G alpha (s) signaling events (Homo sapiens)

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2111, 12, 3189, 16, 26, 279, 16, 26, 2761, 14, 202-4, 19, 28...135, 7, 17, 18, 22212-4, 19, 28...24, 25109, 16, 26, 27endoplasmic reticulum lumencytosolOR6C74 MC1R LHCGR POMC(77-87) OR5B3 OR5T1 MC1R pS-ADRB2:Catecholamine:ARRB1,ARRB2OR4C3 TSHR OR4A8P TAAR6 CRHR2 OR1G1 OR9Q1 OR2T7 OR4Q3 OR2D3 OR9A1P MC2R PTGIR GNB5 PTHLH OR7D4 OR5AC1 OR4C11 TAAR6 HTR6 OR52M1 OR10C1 ADORA2A,B OR4X1 Ligands of GPCRsthat activate GsOR5AL1 PTH2R GNG10 OR5M1 INSL3(21-55) OR1F1 CALCR ADRBK2 ARRB1 OR2G6 OR2B11 OR2V2 OR4B1 Hist OR52E4 OR9A2 ADCY6 OR5M3 MC3R(1-360) OR4F15 OR5H1 ADR HTR6 OR5AR1 Zn2+ ADM(95-146) OR8J3 OR1L8 GNG11 OR2AE1 OR2J2 OR2T1 OR52A4 OR8B12 pS-ADRB2:CatecholamineOR51S1 LHB OR1Q1 OR6K6 OR52R1 OR1D2 GLP1R OR6C76 OR11H6 OR10K2 OR51F2 OR51B2 POMC(138-176) OR6N2 OR51B2 OR6C74 OR2M4 OR8A1 VIPR1 OR10A6 OR5AK3P NPS GIP(52-93) ADR pS-ADRB2:Catecholamine:GRKPTGER4 OR52E2 OR52B6 OR12D3 OR6C4 OR2T12 GNGT1 RXFP2 CGA GPBAR1 HRH2 OR10G9 OR51T1 ADCYAP1(82-129) OR6A2 OR5T2 OR10V1 OR5A1 OR4N4 PGI2 OR4M2 GNG7 LHB GCG(53-81) OR51A7 OR4D11 GNAS2 CGRP ligands OR51A2 OR5K1 OR10R2 OR6C1 ADM(95-146) SCT OR7E24 OR52Z1 OR5M1 OR6C6 OR13C2 PEA OR7A5 OR1K1 OR6F1 OR2F2 ADCY5 OR9A4 OR2A25 OR8J1 OR13C5 OR52N5 OR10J5 GDP TSHB OR4N2 GNB1 OR51G2 NAd OR2AJ1 OR2B2 OR10G6 FSHR RXFP1 GNG3 POMC(217-234) Hist DA CALCB(82-118) OR1L8 GNG4 Hist CALCR OR6C76 OR1L1 OR8K5 GRK5 OR3A1 OR3A1 ADR OR1D2 OR7A17 POMC(138-176) ADRB1-3 TAAR3 OR4F17 OR10J3 OR51F1 GNG13 OR13J1 CALCA(83-119) GNG4 GLP1R OR2Z1 OR4N5 OR2T1 CRHR1 OR6C70 ADCY1 OR4Q2 OR52B2 OR14A16 HTR4 POMC(217-234) OR5G3 OR5L1 ADM(95-146) CRH RAMP2 OR10G8 ADORA2A OR10J3 OR2K2 OR11A1 OR56B4 ADCYAP1(82-129) MC4R SCT OR11A1 OR8H1 OR5B17 OR2B8P OR8U9 ADRB1 OR10A7 OR1B1 OR52N5 OR56B1 OR5H2 Ade-Rib GTP OR52A4 OR11G2 OR6C3 OR2T10 OR4F4 OR2AT4 OR6J1 ADCY6 OR2T12 HeterotrimericG-protein Gs(inactive)OR6Q1 OR51I1 ADCYAP1(132-158) OR5D16 OR2T8 PTGIR GNG11 ADRB2 GHRHR OR6B2 OR10W1 GNG2 OR2D3 OR2L3 OR2M5 GNG12 INSL3(106-131) OR7A10 GCG(146-178) OR13H1 GTP OR10H3 NPS OR52H1 CDCA PGI2 NPSR1 OR4F4 OR1J1 ATPGTP OR10G9 OR4F6 OR10A3 OR6C3 OR5AP2 POMC(77-87) OR2M5 SCTR OR51A2 CALCA(83-119) OR5AR1 OR8G2 OR1A2 OR56A5 OR10T2 OR6C65 OR4A47 OR51F2 OR10J6P OR2L3 OR4K5 RLN2(25-53) OR10G2 OR2L2 OR8D4 OR5B12 P2RY11 ADCY8 ADCY3 OR51B4 RLN3(26-52) ATPTAAR8 OR51I2 OR52P1P GRK2 OR2T35 OR52E5 GNAL OR8B3 RTP3 OR6K3 OR5V1 OR6K2 OR52L1 GCG(146-178) AMPGNGT1 OR1B1 REEP2 OR4F3 OR8H2 OR5T3 OR8H2 OR11G2 AVPR2 OR13C9 ATP OR10A4 GPR39 OR4A16 OR51G1 RXFP2 OR13C8 DCA OR4L1 OR7G3 OR5K2 OR8I2 OR8B4 OR5I1 PTH OR8U9 CRH SCT GPHA2 GCGR OR1D4 PTGIR OR4A47 CCA PEA GLP-1 (7-37) ADCY5 DRD1 OR52J3 OR2M2 OR10D4P RXFP1 OR56A3 GNG11 OR10V1 RLN3(26-52) OR7G2 OR10D3 OR52E1 OR8J2 OR52N2 OR52N1 TSHB OR6X1 OR4A5 Melanocortin receptors REEP1 OR2AG1 OR2T5 GNG5 SCT POMC(138-176) OR51L1 MC5R OR11L1 VIP(125-152) REEPsNPSR1 5HT GNG8 PTH OR52N2 ADCY2 CRHR2 ADRB3 OR10H4 OR9I1 OR5R1 OR14A16 PTGER2,PTGER4 GPHA2 OR6K3 OR10A4 OR5B21 OR9K2 OR7G2 RTP1 OR7G3 OR52A1 OR10A6 OR10K1 OR4K17 GNAT3 PTH2(62-100) OR1L6 OR1L3 OR4K17 GNALGCG(53-81) OR5AU1 OR2A2 ADCY2 GNG12 GNG4 OR51G2 OR2B8P TAAR5 GNAS1 MSH OR4F21 OR5K2 OR51D1 OR4D9 OR10W1 OR13F1 OR2A2 OR2A25 GIPR OR51D1 OR5A2 OR2T11 DA OR51A4 OR8U1 OR2F2 INSL3(106-131) OR2H2 OR5M8 OR2T3 OR9K2 G-protein alpha(i):GTP:AdenylatecyclaseGNAS2 OR4E2 OR4C5 NAd OR5M11 CRHR1 OR5AK3P ADRBK2 OR11L1 DRD5 OR52D1 OR8A1 OR10S1 TAAR2 ADCYAP1R1 OR8K5 OR5AN1 OR6Y1 OR8B2 OR2W3 OR13G1 GRK6 OR14A2 FSHB GNB1ADCY8 OR51I2 OR51L1 OR4K5 RAMP1 OR1E2 TAAR9 OR5K1 GHRHR OR4P4 OR4K13 OR9G4 GPR39 ADCY5 OR4K3 RAMP1 OR5B2 CALCRL FSHB LHB GTP PGI2 Constitutively active orphan GPCRs OR1A1 Relaxin-2, Relaxin-3 RLN2(162-185) OR4D6 OR5F1 OR8H3 OR5I1 POMC(138-150) GHRH OR2AG1 OR13C2 RXFP1 OR5G3 GNB4 ADRB3 GRK5 OR4K14 OR4F17 MC2R OR5K4 OR10P1 ADRB2:CatecholamineOR10G3 ADM2(19-153) OR4N4 OR10H3 OR7D2 OR10J5 FSHB OR2A4 GPHB5 OR8D1 OR52E1 OR6C75 OR3A3 OR5V1 GNAL ADCY5 VIPR2 GIPR OR13G1 Ade-Rib OR2B6 OR2A1 RLN3(26-52) OR2J1 OR4D2 OR1E2 OR2C1 OR6T1 GNG5 RTP4 OR11H6 OR5L2 PGI2 OR10AG1 OR2H2 OR51J1 OR4C6 OR4C12 TSHR Mg2+ PGE2 GNAS1 GNB5 RLN3(119-142) GPR39 G-protein beta-gammacomplexGLP-1 (7-37) OR1E3 OR5R1 OR6C1 OR7D2 POMC(138-176) OR2K2 OR2L13 RAMP3 OR10R2 ADCYAP1(132-158) DRD5 ADCY9 OR5M9 5HT OR6V1 ADCY2 OR52P1P GNG13 OR2Y1 OR6C70 OR2A7 OR1J2 OR10G2 OR56A3 GCGR OR9A2 OR4D10 OR6F1 GNB1 ADCYAP1 peptides TAAR9 OR1N1 OR2A5 OR5M10 ADCY8 OR4L1 ADORA2B GNB1 OR5P2 OR52L2P HTR4,6,7 PTH OR2V2 OR3A2 OR2AT4 Phosphodiesterases, dual (cAMP, cGMP) activity GNB2 OR4A5 TAAR3 Zn2+ GNGT15HT GLP1R OR2M4 OR4K3 OR4D9 HRH2 OR7C2 OR10H1 GNAI3 PTGDR OR4D11 OR5M9 TAAR8 OR52N4 OR2AK2 OR4F3 MC2R OR8H1 PTH2R GPBAR1 OR2A5 ADCYAP1(82-129) CALCA(83-119) ADR OR51T1 GLP2R GDPOR10T2 OR1N2 OR5D18 OR8U1 ADR, NAd GNG3 PTH1R,PTH2R ligands pS-ADRB2 ADCY6 OR52E8 OR9G9 Ade-Rib GNAS1 OR2T33 VIP(125-152) OR51V1 OR52I2 OR2B11 OR2T27 REEP4 OR8G1 OR10A5 OR10H5 OR10Q1 GNG5 LHB OR7E24 PGD2 OR51A4 OR1M1 PTH1R ADRB1 OR6C65 GRK2, GRK3, GRK5,GRK6OR51G1 MC1R OR1C1 OR8B4 AVP(20-28) ADR PPiGLP2R OR4E2 OR4N2 OR10Z1 GNAI2 OR2T27 OR6Y1 OR2W6P Mg2+ GHRH OR2I1P OR6N2 OR2S2 OR5B17 OR5D14 ARRB2 ADCYAP1(132-169) OR2G6 ADCYAP1R1 OR2AJ1 Hist OR52I1 SCTR OR52E4 ADM2(19-153) OR51B5 ADCY3 NAd OR1P1 CALCR OR1I1 OR5H1 OR1E3 OR2T33 OR2F1 ADRBK2 ATP OR4A8P OR4Q2 ADR OR52W1 OR2W5 OR6P1 Ligand:GPCRcomplexes thatactivate GsOR51F1 OR2AP1 OR13H1 GRK2 ADCY3 Constitutively active orphan GPCRs GNG10 