G alpha (s) signaling events (Homo sapiens)

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38, 16, 18, 191, 9, 14, 17, 20...3242, 7, 27, 30, 31296, 11, 22154, 1210, 23, 25138, 16, 18, 191, 9, 14, 17, 20...8, 16, 18, 19cytosolendoplasmic reticulum lumenOR2C3 OR2B3 OR2B6 GTP MC2R OR5L2 OR4F3 Olfactory receptorsOR2Z1 PTH OR4N2 GNB2 OR13C8 OR5M3 OR4C16 VIPR1 OR8J1 OR4E1 OR2A4 OR13J1 OR2K2 OR5AS1 OR52L1 OR2T7 OR6K2 OR52L2P RXFP1 Mg2+ OR10D4P CALCA(83-119) TAAR9 OR4D10 OR2T10 OR5G3 OR6J1 OR8J1 OR2AG1 ArgN-GCG(98-127) OR56A4 OR13C9 PTGIR OR2W1 pS-ADRB2:CatecholamineADM(95-146) OR10J5 RTP5 GNB2 SCTR OR5F1 OR52A4 SCT OR5D18 OR10K2 OR56B4 OR10AC1P OR4F21 OR2T5 NAd OR1J2 OR4D5 OR2W6P OR10C1 OR4C6 GIPR GCG(53-81) OR10J5 OR11H1 OR5B21 IAPP(34-70) CALCRL PTGER2,PTGER4 OR9G9 OR13H1 OR52E8 OR52B6 OR2B6 OR52N2 OR56B1 OR4A16 RAMP1 GNG12 ADRB2 OR6K2 OR2L13 OR5T2 OR10H5 Ligand:GPCRcomplexes thatactivate GsOR51J1 OR2W3 GNAL:GNB1:GNGT1OR8B2 HRH2 GNALOR10W1 OR5J2 TAAR1 OR5AK2 GDP GNG5 OR5T3 PGE2 OR4K15 OR8H3 OR7G2 OR4A8P OR51B6 OR52E1 OR7A17 PTH1R OR2T11 SCTR Zn2+ OR51I1 OR2T33 OR4A47 OR10V1 OR13G1 ADCYAP1R1 Relaxin-2, Relaxin-3 GNAS1 OR5A2 OR5T2 ARRB1 TSHR OR8B2 OR4Q2 OR5D18 GPR39 OR6C1 OR10J6P OR5B12 PEA OR5B21 ADCY9 GPCRs that activateGsOR8I2 RXFP2 RAMP1 HRH2 ADR OR2T34 RLN2(162-185) OR8U1 PTH ADRBK2 OR14J1 OR2AT4 OR3A3 ADCYAP1(82-129) OR3A3 OR51S1 OR6P1 OR51B5 ADCY4 ADORA2A GNG13 NPS OR2M3 OR4S2 OR4C12 OR2M7 OR1L6 OR52R1 OR5A1 GRK6 INSL3(21-55) DRD5 OR5T3 GNG11 5HT SCT OR1C1 OR4A16 RTP3 OR1F12 GNG2 PGD2 ADCYAP1(82-129) OR4F5 OR4D11 OR5M9 OR5AC2 ADCY9 ADM2(19-153) OR6V1 GNB1 LHCGR GHRHR GNAS2 pS-ADRB2 OR5L1 OR5P3 GLP1R DRD1 OR4E2 mature GLP-1 OR2AG1 OR1M1 GNG13 OR2AG2 OR2T8 OR13C3 TAAR9 OR51G2 REEP6 OR56B2P OR5AK2 OR2A1 GRK6 OR3A1 GNB5 Mg2+ GNB5 MC4R TAAR1 OR4A8P TSHB OR4D1 RXFP1 OR2V2 OR2L13 AVPR2 OR4X2 OR2W6P OR4D5 OR8D2 Constitutively active orphan GPCRs ADCY2 MC5R OR10A4 GHRH OR10D4P OR5B17 OR5M9 GTP OR10AG1 OR52N1 OR5T1 PTH OR10AD1 OR4S2 FSHB OR4K5 Zn2+ OR2G3 OR51A2 FSHR OR4A15 OR2H2 OR4D11 OR4C45 OR2AT4 OR52I2 OR14J1 OR10G4 OR1Q1 OR9A1P GRK2, GRK3, GRK5,GRK6MC3R(1-360) OR1I1 OR1C1 OR7G1 MC3R(1-360) OR6C4 OR13C4 OR5D13 Ade-Rib OR6C2 DRD1,5 OR3A2 ADCY4 GTP ADCY4 OR51M1 ADCYAP1(82-129) LCHA GNG4 CALCA(83-119) OR8B8 OR1M1 OR52Z1 GNG11 OR5K1 OR2Z1 OR2T6 OR5H6 POMC(77-87) CALCR ADCY2 POMC(77-87) PTHLH OR4C3 ADCY7 CALCA(83-119) OR6N1 OR1A2 OR4K2 OR52P1P ADCY7 OR4K13 NPSR1 MC4R ADR OR51V1 OR5M8 OR4P4 TAAR2 OR12D3 OR8D4 OR51H1P LHCGR OR4D2 CCA GNB3 OR2T12 OR8K3 OR5P3 OR7A10 OR7A10 OR4E1 ADCY6 GNB3 SCTR OR56B4 OR10G8 OR1G1 Bile acids OR6C76 ADORA2B OR51A4 OR1L1 NPSR1 GCG(53-81) OR4K5 OR10A4 OR5AS1 OR14K1 SCT ADRB1 OR5T1 CDCA ADRB3 OR6C76 OR5H2 TSHB OR10D3 GPBAR1 PTH2R OR1B1 NAd OR11H7 GRK6 