Portal:IEM/FeaturedPathways
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(Difference between revisions)
(New page: * Pathway:WP4156 - Chapter 1 "Disorders of Phenylalanine and Tetrahydrobiopterin (BH4) Metabolism" * Pathway:WP4506 - Chapter 2 "Tyrosine Metabolism" * Pathway:WP4292 - Chapte...) |
Current revision (09:59, 29 March 2023) (view source) |
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| + | Note: these pathways are named after version 4 of the book, and might deviate (significantly) from version 5 names. | ||
| + | For an overview, please see the [https://www.wikipathways.org/index.php/Portal:IEM Covered Pathways] section on the main portal page. | ||
| + | |||
| + | == Amino acids == | ||
| + | |||
* [[Pathway:WP4156]] - Chapter 1 "Disorders of Phenylalanine and Tetrahydrobiopterin (BH4) Metabolism" | * [[Pathway:WP4156]] - Chapter 1 "Disorders of Phenylalanine and Tetrahydrobiopterin (BH4) Metabolism" | ||
* [[Pathway:WP4506]] - Chapter 2 "Tyrosine Metabolism" | * [[Pathway:WP4506]] - Chapter 2 "Tyrosine Metabolism" | ||
* [[Pathway:WP4292]] - Chapter 3 "Sulphur Amino Acids" | * [[Pathway:WP4292]] - Chapter 3 "Sulphur Amino Acids" | ||
| + | * [[Pathway:WP4595]] - Chapter 4 "Hyperammonemias and related disorders" | ||
| - | * | + | * Chapter 5 and 6 have been drawn, however are not fully annotated yet. |
| - | + | ||
{| style="margin: 10px" | {| style="margin: 10px" | ||
| Line 10: | Line 15: | ||
|width=100px|{{#pwImage:Pathway:WP4506|250px||Tyrosine Metabolism}} | |width=100px|{{#pwImage:Pathway:WP4506|250px||Tyrosine Metabolism}} | ||
|width=100px|{{#pwImage:Pathway:WP4292|250px||Sulphur Amino Acids}} | |width=100px|{{#pwImage:Pathway:WP4292|250px||Sulphur Amino Acids}} | ||
| - | |width=100px|{{#pwImage:Pathway: | + | |width=100px|{{#pwImage:Pathway:WP4595|250px||Hyperammonemias and related disorders}} |
| - | + | ||
|} | |} | ||
| - | + | == Organic acids == | |
| + | * Chapter 7 has been drawn, however is not fully annotated yet. | ||
| + | |||
| + | * [[Pathway:WP4519]] - Chapter 8 "Cerebral Organic Acidurias, including diseases" | ||
| + | * [[Pathway:WP5030]] - Chapter 9 "Ethylmalonic Encephalopathy" | ||
| + | |||
| + | {| style="margin: 10px" | ||
| + | |width=100px; cell padding=50px|{{#pwImage:Pathway:WP4519|250px||Cerebral Organic Acidurias, including diseases}} | ||
| + | |width=100px|{{#pwImage:Pathway:WP5030|250px||Ethylmalonic Encephalopathy}} | ||
| + | |} | ||
| + | |||
| + | == Vitamins, Cofactors and Metals == | ||
| + | |||
| + | * [[Pathway:WP4259]] - Chapter 10 "Disorders of Folate Metabolism and Transport" | ||
| + | * [[Pathway:WP4288]] - Chapter 10 "MTHFR deficiency (additional pathway)" | ||
| + | * [[Pathway:WP4228]] - Chapter 11 "Vitamine B6-Dependent and Responsive Disorders" | ||
* [[Pathway:WP4507]] - Chapter 12 "Molybdenum (Moco) cofactor biosynthesis" | * [[Pathway:WP4507]] - Chapter 12 "Molybdenum (Moco) cofactor biosynthesis" | ||
