Neolacto series sphingolipid metabolism (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. ''Handbook of Glycosyltransferases and Related Genes''; doi.org/10.1007/978-4-431-67877-9, 2002
2. Merril AH Jr; ''SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids.''; Glycobiology, 2005 PubMed Europe PMC Scholia
3. Yamashiro S, Haraguchi M, Furukawa K, Takamiya K, Yamamoto A, Nagata Y, Lloyd KO, Shiku H; ''Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.''; J Biol Chem, 1995 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	124624	view	14:24, 17 November 2022	Conroy lipids	another metabolight
	124623	view	13:47, 17 November 2022	Conroy lipids	a couple more steps from sphingomap- no synthesis data available in rhea
	124619	view	15:52, 16 November 2022	Conroy lipids	Ontology Term : 'glycosphingolipid metabolic pathway' added !
	124618	view	15:52, 16 November 2022	Conroy lipids	Ontology Term : 'lipid metabolic pathway' added !
	124617	view	15:52, 16 November 2022	Conroy lipids	Ontology Term : 'PW:0000164' removed !
	124616	view	15:34, 16 November 2022	Conroy lipids
	124615	view	15:22, 16 November 2022	Conroy lipids	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
B3GNT5	GeneProduct	Q9BYG0 (Uniprot-TrEMBL)
B4GALT1	GeneProduct	P15291 (Uniprot-TrEMBL)
B4GALT3	GeneProduct	O60512 (Uniprot-TrEMBL)
B4GALT4	GeneProduct	O60513 (Uniprot-TrEMBL)
FUCA1	GeneProduct	P04066 (Uniprot-TrEMBL)
FUT1	GeneProduct	P19526 (Uniprot-TrEMBL)
FUT2	GeneProduct	Q10981 (Uniprot-TrEMBL)
FUT5	GeneProduct	Q11128 (Uniprot-TrEMBL)
H1 glycolipid, type II antigen	Metabolite	LMSP0505AD00 (LIPID MAPS)
LacCer	Metabolite	LMSP0501AB00 (LIPID MAPS)
Lc3Cer	Metabolite	LMSP0504AA00 (LIPID MAPS)
NAGA	GeneProduct	P17050 (Uniprot-TrEMBL)
NEU2	GeneProduct	Q9Y3R4 (Uniprot-TrEMBL)
NeuAcα2-8NeuAcα2-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ-Cer	Metabolite	LMSP0601EG00 (LIPID MAPS)
SSEA-1, Lex-5	Metabolite	LMSP0505AB00 (LIPID MAPS)
ST3GAL4	GeneProduct	Q11206 (Uniprot-TrEMBL)
Sialosylparagloboside	Metabolite	LMSP0601EF00 (LIPID MAPS)
Sialyl LeX	Metabolite	LMSP0601EE00 (LIPID MAPS)
Type II A antigen	Metabolite	LMSP0505AF00 (LIPID MAPS)
nLc4Cer	Metabolite	LMSP0505AA00 (LIPID MAPS)	ChEBI 17292, Smap 8
nLc5Cer	Metabolite	LMSP0505AK00 (LIPID MAPS)
nLc6Cer i antigen	Metabolite	LMSP0505AL00 (LIPID MAPS)

Annotated Interactions

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Source	Target	Type	Database reference	Comment
H1 glycolipid, type II antigen	nLc4Cer	mim-conversion	48225 (Rhea)
LacCer	Lc3Cer	mim-conversion	13906 (Rhea)
Lc3Cer	nLc4Cer	mim-conversion	31500 (Rhea)
Sialosylparagloboside	nLc4Cer	mim-conversion	47853 (Rhea)
Type II A antigen	H1 glycolipid, type II antigen	mim-conversion	48213 (Rhea)
nLc4Cer	H1 glycolipid, type II antigen	mim-conversion	48305 (Rhea)
nLc4Cer	SSEA-1, Lex-5	mim-conversion	48333 (Rhea)
nLc4Cer	Sialosylparagloboside	mim-conversion	18914 (Rhea)
nLc4Cer	nLc5Cer	mim-conversion	23005 (Rhea)