DNA damage response (only ATM dependent) (Homo sapiens)

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91799999999999NucleusMitochondriaTCRBCROxidative StressresistanceTCF-1/LEFDifferent PathwayDNA damage sourceOrigin DNA damageresponseProliferationMetabolismFrizzled LigandsInhibitionUV radiation --> DNA damageActivationRASCaptionCytokine receptorChange in the Cell conditionPI3KERBB2NFKB2SOS1KRASPIK3C3LEF1CCND3MLKLPIK3R2IRS1WNT5AWNT4SMAD3PDK1WNT7ARAC2PIK3CBPIK3R1Cell CycleWNT7BATMApoptosis FRAT1BCL2L11BBC3MAP3K4PIK3CGPLAUJUNWNT5BBADCDKN1ABBC3BAK1PMAIP1TGFBPPP2R5CAXIN1DNA damage responseCell CyclePIK3C2BMAP3K7WNT16FASLGWNT1SHC1AKT2PIK3C2GCCND1CTNNB1ABL1WNT3Apoptosis Apoptosis CCNG2GRB2DVL1APCAPCHMGB1PIK3CDMAPK2WNT6HRASINSRCDKN2ASCP2PIK3R3WNT2PIK3R4NFKB1TCF-4MYCTP73WNT10ASOD2RAC1MAPK9CDKN1BPEPCKPIK3CAMAPK8WNT16FOSL1BIKWNT11WNT10BBCL6NRASAKT3RAC3CCND2TP53SMAD4WNT3APIK3C2ABAXc-MycAKT1CATTGFB1BCL2L11RHOAPTENApoptosis TCF-1WNT2BAKT2BCL2G6PCCDC42MAPK9AKT3MAPK10SOS2PIK3R5LDLRGSK3BMDM2RAC1AKT1RBL2TCF-3DVL2MAP3K1FOXO3DVL3PPP2R5ECTNNB1P


Description

This is one of two pathways that deal with DNA damage. It has two central gene products (ATM and TP53) which are connected with the other DNA damage response pathway.

In this pathway there is only one source of DNA damage induction, since most DNA damage induction sources and their involvement are mentioned in the first DNA damage response pathway. If it is not mentioned differently, the processes take place in the cell cytoplasm. The purpose of this pathway is to report more gene products and cell condition changes through the DNA damage response pathway and at the same time keep them clearly arranged.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