OR10D3 ADCYAP1R1 GNAS2 OR13F1 OR1D4 OR2AP1 OR4C13 OR51V1 SCT G-protein alpha(i):GTP:AdenylatecyclaseDA OR2T35 CALCB(82-118) NAd Hist OR4F21 OR2T29 OR9Q1 OR10H3 OR10G6 Melanocortin receptors OR8I2 OR2D2 LHCGR OR2B2 OR4C45 ADCY2 MC5R RAMP1 OR5R1 ADORA2A OR4M2 OR1K1 OR6C68 GCG(53-81) OR5AR1 ADCYAP1(132-169) OR51B6 OR8A1 OR6A2 OR10H2 OR10C1 OR51F1 OR6F1 OR5B2 OR9A1P OR7A2P OR1N1 GNGT1 OR5L1 OR56A3 OR1F2P OR1F1 OR8J2 OR2T3 OR6K6 OR4A47 GPR39 RAMP3 OR5M3 OR10T2 ADCY5 OR1D2 OR2T3 OR2A14 MC1R GNB1 OR51B4 GNG10 Zn2+ CRHR2 OR4C46 GNAL OR4M2 OR1J1 OR4K2 ADCYAP1(132-158) RXFP2 OR51S1 GNAS1 OR4X1 OR5D14 OR9A2 OR10R2 OR9G9 OR51Q1 POMC(77-87) OR2L2 OR51G1 OR14C36 OR14C36 GNG5 OR5P2 LCHA OR5J2 ADORA2A TSHR GNG3 ADRB2 CRHR1 PTGDR OR1P1 OR9A2 PGD2 OR9G4 OR4K14 OR13A1 REEP4 OR10J3 OR1A1 GLP-1 (7-37) TAAR2 OR2J2 OR11H2 OR5AC1 OR4C16 OR10J4 PGE2 OR10H4 GNB2 ArgN-GCG(98-127) OR2A4 OR7D2 OR2L3 OR1L8 OR52M1 OR1N1 OR10P1 OR2G6 GPR39 OR52K2 OR52H1 GNAS1 OR6Q1 CRH GNG7 GNG12 OR14I1 OR51A4 RTP4 OR4D1 OR4C5 POMC(138-150) POMC(217-234) ADR ADM(95-146) OR13D1 POMC(138-150) DRD5 GLP1R TAAR6 OR4D2 NPS OR5H1 OR10G2 MC2R CGRP ligands OR51E2 OR2A2 OR4C6 OR6M1 OR8B12 ADCYAP1 peptides DRD1 OR7G3 OR52E5 5HT GNGT2 LHB OR8K5 OR10J1 REEP5 OR4K1 Hist OR6P1 OR2B11 DA HTR4,6,7 GTP OR52E4 Mg2+ OR51L1 PTHLH TAAR9 OR10G2 TAAR5 OR4E2 OR13C4 RLN3(119-142) GHRHR OR2H1 GCG(146-178) OR51A7 OR52N5 ADPADCY8 ADM(95-146) OR10Q1 ADCY1 GDPVIP(125-152) GNG2 GPR39 OR10AC1P OR7E24 OR5AL1 TAAR3 OR52K1 GNG13 OR5K3 OR3A2 GPHB5 GHRH CCA OR52D1 OR11H7 OR8U8 GHRH OR52J3 CGA OR2D2 Ade-Rib OR5AP2 OR5AC2 DA OR1P1 REEP3 OR6S1 ADCY1 ADORA2A,B OR9G4 OR10W1 OR51I2 HTR7 OR2T7 GLP-1 (7-37) OR56B2P REEPsGNAI3 OR10H1 HTR4 OR2A12 GNB5 OR2M4 OR13A1 OR10J3 OR4M1 AVPR2 ADRBK2 OR2G2 PTGER4 RAMP2 OR6C75 OR52B2 OR13C8 OR8B3 OR5AC1 OR51I1 OR4A5 OR2F1 ADRB3 GNAS1 LHB OR10G8 OR10AD1 OR5AN1 OR4N5 DCA OR2J3 OR4N2 pS-ADRB2:Catecholamine:ARRB1,ARRB2cAMPphosphodiesterasesOR5L2 ATP OR6C74 ADM,ADM2 OR5M1 OR8B4 PGE2 ADCY6 OR5I1 OR5B17 OR2T29 OR4K1 VIP(125-152) Adrenomedullin receptor OR2AK2 ATPOR2AG2 OR5C1 PGI2 PTGDR OR8D1 ATP OR6N2 OR5W2 OR1S2 OR11H4 OR51E2 RXFP2 OR8U9 ADRB1 OR51T1 Constitutively active orphan GPCRs INSL3(106-131) ADCY6 OR13J1 OR8J3 OR6B2 GTPOR4S1 CALCA(83-119) GNAS1 OR10V1 NPS OR5R1 GHRH OR5A1 OR6V1 OR51M1 DCA OR14L1P OR6B2 G-protein beta-gammacomplexOR4F15 OR52W1 OR5B3 GCGR ADM2(19-153) GNAS2 OR5AR1 OR56A5 OR2A14 MC1R OR8B3 OR5K1 GNGT1 TAAR8 OR51A7 OR51L1 OR4F6 OR2T5 OR1K1 OR2K2 OR4C11 OR2L2 OR5P2 OR51B5 OR10H5 GPHA2 OR10A2 VIPR2 OR6N1 OR14A16 cAMPOR6B1 OR1F1 OR14A2 OR2B8P OR2T33 ATP ADCYAP1(132-158) ADR OR1L1 CALCB(82-118) INSL3(106-131) G-protein beta:gammasignallingFSHB GNB3 OR4N5 OR9G1 GNG2 OR6S1 DRD5 OR5H15 GNG7 OR10K2 OR51I2 OR2A25 VIPR1,VIPR2 