OR2AK2 GNG8 OR7C1 OR2F1 GLP1R OR5C1 AVP(20-28) GPHB5 GNB3 NPS OR1M1 OR4A15 OR4C15 OR6J1 CALCA(83-119) OR7A17 OR13C8 OR51B4 PGD2 PGE2 OR2T10 NAd OR2J2 GNB3 OR8D4 GNG7 TAAR1 OR14I1 ATP OR9A4 OR52H1 OR2G3 OR2H1 cAMPCALCB(82-118) OR7G1 OR10Q1 GPBAR1 OR5K3 OR5H6 MC4R OR2L13 Zn2+ OR4K2 ADCY1 GPCR:ligandcomplexes that actonGs:HeterotrimericG-protein Gs(active)OR4M2 HTR7 OR52B6 GNGT2 GNG8 OR2W5 pS-ADRB2 OR4S2 OR2V1 FSHR OR4D1 OR52M1 OR8U8 VIP(125-152) OR6T1 OR52E2 ArgN-GCG(98-127) OR4A4P OR5J2 OR4C5 OR3A4P OR56B2P OR51B6 OR56A4 OR11H4 OR51Q1 ADRB2 OR56A1 OR7C2 TSHR OR2G2 ADRB2:Catecholamine:GRKOR5T2 MC4R OR2W1 DCA GNGT2 ADRB2 OR52K1 OR1L4 OR1E1 GCG(146-178) OR5A2 OR52E6 OR52E8 SCTR AVP(20-28) VIPR1 ADCY4 OR2T7 OR5B12 GNB1 OR13C4 GPBAR1 OR2T29 OR2A4 GNG10 G-protein alpha(z):GTP:AdenylatecyclaseGNG8 OR1D5 CALCRL OR2M2 OR4C45 GPHB5 OR11H1 DA ARRB2 OR11H7 OR6C4 OR4A16 OR4S2 OR5H2 CGA OR10G4 OR10AD1 OR7A2P GNGT2 OR4A4P OR10D4P OR6X1 CRH ADRB2 OR5W2 OR9G9 NAd PTH1R,PTH2R CDCA OR5D13 GNB2 OR8B8 OR1E1 OR7A2P OR14K1 OR1F12 OR4D6 OR51M1 OR5H15 LHCGR OR52L1 OR8J3 PTGDR OR2C3 OR5AC1 OR10G7 FSHR OR8H3 OR2G2 CALCB(82-118) RXFP2 OR6N1 OR1S2 PTHLH GDP OR8G2 OR13A1 OR52Z1 OR4C16 OR6C68 TAAR1 OR2M7 POMC(138-150) OR2C1 RXFP2 ligands DA FSHR OR4M1 OR3A3 OR4E1 ARRB1 TSHR OR13C5 POMC(77-87) IAPP(34-70) GLP-1 (7-37) GNB5 OR7G1 CRHR1, CRHR2 OR2T4 OR4K2 OR5AS1 GHRH HTR4 OR1A2 OR4N5 OR6B3 ADCY7 AMY1-3 OR13D1 OR4D1 OR5AU1 DRD5 OR7A10 OR2D2 FSHB OR52D1 CRHR2 RLN2(25-53) Trace amine-associated receptor GRK6 OR10AD1 GIP(52-93) GIP(52-93) AVPR2 GIPR NAd OR2T4 OR5K4 OR4C15 GPHA2 OR1D4 OR51J1 POMC(217-234) OR1P1 GHRHR GLP2R CCA OR4F15 OR6P1 RLN2(25-53) RAMP2 ADORA2A Bile acids ADRB3 OR1L3 OR1F2P RAMP1 OR13A1 OR52A5 Constitutively active orphan GPCRs ADCYAP1R1 OR4A15 CALCRL Zn2+ PGE2 MC3R(1-360) GNB4 OR10H4 OR4P4 OR2L5 H2OGNG2 OR56A1 ADCY1 OR1S1 OR8D2 OR10H2 OR6N1 LHCGR OR5D18 ADCY7 OR2L8 OR5B3 ArgN-GCG(98-127) GPHB5 CGA OR2J3 GNGT2 OR51B6 OR14C36 GTP OR4K15 CGA OR11H2 OR51A7 TAAR8 NAd OR1L1 OR11H1 GNB4 OR2B6 OR2I1P OR2W3 GCG(53-81) OR5M11 OR2T8 OR52K2 OR4C12 OR10AG1 OR52L2P OR5AP2 ADR OR1N2 OR1Q1 ATP GNG3 OR4D2 OR5B2 OR51B5 OR52J3 OR6A2 PTH2R NPSR1 OR10J1 OR10A2 Constitutively active orphan GPCRs OR4C16 OR2L5 OR10A7 OR5P3 INSL3(106-131) OR14A2 OR52B2 OR13D1 PGD2 OR1F2P GCG(146-178) ADCY6 OR56A5 OR1L4 GNAZ DRD1 OR6C6 OR6C2 GNB5 PTGER4 OR2W1 OR5H15 OR1J4 GNB2 OR12D3 OR10J6P OR4F6 ADCYAP1R1 CDCA OR51H1P OR1C1 OR5M10 OR10G6 OR2T11 OR6S1 PTH2(62-100) IAPP(34-70) RAMP3 OR10K2 OR5M3 OR4D10 OR2B3 OR2T34 RAMP3 GNAS2 REEP5 OR4K14 ADORA2A OR52K1 CALCRL POMC(138-150) OR8K1 GNAL:GNB1:GNGT1OR56B1 LCHA G-protein beta:gammasignallingDRD1 OR8I2 OR5D14 RTP5 OR4K1 REEP3 GPHA2 OR56B2P PTGDR HTR4 GNB2 OR51H1P OR1S2 RTP2 ADCY9 OR6C68 Adenylate cyclase(Mg2+ cofactor)PTH1R G alpha (s):GTPOR2T2 OR2AG2 OR4M1 OR51E2 GNG12 OR52E6 OR8S1 OR10A5 OR4E1 OR14C36 OR51Q1 OR14J1 OR4X1 OR2M7 AVPR2 ADCY3 OR5H14 TSHB OR5AN1 GNAS2 OR9Q1 GNG2 OR5F1 Adrenomedullin receptor GNGT1 OR10G8 ADR ADCY9 GNB1 ADCYAP1(132-169) OR8G1 OR8D2 OR10AC1P TAAR5 RAMP2 OR10H5 OR8B2 OR52K2 OR6S1 PTH1R NPSR1 ADORA2B OR5H14 OR6K6 GNAS2 GNG13 OR2T6 ADORA2B GLP2R PTGER4 CRHR1 OR8J2 CRH GNAI1 OR2B2 OR4F21 PGD2 OR6K2 INSL3(21-55) OR10P1 OR5J2 OR4S1 PTH2(62-100) CALCA(83-119) IAPP(34-70) OR1K1 OR51V1 OR10X1 OR4X2 OR1J1 RXFP2 OR4C46 GRK5 OR4C13 RLN3(119-142) GNG2 Mg2+ OR2Y1 OR13F1 TAAR1 OR9Q2 Mg2+ GNG13 OR11H2 OR5AC2 DRD1,5 PTHLH OR52A5 GNG7 ADM,ADM2 INSL3(21-55) OR2AP1 OR56A4 P2RY11 ArgN-GCG(98-127) OR4C46 OR2B3 OR2D2 OR9G1 ADCY4 CALCA(83-119) OR1G1 NPS ADCY1 OR2AE1 PiOR10J4 OR5AS1 HTR7 OR6M1 OR11H4 GNAS1 MC2R P2RY11 OR4C3 OR8D1 OR10H2 OR12D2 PTGIR MC5R OR1D5 REEP6 GIPR GPCRs that activateGsGPR39 OR4K15 OR7D4 OR1L6 OR5AK2 OR2T5 OR9G1 VIP(125-152) OR2A1 GNB3 OR5D16 GHRH LCHA OR6M1 OR10C1 ADCY4 OR8B8 OR2T29 CALCR OR2T3 GNG3 OR9G4 OR4F5 OR8B12 OR4K1 OR10G7 OR1N1 OR52W1 OR6C2 ADCYAP1(132-169) NAd HRH2 OR51E1 Phosphodiesterases, cyclic AMP-selective LHCGR OR1J4 OR2T34 pS-ADRB2 GCG(53-81) OR52N4 Ade-Rib PGE2 VIPR2 OR10J1 OR14L1P OR4K13 GNG11 CCA OR5L1 OR2A7 OR2A14 OR5P3 OR13J1 RAMP1 RLN3(119-142) OR9Q2 OR4D5 OR2L2 DCA OR2L8 OR5M8 OR2V1 OR7C1 G alpha (s):GDPADCYAP1(132-158) GIP(52-93) VIPR1,VIPR2 OR6B1 OR10A2 OR56B4 HTR6 OR6Q1 AVPR2 GCGR OR5C1 OR5T1 OR10X1 ADM2(19-153) GNG10 OR5A1 PTGDR OR5K3 GNAS2 OR2J3 OR9A1P OR11H7 ADCY4 OR2A12 OR2J1 mature GLP-1 AVP(20-28) OR52I2 OR14K1 OR1S1 OR2T2 GNGT1 OR52A1 OR9I1 GNGT1 GNGT1 ADCY9 5HT OR2A12 ADCY8 OR6B3 LCHA OR3A2 OR10S1 OR2Z1 OR2C3 TAAR3 cAMPphosphodiesterasesOlfactory receptorsPEA OR52E5 OR8K3 OR10H1 OR2M3 OR8S1 ADCY2 RTPsOR13C9 OR51M1 OR8G5 GDP ADCY7 OR4B1 OR52I1 GNAS1 OR1F1 GNAS1 OR14I1 TAAR2 OR3A4P OR5T3 ADRB2 RXFP1 OR6C75 GTPOlfactory receptor:Gprotein trimerTAAR9 P2RY11 GRK6 VIPR2 OR14L1P OR4C45 OR10D3 OR1I1 MC5R OR5AL1 Ligand:GPCRcomplexes thatactivateGs:HeterotrimericG-protein Gs(inactive)OR4C6 OR4S1 OR6B1 TAAR5 OR8U8 OR10G3 GCGR OR13C4 OR10K1 GNB3 OR10Z1 OR2W6P OR5W2 OR10A3 GNB4 OR51S1 GNG7 TAAR6 CALCA(83-119) OR51I1 TSHB HTR7 OR4X2 OR10G4 IAPP(34-70) RLN2(162-185) PTGER2 GRK2 OR2H1 OR13C3 GHRHR OR1A1 OR5H6 HRH2 OR13C3 OR2A14 GNB1 OR2G3 GNG12 MC3R(1-360) OR10AC1P SCTR OR2T35 OR52R1 OR6B2 OR5P2 VIPR1 ARRBPEA OR8K1 PTGER2 OR1F12 OR8B3 OR5B21 OR2AG2 GNG4 OR7A5 OR51E1 ADPOR10J4 OR4D5 OR12D2 ADCY7 OR2T6 OR4C13 OR52N1 OR5L2 GNG5 PTGER2 OR1J2 OR14J1 OR4F5 OR8J1 G alpha(s):GTP:AdenylatecyclaseOR8K3 OR5AC2 RLN2(162-185) OR4Q3 OR2S2 OR5D13 OR2M3 TAAR2 ADRB1 OR6V1 OR5AK2 OR8G5 OR51E2 OR4C11 2323232315


