Autophagy in pancreatic ductal adenocarcinoma (Homo sapiens)

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AutophagyProliferationImmunal disruptionAccumulationMDM2KRASATG7MAP1LC3BSHOC2AGERReactive oxygen species TFEBPRKNBECN1SQSTM1NFKB1STAT3NFE2L2HMGB1MITFIPO8mTOR signalingTP53PINK1MAPK signalingTFE3VMP11, 2411, 21, 3431, 21, 331, 244441341, 341, 34


Description

This pathway demonstrates autophagy upregulation during pancreatic ductal adenocarcinoma (PDAC). It covers autophagy accumulation as well as how this promotes cell proliferation in tumor microenvironment. Autophagy in PDAC affects mTOR signaling pathways as well as MAPK signaling pathway.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Congting Guo, Ying Zhao; ''Autophagy in pancreatic cancer''; J Mol Cell Biol ., 2022 PubMed Europe PMC Scholia
  2. Todoric et al; ''Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas''; Cancer Cell ., 2017 PubMed Europe PMC Scholia
  3. Maria New, Tim Van Acker, Jaclyn S Long, Jun-Ichi Sakamaki, Kevin M Ryan, Sharon A Tooze; ''Molecular Pathways Controlling Autophagy in Pancreatic Cancer''; Front Oncol ., 2017 PubMed Europe PMC Scholia
  4. Li et al.; ''Regulation and function of autophagy in pancreatic cancer''; Autophagy ., 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134466view00:31, 22 July 2024EweitzEconomize layout
134465view00:29, 22 July 2024EweitzEconomize layout
134464view00:29, 22 July 2024EweitzEconomize layout, tailor node dimensions
134463view00:24, 22 July 2024EweitzOntology Term : 'adenocarcinoma' added !
134462view00:23, 22 July 2024EweitzOntology Term : 'pancreatic ductal adenocarcinoma' added !
134461view00:23, 22 July 2024EweitzOntology Term : 'pancreatic cancer' added !
134460view00:23, 22 July 2024EweitzOntology Term : 'cancer' added !
126176view13:34, 12 April 2023NcananfilizLayout changes
126173view11:09, 12 April 2023NcananfilizOntology Term : 'DOID:4' removed !
126172view11:09, 12 April 2023NcananfilizOntology Term : 'disease pathway' added !
126171view11:09, 12 April 2023NcananfilizOntology Term : 'Disease' added !
125779view09:24, 10 March 2023IsabelWassinkfix publication references
125727view09:32, 8 March 2023IsabelWassinkOntology Term : 'autophagy pathway' added !
125726view09:16, 8 March 2023IsabelWassinkProtein changed to gene product
125725view09:14, 8 March 2023IsabelWassinkIdentifiers altered
125724view09:09, 8 March 2023IsabelWassinkModified description
125694view13:06, 7 March 2023NcananfilizSome nodes are re-alligned
125692view12:57, 7 March 2023NcananfilizRe-sizing of some of the nodes
125681view00:06, 7 March 2023NcananfilizModified description
125680view23:35, 6 March 2023NcananfilizROS name change and deleted comments
125673view16:31, 6 March 2023DeSlUpdated last refs
125672view16:29, 6 March 2023DeSlUpdated a ref
125613view12:21, 4 March 2023EgonwMade two pathways clickable
125555view13:11, 27 February 2023IsabelWassinkModified title
125554view13:08, 27 February 2023IsabelWassinkOntology Term : 'pancreatic cancer pathway' added !
125553view13:06, 27 February 2023NcananfilizNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AGERGeneProductENSG00000204305 (Ensembl)
ATG7GeneProductENSG00000197548 (Ensembl)
BECN1GeneProductENSG00000126581 (Ensembl)
HMGB1GeneProductENSG00000189403 (Ensembl)
IPO8GeneProductENSG00000133704 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAP1LC3BGeneProductENSG00000140941 (Ensembl)
MAPK signalingPathwayWP382 (WikiPathways)
MDM2GeneProductENSG00000135679 (Ensembl)
MITFGeneProductENSG00000187098 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
PINK1GeneProductENSG00000158828 (Ensembl)
PRKNGeneProductENSG00000185345 (Ensembl)
Reactive oxygen species MetaboliteCHEBI:26523 (ChEBI)
SHOC2GeneProductENSG00000108061 (Ensembl)
SQSTM1GeneProductENSG00000161011 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TFE3GeneProductENSG00000068323 (Ensembl)
TFEBGeneProductENSG00000112561 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
VMP1GeneProductENSG00000062716 (Ensembl)
mTOR signalingPathwayWP3318 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5331"
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