OR4A5 GNB4 HTR6 GNG4 OR2A25 PEA CGA RLN3(26-52) OR8B8 OR4B1 OR51D1 OR51F2 RXFP2 ligands ADM2(19-153) OR6K6 ADORA2B IAPP(34-70) OR2T4 OR2J3 OR8G5 OR6C6 OR52K1 GDP OR4F4 OR4X1 NPS GLP2R H2OLCHA OR2L3 OR10A6 OR6N2 CALCR OR10S1 OR52K2 OR11H1 OR52I1 OR2L5 OR2D3 GRK2 POMC(138-176) OR2T27 OR4A4P ADCYAP1R1 ADCY2 Constitutively active orphan GPCRs OR5AK3P GNG8 OR4K3 ADCY8 CRHR2 OR7D4 REEP1 OR10G9 OR1D5 IAPP(34-70) OR14I1 OR7G1 OR13D1 GPBAR1 OR1S2 OR2Y1 OR6C70 OR5H14 DRD1 OR4K14 OR51J1 NPSR1 OR51H1P GDP ADRB2 OR52E6 GIP(52-93) OR52R1 OR2T6 GRK2 CRHR1 OR13G1 OR2T27 OR52N2 OR6C2 pS-ADRB2:Catecholamine:GRKPGD2 VIP(125-152) OR8S1 OR8H2 PGD2 OR56B1 PTH1R OR1E1 OR11H6 PTGER2 ADCY8 Ade-Rib OR6C3 OR8K3 OR2T8 OR12D3 HTR7 GNGT2 OR4F17 FSHR OR10P1 Hist OR5AN1 OR5M11 GNAI2 ADCY3 GNG7 OR6C74 OR1J2 OR8G2 OR3A4P OR4Q2 CALCA(83-119) OR5K2 RLN2(162-185) OR56A3 OR51G1 ADORA2B RTP2 GNG3 OR2S2 IAPP(34-70) OR11G2 PEA OR5H14 ADCY5 Ligands of GPCRsthat activate GsAVP(20-28) GNGT2 CALCRL CALCRL OR2T4 OR52N1 AVP(20-28) NAd MC4R GPHB5 GNAI1 Zn2+ OR52E8 GNG11 NAd OR7G2 INSL3(21-55) OR7A17 OR52B6 OR52J3 GNG2 OR51D1 OR10T2 5HT OR5V1 OR2C1 ADCY1 OR4D10 OR2T34 OR1L3 NAd OR52E2 GCGR PTGIR OR1L6 GNAZ OR1D5 CRHR1 OR51E1 GNB2 OR52N5 FSHB PTH2(62-100) Phosphodiesterases, cyclic AMP-selective ADCY8 OR2M4 OR56A4 OR6J1 OR1J1 OR2AK2 OR2F2 OR8H2 ADRB1-3 OR2Y1 NAd P2RY11 GNG10 OR2A7 TAAR6 OR10X1 AVPR2 OR5K2 OR10Q1 OR10A6 OR2AE1 OR4A15 OR52I1 P2RY11 OR6Y1 Olfactory receptor:Gprotein trimerOR5K3 GNG10 AVP(20-28) GNB3 OR2M2 VIPR2 GNG8 ARRBOR6C70 GCGR OR10A2 CGA OR10G3 OR8U8 OR2W5 RXFP1 RLN3(119-142) GNGT1OR10G7 OR5G3 OR51E1 PTH2(62-100) RLN3(119-142) PGI2 ADRB2 OR6T1 ADRB2:Catecholamine:GRKRLN2(25-53) adenosine5'-monophosphateG-protein alpha(z):GTP:AdenylatecyclaseOR4K13 DCA OR1A1 OR8G1 OR2J1 OR13C5 OR4F4 OR6X1 OR2A5 OR8D1 OR2T1 PiGCG(146-178) AMY1-3 PTGIR HTR4 TSHB OR5K4 OR7A2P ADR, NAd OR1S1 GNGT1 OR2G3 OR52A5 Trace amine-associated receptor OR11A1 OR4X2 OR10A7 OR1L8 OR2AJ1 OR51B2 GNG11 INSL3(106-131) ADCY1 RTP1 Ligand:GPCRcomplexes thatactivateGs:HeterotrimericG-protein Gs(inactive)OR52B2 OR2W1 OR5D14 OR2B3 HTR6 OR4C15 GNAS2 ARRB2 OR8D2 P2RY11 GNAS2 OR1L4 OR5A2 OR5D16 OR2T12 TAAR8 OR5M11 OR11A1 OR4Q3 OR52N4 RLN3(26-52) NAd VIPR1 GNGT1 OR5I1 OR6C65 OR6C4 OR10H4 OR1B1 CALCRL OR1E2 GIP(52-93) GCGR OR5AK3P GLP2R OR5H2 PTGER4 INSL3(21-55) PGI2 OR52P1P OR5W2 GLP2R OR52E5 OR8U1 OR10G9 HTR7 CCA OR1N2 GNB4 ADCYAP1(132-158) PGI2 GNAS2 OR4F3 OR2A12 ADCY7 OR52W1 HTR4 OR8B12 OR52Z1 OR8S1 GNG4 GPHA2 OR10G6 OR1Q1 OR51B2 OR12D2 OR8K1 OR2B8P GRK5 OR2C3 ADCYAP1R1 CRH RLN2(25-53) Ade-Rib GNB1 OR5AU1 OR4L1 OR8A1 POMC(217-234) PTH1R,PTH2R GIPR OR56A1 OR10J1 GTP MC3R(1-360) P2RY11 OR52A4 RAMP1 OR11G2 GPBAR1 GNG13 OR52A5 OR10H2 OR11H2 VIPR2 OR7D2 