Description

The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase (Tesmer et al. 1997), which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. Another downstream effector of G alpha (s) is the protein tyrosine kinase c-Src (Ma et al. 2000). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 418555
Reactome-version 
Reactome version: 63
Reactome Author 
Reactome Author: Jupe, Steve

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Bibliography

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History

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CompareRevisionActionTimeUserComment
116411view09:06, 7 May 2021EweitzModified title
113271view11:34, 2 November 2020ReactomeTeamReactome version 74
101710view14:50, 1 November 2018DeSlOntology Term : 'PW:0000230' removed !
101709view14:50, 1 November 2018DeSlOntology Term : 'G protein mediated signaling pathway via Galphas family' added !
101708view14:49, 1 November 2018DeSlOntology Term : 'G protein mediated signaling pathway via Galpha12/Galpha13 family' added !
101395view11:28, 1 November 2018ReactomeTeamreactome version 66
100933view21:04, 31 October 2018ReactomeTeamreactome version 65
100471view19:38, 31 October 2018ReactomeTeamreactome version 64
100276view16:57, 31 October 2018ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
5HT MetaboliteCHEBI:28790 (ChEBI)
ADCY1 ProteinQ08828 (Uniprot-TrEMBL)
ADCY2 ProteinQ08462 (Uniprot-TrEMBL)
ADCY3 ProteinO60266 (Uniprot-TrEMBL)
ADCY4 ProteinQ8NFM4 (Uniprot-TrEMBL)
ADCY5 ProteinO95622 (Uniprot-TrEMBL)
ADCY6 ProteinO43306 (Uniprot-TrEMBL)
ADCY7 ProteinP51828 (Uniprot-TrEMBL)
ADCY8 ProteinP40145 (Uniprot-TrEMBL)
ADCY9 ProteinO60503 (Uniprot-TrEMBL)
ADCYAP1 peptides R-HSA-420080 (Reactome)
ADCYAP1(132-158) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1(132-169) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1(82-129) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1R1 ProteinP41586 (Uniprot-TrEMBL)
ADM(95-146) ProteinP35318 (Uniprot-TrEMBL)
ADM,ADM2 R-HSA-420061 (Reactome)
ADM2(19-153) ProteinQ7Z4H4 (Uniprot-TrEMBL)
ADORA2A ProteinP29274 (Uniprot-TrEMBL)
ADORA2A,B R-HSA-418907 (Reactome)
ADORA2B ProteinP29275 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
ADR MetaboliteCHEBI:28918 (ChEBI)
ADR, NAd R-ALL-390627 (Reactome)
ADRB1 ProteinP08588 (Uniprot-TrEMBL)
ADRB1-3 R-HSA-390670 (Reactome)
ADRB2 ProteinP07550 (Uniprot-TrEMBL)
ADRB2:Catecholamine:GRKComplexR-HSA-8982633 (Reactome)
ADRB2:CatecholamineComplexR-HSA-8852028 (Reactome)
ADRB3 ProteinP13945 (Uniprot-TrEMBL)
ADRBK2 ProteinP35626 (Uniprot-TrEMBL)
AMPMetaboliteCHEBI:16027 (ChEBI)
AMY1-3 R-HSA-420237 (Reactome)
ARRB1 ProteinP49407 (Uniprot-TrEMBL)
ARRB2 ProteinP32121 (Uniprot-TrEMBL)
ARRBComplexR-HSA-1911410 (Reactome)
ATP MetaboliteCHEBI:15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
AVP(20-28) ProteinP01185 (Uniprot-TrEMBL)
AVPR2 ProteinP30518 (Uniprot-TrEMBL)
Ade-Rib MetaboliteCHEBI:16335 (ChEBI)
Adenylate cyclase (Mg2+ cofactor)ComplexR-HSA-170665 (Reactome)
Adrenomedullin receptor R-HSA-420118 (Reactome)
ArgN-GCG(98-127) ProteinP01275 (Uniprot-TrEMBL) The amide group at the C-terminus is not necessary for biological activity.
Bile acids R-ALL-444840 (Reactome)
CALCA(83-119) ProteinP01258 (Uniprot-TrEMBL)
CALCA(83-119) ProteinP06881 (Uniprot-TrEMBL)
CALCB(82-118) ProteinP10092 (Uniprot-TrEMBL)
CALCR ProteinP30988 (Uniprot-TrEMBL)
CALCRL ProteinQ16602 (Uniprot-TrEMBL)
CCA MetaboliteCHEBI:16359 (ChEBI)
CDCA MetaboliteCHEBI:16755 (ChEBI)
CGA ProteinP01215 (Uniprot-TrEMBL)
CGRP ligands R-HSA-419795 (Reactome)
CRH ProteinP06850 (Uniprot-TrEMBL)
CRHR1 ProteinP34998 (Uniprot-TrEMBL)
CRHR1, CRHR2 R-HSA-420140 (Reactome)
CRHR2 ProteinQ13324 (Uniprot-TrEMBL)
Constitutively active orphan GPCRs R-HSA-6805225 (Reactome)
DA MetaboliteCHEBI:18243 (ChEBI)
DCA MetaboliteCHEBI:28834 (ChEBI)
DRD1 ProteinP21728 (Uniprot-TrEMBL)
DRD1,5 R-HSA-390836 (Reactome)
DRD5 ProteinP21918 (Uniprot-TrEMBL)
FSHB ProteinP01225 (Uniprot-TrEMBL)
FSHR ProteinP23945 (Uniprot-TrEMBL)
G alpha

(s):GTP:Adenylate

cyclase
ComplexR-HSA-163622 (Reactome)
G alpha (s):GDPComplexR-HSA-164333 (Reactome)
G alpha (s):GTPComplexR-HSA-164358 (Reactome)
G-protein alpha

(i):GTP:Adenylate

cyclase
ComplexR-HSA-396910 (Reactome)
G-protein alpha

(z):GTP:Adenylate

cyclase
ComplexR-HSA-392049 (Reactome)
G-protein beta-gamma complexComplexR-HSA-167434 (Reactome)
G-protein beta:gamma signallingPathwayR-HSA-397795 (Reactome) The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.
GCG(146-178) ProteinP01275 (Uniprot-TrEMBL)
GCG(53-81) ProteinP01275 (Uniprot-TrEMBL)
GCGR ProteinP47871 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GHRH ProteinP01286 (Uniprot-TrEMBL)
GHRHR ProteinQ02643 (Uniprot-TrEMBL)
GIP(52-93) ProteinP09681 (Uniprot-TrEMBL)
GIPR ProteinP48546 (Uniprot-TrEMBL)
GLP-1 (7-37) ProteinP01275 (Uniprot-TrEMBL)
GLP1R ProteinP43220 (Uniprot-TrEMBL)
GLP2R ProteinO95838 (Uniprot-TrEMBL)
GNAI1 ProteinP63096 (Uniprot-TrEMBL)
GNAI2 ProteinP04899 (Uniprot-TrEMBL)
GNAI3 ProteinP08754 (Uniprot-TrEMBL)
GNAL ProteinP38405 (Uniprot-TrEMBL)
GNAL:GNB1:GNGT1ComplexR-HSA-380924 (Reactome) The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of intracellular second messengers. GPCRs activate the G-proteins, which consist of an alpha-subunit that binds and hydrolyses guanosine triphosphate (GTP), a beta and a gamma subunit.
GNALProteinP38405 (Uniprot-TrEMBL)
GNAS1 ProteinQ5JWF2 (Uniprot-TrEMBL)
GNAS2 ProteinP63092 (Uniprot-TrEMBL)
GNAT3 ProteinA8MTJ3 (Uniprot-TrEMBL)
GNAZ ProteinP19086 (Uniprot-TrEMBL)
GNB1 ProteinP62873 (Uniprot-TrEMBL)
GNB1ProteinP62873 (Uniprot-TrEMBL)
GNB2 ProteinP62879 (Uniprot-TrEMBL)
GNB3 ProteinP16520 (Uniprot-TrEMBL)
GNB4 ProteinQ9HAV0 (Uniprot-TrEMBL)
GNB5 ProteinO14775 (Uniprot-TrEMBL)
GNG10 ProteinP50151 (Uniprot-TrEMBL)
GNG11 ProteinP61952 (Uniprot-TrEMBL)
GNG12 ProteinQ9UBI6 (Uniprot-TrEMBL)
GNG13 ProteinQ9P2W3 (Uniprot-TrEMBL)
GNG2 ProteinP59768 (Uniprot-TrEMBL)
GNG3 ProteinP63215 (Uniprot-TrEMBL)
GNG4 ProteinP50150 (Uniprot-TrEMBL)
GNG5 ProteinP63218 (Uniprot-TrEMBL)
GNG7 ProteinO60262 (Uniprot-TrEMBL)
GNG8 ProteinQ9UK08 (Uniprot-TrEMBL)
GNGT1 ProteinP63211 (Uniprot-TrEMBL)
GNGT1ProteinP63211 (Uniprot-TrEMBL)
GNGT2 ProteinO14610 (Uniprot-TrEMBL)
GPBAR1 ProteinQ8TDU6 (Uniprot-TrEMBL)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
ComplexR-HSA-744890 (Reactome)
GPCRs that activate GsComplexR-HSA-790204 (Reactome)
GPHA2 ProteinQ96T91 (Uniprot-TrEMBL)
GPHB5 ProteinQ86YW7 (Uniprot-TrEMBL)
GPR39 ProteinO43194 (Uniprot-TrEMBL)
GRK2 ProteinP25098 (Uniprot-TrEMBL)
GRK2, GRK3, GRK5, GRK6ComplexR-HSA-8852026 (Reactome)
GRK5 ProteinP34947 (Uniprot-TrEMBL)
GRK6 ProteinP43250 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HRH2 ProteinP25021 (Uniprot-TrEMBL)
HTR4 ProteinQ13639 (Uniprot-TrEMBL)
HTR4,6,7 R-HSA-390942 (Reactome)
HTR6 ProteinP50406 (Uniprot-TrEMBL)
HTR7 ProteinP34969 (Uniprot-TrEMBL)
Heterotrimeric

