Enterohepatic circulation of bile acids (Homo sapiens)

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COLONOCYTEILEOCYTEHEPATOCYTERENAL PROXIMALTUBULE CELLHEPATOCYTE1ILEUMSYSTEMIC CIRCULATIONLIVERATPBile Acid SynthesisOATP1B1ILBPNTCPBile AcidsNa+taurine (T) conjugated bile acids (BA) : T-BAglycine (G) conjugated bile acids (BA) : G-BAT-BANa+G-BABILECanalicular effluxOATP1B3BASulfate (S) conjugatedbile acids (BA) : S-BAGlucuronide (U) conjugatedbile acids (BA) : U-BAS-BAU-BAMRP2hydroxylation (H) conjugatedbile acids (BA) : H-BAH-BAMDR1Sulfate (S) conjugatedbile acids (BA) : S-BAGlucuronide (U) conjugatedbile acids (BA) : U-BAS-BAU-BAMRP3taurine (T) conjugated bile acids (BA) : T-BAglycine (G) conjugated bile acids (BA) : G-BAT-BAG-BABSEPMRP4T-BAG-BAT-BAG-BAOSTαOSTβOSTαOSTβCOLONOSTαOSTβKIDNEY,URINARYOUTPUTFECAL OUTPUTPORTAL VEINASBTASBTASBTOSTαOSTβMRP2MRP3MRP4taurine (T) conjugated bile acids (BA) : T-BANa+glycine (G) conjugated bile acids (BA) : G-BAT-BANa+G-BASulfate (S) conjugatedbile acids (BA) : S-BAGlucuronide (U) conjugatedbile acids (BA) : U-BAS-BAU-BAS-BAU-BASulfate (S) conjugatedbile acids (BA) : S-BAGlucuronide (U) conjugatedbile acids (BA) : U-BAT-BAG-BAtaurine (T) conjugated bile acids (BA) : T-BAglycine (G) conjugated bile acids (BA) : G-BAtaurine (T) conjugated bile acids (BA) : T-BAglycine (G) conjugated bile acids (BA) : G-BAT-BAG-BAtaurine (T) conjugated bile acids (BA) : T-BANa+glycine (G) conjugated bile acids (BA) : G-BAT-BANa+G-BAtaurine (T) conjugated bile acids (BA) : T-BAglycine (G) conjugated bile acids (BA) : G-BAS-BAU-BASulfate (S) conjugatedbile acids (BA) : S-BAGlucuronide (U) conjugatedbile acids (BA) : U-BAMRP2Sulfate (S) conjugatedbile acids (BA) : S-BAGlucuronide (U) conjugatedbile acids (BA) : U-BAMRP3BABile AcidsS-BASulfate (S) conjugatedbile acids (BA) : S-BAGlucuronide (U) conjugatedbile acids (BA) : U-BASulfate (S) conjugatedbile acids (BA) : S-BAGlucuronide (U) conjugatedbile acids (BA) : U-BAMRP2MRP3U-BABile AcidsNa+Na+Na+Na+Na+Na+Na+Na+ATPATPATPATPATPATPATPATPATPATPATPATP


Description

Enterohepatic circulation of bile acids showing the individual transport proteins in hepatocytes, ileocytes (ileal enterocytes), and renal proximal tubule cells. The reactions depicted in this pathway provide a continuous supply of bile acids, which are required for the digestion of food. This transport system also reduces fecal and urinary bile acid loss, while also restricting these potentially cytotoxic compounds to reach intestinal and hepatobiliary compartments.

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Ontology Terms

 