OR5M1 OR4D6 GLP2R OR4F5 OR10Z1 OR52A1 OR51Q1 OR2T2 GRK2 OR51F2 ATPGNG5 TAAR6 OR5M10 OR4L1 OR52H1 OR7A5 OR10A3 OR4F17 OR52I2 OR11L1 GCG(53-81) ADRB3 OR8H3 GNG3 OR4C13 OR5D13 OR5M8 GPHA2 GRK5 OR5B2 OR4D9 OR13C9 OR9I1 OR10H3 AVP(20-28) OR52E2 LHB OR3A4P GPHB5 OR5H15 OR6B3 PTH1R,PTH2R ligands GNGT1 OR7E24 VIP(125-152) PTGIR pS-ADRB2 OR8J2 OR4N4 GNAS1 OR13C2 PTH2R OR4K17 RXFP1 REEP2 OR1E3 ADR ADR RLN3(26-52) OR7C2 OR52A1 OR56A1 ADCYAP1(132-169) OR6Y1 OR6T1 OR6K3 OR2T35 ADCY9 OR7C1 pS-ADRB2 TSHR OR6B1 OR2A2 OR14A2 ArgN-GCG(98-127) CRHR1, CRHR2 OR5K4 PTGER2 OR4D6 GNG12 OR4F15 OR5V1 MC2R OR2T10 OR1E3 OR51B4 GIPR ADRB2 OR4D9 MC5R OR10G4 Phosphodiesterases, dual (cAMP, cGMP) activity OR4K17 OR10AG1 OR4M1 RTPsADCY7 OR2A7 OR13C5 GIP(52-93) GNG7 GNGT2 CRH OR52D1 GNG8 FSHR HRH2 ADCY9 GNAT3 OR6F1 OR2L8 POMC(138-176) OR6B3 OR10K1 TSHR FSHB CALCR OR10A5 GCG(146-178) OR9G1 OR7D4 MC1R ADCYAP1(132-169) OR2B2 GRK5 OR10Z1 ADCY5 OR10S1 OR52M1 CRH OR1J4 OR8G5 CALCA(83-119) OR11L1 OR2L8 OR2AE1 OR1D4 OR2T11 OR9Q1 TAAR5 GNB4 OR2T2 OR1I1 ADCY3 OR6K3 OR1J4 OR1N2 OR7A5 OR10R2 OR8B4 OR10G7 OR52E4 OR4F6 OR9Q2 GNB4 OR2M2 GNB1OR3A1 CGA ARRB2 MC2R OR4N4 GLP-1 (7-37) OR7G3 ADCY3 OR6A2 RAMP3 OR1G1 OR6M1 5HT OR5AP2 GPCR:ligandcomplexes that actonGs:HeterotrimericG-protein Gs(active)GIPR OR1F12 PTH2R OR14A16 OR8K5 OR4S1 TAAR1 OR2H2 OR6C68 GNB1 OR1F2P OR10X1 OR10A5 LHCGR OR2M7 OR2L5 OR1S1 ARRB1 OR51F1 OR4C12 OR52E1 OR10A3 RAMP3 HTR6 OR2H1 TAAR5 GNAL RAMP2 GNG8 OR2F1 GHRHR OR9K2 PTH2(62-100) AVPR2 G alpha (s):GTPOR2W5 TAAR3 OR8U9 OR5B12 RLN2(162-185) OR8G1 OR8H1 OR6C1 NPSR1 GNB5 OR5D16 TAAR2 HRH2 ADR OR6C65 OR10G3 LHB GNGT1 OR2I1P OR51A2 OR1D2 OR2G6 OR2F2 ADCY3 OR4C5 OR5H6 GNG3 GPBAR1 OR1E1 GNG12 RXFP2 OR52L1 OR2M5 OR4P4 OR10A7 OR2AJ1 OR8G2 OR2V2 OR10H1 OR2J2 GNG5 OR2A1 G alpha(s):GTP:AdenylatecyclaseOR2J1 RAMP2 OR2G2 OR11H6 ADRB2:CatecholamineOR6X1 OR4B1 HeterotrimericG-protein Gs(inactive)PGE2 GCG(146-178) OR5AL1 OR4Q3 OR2D3 GLP1R OR8K1 CALCA(83-119) OR52L2P Mg2+ GNG10 OR9A4 OR4C15 OR13F1 OR13C3 OR5B3 ADCY6 G alpha (s):GDPTAAR8 CALCB(82-118) OR14L1P OR2I1P OR10K1 GPHB5 OR5AU1 OR4C46 OR4C3 OR2M5 OR14K1 GNG4 PEA ATP OR2T1 PTGER2 CDCA OR2V1 OR5M10 GPHA2 RLN2(25-53) OR8J3 Hist OR2C1 OR8D4 PTHLH OR6C3 GLP1R GIP(52-93) OR52N4 OR2AP1 OR2V1 OR9I1 OR4C11 VIPR1 CRHR2 OR6C75 OR8H1 OR9Q2 OR2A5 OR51G2 OR2M3 OR2W3 DA GHRHR OR7C1 PTH1R PTGER4 OR9A4 Constitutively active orphan GPCRs FSHR OR4A4P CALCR GNB1 OR13C2 OR12D2 POMC(138-150) OR2B11 OR1E2 OR52E6 MSH OR9K2 Adenylate cyclase(Mg2+ cofactor)ADCY5 POMC(138-176) CDCA OR5C1 PTGDR OR1A2 SCTR ADCY4 OR51T1 OR1L4 OR10J6P OR5H1 OR4K15 POMC(138-176) OR1L3 OR56A5 OR2S2 OR10J4 OR11H4 OR4K3 PPiTSHB OR7C2 PTGDR ADRB1 ADRBK2 OR6C6 OR13H1 GNB1 POMC(217-234) OR5F1 OR6Q1 TAAR3 ADR 552655


