Polyol pathway (Homo sapiens)
From WikiPathways
Description
When glucose is unused, it is metabolized via the polyol pathway. This pathway consists of two main enzymatic steps. First, glucose is reduced to sorbitol by aldose reductase. In this step, NADPH is oxidized to NADP+. The next step is the oxidation of sorbitol to D-fructose by sorbitol dehydrogenase.
Fructose can then be phosphorylated by fructokinase and subsequently be metabolized via dihydroxyacetone phosphate or glyceraldehyde to D-glyceraldehyde 3-phosphate, which can be used as a substrate in the process of glycolysis.
The sorbitol pathway plays a role in diabetic renal complications because aldose reductase metabolizes the excess of glucose to toxic metabolites that induce hyperfiltration and glomerular dysfunction.Quality Tags
Ontology Terms
Bibliography
- Brownlee M; ''Biochemistry and molecular cell biology of diabetic complications.''; Nature, 2001 PubMed Europe PMC Scholia
- Tolan DR; ''Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene.''; Hum Mutat, 1995 PubMed Europe PMC Scholia
- Dunlop M; ''Aldose reductase and the role of the polyol pathway in diabetic nephropathy.''; Kidney Int Suppl, 2000 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
1,4,3,6-dianhydrosorbitol | Metabolite | 16739231 (Chemspider) | |
1,4-anhydrosorbitol | Metabolite | 10953859 (PubChem-compound) | Main reaction product |
1,5-anhydrosorbitol | Metabolite | Q4545703 (Wikidata) | |
ALDOB | GeneProduct | ENSG00000136872 (Ensembl) | |
ALR2 | GeneProduct | 231 (Entrez Gene) | |
D-Fructose | Metabolite | HMDB0000660 (HMDB) | |
D-Glucose | Metabolite | HMDB0000122 (HMDB) | |
D-Glyceraldehyde 3-phosphate | Metabolite | HMDB0001112 (HMDB) | |
D-Sorbitol | Metabolite | HMDB0000247 (HMDB) | |
Dihydroxyacetone phosphate | Metabolite | HMDB0001473 (HMDB) | |
Fructokinase | GeneProduct | ENSG00000138030 (Ensembl) | |
Fructose 1-phosphate | Metabolite | HMDB0001076 (HMDB) | |
Glyceraldehyde | Metabolite | HMDB0001051 (HMDB) | |
Glycolysis | Pathway | WP534 (WikiPathways) | |
Isosorbid | Metabolite | Q1243800 (Wikidata) | |
SORD | GeneProduct | ENSG00000140263 (Ensembl) |
Annotated Interactions
No annotated interactions