G-protein Gs

(inactive)
ComplexR-HSA-391179 (Reactome)
Hist MetaboliteCHEBI:18295 (ChEBI)
IAPP(34-70) ProteinP10997 (Uniprot-TrEMBL)
INSL3(106-131) ProteinP51460 (Uniprot-TrEMBL)
INSL3(21-55) ProteinP51460 (Uniprot-TrEMBL)
LCHA MetaboliteCHEBI:16325 (ChEBI)
LHB ProteinP01229 (Uniprot-TrEMBL)
LHCGR ProteinP22888 (Uniprot-TrEMBL)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
ComplexR-HSA-744885 (Reactome)
Ligand:GPCR

complexes that

activate Gs
ComplexR-HSA-391181 (Reactome)
Ligands of GPCRs that activate GsComplexR-HSA-790205 (Reactome)
MC1R ProteinQ01726 (Uniprot-TrEMBL)
MC2R ProteinQ01718 (Uniprot-TrEMBL)
MC3R(1-360) ProteinP41968 (Uniprot-TrEMBL)
MC4R ProteinP32245 (Uniprot-TrEMBL)
MC5R ProteinP33032 (Uniprot-TrEMBL)
MSH R-HSA-388597 (Reactome)
Melanocortin receptors R-HSA-388601 (Reactome)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)
NAd MetaboliteCHEBI:18357 (ChEBI)
NPS ProteinP0C0P6 (Uniprot-TrEMBL)
NPSR1 ProteinQ6W5P4 (Uniprot-TrEMBL)
OR10A2 ProteinQ9H208 (Uniprot-TrEMBL)
OR10A3 ProteinP58181 (Uniprot-TrEMBL)
OR10A4 ProteinQ9H209 (Uniprot-TrEMBL)
OR10A5 ProteinQ9H207 (Uniprot-TrEMBL)
OR10A6 ProteinQ8NH74 (Uniprot-TrEMBL)
OR10A7 ProteinQ8NGE5 (Uniprot-TrEMBL)
OR10AC1P ProteinQ8NH08 (Uniprot-TrEMBL)
OR10AD1 ProteinQ8NGE0 (Uniprot-TrEMBL)
OR10AG1 ProteinQ8NH19 (Uniprot-TrEMBL)
OR10C1 ProteinQ96KK4 (Uniprot-TrEMBL)
OR10D3 ProteinQ8NH80 (Uniprot-TrEMBL)
OR10D4P ProteinQ8NGN7 (Uniprot-TrEMBL)
OR10G2 ProteinQ8NGC3 (Uniprot-TrEMBL)
OR10G3 ProteinQ8NGC4 (Uniprot-TrEMBL)
OR10G4 ProteinQ8NGN3 (Uniprot-TrEMBL)
OR10G6 ProteinQ8NH81 (Uniprot-TrEMBL)
OR10G7 ProteinQ8NGN6 (Uniprot-TrEMBL)
OR10G8 ProteinQ8NGN5 (Uniprot-TrEMBL)
OR10G9 ProteinQ8NGN4 (Uniprot-TrEMBL)
OR10H1 ProteinQ9Y4A9 (Uniprot-TrEMBL)
OR10H2 ProteinO60403 (Uniprot-TrEMBL)
OR10H3 ProteinO60404 (Uniprot-TrEMBL)
OR10H4 ProteinQ8NGA5 (Uniprot-TrEMBL)
OR10H5 ProteinQ8NGA6 (Uniprot-TrEMBL)
OR10J1 ProteinP30954 (Uniprot-TrEMBL)
OR10J3 ProteinQ5JRS4 (Uniprot-TrEMBL)
OR10J4 ProteinP0C629 (Uniprot-TrEMBL)
OR10J5 ProteinQ8NHC4 (Uniprot-TrEMBL)
OR10J6P ProteinQ8NGY7 (Uniprot-TrEMBL)
OR10K1 ProteinQ8NGX5 (Uniprot-TrEMBL)
OR10K2 ProteinQ6IF99 (Uniprot-TrEMBL)
OR10P1 ProteinQ8NGE3 (Uniprot-TrEMBL)
OR10Q1 ProteinQ8NGQ4 (Uniprot-TrEMBL)
OR10R2 ProteinQ8NGX6 (Uniprot-TrEMBL)
OR10S1 ProteinQ8NGN2 (Uniprot-TrEMBL)
OR10T2 ProteinQ8NGX3 (Uniprot-TrEMBL)
OR10V1 ProteinQ8NGI7 (Uniprot-TrEMBL)
OR10W1 ProteinQ8NGF6 (Uniprot-TrEMBL)
OR10X1 ProteinQ8NGY0 (Uniprot-TrEMBL)
OR10Z1 ProteinQ8NGY1 (Uniprot-TrEMBL)
OR11A1 ProteinQ9GZK7 (Uniprot-TrEMBL)
OR11G2 ProteinQ8NGC1 (Uniprot-TrEMBL)
OR11H1 ProteinQ8NG94 (Uniprot-TrEMBL)
OR11H2 ProteinQ8NH07 (Uniprot-TrEMBL)
OR11H4 ProteinQ8NGC9 (Uniprot-TrEMBL)
OR11H6 ProteinQ8NGC7 (Uniprot-TrEMBL)
OR11H7 ProteinQ8NGC8 (Uniprot-TrEMBL)
OR11L1 ProteinQ8NGX0 (Uniprot-TrEMBL)
OR12D2 ProteinP58182 (Uniprot-TrEMBL)
OR12D3 ProteinQ9UGF7 (Uniprot-TrEMBL)
OR13A1 ProteinQ8NGR1 (Uniprot-TrEMBL)
OR13C2 ProteinQ8NGS9 (Uniprot-TrEMBL)
OR13C3 ProteinQ8NGS6 (Uniprot-TrEMBL)
OR13C4 ProteinQ8NGS5 (Uniprot-TrEMBL)
OR13C5 ProteinQ8NGS8 (Uniprot-TrEMBL)
OR13C8 ProteinQ8NGS7 (Uniprot-TrEMBL)
OR13C9 ProteinQ8NGT0 (Uniprot-TrEMBL)
OR13D1 ProteinQ8NGV5 (Uniprot-TrEMBL)
OR13F1 ProteinQ8NGS4 (Uniprot-TrEMBL)
OR13G1 ProteinQ8NGZ3 (Uniprot-TrEMBL)
OR13H1 ProteinQ8NG92 (Uniprot-TrEMBL)
OR13J1 ProteinQ8NGT2 (Uniprot-TrEMBL)
OR14A16 ProteinQ8NHC5 (Uniprot-TrEMBL)
OR14A2 ProteinQ96R54 (Uniprot-TrEMBL)
OR14C36 ProteinQ8NHC7 (Uniprot-TrEMBL)
OR14I1 ProteinA6ND48 (Uniprot-TrEMBL)
OR14J1 ProteinQ9UGF5 (Uniprot-TrEMBL)
OR14K1 ProteinQ8NGZ2 (Uniprot-TrEMBL)
OR14L1P ProteinQ8NHC6 (Uniprot-TrEMBL)
OR1A1 ProteinQ9P1Q5 (Uniprot-TrEMBL)
OR1A2 ProteinQ9Y585 (Uniprot-TrEMBL)
OR1B1 ProteinQ8NGR6 (Uniprot-TrEMBL)
OR1C1 ProteinQ15619 (Uniprot-TrEMBL)
OR1D2 ProteinP34982 (Uniprot-TrEMBL)
OR1D4 ProteinP47884 (Uniprot-TrEMBL)
OR1D5 ProteinP58170 (Uniprot-TrEMBL)
OR1E1 ProteinP30953 (Uniprot-TrEMBL)
OR1E2 ProteinP47887 (Uniprot-TrEMBL)
OR1E3 ProteinQ8WZA6 (Uniprot-TrEMBL)
OR1F1 ProteinO43749 (Uniprot-TrEMBL)
OR1F12 ProteinQ8NHA8 (Uniprot-TrEMBL)
OR1F2P ProteinQ96R84 (Uniprot-TrEMBL)
OR1G1 ProteinP47890 (Uniprot-TrEMBL)
OR1I1 ProteinO60431 (Uniprot-TrEMBL)
OR1J1 ProteinQ8NGS3 (Uniprot-TrEMBL)
OR1J2 ProteinQ8NGS2 (Uniprot-TrEMBL)
OR1J4 ProteinQ8NGS1 (Uniprot-TrEMBL)
OR1K1 ProteinQ8NGR3 (Uniprot-TrEMBL)
OR1L1 ProteinQ8NH94 (Uniprot-TrEMBL)
OR1L3 ProteinQ8NH93 (Uniprot-TrEMBL)
OR1L4 ProteinQ8NGR5 (Uniprot-TrEMBL)
OR1L6 ProteinQ8NGR2 (Uniprot-TrEMBL)
OR1L8 ProteinQ8NGR8 (Uniprot-TrEMBL)
OR1M1 ProteinQ8NGA1 (Uniprot-TrEMBL)
OR1N1 ProteinQ8NGS0 (Uniprot-TrEMBL)
OR1N2 ProteinQ8NGR9 (Uniprot-TrEMBL)
OR1P1 ProteinQ8NH06 (Uniprot-TrEMBL)
OR1Q1 ProteinQ15612 (Uniprot-TrEMBL)
OR1S1 ProteinQ8NH92 (Uniprot-TrEMBL)
OR1S2 ProteinQ8NGQ3 (Uniprot-TrEMBL)
OR2A1 ProteinQ8NGT9 (Uniprot-TrEMBL)
OR2A12 ProteinQ8NGT7 (Uniprot-TrEMBL)
OR2A14 ProteinQ96R47 (Uniprot-TrEMBL)
OR2A2 ProteinQ6IF42 (Uniprot-TrEMBL)
OR2A25 ProteinA4D2G3 (Uniprot-TrEMBL)
OR2A4 ProteinO95047 (Uniprot-TrEMBL)
OR2A5 ProteinQ96R48 (Uniprot-TrEMBL)
OR2A7 ProteinQ96R45 (Uniprot-TrEMBL)
OR2AE1 ProteinQ8NHA4 (Uniprot-TrEMBL)
OR2AG1 ProteinQ9H205 (Uniprot-TrEMBL)
OR2AG2 ProteinA6NM03 (Uniprot-TrEMBL)
OR2AJ1 ProteinQ8NGZ0 (Uniprot-TrEMBL)
OR2AK2 ProteinQ8NG84 (Uniprot-TrEMBL)
OR2AP1 ProteinQ8NGE2 (Uniprot-TrEMBL)
OR2AT4 ProteinA6NND4 (Uniprot-TrEMBL)
OR2B11 ProteinQ5JQS5 (Uniprot-TrEMBL)
OR2B2 ProteinQ9GZK3 (Uniprot-TrEMBL)
OR2B3 ProteinO76000 (Uniprot-TrEMBL)
OR2B6 ProteinP58173 (Uniprot-TrEMBL)
OR2B8P ProteinP59922 (Uniprot-TrEMBL)
OR2C1 ProteinO95371 (Uniprot-TrEMBL)
OR2C3 ProteinQ8N628 (Uniprot-TrEMBL)
OR2D2 ProteinQ9H210 (Uniprot-TrEMBL)
OR2D3 ProteinQ8NGH3 (Uniprot-TrEMBL)
OR2F1 ProteinQ13607 (Uniprot-TrEMBL)
OR2F2 ProteinO95006 (Uniprot-TrEMBL)
OR2G2 ProteinQ8NGZ5 (Uniprot-TrEMBL)
OR2G3 ProteinQ8NGZ4 (Uniprot-TrEMBL)
OR2G6 ProteinQ5TZ20 (Uniprot-TrEMBL)
OR2H1 ProteinQ9GZK4 (Uniprot-TrEMBL)