Description

The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase (Tesmer et al. 1997), which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. Another downstream effector of G alpha (s) is the protein tyrosine kinase c-Src (Ma et al. 2000). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 418555
Reactome-version 
Reactome version: 64
Reactome Author 
Reactome Author: Jupe, Steve

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Bibliography

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History

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CompareRevisionActionTimeUserComment
116411view09:06, 7 May 2021EweitzModified title
113271view11:34, 2 November 2020ReactomeTeamReactome version 74
101710view14:50, 1 November 2018DeSlOntology Term : 'PW:0000230' removed !
101709view14:50, 1 November 2018DeSlOntology Term : 'G protein mediated signaling pathway via Galphas family' added !
101708view14:49, 1 November 2018DeSlOntology Term : 'G protein mediated signaling pathway via Galpha12/Galpha13 family' added !
101395view11:28, 1 November 2018ReactomeTeamreactome version 66
100933view21:04, 31 October 2018ReactomeTeamreactome version 65
100471view19:38, 31 October 2018ReactomeTeamreactome version 64
100276view16:57, 31 October 2018ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
5HT MetaboliteCHEBI:28790 (ChEBI)
ADCY1 ProteinQ08828 (Uniprot-TrEMBL)
ADCY2 ProteinQ08462 (Uniprot-TrEMBL)
ADCY3 ProteinO60266 (Uniprot-TrEMBL)
ADCY4 ProteinQ8NFM4 (Uniprot-TrEMBL)
ADCY5 ProteinO95622 (Uniprot-TrEMBL)
ADCY6 ProteinO43306 (Uniprot-TrEMBL)
ADCY7 ProteinP51828 (Uniprot-TrEMBL)
ADCY8 ProteinP40145 (Uniprot-TrEMBL)
ADCY9 ProteinO60503 (Uniprot-TrEMBL)
ADCYAP1 peptides R-HSA-420080 (Reactome)
ADCYAP1(132-158) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1(132-169) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1(82-129) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1R1 ProteinP41586 (Uniprot-TrEMBL)
ADM(95-146) ProteinP35318 (Uniprot-TrEMBL)
ADM,ADM2 R-HSA-420061 (Reactome)
ADM2(19-153) ProteinQ7Z4H4 (Uniprot-TrEMBL)
ADORA2A ProteinP29274 (Uniprot-TrEMBL)
ADORA2A,B R-HSA-418907 (Reactome)
ADORA2B ProteinP29275 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
ADR MetaboliteCHEBI:28918 (ChEBI)
ADR, NAd R-ALL-390627 (Reactome)
ADRB1 ProteinP08588 (Uniprot-TrEMBL)
ADRB1-3 R-HSA-390670 (Reactome)
ADRB2 ProteinP07550 (Uniprot-TrEMBL)
ADRB2:Catecholamine:GRKComplexR-HSA-8982633 (Reactome)
ADRB2:CatecholamineComplexR-HSA-8852028 (Reactome)
ADRB3 ProteinP13945 (Uniprot-TrEMBL)
ADRBK2 ProteinP35626 (Uniprot-TrEMBL)
AMY1-3 R-HSA-420237 (Reactome)
ARRB1 ProteinP49407 (Uniprot-TrEMBL)
ARRB2 ProteinP32121 (Uniprot-TrEMBL)
ARRBComplexR-HSA-1911410 (Reactome)
ATP MetaboliteCHEBI:15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
AVP(20-28) ProteinP01185 (Uniprot-TrEMBL)
AVPR2 ProteinP30518 (Uniprot-TrEMBL)
Ade-Rib MetaboliteCHEBI:16335 (ChEBI)
Adenylate cyclase (Mg2+ cofactor)ComplexR-HSA-170665 (Reactome)
Adrenomedullin receptor R-HSA-420118 (Reactome)
ArgN-GCG(98-127) ProteinP01275 (Uniprot-TrEMBL) The amide group at the C-terminus is not necessary for biological activity.
Bile acids R-ALL-444840 (Reactome)
CALCA(83-119) ProteinP01258 (Uniprot-TrEMBL)
CALCA(83-119) ProteinP06881 (Uniprot-TrEMBL)
CALCB(82-118) ProteinP10092 (Uniprot-TrEMBL)
CALCR ProteinP30988 (Uniprot-TrEMBL)
CALCRL ProteinQ16602 (Uniprot-TrEMBL)
CCA MetaboliteCHEBI:16359 (ChEBI)
CDCA MetaboliteCHEBI:16755 (ChEBI)
CGA ProteinP01215 (Uniprot-TrEMBL)
CGRP ligands R-HSA-419795 (Reactome)
CRH ProteinP06850 (Uniprot-TrEMBL)
CRHR1 ProteinP34998 (Uniprot-TrEMBL)
CRHR1, CRHR2 R-HSA-420140 (Reactome)
CRHR2 ProteinQ13324 (Uniprot-TrEMBL)
Constitutively active orphan GPCRs R-HSA-6805225 (Reactome)
DA MetaboliteCHEBI:18243 (ChEBI)
DCA MetaboliteCHEBI:28834 (ChEBI)
DRD1 ProteinP21728 (Uniprot-TrEMBL)
DRD1,5 R-HSA-390836 (Reactome)
DRD5 ProteinP21918 (Uniprot-TrEMBL)
FSHB ProteinP01225 (Uniprot-TrEMBL)
FSHR ProteinP23945 (Uniprot-TrEMBL)
G alpha

(s):GTP:Adenylate

cyclase
ComplexR-HSA-163622 (Reactome)
G alpha (s):GDPComplexR-HSA-164333 (Reactome)
G alpha (s):GTPComplexR-HSA-164358 (Reactome)
G-protein alpha

(i):GTP:Adenylate

cyclase
ComplexR-HSA-396910 (Reactome)
G-protein alpha

(z):GTP:Adenylate

cyclase
ComplexR-HSA-392049 (Reactome)
G-protein beta-gamma complexComplexR-HSA-167434 (Reactome)
G-protein beta:gamma signallingPathwayR-HSA-397795 (Reactome) The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.
GCG(146-178) ProteinP01275 (Uniprot-TrEMBL)
GCG(53-81) ProteinP01275 (Uniprot-TrEMBL)
GCGR ProteinP47871 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GHRH ProteinP01286 (Uniprot-TrEMBL)
GHRHR ProteinQ02643 (Uniprot-TrEMBL)
GIP(52-93) ProteinP09681 (Uniprot-TrEMBL)
GIPR ProteinP48546 (Uniprot-TrEMBL)
GLP-1 (7-37) ProteinP01275 (Uniprot-TrEMBL)
GLP1R ProteinP43220 (Uniprot-TrEMBL)
GLP2R ProteinO95838 (Uniprot-TrEMBL)
GNAI1 ProteinP63096 (Uniprot-TrEMBL)
GNAI2 ProteinP04899 (Uniprot-TrEMBL)
GNAI3 ProteinP08754 (Uniprot-TrEMBL)
GNAL ProteinP38405 (Uniprot-TrEMBL)
GNAL:GNB1:GNGT1ComplexR-HSA-380924 (Reactome) The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of intracellular second messengers. GPCRs activate the G-proteins, which consist of an alpha-subunit that binds and hydrolyses guanosine triphosphate (GTP), a beta and a gamma subunit.
GNALProteinP38405 (Uniprot-TrEMBL)
GNAS1 ProteinQ5JWF2 (Uniprot-TrEMBL)
GNAS2 ProteinP63092 (Uniprot-TrEMBL)
GNAT3 ProteinA8MTJ3 (Uniprot-TrEMBL)
GNAZ ProteinP19086 (Uniprot-TrEMBL)
GNB1 ProteinP62873 (Uniprot-TrEMBL)
GNB1ProteinP62873 (Uniprot-TrEMBL)
GNB2 ProteinP62879 (Uniprot-TrEMBL)
GNB3 ProteinP16520 (Uniprot-TrEMBL)
GNB4 ProteinQ9HAV0 (Uniprot-TrEMBL)
GNB5 ProteinO14775 (Uniprot-TrEMBL)
GNG10 ProteinP50151 (Uniprot-TrEMBL)
GNG11 ProteinP61952 (Uniprot-TrEMBL)
GNG12 ProteinQ9UBI6 (Uniprot-TrEMBL)
GNG13 ProteinQ9P2W3 (Uniprot-TrEMBL)
GNG2 ProteinP59768 (Uniprot-TrEMBL)
GNG3 ProteinP63215 (Uniprot-TrEMBL)
GNG4 ProteinP50150 (Uniprot-TrEMBL)
GNG5 ProteinP63218 (Uniprot-TrEMBL)
GNG7 ProteinO60262 (Uniprot-TrEMBL)
GNG8 ProteinQ9UK08 (Uniprot-TrEMBL)
GNGT1 ProteinP63211 (Uniprot-TrEMBL)
GNGT1ProteinP63211 (Uniprot-TrEMBL)
GNGT2 ProteinO14610 (Uniprot-TrEMBL)
GPBAR1 ProteinQ8TDU6 (Uniprot-TrEMBL)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
ComplexR-HSA-744890 (Reactome)
GPCRs that activate GsComplexR-HSA-790204 (Reactome)
GPHA2 ProteinQ96T91 (Uniprot-TrEMBL)
GPHB5 ProteinQ86YW7 (Uniprot-TrEMBL)
GPR39 ProteinO43194 (Uniprot-TrEMBL)
GRK2 ProteinP25098 (Uniprot-TrEMBL)
GRK2, GRK3, GRK5, GRK6ComplexR-HSA-8852026 (Reactome)
GRK5 ProteinP34947 (Uniprot-TrEMBL)
GRK6 ProteinP43250 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HRH2 ProteinP25021 (Uniprot-TrEMBL)
HTR4 ProteinQ13639 (Uniprot-TrEMBL)
HTR4,6,7 R-HSA-390942 (Reactome)
HTR6 ProteinP50406 (Uniprot-TrEMBL)
HTR7 ProteinP34969 (Uniprot-TrEMBL)
Heterotrimeric

