocorticosterone5beta-DihydroaldosteroneCYP11B1AKR1D1CYP11B25beta-pregnan-21-ol-3,11,20-trione11β,18,21-trihydroxy-5β-pregnan-3,20-dioneUGT1A105beta-dihydrodeoxycorticosterone11-deoxycorticosteroneProgesteroneAKR1D1AKR1D1AKR1D1CYP11B2CYP11B2SRD5A2SRD5A1AKR1C2AKR1C4AKR1C3AKR1C1AKR1C2AKR1C4AKR1C3AKR1C1AKR1C2AKR1C4AKR1C3AKR1C1AKR1C2


Description

Mineralocorticoid synthesis and metabolism, which produce adrenal steroid hormones from cholesterol. These hromones regulate sodium retention in the kidneys and are therefore essential in sodium balance, intravascular volume, and blood pressure [PMID:8839934].

The pathway knowledge depicted in this model stems from William Griffths.

Metabolic reactions currently without a Rhea ID have been added in bold to the pathway model.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, Shackleton CHL, Storbeck KH; ''Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.''; J Steroid Biochem Mol Biol, 2019 PubMed Europe PMC Scholia
  2. C Fardella, W Miller; ''Molecular biology of mineralocorticoid metabolism''; Annu Rev Nutr ., 1996 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126878view15:01, 29 June 2023DeSlAdded Rhea info in introduction
125494view10:29, 20 February 2023LinaSchifferModified description
125454view20:54, 14 February 2023EgonwAll TrEMBL
125448view13:44, 14 February 2023Conroy lipidsadd more enzymes
124378view09:41, 20 October 2022DeSlFound a more general Rhea ID for reaction catalyzed by SRD5A1 and A2
124377view09:19, 20 October 2022DeSlAdded a more elaborate description
124373view09:04, 20 October 2022DeSlChanged width for interactions missing a Rhea ID
124372view09:01, 20 October 2022DeSlUpdated layout of nodes for readability
124370view08:52, 20 October 2022DeSlOntology Term : 'classic metabolic pathway' added !
124368view08:51, 20 October 2022DeSlOntology Term : 'aldosterone biosynthetic pathway' added !
124362view08:45, 20 October 2022DeSlUpdated description
124309view08:00, 13 October 2022Conroy lipidscorrect typo in name
124049view09:36, 15 September 2022DeSlReplace UniProt ID for UGT2B7 to reviewed version.
124048view09:34, 15 September 2022DeSlOntology Term : 'mineralocorticoid biosynthetic pathway' added !
123924view05:17, 2 September 2022EgonwReplace SwissProt with TrEMBL
123906view08:28, 26 August 2022Conroy lipids
123905view08:25, 26 August 2022Conroy lipids
123904view08:19, 26 August 2022Conroy lipids
123903view08:10, 26 August 2022Conroy lipids
123902view07:59, 26 August 2022Conroy lipidsmove rhea annotation from catalysis to conversin
123891view07:58, 25 August 2022Conroy lipidscorrect typo in title
123884view07:49, 24 August 2022Conroy lipids
123883view11:21, 23 August 2022Conroy lipids
123882view11:04, 23 August 2022Conroy lipids
123881view10:52, 23 August 2022Conroy lipids
123878view10:22, 23 August 2022Conroy lipidsanchors
123877view10:11, 23 August 2022Conroy lipids
123870view10:38, 22 August 2022Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