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  1. Reshmi SC, Gollin SM; ''Chromosomal instability in oral cancer cells.''; J Dent Res, 2005 PubMed Europe PMC Scholia
  2. Zhou BB, Bartek J; ''Targeting the checkpoint kinases: chemosensitization versus chemoprotection.''; Nat Rev Cancer, 2004 PubMed Europe PMC Scholia
  3. Boutros R, Lobjois V, Ducommun B; ''CDC25 phosphatases in cancer cells: key players? Good targets?''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  4. Sengupta S, Harris CC; ''p53: traffic cop at the crossroads of DNA repair and recombination.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  5. Chargari C, Toillon RA, Macdermed D, Castadot P, Magnأ¯آ؟آ½أ¯آ؟آ½أژآ© N; ''Concurrent hormone and radiation therapy in patients with breast cancer: what is the rationale?''; Lancet Oncol, 2009 PubMed Europe PMC Scholia
  6. Ljungman M, Lane DP; ''Transcription - guarding the genome by sensing DNA damage.''; Nat Rev Cancer, 2004 PubMed Europe PMC Scholia
  7. Lأ¯آ؟آ½أ¯آ؟آ½أژآ©brich M, Jeggo PA; ''The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  8. Sherr CJ, Roberts JM; ''Living with or without cyclins and cyclin-dependent kinases.''; Genes Dev, 2004 PubMed Europe PMC Scholia
  9. Strasser A; ''The role of BH3-only proteins in the immune system.''; Nat Rev Immunol, 2005 PubMed Europe PMC Scholia
  10. Gil J, Peters G; ''Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  11. Cory S, Huang DC, Adams JM; ''The Bcl-2 family: roles in cell survival and oncogenesis.''; Oncogene, 2003 PubMed Europe PMC Scholia
  12. Antoni L, Sodha N, Collins I, Garrett MD; ''CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  13. Vousden KH, Lane DP; ''p53 in health and disease.''; Nat Rev Mol Cell Biol, 2007 PubMed Europe PMC Scholia
  14. Wang W; ''Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.''; Nat Rev Genet, 2007 PubMed Europe PMC Scholia
  15. Harrison JC, Haber JE; ''Surviving the breakup: the DNA damage checkpoint.''; Annu Rev Genet, 2006 PubMed Europe PMC Scholia
  16. Sparmann A, van Lohuizen M; ''Polycomb silencers control cell fate, development and cancer.''; Nat Rev Cancer, 2006 PubMed Europe PMC Scholia
  17. Fan HY, O'Connor A, Shitanaka M, Shimada M, Liu Z, Richards JS; ''Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization.''; Mol Endocrinol, 2010 PubMed Europe PMC Scholia
  18. Pagano M, Jackson PK; ''Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.''; Cell, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126217view15:02, 16 April 2023EgonwLicense is CCZero
116542view12:11, 7 May 2021EweitzModified title
113791view08:53, 24 November 2020Finterlymake pathways clickable and small graphical update
109435view10:17, 17 March 2020L DupuisConverted interaction to graphical line in legend
106372view00:55, 23 August 2019KhanspersModified description
105500view05:53, 8 August 2019KhanspersModified description
105238view20:32, 23 July 2019Khansperslayout changes and updated legend
104836view14:14, 20 June 2019Fehrhartinteraction between CTNNB1 and TCF complex
104835view14:12, 20 June 2019Fehrhart
104833view13:59, 20 June 2019Fehrhart
104309view21:41, 15 May 2019Khanspersupdated legend, clarified phosphorylation of CTNNB1, unified fonts, cleanup
104308view21:00, 15 May 2019KhanspersModified description
104307view20:59, 15 May 2019KhanspersModified description
95580view03:04, 3 January 2018Asios OliaModified description
94761view15:50, 5 October 2017Ryanmillerconnected lines
79974view08:10, 29 April 2015ZariChanged uniprot Id to Entrez gene for RAS, PI3K and TCF-1/LEF genes
70109view19:06, 12 July 2013MaintBotupdating to 2013 schema
69906view19:31, 11 July 2013AlexanderPicoModified title
67156view10:14, 26 June 2013Christine ChichesterOntology Term : 'p53-dependent G1/S DNA damage checkpoint pathway' added !
59215view20:07, 22 February 2013MaintBotUpdated Ensembl data source
46091view03:26, 15 December 2011AlexanderPicoconverted more hugo to hgnc
46084view02:18, 15 December 2011AllanKuchinskySpecify description
46083view02:17, 15 December 2011AllanKuchinskyupdated HGNC IDs
46082view02:12, 15 December 2011AllanKuchinskySpecify description
46081view19:32, 14 December 2011AlexanderPicoconverted a couple HUGOs to HGNC
45197view10:06, 7 October 2011MartijnVanIerselOntology Term : 'p53 signaling pathway' added !
41219view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
38810view08:13, 24 September 2010Jildaucompartments
38809view08:10, 24 September 2010Jildautransparent
38808view08:01, 24 September 2010JildauReverted to version '13:13, 23 September 2010' by Jildau
38807view08:01, 24 September 2010JildauReverted to version '07:53, 24 September 2010' by Jildau
38806view07:56, 24 September 2010JildauReverted to version '13:13, 23 September 2010' by Jildau
38805view07:53, 24 September 2010Jildaucompartments
38658view13:13, 23 September 2010Mkutmonadded pathway links for "apoptosis", "dna damage response", "cell cycle"
33421view14:52, 30 November 2009MaintBotRemoved group label
30260view04:51, 25 July 2009AlexanderPicoModified categories
29695view07:30, 28 May 2009I379077Modified description
29688view13:25, 27 May 2009I379077Modified description
29679view13:05, 26 May 2009I379077Specify description
29678view12:53, 26 May 2009I379077Specify description
29677view12:49, 26 May 2009I379077Specify description
29676view12:14, 26 May 2009I379077Modified description
29665view09:28, 25 May 2009I379077Modified description
29664view09:21, 25 May 2009I379077Specify description
29663view08:48, 25 May 2009I379077Specify description
29662view08:46, 25 May 2009I379077Specify description
29554view07:39, 15 May 2009I379077Specify description
29546view14:45, 14 May 2009I379077Specify description
29544view11:28, 14 May 2009I379077Specify description
29543view09:46, 14 May 2009I379077Specify description