G-protein Gs

(inactive)
ComplexR-HSA-391179 (Reactome)
Hist MetaboliteCHEBI:18295 (ChEBI)
IAPP(34-70) ProteinP10997 (Uniprot-TrEMBL)
INSL3(106-131) ProteinP51460 (Uniprot-TrEMBL)
INSL3(21-55) ProteinP51460 (Uniprot-TrEMBL)
LCHA MetaboliteCHEBI:16325 (ChEBI)
LHB ProteinP01229 (Uniprot-TrEMBL)
LHCGR ProteinP22888 (Uniprot-TrEMBL)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
ComplexR-HSA-744885 (Reactome)
Ligand:GPCR

complexes that

activate Gs
ComplexR-HSA-391181 (Reactome)
Ligands of GPCRs that activate GsComplexR-HSA-790205 (Reactome)
MC1R ProteinQ01726 (Uniprot-TrEMBL)
MC2R ProteinQ01718 (Uniprot-TrEMBL)
MC3R(1-360) ProteinP41968 (Uniprot-TrEMBL)
MC4R ProteinP32245 (Uniprot-TrEMBL)
MC5R ProteinP33032 (Uniprot-TrEMBL)
MSH R-HSA-388597 (Reactome)
Melanocortin receptors R-HSA-388601 (Reactome)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)
NAd MetaboliteCHEBI:18357 (ChEBI)
NPS ProteinP0C0P6 (Uniprot-TrEMBL)
NPSR1 ProteinQ6W5P4 (Uniprot-TrEMBL)
OR10A2 ProteinQ9H208 (Uniprot-TrEMBL)
OR10A3 ProteinP58181 (Uniprot-TrEMBL)
OR10A4 ProteinQ9H209 (Uniprot-TrEMBL)
OR10A5 ProteinQ9H207 (Uniprot-TrEMBL)
OR10A6 ProteinQ8NH74 (Uniprot-TrEMBL)
OR10A7 ProteinQ8NGE5 (Uniprot-TrEMBL)
OR10AC1P ProteinQ8NH08 (Uniprot-TrEMBL)
OR10AD1 ProteinQ8NGE0 (Uniprot-TrEMBL)
OR10AG1 ProteinQ8NH19 (Uniprot-TrEMBL)
OR10C1 ProteinQ96KK4 (Uniprot-TrEMBL)
OR10D3 ProteinQ8NH80 (Uniprot-TrEMBL)
OR10D4P ProteinQ8NGN7 (Uniprot-TrEMBL)
OR10G2 ProteinQ8NGC3 (Uniprot-TrEMBL)
OR10G3 ProteinQ8NGC4 (Uniprot-TrEMBL)
OR10G4 ProteinQ8NGN3 (Uniprot-TrEMBL)
OR10G6 ProteinQ8NH81 (Uniprot-TrEMBL)
OR10G7 ProteinQ8NGN6 (Uniprot-TrEMBL)
OR10G8 ProteinQ8NGN5 (Uniprot-TrEMBL)
OR10G9 ProteinQ8NGN4 (Uniprot-TrEMBL)
OR10H1 ProteinQ9Y4A9 (Uniprot-TrEMBL)
OR10H2 ProteinO60403 (Uniprot-TrEMBL)
OR10H3 ProteinO60404 (Uniprot-TrEMBL)
OR10H4 ProteinQ8NGA5 (Uniprot-TrEMBL)
OR10H5 ProteinQ8NGA6 (Uniprot-TrEMBL)
OR10J1 ProteinP30954 (Uniprot-TrEMBL)
OR10J3 ProteinQ5JRS4 (Uniprot-TrEMBL)
OR10J4 ProteinP0C629 (Uniprot-TrEMBL)
OR10J5 ProteinQ8NHC4 (Uniprot-TrEMBL)
OR10J6P ProteinQ8NGY7 (Uniprot-TrEMBL)
OR10K1 ProteinQ8NGX5 (Uniprot-TrEMBL)
OR10K2 ProteinQ6IF99 (Uniprot-TrEMBL)
OR10P1 ProteinQ8NGE3 (Uniprot-TrEMBL)
OR10Q1 ProteinQ8NGQ4 (Uniprot-TrEMBL)
OR10R2 ProteinQ8NGX6 (Uniprot-TrEMBL)
OR10S1 ProteinQ8NGN2 (Uniprot-TrEMBL)
OR10T2 ProteinQ8NGX3 (Uniprot-TrEMBL)
OR10V1 ProteinQ8NGI7 (Uniprot-TrEMBL)
OR10W1 ProteinQ8NGF6 (Uniprot-TrEMBL)
OR10X1 ProteinQ8NGY0 (Uniprot-TrEMBL)
OR10Z1 ProteinQ8NGY1 (Uniprot-TrEMBL)
OR11A1 ProteinQ9GZK7 (Uniprot-TrEMBL)
OR11G2 ProteinQ8NGC1 (Uniprot-TrEMBL)
OR11H1 ProteinQ8NG94 (Uniprot-TrEMBL)
OR11H2 ProteinQ8NH07 (Uniprot-TrEMBL)
OR11H4 ProteinQ8NGC9 (Uniprot-TrEMBL)
OR11H6 ProteinQ8NGC7 (Uniprot-TrEMBL)
OR11H7 ProteinQ8NGC8 (Uniprot-TrEMBL)