* [[Pathway:WP4504]] - Chapter 12 "Cysteine and Methionine catabolism" | * [[Pathway:WP4504]] - Chapter 12 "Cysteine and Methionine catabolism" | ||
| + | |||
| + | {| style="margin: 10px" | ||
| + | |width=100px; cell padding=50px|{{#pwImage:Pathway:WP4259|250px||Disorders of Folate Metabolism and Transport}} | ||
| + | |width=100px|{{#pwImage:Pathway:WP4288|250px||MTHFR deficiency (additional pathway)}} | ||
| + | |width=100px|{{#pwImage:Pathway:WP4228|250px||Vitamine B6-Dependent and Responsive Disorders}} | ||
| + | |width=100px|{{#pwImage:Pathway:WP4507|250px||Molybdenum (Moco) cofactor biosynthesis}} | ||
| + | |width=100px|{{#pwImage:Pathway:WP4504|250px||Cysteine and Methionine catabolism}} | ||
| + | |} | ||
* [[Pathway:WP4271]] - Chapter 13 "Vitamin B12 Disorders" | * [[Pathway:WP4271]] - Chapter 13 "Vitamin B12 Disorders" | ||
| + | * [[Pathway:WP5031]] - Chapter 14 "Biotin Metabolism" | ||
* [[Pathway:WP4297]] - Chapter 15 "Thiamine Disorders" | * [[Pathway:WP4297]] - Chapter 15 "Thiamine Disorders" | ||
{| style="margin: 10px" | {| style="margin: 10px" | ||
| - | |width=100px; cell padding=50px | + | |width=100px; cell padding=50px{{#pwImage:Pathway:WP4271|250px||Vitamin B12 Disorders}} |
| - | |width=100px|{{#pwImage:Pathway: | + | |width=100px|{{#pwImage:Pathway:WP5031|250px||Biotin Metabolism}} |
| - | + | ||
| - | + | ||
|width=100px|{{#pwImage:Pathway:WP4297|250px||Thiamine Disorders}} | |width=100px|{{#pwImage:Pathway:WP4297|250px||Thiamine Disorders}} | ||
|} | |} | ||
| + | |||
| + | == Energy Metabolism == | ||
* [[Pathway:WP4236]] - Chapter 20 "Disorders of the Krebs Cycle" | * [[Pathway:WP4236]] - Chapter 20 "Disorders of the Krebs Cycle" | ||
| + | |||
| + | {| style="margin: 10px" | ||
| + | |width=100px; cell padding=50px|{{#pwImage:Pathway:WP4236|250px||Disorders of the Krebs Cycle}} | ||
| + | |} | ||
| + | |||
| + | == Organelles == | ||
| + | |||
* [[Pathway:WP4153]] - Chapter 25 "Lysosomal Storage Disorders Including Neuronal Ceroid Lipofuscinoses (Sphingolipid degradation)" | * [[Pathway:WP4153]] - Chapter 25 "Lysosomal Storage Disorders Including Neuronal Ceroid Lipofuscinoses (Sphingolipid degradation)" | ||
| + | * [[Pathway:WP4521]] - Chapter 30 "Glycosylation and related congenital defects." | ||
| + | |||
| + | {| style="margin: 10px" | ||
| + | |width=100px; cell padding=50px|{{#pwImage:Pathway:WP4153|250px||Lysosomal Storage Disorders Including Neuronal Ceroid Lipofuscinoses (Sphingolipid degradation)}} | ||
| + | |width=100px|{{#pwImage:Pathway:WP4521|250px||Glycosylation and related congenital defects}} | ||
| + | |} | ||
| + | |||
| + | == Selected Disorders == | ||
| + | |||
* [[Pathway:WP4220]] - Chapter 31 "Neurotransmitter Disorders" | * [[Pathway:WP4220]] - Chapter 31 "Neurotransmitter Disorders" | ||
| + | * [[Pathway:WP4523]] - Chapter 37 "Classical pathway of steroidogenesis, including diseases" | ||
| + | * [[Pathway:WP4524]] - Chapter 37 "The alternative pathway of fetal androgen synthesis, including diseases" | ||
