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• Pathway:WP4415
  ... cers. Activating mutations in RAS are found in approximately one third of human cancers, while ~8% of tumors express an activated form of BRAF (Roberts an ... ... umans, the pathways do show points of significant divergence. Notably, the human genome encodes three Ci homologues, GLI1, 2 and 3 that each play slightly ...
  388 KB (46676 words) - 16:11, 25 January 2021
• Pathway:WP244
  <Comment>SHC1 interacts with GRB2 in primary human keratinocytes and A431 cells. </Comment>
  73 KB (7295 words) - 01:22, 22 May 2024
• Pathway:WP306
  ... .org/2001/XMLSchema#string">The protein kinase B/Akt signalling pathway in human malignancy.</bp:TITLE>
  138 KB (13660 words) - 11:51, 6 August 2024
• Pathway:WP85
  ... .org/2001/XMLSchema#string">The protein kinase B/Akt signalling pathway in human malignancy.</bp:TITLE>
  129 KB (12809 words) - 22:50, 21 January 2024
• Pathway:WP188
  ... .org/2001/XMLSchema#string">The protein kinase B/Akt signalling pathway in human malignancy.</bp:TITLE>
  131 KB (12447 words) - 10:24, 16 May 2021
• Pathway:WP69
  ... >TCR stimulation induces the phosphorylation of MEK2 in DP thymocytes, the human Jurkat T leukemia cell line (clone E6-1)and jurkat T cells.</Comment> ... stimulation induces the phosphorylation of LCK at Tyrosine 192 and 505 in human Jurkat T cell lines and T lymphoblastoid cell line, H9 (TCR/CD3 cross link ...
  111 KB (11290 words) - 01:47, 7 August 2024
• Pathway:WP722
  <Comment>Coexpression of the human 5-HT(1D) receptor with Galpha(i1), alpha(i2), alpha(i3), or Galpha(o)-prot ... <Comment>Coexpression of the human 5-HT(1D) receptor with Galpha(i1), alpha(i2), alpha(i3), or Galpha(o)-prot ...
  709 KB (96586 words) - 14:31, 9 March 2023
• Pathway:WP727
  ... ing L, Farley RA, Lester HA (2002) Voltage-dependent transient currents of human and rat 5-HT transporters (SERT) are blocked by HEPES and ion channel liga ... ... tamine H 3 receptors inhibits carrier-mediated norepinephrine release in a human model of protracted myocardial ischemia.</Comment>
  107 KB (12413 words) - 00:36, 16 July 2024
• Pathway:WP734
  ... n activation of the transcriptional factor CREB ( 44 ) as well as HSP27 in human cells and HSP25 in bovine and murine cells ( 4 , 17 ). 16189297 The insensitivity of the high-affinity agonist binding of the human 5-HT 7 receptor to the destabilizing effect of guanine nucleotides (Albert ...
  180 KB (24396 words) - 16:06, 6 March 2023
• Pathway:WP732
  ... kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.</bp:TITLE> ... inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinase ...
  183 KB (24555 words) - 01:10, 30 July 2024
• Pathway:WP985
  <Comment>SHC1 interacts with GRB2 in primary human keratinocytes and A431 cells. </Comment>
  83 KB (8411 words) - 10:13, 23 May 2021
• Pathway:WP1011
  ... >TCR stimulation induces the phosphorylation of MEK2 in DP thymocytes, the human Jurkat T leukemia cell line (clone E6-1)and jurkat T cells.</Comment> ... stimulation induces the phosphorylation of LCK at Tyrosine 192 and 505 in human Jurkat T cell lines and T lymphoblastoid cell line, H9 (TCR/CD3 cross link ...
  128 KB (13229 words) - 11:43, 21 May 2021
• Pathway:WP1763
  ... full name: alpha thalassemia/mental retardation syndrome X-linked homolog (human)</Comment> ... ing">Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells</bp:TITLE>
  741 KB (73570 words) - 19:29, 26 April 2023
• Pathway:WP1784
  ... t al., 2003). Evidence for this reaction comes from experiments using both human and rabbit proteins.</Comment> ... ww.w3.org/2001/XMLSchema#string">Subunit structures and stoichiometries of human DNA fragmentation factor proteins before and after induction of apoptosis. ...
  247 KB (26670 words) - 16:34, 25 January 2021
• Pathway:WP1785
  ... yet, representing one of the major challenges after the sequencing of the human genome (Hossler et al. 2006).&lt;br&gt;Since N-glycosylation is involved i ... ... ribe the biosynthesis, transport, utilization and degradation of Neu5Ac in humans.</Comment>
  552 KB (62663 words) - 16:59, 25 January 2021
• Pathway:WP2742
  ... oliferation and differentiation, and it is implicated in a great number of human diseases.&lt;br&gt;TGF beta (TGFB1) is secreted as a homodimer, and as suc ... ... t al. 2002, Tajima et al. 2003). A recombinant mouse Smad7 and recombinant human SMURF1 were used in these experiments.</Comment>
  325 KB (36015 words) - 01:48, 22 May 2024
• Pathway:WP1793
  ... en tissue (Van Itallie and Anderson, 2006). 24 claudins were identified in humans, which allows a large number of possible combinations and specific barrie ... <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial h ...
  236 KB (25414 words) - 16:20, 25 January 2021
• Pathway:WP1794
  <Comment Source="Reactome">The crystal structure of the human CD2-CD58 complex also shows that most of the residues at the interface bet ... ... tein of the Ang family that binds to the Tie2 receptor. The mouse Ang3 and human Ang4 are interspecies orthologs. Ang4 acts as an activating ligand and ind ...
  520 KB (57910 words) - 15:56, 9 October 2020
• Pathway:WP1799
  ... 2 and down regulate proximal TCR signalling. Phosphorylated Y245 (Y226 in human BTLA) in BTLA associates with growth receptor bound 2 (GRB2) (Murphy et al ... ... or many cancers (Yaghoubi et al. 2019). Camrelizumab (SHR-1210) is a fully human anti-programmed cell death 1 (PD1) monoclonal antibody being developed as ...
  309 KB (34357 words) - 16:56, 25 January 2021
• Pathway:WP1809
  ... .w3.org/2001/XMLSchema#string">Release of arachidonate from diglyceride in human platelets requires the sequential action of a diglyceride lipase and a mon ... ... w3.org/2001/XMLSchema#string">Receptor-activated single channels in intact human platelets.</bp:TITLE>
  67 KB (7535 words) - 16:07, 25 January 2021

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