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• Pathway:WP4415
  ... cers. Activating mutations in RAS are found in approximately one third of human cancers, while ~8% of tumors express an activated form of BRAF (Roberts an ... ... umans, the pathways do show points of significant divergence. Notably, the human genome encodes three Ci homologues, GLI1, 2 and 3 that each play slightly ...
  388 KB (46676 words) - 16:11, 25 January 2021
• Pathway:WP138
  <Comment>AR interacts with ARA55 in H1299 human lung cancer cells in a ligand dependent manner.</Comment>
  103 KB (10258 words) - 11:36, 6 August 2024
• Pathway:WP706
  ... s are predicted to be transcriptionally regulated by a common factor, FEV (human orthologue of PET-1). PET-1 knock-out results in up to a 90% loss of serot ... <Comment Source="GenMAPP remarks">KAP0 HUMAN</Comment>
  548 KB (56246 words) - 00:19, 30 July 2024
• Pathway:WP897
  <Comment>AR interacts with ARA55 in H1299 human lung cancer cells in a ligand dependent manner.</Comment>
  108 KB (10840 words) - 22:00, 19 March 2021
• Pathway:WP1014
  <Comment>AR interacts with ARA55 in H1299 human lung cancer cells in a ligand dependent manner.</Comment>
  119 KB (11968 words) - 08:33, 22 March 2021
• Pathway:WP1133
  <Comment>AR interacts with ARA55 in H1299 human lung cancer cells in a ligand dependent manner.</Comment>
  108 KB (10858 words) - 17:01, 20 March 2021
• Pathway:WP1266
  ... is responsible for the large majority of serotonin that is produced in the human body and is functionally important in the regulation of normal cardiopulmo ... ... s are predicted to be transcriptionally regulated by a common factor, FEV (human orthologue of PET-1). PET-1 knock-out results in up to a 90% loss of serot ...
  821 KB (72732 words) - 10:44, 23 May 2021
• Pathway:WP3357
  ... t;50% of human tumors. Thus, the importance of the checkpoint pathways to human biology is clear.</Comment> ... fity of the phosphatase. The Large Mypt subunit is encoded by one of three human genes, PPP1R12A (MYPT1), PPP1R12B (MYPT2) and PPP1R12C. Only MYPT1 is repr ...
  107 KB (13003 words) - 16:57, 25 January 2021
• Pathway:WP1917
  <Comment Source="Reactome">The human genome includes approximately 70 genes that are predicted to encode Rho-sp ... ... guanine nucleotide (usually GDP) from their partner GTPases. So far, three human GDIs with proven biological functions have been found: RhoGDI/GDIalpha/GDI ...
  190 KB (23008 words) - 16:32, 25 January 2021
• Pathway:WP1984
  ... by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCart ... ... eceptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.</bp:TITLE>
  266 KB (25060 words) - 20:57, 5 May 2023
• Pathway:WP2691
  ... anterior pituitary gland. FSH regulates the reproductive processes of the human body. FSH and Luteinizing hormone (LH) act synergistically in reproduction ... <Comment Source="Reactome">Human chorionic gonadotropin is a glycoprotein hormone produced in pregnancy. It ...
  35 KB (3881 words) - 16:19, 25 January 2021
• Pathway:WP2749
  ... tions in the gene encoding STAR block synthesis of all steroid hormones in humans, indicating the critical importance of this transport step in the biosynt ... ... yze this reaction efficiently in vitro; its abundance in adrenal tissue in humans and other mammals and its concordant expression with other enzymes of ste ...
  237 KB (25084 words) - 17:04, 25 January 2021
• Pathway:WP3130
  ... s are predicted to be transcriptionally regulated by a common factor, FEV (human orthologue of PET-1). PET-1 knock-out results in up to a 90% loss of serot ... <Comment Source="GenMAPP remarks">KAP0 HUMAN</Comment>
  597 KB (61997 words) - 13:03, 21 February 2024
• Pathway:WP3260
  ... by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCart ... ... eceptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.</bp:TITLE>
  287 KB (27466 words) - 11:17, 21 May 2021
• Pathway:WP3376
  ... fity of the phosphatase. The Large Mypt subunit is encoded by one of three human genes, PPP1R12A (MYPT1), PPP1R12B (MYPT2) and PPP1R12C. Only MYPT1 is repr ... ... ral basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.</bp:TITLE>
  79 KB (9703 words) - 16:43, 25 January 2021
• Pathway:WP3397
  ... ral basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.</bp:TITLE>
  197 KB (21194 words) - 01:48, 22 May 2024
• Pathway:WP4086
  ... TFAP2A and TFAP2C directly stimulate transcription of both subunits of the human chorionic gonadotropin, CGA and CGB (Johnson et al. 1997, LiCalsi et al. 2 ... <Comment Source="Reactome">Human chorionic gonadotropin is a glycoprotein hormone produced in pregnancy. It ...
  215 KB (24060 words) - 16:52, 25 January 2021
• Pathway:WP3574
  ... lation and reduction. Only plants and microorganisms employ all processes. Humans cannot de novo synthesize any sulfur amino acid, nor convert cysteine to ... ... anes such as the blood brain barrier and mitochondrial membranes. Although humans are not typically exposed to cyanide,
  206 KB (22583 words) - 21:08, 31 October 2018
• Pathway:WP4058
  ... al. 2006; Prodromou C et al. 2000; Prodromou C 2012). The ATPase cycle of human HSP90 is less well understood, however several studies suggest that the un ... ... 012). Furthermore, cryoelectron microscopy (cryo-EM) reconstruction of the human HSP90:STIP1 complex revealed that STIP1 may also form interactions in seve ...
  200 KB (22599 words) - 16:48, 25 January 2021
• Pathway:WP3799
  ... f:datatype="http://www.w3.org/2001/XMLSchema#string">Molecular features of human ubiquitin-like SUMO genes and their encoded proteins.</bp:TITLE> ... XMLSchema#string">Molecular architecture of the inner ring scaffold of the human nuclear pore complex.</bp:TITLE>
  134 KB (14653 words) - 16:53, 25 January 2021

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