123869view10:37, 22 August 2022Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-DehydrocorticosteroneMetaboliteLMST02030284 (LIPID MAPS)
11-deoxycorticosteroneMetaboliteLMST02030087 (LIPID MAPS)
11β,18,21-trihydroxy-5β-pregnan-3,20-dioneMetaboliteLMST02030277 (LIPID MAPS)
18-Hydroxy-11-dehydrotetrahydrocorticosteroneMetaboliteLMST02030279 (LIPID MAPS)
18-HydroxycorticosteroneMetaboliteLMST02030091 (LIPID MAPS)
3alpha,11beta,18,21-tetrahydroxy-5beta-pregnan-20-oneMetaboliteLMST02030278 (LIPID MAPS)
3alpha,21-dihydroxy-5beta-pregnane-11,20-dioneMetaboliteLMST02030288 (LIPID MAPS)
5alpha-DihydrocorticosteroneMetaboliteLMST02030281 (LIPID MAPS)
5alpha-pregnan-21-ol-3,11,20-trioneMetaboliteLMST02030286 (LIPID MAPS)
5beta-DihydroaldosteroneMetaboliteLMST02030276 (LIPID MAPS)
5beta-DihydrocorticosteroneMetaboliteLMST02030280 (LIPID MAPS)
5beta-dihydrodeoxycorticosteroneMetaboliteLMST02030282 (LIPID MAPS)
5beta-dihydrodeoxycorticosteroneMetaboliteLMST02030283 (LIPID MAPS)
5beta-pregnan-21-ol-3,11,20-trioneMetaboliteLMST02030285 (LIPID MAPS)
AKR1C1GeneProductQ04828 (Uniprot-TrEMBL)
AKR1C2GeneProductP52895 (Uniprot-TrEMBL)
AKR1C3GeneProductP42330 (Uniprot-TrEMBL)
AKR1C4GeneProductP17516 (Uniprot-TrEMBL)
AKR1D1GeneProductP51857 (Uniprot-TrEMBL)
Aldosterone 18-glucuronideMetaboliteLMST05010062 (LIPID MAPS)
AldosteroneMetaboliteLMST02030026 (LIPID MAPS)
AlfadoloneMetaboliteLMST02030287 (LIPID MAPS)
AllotetrahydrocorticosteroneMetaboliteLMST02030142 (LIPID MAPS)
CYP11B1GeneProductP15538 (Uniprot-TrEMBL)
CYP11B2GeneProductP19099 (Uniprot-TrEMBL)
CYP21A2GeneProductP08686 (Uniprot-TrEMBL)
CorticosteroneMetaboliteLMST02030186 (LIPID MAPS)
HSD11B1GeneProductP28845 (Uniprot-TrEMBL)
HSD11B2GeneProductP80365 (Uniprot-TrEMBL)
ProgesteroneMetaboliteLMST02030159 (LIPID MAPS)
SRD5A1GeneProductP18405 (Uniprot-TrEMBL)
SRD5A2GeneProductP31213 (Uniprot-TrEMBL)
Steroid hormone precursor biosynthesisPathwayWP5277 (WikiPathways)
TetrahydroaldosteroneMetaboliteLMST02030275 (LIPID MAPS)
TetrahydrocorticosteroneMetaboliteLMST02030100 (LIPID MAPS)
UGT1A10GeneProductQ9HAW8 (Uniprot-TrEMBL)
UGT2B7GeneProductP16662 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
11-Dehydrocorticosterone5alpha-pregnan-21-ol-3,11,20-trionemim-conversion54386 (Rhea) Tentatively annotated with this more general Rhea ID.
11-DehydrocorticosteroneCorticosteronemim-conversion42202 (Rhea) EC:1.1.1.146
11-deoxycorticosterone5beta-dihydrodeoxycorticosteronemim-conversion46669 (Rhea) EC:1.3.1.3
11-deoxycorticosteroneCorticosteronemim-conversion46105 (Rhea)
18-HydroxycorticosteroneAldosteronemim-conversion50793 (Rhea)
Aldosterone5beta-Dihydroaldosteronemim-conversion46673 (Rhea) EC:1.3.1.3
Corticosterone11-Dehydrocorticosteronemim-conversion42205 (Rhea)
Corticosterone18-Hydroxycorticosteronemim-conversion11873 (Rhea) EC:1.14.15.4
Corticosterone5beta-Dihydrocorticosteronemim-conversion46665 (Rhea) EC:1.3.1.3
Progesterone11-deoxycorticosteronemim-conversion50305 (Rhea) EC:1.14.14.16
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