OR11L1 ProteinQ8NGX0 (Uniprot-TrEMBL)
OR12D2 ProteinP58182 (Uniprot-TrEMBL)
OR12D3 ProteinQ9UGF7 (Uniprot-TrEMBL)
OR13A1 ProteinQ8NGR1 (Uniprot-TrEMBL)
OR13C2 ProteinQ8NGS9 (Uniprot-TrEMBL)
OR13C3 ProteinQ8NGS6 (Uniprot-TrEMBL)
OR13C4 ProteinQ8NGS5 (Uniprot-TrEMBL)
OR13C5 ProteinQ8NGS8 (Uniprot-TrEMBL)
OR13C8 ProteinQ8NGS7 (Uniprot-TrEMBL)
OR13C9 ProteinQ8NGT0 (Uniprot-TrEMBL)
OR13D1 ProteinQ8NGV5 (Uniprot-TrEMBL)
OR13F1 ProteinQ8NGS4 (Uniprot-TrEMBL)
OR13G1 ProteinQ8NGZ3 (Uniprot-TrEMBL)
OR13H1 ProteinQ8NG92 (Uniprot-TrEMBL)
OR13J1 ProteinQ8NGT2 (Uniprot-TrEMBL)
OR14A16 ProteinQ8NHC5 (Uniprot-TrEMBL)
OR14A2 ProteinQ96R54 (Uniprot-TrEMBL)
OR14C36 ProteinQ8NHC7 (Uniprot-TrEMBL)
OR14I1 ProteinA6ND48 (Uniprot-TrEMBL)
OR14J1 ProteinQ9UGF5 (Uniprot-TrEMBL)
OR14K1 ProteinQ8NGZ2 (Uniprot-TrEMBL)
OR14L1P ProteinQ8NHC6 (Uniprot-TrEMBL)
OR1A1 ProteinQ9P1Q5 (Uniprot-TrEMBL)
OR1A2 ProteinQ9Y585 (Uniprot-TrEMBL)
OR1B1 ProteinQ8NGR6 (Uniprot-TrEMBL)
OR1C1 ProteinQ15619 (Uniprot-TrEMBL)
OR1D2 ProteinP34982 (Uniprot-TrEMBL)
OR1D4 ProteinP47884 (Uniprot-TrEMBL)
OR1D5 ProteinP58170 (Uniprot-TrEMBL)
OR1E1 ProteinP30953 (Uniprot-TrEMBL)
OR1E2 ProteinP47887 (Uniprot-TrEMBL)
OR1E3 ProteinQ8WZA6 (Uniprot-TrEMBL)
OR1F1 ProteinO43749 (Uniprot-TrEMBL)
OR1F12 ProteinQ8NHA8 (Uniprot-TrEMBL)
OR1F2P ProteinQ96R84 (Uniprot-TrEMBL)
OR1G1 ProteinP47890 (Uniprot-TrEMBL)
OR1I1 ProteinO60431 (Uniprot-TrEMBL)
OR1J1 ProteinQ8NGS3 (Uniprot-TrEMBL)
OR1J2 ProteinQ8NGS2 (Uniprot-TrEMBL)
OR1J4 ProteinQ8NGS1 (Uniprot-TrEMBL)
OR1K1 ProteinQ8NGR3 (Uniprot-TrEMBL)
OR1L1 ProteinQ8NH94 (Uniprot-TrEMBL)
OR1L3 ProteinQ8NH93 (Uniprot-TrEMBL)
OR1L4 ProteinQ8NGR5 (Uniprot-TrEMBL)
OR1L6 ProteinQ8NGR2 (Uniprot-TrEMBL)
OR1L8 ProteinQ8NGR8 (Uniprot-TrEMBL)
OR1M1 ProteinQ8NGA1 (Uniprot-TrEMBL)
OR1N1 ProteinQ8NGS0 (Uniprot-TrEMBL)
OR1N2 ProteinQ8NGR9 (Uniprot-TrEMBL)
OR1P1 ProteinQ8NH06 (Uniprot-TrEMBL)
OR1Q1 ProteinQ15612 (Uniprot-TrEMBL)
OR1S1 ProteinQ8NH92 (Uniprot-TrEMBL)
OR1S2 ProteinQ8NGQ3 (Uniprot-TrEMBL)
OR2A1 ProteinQ8NGT9 (Uniprot-TrEMBL)
OR2A12 ProteinQ8NGT7 (Uniprot-TrEMBL)
OR2A14 ProteinQ96R47 (Uniprot-TrEMBL)
OR2A2 ProteinQ6IF42 (Uniprot-TrEMBL)
OR2A25 ProteinA4D2G3 (Uniprot-TrEMBL)
OR2A4 ProteinO95047 (Uniprot-TrEMBL)
OR2A5 ProteinQ96R48 (Uniprot-TrEMBL)
OR2A7 ProteinQ96R45 (Uniprot-TrEMBL)
OR2AE1 ProteinQ8NHA4 (Uniprot-TrEMBL)
OR2AG1 ProteinQ9H205 (Uniprot-TrEMBL)
OR2AG2 ProteinA6NM03 (Uniprot-TrEMBL)
OR2AJ1 ProteinQ8NGZ0 (Uniprot-TrEMBL)
OR2AK2 ProteinQ8NG84 (Uniprot-TrEMBL)
OR2AP1 ProteinQ8NGE2 (Uniprot-TrEMBL)
OR2AT4 ProteinA6NND4 (Uniprot-TrEMBL)
OR2B11 ProteinQ5JQS5 (Uniprot-TrEMBL)
OR2B2 ProteinQ9GZK3 (Uniprot-TrEMBL)
OR2B3 ProteinO76000 (Uniprot-TrEMBL)
OR2B6 ProteinP58173 (Uniprot-TrEMBL)
OR2B8P ProteinP59922 (Uniprot-TrEMBL)