OR2H2 ProteinO95918 (Uniprot-TrEMBL)
OR2I1P ProteinQ8NGU4 (Uniprot-TrEMBL)
OR2J1 ProteinQ9GZK6 (Uniprot-TrEMBL)
OR2J2 ProteinO76002 (Uniprot-TrEMBL)
OR2J3 ProteinO76001 (Uniprot-TrEMBL)
OR2K2 ProteinQ8NGT1 (Uniprot-TrEMBL)
OR2L13 ProteinQ8N349 (Uniprot-TrEMBL)
OR2L2 ProteinQ8NH16 (Uniprot-TrEMBL)
OR2L3 ProteinQ8NG85 (Uniprot-TrEMBL)
OR2L5 ProteinQ8NG80 (Uniprot-TrEMBL)
OR2L8 ProteinQ8NGY9 (Uniprot-TrEMBL)
OR2M2 ProteinQ96R28 (Uniprot-TrEMBL)
OR2M3 ProteinQ8NG83 (Uniprot-TrEMBL)
OR2M4 ProteinQ96R27 (Uniprot-TrEMBL)
OR2M5 ProteinA3KFT3 (Uniprot-TrEMBL)
OR2M7 ProteinQ8NG81 (Uniprot-TrEMBL)
OR2S2 ProteinQ9NQN1 (Uniprot-TrEMBL)
OR2T1 ProteinO43869 (Uniprot-TrEMBL)
OR2T10 ProteinQ8NGZ9 (Uniprot-TrEMBL)
OR2T11 ProteinQ8NH01 (Uniprot-TrEMBL)
OR2T12 ProteinQ8NG77 (Uniprot-TrEMBL)
OR2T2 ProteinQ6IF00 (Uniprot-TrEMBL)
OR2T27 ProteinQ8NH04 (Uniprot-TrEMBL)
OR2T29 ProteinQ8NH02 (Uniprot-TrEMBL)
OR2T3 ProteinQ8NH03 (Uniprot-TrEMBL)
OR2T33 ProteinQ8NG76 (Uniprot-TrEMBL)
OR2T34 ProteinQ8NGX1 (Uniprot-TrEMBL)
OR2T35 ProteinQ8NGX2 (Uniprot-TrEMBL)
OR2T4 ProteinQ8NH00 (Uniprot-TrEMBL)
OR2T5 ProteinQ6IEZ7 (Uniprot-TrEMBL)
OR2T6 ProteinQ8NHC8 (Uniprot-TrEMBL)
OR2T7 ProteinP0C7T2 (Uniprot-TrEMBL)
OR2T8 ProteinA6NH00 (Uniprot-TrEMBL)
OR2V1 ProteinQ8NHB1 (Uniprot-TrEMBL)
OR2V2 ProteinQ96R30 (Uniprot-TrEMBL)
OR2W1 ProteinQ9Y3N9 (Uniprot-TrEMBL)
OR2W3 ProteinQ7Z3T1 (Uniprot-TrEMBL)
OR2W5 ProteinA6NFC9 (Uniprot-TrEMBL)
OR2W6P ProteinQ8NHA6 (Uniprot-TrEMBL)
OR2Y1 ProteinQ8NGV0 (Uniprot-TrEMBL)
OR2Z1 ProteinQ8NG97 (Uniprot-TrEMBL)
OR3A1 ProteinP47881 (Uniprot-TrEMBL)
OR3A2 ProteinP47893 (Uniprot-TrEMBL)
OR3A3 ProteinP47888 (Uniprot-TrEMBL)
OR3A4P ProteinP47883 (Uniprot-TrEMBL)
OR4A15 ProteinQ8NGL6 (Uniprot-TrEMBL)
OR4A16 ProteinQ8NH70 (Uniprot-TrEMBL)
OR4A47 ProteinQ6IF82 (Uniprot-TrEMBL)
OR4A4P ProteinQ8NGN8 (Uniprot-TrEMBL)
OR4A5 ProteinQ8NH83 (Uniprot-TrEMBL)
OR4A8P ProteinP0C604 (Uniprot-TrEMBL)
OR4B1 ProteinQ8NGF8 (Uniprot-TrEMBL)
OR4C11 ProteinQ6IEV9 (Uniprot-TrEMBL)
OR4C12 ProteinQ96R67 (Uniprot-TrEMBL)
OR4C13 ProteinQ8NGP0 (Uniprot-TrEMBL)
OR4C15 ProteinQ8NGM1 (Uniprot-TrEMBL)
OR4C16 ProteinQ8NGL9 (Uniprot-TrEMBL)
OR4C3 ProteinQ8NH37 (Uniprot-TrEMBL)
OR4C45 ProteinA6NMZ5 (Uniprot-TrEMBL)
OR4C46 ProteinA6NHA9 (Uniprot-TrEMBL)
OR4C5 ProteinQ8NGB2 (Uniprot-TrEMBL)
OR4C6 ProteinQ8NH72 (Uniprot-TrEMBL)
OR4D1 ProteinQ15615 (Uniprot-TrEMBL)
OR4D10 ProteinQ8NGI6 (Uniprot-TrEMBL)
OR4D11 ProteinQ8NGI4 (Uniprot-TrEMBL)
OR4D2 ProteinP58180 (Uniprot-TrEMBL)
OR4D5 ProteinQ8NGN0 (Uniprot-TrEMBL)
OR4D6 ProteinQ8NGJ1 (Uniprot-TrEMBL)
OR4D9 ProteinQ8NGE8 (Uniprot-TrEMBL)
OR4E1 ProteinP0C645 (Uniprot-TrEMBL)
OR4E2 ProteinQ8NGC2 (Uniprot-TrEMBL)
OR4F15 ProteinQ8NGB8 (Uniprot-TrEMBL)
OR4F17 ProteinQ8NGA8 (Uniprot-TrEMBL)
OR4F21 ProteinO95013 (Uniprot-TrEMBL)
OR4F3 ProteinQ6IEY1 (Uniprot-TrEMBL)
OR4F4 ProteinQ96R69 (Uniprot-TrEMBL)
OR4F5 ProteinQ8NH21 (Uniprot-TrEMBL)
OR4F6 ProteinQ8NGB9 (Uniprot-TrEMBL)
OR4K1 ProteinQ8NGD4 (Uniprot-TrEMBL)
OR4K13 ProteinQ8NH42 (Uniprot-TrEMBL)
OR4K14 ProteinQ8NGD5 (Uniprot-TrEMBL)
OR4K15 ProteinQ8NH41 (Uniprot-TrEMBL)
OR4K17 ProteinQ8NGC6 (Uniprot-TrEMBL)
OR4K2 ProteinQ8NGD2 (Uniprot-TrEMBL)
OR4K3 ProteinQ96R72 (Uniprot-TrEMBL)
OR4K5 ProteinQ8NGD3 (Uniprot-TrEMBL)
OR4L1 ProteinQ8NH43 (Uniprot-TrEMBL)
OR4M1 ProteinQ8NGD0 (Uniprot-TrEMBL)
OR4M2 ProteinQ8NGB6 (Uniprot-TrEMBL)
OR4N2 ProteinQ8NGD1 (Uniprot-TrEMBL)
OR4N4 ProteinQ8N0Y3 (Uniprot-TrEMBL)
OR4N5 ProteinQ8IXE1 (Uniprot-TrEMBL)
OR4P4 ProteinQ8NGL7 (Uniprot-TrEMBL)
OR4Q2 ProteinP0C623 (Uniprot-TrEMBL)
OR4Q3 ProteinQ8NH05 (Uniprot-TrEMBL)
OR4S1 ProteinQ8NGB4 (Uniprot-TrEMBL)
OR4S2 ProteinQ8NH73 (Uniprot-TrEMBL)
OR4X1 ProteinQ8NH49 (Uniprot-TrEMBL)
OR4X2 ProteinQ8NGF9 (Uniprot-TrEMBL)
OR51A2 ProteinQ8NGJ7 (Uniprot-TrEMBL)
OR51A4 ProteinQ8NGJ6 (Uniprot-TrEMBL)
OR51A7 ProteinQ8NH64 (Uniprot-TrEMBL)
OR51B2 ProteinQ9Y5P1 (Uniprot-TrEMBL)
OR51B4 ProteinQ9Y5P0 (Uniprot-TrEMBL)
OR51B5 ProteinQ9H339 (Uniprot-TrEMBL)
OR51B6 ProteinQ9H340 (Uniprot-TrEMBL)
OR51D1 ProteinQ8NGF3 (Uniprot-TrEMBL)
OR51E1 ProteinQ8TCB6 (Uniprot-TrEMBL)
OR51E2 ProteinQ9H255 (Uniprot-TrEMBL)
OR51F1 ProteinA6NGY5 (Uniprot-TrEMBL)
OR51F2 ProteinQ8NH61 (Uniprot-TrEMBL)
OR51G1 ProteinQ8NGK1 (Uniprot-TrEMBL)
OR51G2 ProteinQ8NGK0 (Uniprot-TrEMBL)
OR51H1P ProteinQ8NH63 (Uniprot-TrEMBL)
OR51I1 ProteinQ9H343 (Uniprot-TrEMBL)
OR51I2 ProteinQ9H344 (Uniprot-TrEMBL)
OR51J1 ProteinQ9H342 (Uniprot-TrEMBL)
OR51L1 ProteinQ8NGJ5 (Uniprot-TrEMBL)
OR51M1 ProteinQ9H341 (Uniprot-TrEMBL)
OR51Q1 ProteinQ8NH59 (Uniprot-TrEMBL)
OR51S1 ProteinQ8NGJ8 (Uniprot-TrEMBL)
OR51T1 ProteinQ8NGJ9 (Uniprot-TrEMBL)
OR51V1 ProteinQ9H2C8 (Uniprot-TrEMBL)
OR52A1 ProteinQ9UKL2 (Uniprot-TrEMBL)
OR52A4 ProteinA6NMU1 (Uniprot-TrEMBL)
OR52A5 ProteinQ9H2C5 (Uniprot-TrEMBL)
OR52B2 ProteinQ96RD2 (Uniprot-TrEMBL)
OR52B6 ProteinQ8NGF0 (Uniprot-TrEMBL)
OR52D1 ProteinQ9H346 (Uniprot-TrEMBL)
OR52E1 ProteinQ8NGJ3 (Uniprot-TrEMBL)
OR52E2 ProteinQ8NGJ4 (Uniprot-TrEMBL)
OR52E4 ProteinQ8NGH9 (Uniprot-TrEMBL)
OR52E5 ProteinQ8NH55 (Uniprot-TrEMBL)
OR52E6 ProteinQ96RD3 (Uniprot-TrEMBL)
OR52E8 ProteinQ6IFG1 (Uniprot-TrEMBL)
OR52H1 ProteinQ8NGJ2 (Uniprot-TrEMBL)
OR52I1 ProteinQ8NGK6 (Uniprot-TrEMBL)
OR52I2 ProteinQ8NH67 (Uniprot-TrEMBL)
OR52J3 ProteinQ8NH60 (Uniprot-TrEMBL)
OR52K1 ProteinQ8NGK4 (Uniprot-TrEMBL)
OR52K2 ProteinQ8NGK3 (Uniprot-TrEMBL)
OR52L1 ProteinQ8NGH7 (Uniprot-TrEMBL)
OR52L2P ProteinQ8NGH6 (Uniprot-TrEMBL)
OR52M1 ProteinQ8NGK5 (Uniprot-TrEMBL)
OR52N1 ProteinQ8NH53 (Uniprot-TrEMBL)
OR52N2 ProteinQ8NGI0 (Uniprot-TrEMBL)
OR52N4 ProteinQ8NGI2 (Uniprot-TrEMBL)
OR52N5 ProteinQ8NH56 (Uniprot-TrEMBL)
OR52P1P ProteinQ8NH57 (Uniprot-TrEMBL)
OR52R1 ProteinQ8NGF1 (Uniprot-TrEMBL)
OR52W1 ProteinQ6IF63 (Uniprot-TrEMBL)
OR52Z1 ProteinP0C646 (Uniprot-TrEMBL)
OR56A1 ProteinQ8NGH5 (Uniprot-TrEMBL)
OR56A3 ProteinQ8NH54 (Uniprot-TrEMBL)
OR56A4 ProteinQ8NGH8 (Uniprot-TrEMBL)
OR56A5 ProteinP0C7T3 (Uniprot-TrEMBL)
OR56B1 ProteinQ8NGI3 (Uniprot-TrEMBL)