| + | |||
| + | {| style="margin: 10px" | ||
| + | |width=100px; cell padding=50px|{{#pwImage:Pathway:WP4220|250px||Neurotransmitter Disorders}} | ||
| + | |width=100px|{{#pwImage:Pathway:WP4523|250px||Classical pathway of steroidogenesis}} | ||
| + | |width=100px|{{#pwImage:Pathway:WP4524|250px||The alternative pathway of fetal androgen synthesis}} | ||
| + | |} | ||
* [[Pathway:WP4224]] - Chapter 41 "Purine Disorders" | * [[Pathway:WP4224]] - Chapter 41 "Purine Disorders" | ||
* [[Pathway:WP4225]] - Chapter 41 "Pyrimidine Disorders" | * [[Pathway:WP4225]] - Chapter 41 "Pyrimidine Disorders" | ||
| - | + | * [[Pathway:WP4518]] - Chapter 42 "Gamma-Glutamyl Cycle for the biosynthesis and degradation of glutathione, including diseases" | |
* [[Pathway:WP4522]] - Chapter 43 "Metabolic pathway of LDL, HDL and TG, including diseases" | * [[Pathway:WP4522]] - Chapter 43 "Metabolic pathway of LDL, HDL and TG, including diseases" | ||
{| style="margin: 10px" | {| style="margin: 10px" | ||
| - | |width=100px; cell padding=50px | + | |width=100px; cell padding=50px|{{#pwImage:Pathway:WP4224|250px||Purine Disorders}} |
| - | + | ||
| - | + | ||
| - | + | ||
|width=100px|{{#pwImage:Pathway:WP4225|250px||Pyrimidine Disorders}} | |width=100px|{{#pwImage:Pathway:WP4225|250px||Pyrimidine Disorders}} | ||
| - | |width= | + | |width=100px|{{#pwImage:Pathway:WP4518|250px||Gamma-Glutamyl Cycle for the biosynthesis and degradation of glutathione}} |
| + | |width=100px|{{#pwImage:Pathway:WP4522|230px||Metabolic pathway of LDL, HDL and TG, including diseases}} | ||
|} | |} | ||
| - | Pathways with kinetics data | + | == Pathways with kinetics data (under development) == |
* [[Pathway:WP4519]] - Chapter 8 "Cerebral Organic Acidurias, including diseases" | * [[Pathway:WP4519]] - Chapter 8 "Cerebral Organic Acidurias, including diseases" | ||
* [[Pathway:WP4521]] - Chapter 30 "Glycosylation and related congenital defects." | * [[Pathway:WP4521]] - Chapter 30 "Glycosylation and related congenital defects." | ||
Current revision
Note: these pathways are named after version 4 of the book, and might deviate (significantly) from version 5 names. For an overview, please see the Covered Pathways section on the main portal page.
Contents[hide] |
Amino acids
- Pathway:WP4156 - Chapter 1 "Disorders of Phenylalanine and Tetrahydrobiopterin (BH4) Metabolism"
- Pathway:WP4506 - Chapter 2 "Tyrosine Metabolism"
- Pathway:WP4292 - Chapter 3 "Sulphur Amino Acids"
- Pathway:WP4595 - Chapter 4 "Hyperammonemias and related disorders"
- Chapter 5 and 6 have been drawn, however are not fully annotated yet.
|
Image does not exist Disorders of Phenylalanine and Tetrahydrobiopterin (BH4) Metabolism |
Image does not exist Tyrosine Metabolism |
Image does not exist Sulphur Amino Acids |
Image does not exist Hyperammonemias and related disorders |
Organic acids
- Chapter 7 has been drawn, however is not fully annotated yet.
