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• Pathway:WP3348
  ... e involves the fusion of a narrow opening, a process that is distinct from other membrane fusion events (Carlsson & Simonsen 2015). The topology of the ... ... formation of the core complex but may be important for the recruitment of other proteins or have a direct role in subsequent autophagosome formation. Exac ...
  308 KB (33804 words) - 16:08, 25 January 2021
• Pathway:WP1857
  ... atalytically active extended oligomers (Weatherly et al. 2004). Unlike the other biotin-dependent carboxylases that reside inside the mitochondrion, ACACA ... ... atalytically active extended oligomers (Weatherly et al. 2004). Unlike the other biotin-dependent carboxylases that reside inside the mitochondrion, ACACA ...
  501 KB (55177 words) - 16:11, 25 January 2021
• Pathway:WP1896
  ... Defects in control of this balance may contribute to autoimmune disease, neurodegeneration and cancer. Protein ubiquitination and degradation is one of the major me ...
  49 KB (5397 words) - 10:45, 25 May 2021
• Pathway:WP1938
  ... yl tRNA synthesis, are associated with a diverse array of neurological and other diseases (Antonellis and Green 2008; Park et al. 2008). These findings rai ... ... ma#string">Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration.</bp:TITLE>
  315 KB (32921 words) - 12:24, 9 May 2021
• Pathway:WP2007
  ... posed to understand the effect of Iron deficiency or Iron overload of the mother on the fetus. ... ld pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.</bp:TITLE>
  75 KB (8226 words) - 20:53, 12 September 2019
• Pathway:WP2011
  ... ttp://www.w3.org/2001/XMLSchema#string">SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.</bp:T ...
  29 KB (3577 words) - 03:02, 23 September 2024
• Pathway:WP2084
  ... ttp://www.w3.org/2001/XMLSchema#string">SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.</bp:T ...
  28 KB (3405 words) - 16:14, 31 January 2023
• Pathway:WP2371
  ... synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.</bp:TITLE>
  87 KB (9746 words) - 02:46, 30 January 2024
• Pathway:WP2788
  ... eramide, and the desaturation of dihydroceramide to form ceramide.&lt;p&gt;Other sphingolipids involved in signaling are derived from ceramide and its bios ... ... a lysosomal sialidase which, unlike NEU1, doesn't require association with other proteins for enzymatic activity. Isoform 2 is thought to be the lysosomal ...
  409 KB (45807 words) - 16:26, 25 January 2021
• Pathway:WP2376
  ... to pathological conditions such as inflammation, autoimmunity, cancer, and neurodegeneration.</Comment>
  79 KB (7008 words) - 02:34, 24 February 2023
• Pathway:WP2717
  ... in human), PIC, TIM22 (TIMM22 in human), and TIM23 (TIMM23 in human). Many other inner membrane proteins are anticipated to be substrates ofthe TIMM22 comp ... ... . 2007, homologous to yeast Porin1) have been shown to be substrates. Many other mitochondrial proteins are anticipated to be substrates of the SAMM50 comp ...
  196 KB (21953 words) - 16:45, 25 January 2021
• Pathway:WP2908
  ... posed to understand the effect of Iron deficiency or Iron overload of the mother on the fetus.</Comment> ... ld pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.</bp:TITLE>
  77 KB (8466 words) - 15:30, 30 June 2015
• Pathway:WP3644
  ... "http://www.w3.org/2001/XMLSchema#string">NAD⁺ in aging, metabolism, and neurodegeneration.</bp:TITLE>
  47 KB (4188 words) - 21:10, 6 June 2021
• Pathway:WP3645
  ... p://www.w3.org/2001/XMLSchema#string">NAD� in aging, metabolism, and neurodegeneration.</bp:TITLE>
  30 KB (2906 words) - 03:03, 29 July 2024
• Pathway:WP3137
  ... ttp://www.w3.org/2001/XMLSchema#string">SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.</bp:T ...
  30 KB (3632 words) - 17:19, 31 January 2023
• Pathway:WP3310
  ... factors. These have been shown to be pathogenic, causing neurological and other diseases (reviewed in Koopman et al. 2013, Pearce et al. 2013). ... df:datatype="http://www.w3.org/2001/XMLSchema#string">OXPHOS mutations and neurodegeneration.</bp:TITLE>
  636 KB (66337 words) - 16:22, 25 January 2021
• Pathway:WP4088
  ... nase, isocitrate dehydrogenase, 2-oxoglutarate dehydrogenase, and possibly other enzymes (Rizzuto et al. 2012). Matrix calcium is also observed to regulate ... ... but its function is uncertain (Paupe et al. 2015, Chaudhuri et al. 2016). Other calcium channels are also detected in the mitochondrial inner membrane (Bo ...
  56 KB (7122 words) - 16:12, 25 January 2021
• Pathway:WP3574
  ... erred to ubiquinone. After that the additional sulfur is dioxygenated by another enzyme (ETHE1). The activity of human SQR was deduced from the orthologue ... ... e">Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoa ...
  206 KB (22583 words) - 21:08, 31 October 2018
• Pathway:WP3625
  ... ing">Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.</bp:TITLE>
  43 KB (4556 words) - 13:22, 9 May 2021
• Pathway:WP3630
  ... "http://www.w3.org/2001/XMLSchema#string">NAD⁺ in aging, metabolism, and neurodegeneration.</bp:TITLE>
  28 KB (2791 words) - 14:27, 11 February 2024

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