Bibliography

  1. Paul A. Dawson; ''Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition''; Handb Exp Pharmacol., 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128532view17:57, 11 February 2024EweitzOntology Term : 'hepatocyte' added !
127770view13:18, 3 December 2023EgonwChEBI id for Na+ instead of the "Na" atom
126992view15:03, 12 July 2023DeSlAdded ATP dependant reactions
126989view14:49, 12 July 2023DeSlAdded a more detailed description
126986view14:27, 12 July 2023DeSlConnected enzymes to interactions, added Na involvement
126984view14:14, 12 July 2023DeSlAdded specific hydroxylation conjugate IDs
126983view14:12, 12 July 2023DeSlAdded specific glucuronide conjugate IDs
126982view14:06, 12 July 2023DeSlAdded specific sulfate conjugate IDs
126961view16:08, 7 July 2023DeSlAdded all transport reaction (still need to be connected to enzymes)
126960view15:54, 7 July 2023DeSlAdded transport for renal cells
126959view15:42, 7 July 2023DeSlAdded more visual descriptors from pathway
126958view15:33, 7 July 2023DeSlAdded more transport reactions
126956view15:17, 7 July 2023DeSlAdded first transport reactions to Bile
126954view13:55, 7 July 2023DeSlAnnotated metabolite with group IDs
126953view13:52, 7 July 2023DeSlAdded pathway link
126949view13:38, 7 July 2023DeSlOntology Term : 'bile acid transport pathway' added !
126947view13:36, 7 July 2023DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASBTProteinQ12908 (Uniprot-TrEMBL) AKA SLC10A2
ATPMetaboliteCHEBI:15422 (ChEBI)
BAMetaboliteCHEBI:36078 (ChEBI) Annotated with ChEBI group ID for cholanoids
BSEPProteinO95342 (Uniprot-TrEMBL)
  • AKA ABCB11
  • ATP dependant export of Bile Acids
Bile Acid SynthesisPathwayWP5176 (WikiPathways)
Bile AcidsMetaboliteCHEBI:36078 (ChEBI) Annotated with ChEBI group ID for cholanoids
G-BAMetaboliteCHEBI:36255 (ChEBI) Annotated with ChEBI group ID for bile acid glycine conjugates
Glucuronide (U) conjugated bile acids (BA) : U-BAMetaboliteCHEBI:195350 (ChEBI) Annotated with ChEBI group ID for bile acid glucuronide conjugates
H-BAMetaboliteCHEBI:195351 (ChEBI) Annotated with ChEBI group ID for bile acid hydroxylation conjugates
ILBPProteinP51161 (Uniprot-TrEMBL) AKA FABP6
MDR1ProteinP08183 (Uniprot-TrEMBL)
  • AKA ABCB1A (PMID:21103970), UniProt: ABCB1 (ABCB1A is used for mouse). MDR1A in Figure (PMID:21103970)
  • ATP dependant export of tetrahydroxylated Bile Acids
MRP2ProteinQ92887 (Uniprot-TrEMBL) AKA ABCC2
MRP3ProteinO15438 (Uniprot-TrEMBL) AKA ABCC3
MRP4ProteinO15439 (Uniprot-TrEMBL)
  • AKA ABBC4 (PMID:21103970); according to UniProt ABCC4 is the correct gene name.
  • ATP dependant export of Bile Acids, Bile Acid sulfates/glucuronides
NTCPProteinQ14973 (Uniprot-TrEMBL)
  • AKA SLC10A1
  • Na+ dependant uptake of Bile Acids
Na+MetaboliteCHEBI:29101 (ChEBI)
OATP1B1ProteinQ9Y6L6 (Uniprot-TrEMBL)
  • AKA SLCO1B1
  • Na+ independant uptake of Bile Acids
OATP1B3ProteinQ9NPD5 (Uniprot-TrEMBL)
  • AKA SLCO1B3
  • Na+ independant uptake of Bile Acids
OSTαProteinQ86UW1 (Uniprot-TrEMBL) heteromeric transporter OSTα-OSTβ , assumed to be gene SLC51A based on UniProt entry (gene name not mentioned in publication)
OSTβProteinQ86UW2 (Uniprot-TrEMBL) heteromeric transporter OSTα-OSTβ , assumed to be gene SLC51B based on UniProt entry (gene name not mentioned in publication)
S-BAMetaboliteCHEBI:195349 (ChEBI) Annotated with ChEBI group ID for bile acid sulfate conjugates
Sulfate (S) conjugated bile acids (BA) : S-BAMetaboliteCHEBI:195349 (ChEBI) Annotated with ChEBI group ID for bile acid sulfate conjugates
T-BAMetaboliteCHEBI:23219 (ChEBI) Annotated with ChEBI group ID for bile acid taurine conjugates
U-BAMetaboliteCHEBI:195350 (ChEBI) Annotated with ChEBI group ID for bile acid glucuronide conjugates
glycine (G) conjugated bile acids (BA) : G-BAMetaboliteCHEBI:36255 (ChEBI) Annotated with ChEBI group ID for bile acid glycine conjugates
hydroxylation (H) conjugated bile acids (BA) : H-BAMetaboliteCHEBI:195351 (ChEBI) Annotated with ChEBI group ID for bile acid hydroxylation conjugates
taurine (T) conjugated bile acids (BA) : T-BAMetaboliteCHEBI:23219 (ChEBI) Annotated with ChEBI group ID for bile acid taurine conjugates

Annotated Interactions

No annotated interactions

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