Serotonin HTR1 group and FOS pathway (Homo sapiens)

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366. Malaspina A, Kaushik N, de Belleroche J, De Sagher RM, De Leenheer AP, Cruyl AA, Claeys AE; ''Identification and urinary excretion of p-chlorophenoxyacetamide, a metabolite of iproclozide, in humans.''; Drug Metab Dispos, 1975 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
1,2-Diacetin	Metabolite	102-62-5 (CAS)	diacylglycerol
1,4,5-Insp3	Metabolite	85166-31-0 (CAS)
BRAF	GeneProduct	673 (Entrez Gene)	v-raf murine sarcoma viral oncogene homolog B1
CALCIUM	Metabolite	7440-70-2 (CAS)
CREB1	GeneProduct	1385 (Entrez Gene)	cAMP response element-binding protein 1
ELK1	GeneProduct	2002 (Entrez Gene)	ELK1, member of ETS oncogene family
ELK4	GeneProduct	2005 (Entrez Gene)	ETS domain-containing protein Elk-4 (SRF accessory protein 1)
FOS	GeneProduct	2353 (Entrez Gene)	proto-oncogene protein c-fos
GNAI1	Protein	2770 (Entrez Gene)
GNAI2	Protein	2771 (Entrez Gene)
GNAI3	Protein	2773 (Entrez Gene)
GNAO1	Protein	2775 (Entrez Gene)
GNAQ	GeneProduct	2776 (Entrez Gene)	guanine nucleotide binding protein, alpha q polypeptide
Gb/g	Complex
HTR1A	Protein	3350 (Entrez Gene)
HTR1B	Protein	3351 (Entrez Gene)
HTR1D	Protein	3352 (Entrez Gene)
HTR1E	Protein	3354 (Entrez Gene)
HTR1F	Protein	3355 (Entrez Gene)
HTR2A	GeneProduct	3356 (Entrez Gene)	5-hydroxytryptamine (serotonin) receptor 2A
ITPR1	GeneProduct	3708 (Entrez Gene)	inositol 1,4,5-triphosphate receptor 1
JAK2	GeneProduct	3717 (Entrez Gene)	Janus kinase 2
MAP2K1	GeneProduct	5604 (Entrez Gene)	mitogen activated protein kinase kinase 1
MAP2K2	GeneProduct	5605 (Entrez Gene)	mitogen activated protein kinase kinase 2
MAP2K3	GeneProduct	5606 (Entrez Gene)	mitogen activated protein kinase kinase 3
MAP2K6	GeneProduct	5608 (Entrez Gene)	mitogen activated protein kinase kinase 6
MAP3K1	GeneProduct	4214 (Entrez Gene)	mitogen activated protein kinase kinase kinase 1
MAPK14	GeneProduct	1432 (Entrez Gene)	mitogen activated protein kinase 14
MAPK1	GeneProduct	MAPK1 (HGNC)	mitogen activated protein kinase 1
MAPK3	GeneProduct	5595 (Entrez Gene)	mitogen activated protein kinase 3
MAPKAPK2	GeneProduct	9261 (Entrez Gene)	mitogen activated protein kinase 3
MAPKAPK3	GeneProduct	7867 (Entrez Gene)	mitogen-activated protein kinase-activated protein kinase 3
PDPK1	GeneProduct	5170 (Entrez Gene)	3-phosphoinositide dependent protein kinase-1
PI3K	GeneProduct	5290 (Entrez Gene)	phosphatidylinositol 3-kinase
PKC	GeneProduct	50818 (Entrez Gene)	protein kinase C
PLC	GeneProduct	3.1.4.11 (Enzyme Nomenclature)	phospholipase C
PtdIns2P	Metabolite	CHEBI:58456 (ChEBI)	phosphatidylinositol 4,5-diphosphate
PtdIns3P	Metabolite	57836 (ChEBI)	phosphatidylinositol 3,4,5-triphosphate
RAP1A	GeneProduct	5906 (Entrez Gene)	RAS-related protein-1a
RASGRF1	GeneProduct	5923 (Entrez Gene)	RAS protein-specific guanine nucleotide-releasing factor 1
RASGRP1	GeneProduct	10125 (Entrez Gene)	RAS guanyl releasing protein 1
RHOA	GeneProduct	387 (Entrez Gene)	ras homolog gene family, member A
RPS6K	GeneProduct		Functional Class RPS6K (ribosomal protein S6 kinase)
RPS6KA5	GeneProduct	9252 (Entrez Gene)	ribosomal protein S6 kinase, polypeptide 5
Ras	GeneProduct		RAS oncogene homolog
SRF	GeneProduct	6722 (Entrez Gene)	serum response factor
STAT3	GeneProduct	6774 (Entrez Gene)	signal transducer and activator of transcription
Serotonin	Metabolite	HMDB0000259 (HMDB)

Annotated Interactions

Source	Target	Type	Database reference	Comment
PtdIns2P	PtdIns3P	mim-conversion	21293 (Rhea)