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProductENSG00000097007 (Ensembl)
AKT1GeneProductAKT1 (HGNC)
AKT2GeneProductAKT2 (HGNC)
AKT3GeneProductAKT3 (HGNC)
APCGeneProduct324 (Entrez Gene)
APCGeneProductENSG00000134982 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
AXIN1GeneProduct8312 (Entrez Gene)
Apoptosis PathwayWP254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductBBC3 (HGNC)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L11GeneProductENSG00000153094 (Ensembl)
BCL6GeneProductENSG00000113916 (Ensembl)
BIKGeneProductENSG00000100290 (Ensembl)
CATGeneProductENSG00000121691 (Ensembl)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNG2GeneProductENSG00000138764 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CDKN2AGeneProductCDKN2A (HGNC)
CTNNB1GeneProduct1499 (Entrez Gene)
Cell CyclePathwayWP179 (WikiPathways)
DNA damage responsePathwayWP707 (WikiPathways)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
ERBB2GeneProductENSG00000141736 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FOSL1GeneProduct8061 (Entrez Gene)
FOXO3GeneProductENSG00000118689 (Ensembl)
FRAT1GeneProduct10023 (Entrez Gene)
G6PCGeneProductENSG00000131482 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
HMGB1GeneProductENSG00000189403 (Ensembl)
HRASGeneProduct3265 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl)
JUNGeneProduct3725 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
LDLRGeneProduct3949 (Entrez Gene)
LEF1GeneProduct51176 (Entrez Gene)
MAP3K1GeneProductENSG00000095015 (Ensembl)
MAP3K4GeneProductENSG00000085511 (Ensembl)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK2GeneProduct5594 (Entrez Gene)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProduct5601 (Entrez Gene)
MAPK9GeneProductENSG00000050748 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MLKLGeneProductENSG00000168404 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
NFKB1GeneProductNFKB1 (HGNC)
NFKB2GeneProductNFKB2 (HGNC)
NRASGeneProduct4893 (Entrez Gene)
PDK1GeneProductENSG00000152256 (Ensembl)
PEPCKGeneProduct5106 (Entrez Gene)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2BGeneProduct5287 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PIK3R5GeneProduct23533 (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PPP2R5CGeneProduct5527 (Entrez Gene)
PPP2R5EGeneProduct5529 (Entrez Gene)
PTENGeneProductENSG00000171862 (Ensembl)
RAC1GeneProduct5879 (Entrez Gene)
RAC1GeneProductENSG00000136238 (Ensembl)
RAC2GeneProductENSG00000128340 (Ensembl)
RAC3GeneProductRAC3 (HGNC)
RBL2GeneProductENSG00000103479 (Ensembl)
RHOAGeneProduct387 (Entrez Gene)
SCP2GeneProductENSG00000116171 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SOD2GeneProductENSG00000112096 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
TCF-1GeneProduct6932 (Entrez Gene)
TCF-3GeneProduct83439 (Entrez Gene)
TCF-4GeneProduct6934 (Entrez Gene)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBGeneProduct7040 (Entrez Gene)
TP53GeneProductENSG00000141510 (Ensembl)
TP73GeneProductENSG00000078900 (Ensembl)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
c-MycGeneProduct4609 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP710"
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