OR56B2P ProteinQ8NGI1 (Uniprot-TrEMBL)
OR56B4 ProteinQ8NH76 (Uniprot-TrEMBL)
OR5A1 ProteinQ8NGJ0 (Uniprot-TrEMBL)
OR5A2 ProteinQ8NGI9 (Uniprot-TrEMBL)
OR5AC1 ProteinP0C628 (Uniprot-TrEMBL)
OR5AC2 ProteinQ9NZP5 (Uniprot-TrEMBL)
OR5AK2 ProteinQ8NH90 (Uniprot-TrEMBL)
OR5AK3P ProteinQ8NH89 (Uniprot-TrEMBL)
OR5AL1 ProteinP0C617 (Uniprot-TrEMBL)
OR5AN1 ProteinQ8NGI8 (Uniprot-TrEMBL)
OR5AP2 ProteinQ8NGF4 (Uniprot-TrEMBL)
OR5AR1 ProteinQ8NGP9 (Uniprot-TrEMBL)
OR5AS1 ProteinQ8N127 (Uniprot-TrEMBL)
OR5AU1 ProteinQ8NGC0 (Uniprot-TrEMBL)
OR5B12 ProteinQ96R08 (Uniprot-TrEMBL)
OR5B17 ProteinQ8NGF7 (Uniprot-TrEMBL)
OR5B2 ProteinQ96R09 (Uniprot-TrEMBL)
OR5B21 ProteinA6NL26 (Uniprot-TrEMBL)
OR5B3 ProteinQ8NH48 (Uniprot-TrEMBL)
OR5C1 ProteinQ8NGR4 (Uniprot-TrEMBL)
OR5D13 ProteinQ8NGL4 (Uniprot-TrEMBL)
OR5D14 ProteinQ8NGL3 (Uniprot-TrEMBL)
OR5D16 ProteinQ8NGK9 (Uniprot-TrEMBL)
OR5D18 ProteinQ8NGL1 (Uniprot-TrEMBL)
OR5F1 ProteinO95221 (Uniprot-TrEMBL)
OR5G3 ProteinP0C626 (Uniprot-TrEMBL)
OR5H1 ProteinA6NKK0 (Uniprot-TrEMBL)
OR5H14 ProteinA6NHG9 (Uniprot-TrEMBL)
OR5H15 ProteinA6NDH6 (Uniprot-TrEMBL)
OR5H2 ProteinQ8NGV7 (Uniprot-TrEMBL)
OR5H6 ProteinQ8NGV6 (Uniprot-TrEMBL)
OR5I1 ProteinQ13606 (Uniprot-TrEMBL)
OR5J2 ProteinQ8NH18 (Uniprot-TrEMBL)
OR5K1 ProteinQ8NHB7 (Uniprot-TrEMBL)
OR5K2 ProteinQ8NHB8 (Uniprot-TrEMBL)
OR5K3 ProteinA6NET4 (Uniprot-TrEMBL)
OR5K4 ProteinA6NMS3 (Uniprot-TrEMBL)
OR5L1 ProteinQ8NGL2 (Uniprot-TrEMBL)
OR5L2 ProteinQ8NGL0 (Uniprot-TrEMBL)
OR5M1 ProteinQ8NGP8 (Uniprot-TrEMBL)
OR5M10 ProteinQ6IEU7 (Uniprot-TrEMBL)
OR5M11 ProteinQ96RB7 (Uniprot-TrEMBL)
OR5M3 ProteinQ8NGP4 (Uniprot-TrEMBL)
OR5M8 ProteinQ8NGP6 (Uniprot-TrEMBL)
OR5M9 ProteinQ8NGP3 (Uniprot-TrEMBL)
OR5P2 ProteinQ8WZ92 (Uniprot-TrEMBL)
OR5P3 ProteinQ8WZ94 (Uniprot-TrEMBL)
OR5R1 ProteinQ8NH85 (Uniprot-TrEMBL)
OR5T1 ProteinQ8NG75 (Uniprot-TrEMBL)
OR5T2 ProteinQ8NGG2 (Uniprot-TrEMBL)
OR5T3 ProteinQ8NGG3 (Uniprot-TrEMBL)
OR5V1 ProteinQ9UGF6 (Uniprot-TrEMBL)
OR5W2 ProteinQ8NH69 (Uniprot-TrEMBL)
OR6A2 ProteinO95222 (Uniprot-TrEMBL)
OR6B1 ProteinO95007 (Uniprot-TrEMBL)
OR6B2 ProteinQ6IFH4 (Uniprot-TrEMBL)
OR6B3 ProteinQ8NGW1 (Uniprot-TrEMBL)
OR6C1 ProteinQ96RD1 (Uniprot-TrEMBL)
OR6C2 ProteinQ9NZP2 (Uniprot-TrEMBL)
OR6C3 ProteinQ9NZP0 (Uniprot-TrEMBL)
OR6C4 ProteinQ8NGE1 (Uniprot-TrEMBL)
OR6C6 ProteinA6NF89 (Uniprot-TrEMBL)
OR6C65 ProteinA6NJZ3 (Uniprot-TrEMBL)
OR6C68 ProteinA6NDL8 (Uniprot-TrEMBL)
OR6C70 ProteinA6NIJ9 (Uniprot-TrEMBL)
OR6C74 ProteinA6NCV1 (Uniprot-TrEMBL)
OR6C75 ProteinA6NL08 (Uniprot-TrEMBL)
OR6C76 ProteinA6NM76 (Uniprot-TrEMBL)
OR6F1 ProteinQ8NGZ6 (Uniprot-TrEMBL)
OR6J1 ProteinQ8NGC5 (Uniprot-TrEMBL)
OR6K2 ProteinQ8NGY2 (Uniprot-TrEMBL)
OR6K3 ProteinQ8NGY3 (Uniprot-TrEMBL)
OR6K6 ProteinQ8NGW6 (Uniprot-TrEMBL)
OR6M1 ProteinQ8NGM8 (Uniprot-TrEMBL)
OR6N1 ProteinQ8NGY5 (Uniprot-TrEMBL)
OR6N2 ProteinQ8NGY6 (Uniprot-TrEMBL)
OR6P1 ProteinQ8NGX9 (Uniprot-TrEMBL)
OR6Q1 ProteinQ8NGQ2 (Uniprot-TrEMBL)
OR6S1 ProteinQ8NH40 (Uniprot-TrEMBL)
OR6T1 ProteinQ8NGN1 (Uniprot-TrEMBL)
OR6V1 ProteinQ8N148 (Uniprot-TrEMBL)
OR6X1 ProteinQ8NH79 (Uniprot-TrEMBL)
OR6Y1 ProteinQ8NGX8 (Uniprot-TrEMBL)
OR7A10 ProteinO76100 (Uniprot-TrEMBL)
OR7A17 ProteinO14581 (Uniprot-TrEMBL)
OR7A2P ProteinQ8NGA2 (Uniprot-TrEMBL)
OR7A5 ProteinQ15622 (Uniprot-TrEMBL)
OR7C1 ProteinO76099 (Uniprot-TrEMBL)
OR7C2 ProteinO60412 (Uniprot-TrEMBL)
OR7D2 ProteinQ96RA2 (Uniprot-TrEMBL)
OR7D4 ProteinQ8NG98 (Uniprot-TrEMBL)
OR7E24 ProteinQ6IFN5 (Uniprot-TrEMBL)
OR7G1 ProteinQ8NGA0 (Uniprot-TrEMBL)
OR7G2 ProteinQ8NG99 (Uniprot-TrEMBL)
OR7G3 ProteinQ8NG95 (Uniprot-TrEMBL)
OR8A1 ProteinQ8NGG7 (Uniprot-TrEMBL)
OR8B12 ProteinQ8NGG6 (Uniprot-TrEMBL)
OR8B2 ProteinQ96RD0 (Uniprot-TrEMBL)
OR8B3 ProteinQ8NGG8 (Uniprot-TrEMBL)
OR8B4 ProteinQ96RC9 (Uniprot-TrEMBL)
OR8B8 ProteinQ15620 (Uniprot-TrEMBL)
OR8D1 ProteinQ8WZ84 (Uniprot-TrEMBL)
OR8D2 ProteinQ9GZM6 (Uniprot-TrEMBL)
OR8D4 ProteinQ8NGM9 (Uniprot-TrEMBL)
OR8G1 ProteinQ15617 (Uniprot-TrEMBL)
OR8G2 ProteinQ6IF36 (Uniprot-TrEMBL)
OR8G5 ProteinQ8NG78 (Uniprot-TrEMBL)
OR8H1 ProteinQ8NGG4 (Uniprot-TrEMBL)
OR8H2 ProteinQ8N162 (Uniprot-TrEMBL)
OR8H3 ProteinQ8N146 (Uniprot-TrEMBL)
OR8I2 ProteinQ8N0Y5 (Uniprot-TrEMBL)
OR8J1 ProteinQ8NGP2 (Uniprot-TrEMBL)
OR8J2 ProteinQ8NGG1 (Uniprot-TrEMBL)
OR8J3 ProteinQ8NGG0 (Uniprot-TrEMBL)
OR8K1 ProteinQ8NGG5 (Uniprot-TrEMBL)
OR8K3 ProteinQ8NH51 (Uniprot-TrEMBL)
OR8K5 ProteinQ8NH50 (Uniprot-TrEMBL)
OR8S1 ProteinQ8NH09 (Uniprot-TrEMBL)
OR8U1 ProteinQ8NH10 (Uniprot-TrEMBL)
OR8U8 ProteinP0C7N1 (Uniprot-TrEMBL)
OR8U9 ProteinP0C7N5 (Uniprot-TrEMBL)
OR9A1P ProteinQ8NGU1 (Uniprot-TrEMBL)
OR9A2 ProteinQ8NGT5 (Uniprot-TrEMBL)
OR9A4 ProteinQ8NGU2 (Uniprot-TrEMBL)
OR9G1 ProteinQ8NH87 (Uniprot-TrEMBL)
OR9G4 ProteinQ8NGQ1 (Uniprot-TrEMBL)
OR9G9 ProteinP0C7N8 (Uniprot-TrEMBL)
OR9I1 ProteinQ8NGQ6 (Uniprot-TrEMBL)
OR9K2 ProteinQ8NGE7 (Uniprot-TrEMBL)
OR9Q1 ProteinQ8NGQ5 (Uniprot-TrEMBL)
OR9Q2 ProteinQ8NGE9 (Uniprot-TrEMBL)
Olfactory receptor:G protein trimerComplexR-HSA-381747 (Reactome) Olfactory receptors (ORs) have diverse protein sequences but can be assigned to subfamilies on the basis of sequence relationships. Odorants and pheromones bind to these seven transmembrane domain G-protein-coupled receptors that permit signal transduction. These receptors are encoded by large multigene families that evolved in mammal species in function of specific olfactory needs. Members of the same subfamily have related sequences and are likely to recognize structurally related odorants.
Of the 960 human OR genes and pseudogenes, there is experimental evidence which indicates that at least 437 actually are expressed in human olfactory epithelium; this includes 357 OR genes, and 80 OR pseudogenes (Zhang, 2007). These 357 olfactory-expressed OR genes are therefore expected to be functional in the Olfactory Signaling Pathway, and to interact directly with human G alpha olf in human olfactory cells.

