Autophagy in pancreatic ductal adenocarcinoma (Homo sapiens)

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AutophagyAccumulationImmunal disruptionProliferationNFKB1VMP1reactive oxygen species KRASSQSTM1SHOC2MAP1LC3BTFEBTFE3mTOR signalingMAPK signalingNFE2L2HMGB1AGERBECN1STAT3TP53ATG7PINK1PRKNMDM2IPO8MITF1, 21, 2441, 344343411, 31, 241, 31, 2411, 343


Description

This pathway demonstrates autophagy upregulation during pancreatic ductal adenocarcinoma (PDAC). It covers autophagy accumulation as well as how this promotes cell proliferation in tumor microenvironment. Autophagy in PDAC affects mTOR signaling pathways as well as MAPK signaling pathway.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Congting Guo, Ying Zhao; ''Autophagy in pancreatic cancer''; J Mol Cell Biol ., 2022 PubMed Europe PMC Scholia
  2. Todoric et al; ''Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas''; Cancer Cell ., 2017 PubMed Europe PMC Scholia
  3. Maria New, Tim Van Acker, Jaclyn S Long, Jun-Ichi Sakamaki, Kevin M Ryan, Sharon A Tooze; ''Molecular Pathways Controlling Autophagy in Pancreatic Cancer''; Front Oncol ., 2017 PubMed Europe PMC Scholia
  4. Li et al.; ''Regulation and function of autophagy in pancreatic cancer''; Autophagy ., 2021 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126176view13:34, 12 April 2023NcananfilizLayout changes
126173view11:09, 12 April 2023NcananfilizOntology Term : 'DOID:4' removed !
126172view11:09, 12 April 2023NcananfilizOntology Term : 'disease pathway' added !
126171view11:09, 12 April 2023NcananfilizOntology Term : 'Disease' added !
125779view09:24, 10 March 2023IsabelWassinkfix publication references
125727view09:32, 8 March 2023IsabelWassinkOntology Term : 'autophagy pathway' added !
125726view09:16, 8 March 2023IsabelWassinkProtein changed to gene product
125725view09:14, 8 March 2023IsabelWassinkIdentifiers altered
125724view09:09, 8 March 2023IsabelWassinkModified description
125694view13:06, 7 March 2023NcananfilizSome nodes are re-alligned
125692view12:57, 7 March 2023NcananfilizRe-sizing of some of the nodes
125681view00:06, 7 March 2023NcananfilizModified description
125680view23:35, 6 March 2023NcananfilizROS name change and deleted comments
125673view16:31, 6 March 2023DeSlUpdated last refs
125672view16:29, 6 March 2023DeSlUpdated a ref
125613view12:21, 4 March 2023EgonwMade two pathways clickable
125555view13:11, 27 February 2023IsabelWassinkModified title
125554view13:08, 27 February 2023IsabelWassinkOntology Term : 'pancreatic cancer pathway' added !
125553view13:06, 27 February 2023NcananfilizNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AGERGeneProductENSG00000204305 (Ensembl)
ATG7GeneProductENSG00000197548 (Ensembl)
BECN1GeneProductENSG00000126581 (Ensembl)
HMGB1GeneProductENSG00000189403 (Ensembl)
IPO8GeneProductENSG00000133704 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAP1LC3BGeneProductENSG00000140941 (Ensembl)
MAPK signalingPathwayWP382 (WikiPathways)
MDM2GeneProductENSG00000135679 (Ensembl)
MITFGeneProductENSG00000187098 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
PINK1GeneProductENSG00000158828 (Ensembl)
PRKNGeneProductENSG00000185345 (Ensembl)
SHOC2GeneProductENSG00000108061 (Ensembl)
SQSTM1GeneProductENSG00000161011 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TFE3GeneProductENSG00000068323 (Ensembl)
TFEBGeneProductENSG00000112561 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
VMP1GeneProductENSG00000062716 (Ensembl)
mTOR signalingPathwayWP3318 (WikiPathways)
reactive oxygen species MetaboliteCHEBI:26523 (ChEBI)

Annotated Interactions

No annotated interactions

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