- Pathway:WP4519 - Chapter 8 "Cerebral Organic Acidurias, including diseases"
- Pathway:WP5030 - Chapter 9 "Ethylmalonic Encephalopathy"
|
Image does not exist Cerebral Organic Acidurias, including diseases |
Image does not exist Ethylmalonic Encephalopathy |
Vitamins, Cofactors and Metals
- Pathway:WP4259 - Chapter 10 "Disorders of Folate Metabolism and Transport"
- Pathway:WP4288 - Chapter 10 "MTHFR deficiency (additional pathway)"
- Pathway:WP4228 - Chapter 11 "Vitamine B6-Dependent and Responsive Disorders"
- Pathway:WP4507 - Chapter 12 "Molybdenum (Moco) cofactor biosynthesis"
- Pathway:WP4504 - Chapter 12 "Cysteine and Methionine catabolism"
|
Image does not exist Disorders of Folate Metabolism and Transport |
Image does not exist MTHFR deficiency (additional pathway) |
Image does not exist Vitamine B6-Dependent and Responsive Disorders |
Image does not exist Molybdenum (Moco) cofactor biosynthesis |
Image does not exist Cysteine and Methionine catabolism |
- Pathway:WP4271 - Chapter 13 "Vitamin B12 Disorders"
- Pathway:WP5031 - Chapter 14 "Biotin Metabolism"
- Pathway:WP4297 - Chapter 15 "Thiamine Disorders"
| width=100px; cell padding=50px
Image does not exist Vitamin B12 Disorders |
Image does not exist Biotin Metabolism |
Image does not exist Thiamine Disorders |
Energy Metabolism
- Pathway:WP4236 - Chapter 20 "Disorders of the Krebs Cycle"
|
Image does not exist Disorders of the Krebs Cycle |
Organelles
- Pathway:WP4153 - Chapter 25 "Lysosomal Storage Disorders Including Neuronal Ceroid Lipofuscinoses (Sphingolipid degradation)"
- Pathway:WP4521 - Chapter 30 "Glycosylation and related congenital defects."
|
Image does not exist Lysosomal Storage Disorders Including Neuronal Ceroid Lipofuscinoses (Sphingolipid degradation) |
Image does not exist Glycosylation and related congenital defects |
Selected Disorders
- Pathway:WP4220 - Chapter 31 "Neurotransmitter Disorders"
- Pathway:WP4523 - Chapter 37 "Classical pathway of steroidogenesis, including diseases"
- Pathway:WP4524 - Chapter 37 "The alternative pathway of fetal androgen synthesis, including diseases"
|
Image does not exist Neurotransmitter Disorders |
Image does not exist Classical pathway of steroidogenesis |
Image does not exist The alternative pathway of fetal androgen synthesis |
- Pathway:WP4224 - Chapter 41 "Purine Disorders"
- Pathway:WP4225 - Chapter 41 "Pyrimidine Disorders"
- Pathway:WP4518 - Chapter 42 "Gamma-Glutamyl Cycle for the biosynthesis and degradation of glutathione, including diseases"
- Pathway:WP4522 - Chapter 43 "Metabolic pathway of LDL, HDL and TG, including diseases"
|
Image does not exist Purine Disorders |
Image does not exist Pyrimidine Disorders |
Image does not exist Gamma-Glutamyl Cycle for the biosynthesis and degradation of glutathione |
Image does not exist Metabolic pathway of LDL, HDL and TG, including diseases |
Pathways with kinetics data (under development)
- Pathway:WP4519 - Chapter 8 "Cerebral Organic Acidurias, including diseases"
- Pathway:WP4521 - Chapter 30 "Glycosylation and related congenital defects."
- Pathway:WP4523 - Chapter 37 "Classical pathway of steroidogenesis, including diseases"
- Pathway:WP4524 - Chapter 37 "The alternative pathway of fetal androgen synthesis, including diseases"
- Pathway:WP4518 - Chapter 42 "Gamma-Glutamyl Cycle for the biosynthesis and degradation of glutathione, including diseases"
|
Image does not exist Cerebral Organic Acidurias, including diseases |
Image does not exist Glycosylation and related congenital defects. |
Image does not exist Classical pathway of steroidogenesis, including diseases |
Image does not exist The alternative pathway of fetal androgen synthesis, including diseases |
Image does not exist Gamma-Glutamyl Cycle for the biosynthesis and degradation of glutathione, including diseases |
