Aflatoxin B1 metabolism (Homo sapiens)

From WikiPathways

Jump to: navigation, search
1-4, 7-105, 65, 6nonenzymatic(pH-dependent)nonenzymaticDNA adductsAflatoxin M1Aflatoxin B1 exo-8,9-epoxideCYP2A13Aflatoxin B1 8,9-dihydrodiolaflatoxin B1Aflatoxin Q1Aflatoxin B1-6,8-dialcoholAflatoxin B1 exo-8,9-epoxide-GSHAKR7A3EPHX1Aflatoxin M1 epoxideAflatoxin B1 C6-monoalcoholCYP1A2CYP1A2Aflatoxin B1 C8-monoaldehydeAflatoxin B1 C8-monoalcoholAflatoxin B1 C6-monoaldehydeCYP3A4GSTT1GSTM1Aflatoxin-endo-B1-8,9-epoxideCYP1A2CYP3A4AKR7A2Aflatoxin B1 dialdehydeCYP2A13


Description

Aflatoxins are naturally occurring mycotoxins that are produced by many species of Aspergillus, a fungus, most notably Aspergillus flavus and Aspergillus parasiticus. After entering the body, aflatoxins are metabolized by the liver to a reactive intermediate, aflatoxin M1, an epoxide. Aflatoxin B1 is considered the most toxic and is produced by both Aspergillus flavus and Aspergillus parasiticus.

Source: Wikipedia

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Guengerich FP; ''Cytochrome P450s and other enzymes in drug metabolism and toxicity.''; AAPS J, 2006 PubMed Europe PMC Scholia
  2. Stewart RK, Smith GB, Donnelly PJ, Reid KR, Petsikas D, Conlan AA, Massey TE; ''Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B(1) in human lung: differential cellular distribution and lack of significance of the GSTM1 genetic polymorphism.''; Carcinogenesis, 1999 PubMed Europe PMC Scholia
  3. Barski OA, Tipparaju SM, Bhatnagar A; ''The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.''; Drug Metab Rev, 2008 PubMed Europe PMC Scholia
  4. Jin Y, Penning TM; ''Aldo-keto reductases and bioactivation/detoxication.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
  5. Zhu LR, Thomas PE, Lu G, Reuhl KR, Yang GY, Wang LD, Wang SL, Yang CS, He XY, Hong JY; ''CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody.''; Drug Metab Dispos, 2006 PubMed Europe PMC Scholia
  6. He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY; ''Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract.''; Int J Cancer, 2006 PubMed Europe PMC Scholia
  7. Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM; ''Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.''; Chem Res Toxicol, 2001 PubMed Europe PMC Scholia
  8. Tiemersma EW, Omer RE, Bunschoten A, van't Veer P, Kok FJ, Idris MO, Kadaru AM, Fedail SS, Kampman E; ''Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma.''; Cancer Epidemiol Biomarkers Prev, 2001 PubMed Europe PMC Scholia
  9. Kensler TW, Qian GS, Chen JG, Groopman JD; ''Translational strategies for cancer prevention in liver.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
  10. Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM; ''Reaction of aflatoxin B(1) oxidation products with lysine.''; Chem Res Toxicol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124934view13:57, 1 January 2023EgonwOntology Term : 'xenobiotic metabolic pathway' added !
106828view13:30, 17 September 2019MaintBotHMDB identifier normalization
105874view04:49, 16 August 2019KhanspersModified description
105435view04:35, 8 August 2019KhanspersModified description
102199view07:25, 9 December 2018EgonwMmm... only the ENSG00000277656 link works.
102198view06:58, 9 December 2018EgonwReplaced an outdated Ensembl identifiers with the new one.
93244view11:16, 8 August 2017DeSlOntology Term : 'cancer' added !
93243view11:11, 8 August 2017DeSlChanged ID of Aflatoxin B1 exo-8,9-epoxide-GSH to more stereo scpecifi one; checked all other nodes missing IDs, found 2.
70509view11:59, 9 August 2013Mkutmonfixed unconnected line
67032view09:56, 26 June 2013Christine ChichesterOntology Term : 'aflatoxin metabolic pathway' added !
63149view20:16, 8 May 2013MaintBotUpdating GPML version
59135view22:37, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48240view06:05, 17 May 2012MaintBotUpdating PubChem xrefs
48215view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
44823view15:42, 5 October 2011MartijnVanIerselOntology Term : 'cellular detoxification pathway' added !
41090view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
35014view08:24, 11 February 2010ThomasModified description
35013view08:23, 11 February 2010ThomasModified description
33414view14:50, 30 November 2009MaintBotRemoved group label
30253view04:37, 25 July 2009AlexanderPicoModified categories
29946view17:55, 14 June 2009Pieter GiesbertzExpanded pathway
29865view13:10, 8 June 2009Pieter GiesbertzAdded literature reference
29864view13:07, 8 June 2009Pieter GiesbertzAdded literature reference
29545view11:45, 14 May 2009Pieter GiesbertzAdded literature references
29338view14:36, 24 April 2009Pieter GiesbertzAdded compound identifiers
29286view07:57, 22 April 2009Pieter GiesbertzSpecify description
29267view10:50, 21 April 2009Pieter GiesbertzSpecify description
29260view14:25, 20 April 2009Pieter GiesbertzSpecify description
29259view13:43, 20 April 2009Pieter GiesbertzSpecify description
29258view13:20, 20 April 2009Pieter GiesbertzSpecify description
29257view13:19, 20 April 2009Pieter GiesbertzSpecify description
29256view12:30, 20 April 2009Pieter GiesbertzPeriodical save, work in progress
29254view09:37, 20 April 2009Pieter GiesbertzSpecify description
29253view09:29, 20 April 2009Pieter GiesbertzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKR7A2GeneProductENSG00000053371 (Ensembl)
AKR7A3GeneProductENSG00000162482 (Ensembl)
Aflatoxin B1 8,9-dihydrodiolMetaboliteCHEBI:53106 (ChEBI)
Aflatoxin B1 C6-monoalcoholMetabolite
Aflatoxin B1 C6-monoaldehydeMetabolite
Aflatoxin B1 C8-monoalcoholMetabolite
Aflatoxin B1 C8-monoaldehydeMetabolite
Aflatoxin B1 dialdehydeMetaboliteCHEBI:53107 (ChEBI)
Aflatoxin B1 exo-8,9-epoxide-GSHMetabolite5486953 (PubChem-compound)
Aflatoxin B1 exo-8,9-epoxideMetaboliteHMDB0006558 (HMDB)
Aflatoxin B1-6,8-dialcoholMetabolite
Aflatoxin M1 epoxideMetabolite
Aflatoxin M1Metabolite15558498 (PubChem-compound)
Aflatoxin Q1Metabolite104757 (PubChem-compound)
Aflatoxin-endo-B1-8,9-epoxideMetabolite
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP2A13GeneProductENSG00000197838 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
EPHX1GeneProductENSG00000143819 (Ensembl)
GSTM1GeneProductENSG00000134184 (Ensembl)
GSTT1GeneProductENSG00000277656 (Ensembl)
aflatoxin B1MetaboliteHMDB0006552 (HMDB)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP699"
Personal tools