(Note: A subset of 200 of these 357 OR genes are shown as components of OR-G Protein reaction. The others will be added to Reactome later.)

Olfactory receptorsComplexR-HSA-381741 (Reactome)
P2RY11 ProteinQ96G91 (Uniprot-TrEMBL)
PEA MetaboliteCHEBI:18397 (ChEBI)
PGD2 MetaboliteCHEBI:15555 (ChEBI)
PGE2 MetaboliteCHEBI:15551 (ChEBI)
PGI2 MetaboliteCHEBI:15552 (ChEBI)
POMC(138-150) ProteinP01189 (Uniprot-TrEMBL)
POMC(138-176) ProteinP01189 (Uniprot-TrEMBL)
POMC(217-234) ProteinP01189 (Uniprot-TrEMBL)
POMC(77-87) ProteinP01189 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PTGDR ProteinQ13258 (Uniprot-TrEMBL)
PTGER2 ProteinP43116 (Uniprot-TrEMBL)
PTGER2,PTGER4 R-HSA-391921 (Reactome)
PTGER4 ProteinP35408 (Uniprot-TrEMBL)
PTGIR ProteinP43119 (Uniprot-TrEMBL)
PTH ProteinP01270 (Uniprot-TrEMBL)
PTH1R ProteinQ03431 (Uniprot-TrEMBL)
PTH1R,PTH2R R-HSA-420554 (Reactome)
PTH1R,PTH2R ligands R-HSA-420569 (Reactome)
PTH2(62-100) ProteinQ96A98 (Uniprot-TrEMBL)
PTH2R ProteinP49190 (Uniprot-TrEMBL)
PTHLH ProteinP12272 (Uniprot-TrEMBL)
Phosphodiesterases, cyclic AMP-selective R-HSA-418543 (Reactome)
Phosphodiesterases, dual (cAMP, cGMP) activity R-HSA-418547 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RAMP1 ProteinO60894 (Uniprot-TrEMBL)
RAMP2 ProteinO60895 (Uniprot-TrEMBL)
RAMP3 ProteinO60896 (Uniprot-TrEMBL)
REEP1 ProteinQ9H902 (Uniprot-TrEMBL)
REEP2 ProteinQ9BRK0 (Uniprot-TrEMBL)
REEP3 ProteinQ6NUK4 (Uniprot-TrEMBL)
REEP4 ProteinQ9H6H4 (Uniprot-TrEMBL)
REEP5 ProteinQ00765 (Uniprot-TrEMBL)
REEP6 ProteinQ96HR9 (Uniprot-TrEMBL)
REEPsComplexR-HSA-8939723 (Reactome)
RLN2(162-185) ProteinP04090 (Uniprot-TrEMBL)
RLN2(25-53) ProteinP04090 (Uniprot-TrEMBL)
RLN3(119-142) ProteinQ8WXF3 (Uniprot-TrEMBL)
RLN3(26-52) ProteinQ8WXF3 (Uniprot-TrEMBL)
RTP1 ProteinP59025 (Uniprot-TrEMBL)
RTP2 ProteinQ5QGT7 (Uniprot-TrEMBL)
RTP3 ProteinQ9BQQ7 (Uniprot-TrEMBL)
RTP4 ProteinQ96DX8 (Uniprot-TrEMBL)
RTP5 ProteinQ14D33 (Uniprot-TrEMBL)
RTPsComplexR-HSA-8939445 (Reactome)
RXFP1 ProteinQ9HBX9 (Uniprot-TrEMBL)
RXFP2 ProteinQ8WXD0 (Uniprot-TrEMBL)
RXFP2 ligands R-HSA-444902 (Reactome)
Relaxin-2, Relaxin-3 R-HSA-444858 (Reactome)
SCT ProteinP09683 (Uniprot-TrEMBL)
SCTR ProteinP47872 (Uniprot-TrEMBL)
TAAR1 ProteinQ96RJ0 (Uniprot-TrEMBL)
TAAR2 ProteinQ9P1P5 (Uniprot-TrEMBL)
TAAR3 ProteinQ9P1P4 (Uniprot-TrEMBL)
TAAR5 ProteinO14804 (Uniprot-TrEMBL)
TAAR6 ProteinQ96RI8 (Uniprot-TrEMBL)
TAAR8 ProteinQ969N4 (Uniprot-TrEMBL)
TAAR9 ProteinQ96RI9 (Uniprot-TrEMBL)
TSHB ProteinP01222 (Uniprot-TrEMBL)
TSHR ProteinP16473 (Uniprot-TrEMBL)
Trace amine-associated receptor R-HSA-391201 (Reactome)
VIP(125-152) ProteinP01282 (Uniprot-TrEMBL)
VIPR1 ProteinP32241 (Uniprot-TrEMBL)
VIPR1,VIPR2 R-HSA-420267 (Reactome)
VIPR2 ProteinP41587 (Uniprot-TrEMBL)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)
cAMP phosphodiesterasesComplexR-HSA-418562 (Reactome)
cAMPMetaboliteCHEBI:17489 (ChEBI)
mature GLP-1 R-HSA-381662 (Reactome)
pS-ADRB2 ProteinP07550 (Uniprot-TrEMBL)
pS-ADRB2:Catecholamine:ARRB1,ARRB2ComplexR-HSA-8852170 (Reactome)
pS-ADRB2:Catecholamine:GRKComplexR-HSA-8982648 (Reactome)
pS-ADRB2:CatecholamineComplexR-HSA-8852152 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADPArrowR-HSA-8851797 (Reactome)
ADRB2:Catecholamine:GRKArrowR-HSA-8982645 (Reactome)
ADRB2:Catecholamine:GRKR-HSA-8851797 (Reactome)
ADRB2:Catecholamine:GRKmim-catalysisR-HSA-8851797 (Reactome)
ADRB2:CatecholamineR-HSA-8982645 (Reactome)
AMPArrowR-HSA-418553 (Reactome)
ARRBR-HSA-8852167 (Reactome)
ATPR-HSA-392129 (Reactome)
ATPR-HSA-8851797 (Reactome)
Adenylate cyclase (Mg2+ cofactor)R-HSA-163617 (Reactome)
Adenylate cyclase (Mg2+ cofactor)mim-catalysisR-HSA-392129 (Reactome)
G alpha

(s):GTP:Adenylate

cyclase
ArrowR-HSA-163617 (Reactome)
G alpha

(s):GTP:Adenylate

cyclase
ArrowR-HSA-392129 (Reactome)
G alpha (s):GDPArrowR-HSA-164381 (Reactome)
G alpha (s):GDPR-HSA-751013 (Reactome)
G alpha (s):GTPArrowR-HSA-744886 (Reactome)
G alpha (s):GTPR-HSA-163617 (Reactome)
G alpha (s):GTPR-HSA-164381 (Reactome)
G alpha (s):GTPmim-catalysisR-HSA-164381 (Reactome)
G-protein alpha

(i):GTP:Adenylate

cyclase
TBarR-HSA-392129 (Reactome)
G-protein alpha

(z):GTP:Adenylate

cyclase
TBarR-HSA-392129 (Reactome)
G-protein beta-gamma complexArrowR-HSA-744886 (Reactome)
G-protein beta-gamma complexR-HSA-751013 (Reactome)
GDPArrowR-HSA-379044 (Reactome)
GNAL:GNB1:GNGT1ArrowR-HSA-381749 (Reactome)
GNAL:GNB1:GNGT1R-HSA-381750 (Reactome)
GNALR-HSA-381749 (Reactome)
GNB1R-HSA-381749 (Reactome)
GNGT1R-HSA-381749 (Reactome)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
ArrowR-HSA-379044 (Reactome)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
R-HSA-744886 (Reactome)
GPCRs that activate GsArrowR-HSA-744886 (Reactome)
GRK2, GRK3, GRK5, GRK6ArrowR-HSA-8982641 (Reactome)
GRK2, GRK3, GRK5, GRK6R-HSA-8982645 (Reactome)
GTPR-HSA-379044 (Reactome)
H2OR-HSA-418553 (Reactome)
Heterotrimeric

G-protein Gs

(inactive)
ArrowR-HSA-751013 (Reactome)
Heterotrimeric

G-protein Gs

(inactive)
R-HSA-744887 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
ArrowR-HSA-744887 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
R-HSA-379044 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
mim-catalysisR-HSA-379044 (Reactome)
Ligand:GPCR

complexes that

activate Gs
R-HSA-744887 (Reactome)
Ligands of GPCRs that activate GsArrowR-HSA-744886 (Reactome)
Olfactory receptor:G protein trimerArrowR-HSA-381750 (Reactome)
Olfactory receptorsR-HSA-381750 (Reactome)
PPiArrowR-HSA-392129 (Reactome)
PiArrowR-HSA-164381 (Reactome)
R-HSA-163617 (Reactome) G(s)-alpha:GTP binds to inactive adenylate cyclase, causing a conformational transition in adenylate cyclase exposing the catalytic site and activating it.
R-HSA-164381 (Reactome) When a ligand activates a G protein-coupled receptor, it induces a conformational change in the receptor (a change in shape) that allows the receptor to function as a guanine nucleotide exchange factor (GEF), stimulating the exchange of GDP for GTP on the G alpha subunit. In the traditional view of heterotrimeric protein activation, this exchange triggers the dissociation of the now active G alpha subunit from the beta:gamma dimer, initiating downstream signalling events. The G alpha subunit has intrinsic GTPase activity and will eventually hydrolyze the attached GTP to GDP, allowing reassociation with G beta:gamma. Additional GTPase-activating proteins (GAPs) stimulate the GTPase activity of G alpha, leading to more rapid termination of the transduced signal. In some cases the downstream effector may have GAP activity, helping to deactivate the pathway. This is the case for phospholipase C beta, which possesses GAP activity within its C-terminal region (Kleuss et al. 1994).
R-HSA-379044 (Reactome) The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein. This event is negatively regulated by some Activators of G protein signaling (AGS) proteins, a class of proteins identified in yeast functional screens for proteins able to activate G protein signaling in the absence of a G protein–coupled receptor (GPCR) (Cismowski et al. 1999, Takesono et al. 1999). AGS proteins contain G protein regulatory (GPR) motifs (also referred to as the GoLoco motif) that bind and stabilize the Galpha subunit in its GDP-bound conformation (Mochizuki et al. 1996, Peterson et al. 2000, Cao et al. 2004, Blumer & Lanier 2014). Some RGS proteins similarly bind to Galpha preventing the exchange of GDP for GTP (Soundararajan et al. 2008).
R-HSA-381749 (Reactome) The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of intracellular second messengers. GPCRs activate the G-proteins, which consist of an alpha-subunit that binds and hydrolyses guanosine triphosphate (GTP), a beta and a gamma subunit.
R-HSA-381750 (Reactome) Olfactory receptors (ORs) have diverse protein sequences but can be assigned to subfamilies on the basis of sequence relationships. Odorants and pheromones bind to these seven transmembrane domain G-protein-coupled receptors that permit signal transduction. These receptors are encoded by large multigene families that evolved in mammal species in function of specific olfactory needs. Members of the same subfamily have related sequences and are likely to recognize structurally related odorants.
Of the 960 human OR genes and pseudogenes, there is experimental evidence which indicates that at least 437 actually are expressed in human olfactory epithelium; this includes 357 OR genes, and 80 OR pseudogenes (Zhang, 2007). These 357 olfactory-expressed OR genes are therefore expected to be functional in the Olfactory Signaling Pathway, and to interact directly with human G alpha olf in human olfactory cells.

(Note: A subset of 200 of these 357 OR genes are shown as components of OR-G Protein reaction. The others will be added to Reactome later.)

R-HSA-392129 (Reactome) The activation of adenylyl (adenylate) cyclase (AC) results in the production of adenosine-3',5'-monophosphate i.e. cyclic AMP. Humans have 9 genes encoding membrane-associated AC and one encoding a soluble AC. Two of the classes of heterotrimeric G-proteins are named according to their effect on AC; Gs stimulates all membrane-bound ACs (the s in Gs denotes AC stimulatory); the Gi class inhibits some AC isoforms, particularly 5 and 6. Beta-gamma subunits of heterotrimeric G-proteins can also regulate AC. Ca2+/Calmodulin activates some AC isoforms (1, 8 and 3) but is inhibitory to others (5 and 6).
R-HSA-418553 (Reactome) Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.
R-HSA-744886 (Reactome) The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
R-HSA-744887 (Reactome) The role of the guanine nucleotide-binding protein G alpha-s subunit (G alpha-s) (Kozasa T et al, 1988) is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn, activates cAMP-dependent protein kinase.
R-HSA-751013 (Reactome) The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active alpha subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (s):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates into the inactive heterotrimeric G-protein.
R-HSA-8851797 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 phosphorylate the beta-2 adrenergic receptor (ADRB2) in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011). GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
R-HSA-8852167 (Reactome) Two ubiquitously expressed forms of arrestin, arrestin-2 (ARRB1) and arrestin-3 (ARRB2), can bind and desensitize B2AR (Lohse et al. 1990, Attramadal et al. 1992, Sterne-Marr et al. 1993). Unlike visual arrestin, which has 10-fold greater affinity for phosphorylated rather than unphosphorylated rhodopsin, ARRB1 and ARRB2 show only a 2-fold difference in binding levels and are much less selective in their receptor preferences (Gurevich & Gurevich 2006). GRK-mediated receptor phosphorylation followed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs. included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region.
R-HSA-8982641 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 can bind and phosphorylate the beta-2 adrenergic receptor (ADRB2) in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). Following this, phosphorylated ADRB2 dissociates from the ADRB2:GRK complex. GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011).

GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
R-HSA-8982645 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 can bind to beta-2 adrenergic receptor (ADRB2) and subsequently phosphorylate them in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011).

GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
REEPsArrowR-HSA-381750 (Reactome)
RTPsArrowR-HSA-381750 (Reactome)
cAMP phosphodiesterasesmim-catalysisR-HSA-418553 (Reactome)
cAMPArrowR-HSA-392129 (Reactome)
cAMPR-HSA-418553 (Reactome)
pS-ADRB2:Catecholamine:ARRB1,ARRB2ArrowR-HSA-8852167 (Reactome)
pS-ADRB2:Catecholamine:GRKArrowR-HSA-8851797 (Reactome)
pS-ADRB2:Catecholamine:GRKR-HSA-8982641 (Reactome)
pS-ADRB2:CatecholamineArrowR-HSA-8982641 (Reactome)
pS-ADRB2:CatecholamineR-HSA-8852167 (Reactome)
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