OR2C1 ProteinO95371 (Uniprot-TrEMBL)
OR2C3 ProteinQ8N628 (Uniprot-TrEMBL)
OR2D2 ProteinQ9H210 (Uniprot-TrEMBL)
OR2D3 ProteinQ8NGH3 (Uniprot-TrEMBL)
OR2F1 ProteinQ13607 (Uniprot-TrEMBL)
OR2F2 ProteinO95006 (Uniprot-TrEMBL)
OR2G2 ProteinQ8NGZ5 (Uniprot-TrEMBL)
OR2G3 ProteinQ8NGZ4 (Uniprot-TrEMBL)
OR2G6 ProteinQ5TZ20 (Uniprot-TrEMBL)
OR2H1 ProteinQ9GZK4 (Uniprot-TrEMBL)
OR2H2 ProteinO95918 (Uniprot-TrEMBL)
OR2I1P ProteinQ8NGU4 (Uniprot-TrEMBL)
OR2J1 ProteinQ9GZK6 (Uniprot-TrEMBL)
OR2J2 ProteinO76002 (Uniprot-TrEMBL)
OR2J3 ProteinO76001 (Uniprot-TrEMBL)
OR2K2 ProteinQ8NGT1 (Uniprot-TrEMBL)
OR2L13 ProteinQ8N349 (Uniprot-TrEMBL)
OR2L2 ProteinQ8NH16 (Uniprot-TrEMBL)
OR2L3 ProteinQ8NG85 (Uniprot-TrEMBL)
OR2L5 ProteinQ8NG80 (Uniprot-TrEMBL)
OR2L8 ProteinQ8NGY9 (Uniprot-TrEMBL)
OR2M2 ProteinQ96R28 (Uniprot-TrEMBL)
OR2M3 ProteinQ8NG83 (Uniprot-TrEMBL)
OR2M4 ProteinQ96R27 (Uniprot-TrEMBL)
OR2M5 ProteinA3KFT3 (Uniprot-TrEMBL)
OR2M7 ProteinQ8NG81 (Uniprot-TrEMBL)
OR2S2 ProteinQ9NQN1 (Uniprot-TrEMBL)
OR2T1 ProteinO43869 (Uniprot-TrEMBL)
OR2T10 ProteinQ8NGZ9 (Uniprot-TrEMBL)
OR2T11 ProteinQ8NH01 (Uniprot-TrEMBL)
OR2T12 ProteinQ8NG77 (Uniprot-TrEMBL)
OR2T2 ProteinQ6IF00 (Uniprot-TrEMBL)
OR2T27 ProteinQ8NH04 (Uniprot-TrEMBL)
OR2T29 ProteinQ8NH02 (Uniprot-TrEMBL)
OR2T3 ProteinQ8NH03 (Uniprot-TrEMBL)
OR2T33 ProteinQ8NG76 (Uniprot-TrEMBL)
OR2T34 ProteinQ8NGX1 (Uniprot-TrEMBL)
OR2T35 ProteinQ8NGX2 (Uniprot-TrEMBL)
OR2T4 ProteinQ8NH00 (Uniprot-TrEMBL)
OR2T5 ProteinQ6IEZ7 (Uniprot-TrEMBL)
OR2T6 ProteinQ8NHC8 (Uniprot-TrEMBL)
OR2T7 ProteinP0C7T2 (Uniprot-TrEMBL)
OR2T8 ProteinA6NH00 (Uniprot-TrEMBL)
OR2V1 ProteinQ8NHB1 (Uniprot-TrEMBL)
OR2V2 ProteinQ96R30 (Uniprot-TrEMBL)
OR2W1 ProteinQ9Y3N9 (Uniprot-TrEMBL)
OR2W3 ProteinQ7Z3T1 (Uniprot-TrEMBL)
OR2W5 ProteinA6NFC9 (Uniprot-TrEMBL)
OR2W6P ProteinQ8NHA6 (Uniprot-TrEMBL)
OR2Y1 ProteinQ8NGV0 (Uniprot-TrEMBL)
OR2Z1 ProteinQ8NG97 (Uniprot-TrEMBL)
OR3A1 ProteinP47881 (Uniprot-TrEMBL)
OR3A2 ProteinP47893 (Uniprot-TrEMBL)
OR3A3 ProteinP47888 (Uniprot-TrEMBL)
OR3A4P ProteinP47883 (Uniprot-TrEMBL)
OR4A15 ProteinQ8NGL6 (Uniprot-TrEMBL)
OR4A16 ProteinQ8NH70 (Uniprot-TrEMBL)
OR4A47 ProteinQ6IF82 (Uniprot-TrEMBL)
OR4A4P ProteinQ8NGN8 (Uniprot-TrEMBL)
OR4A5 ProteinQ8NH83 (Uniprot-TrEMBL)
OR4A8P ProteinP0C604 (Uniprot-TrEMBL)
OR4B1 ProteinQ8NGF8 (Uniprot-TrEMBL)
OR4C11 ProteinQ6IEV9 (Uniprot-TrEMBL)
OR4C12 ProteinQ96R67 (Uniprot-TrEMBL)
OR4C13 ProteinQ8NGP0 (Uniprot-TrEMBL)
OR4C15 ProteinQ8NGM1 (Uniprot-TrEMBL)
OR4C16 ProteinQ8NGL9 (Uniprot-TrEMBL)
OR4C3 ProteinQ8NH37 (Uniprot-TrEMBL)
OR4C45 ProteinA6NMZ5 (Uniprot-TrEMBL)
OR4C46 ProteinA6NHA9 (Uniprot-TrEMBL)
OR4C5 ProteinQ8NGB2 (Uniprot-TrEMBL)
OR4C6 ProteinQ8NH72 (Uniprot-TrEMBL)
OR4D1 ProteinQ15615 (Uniprot-TrEMBL)
OR4D10 ProteinQ8NGI6 (Uniprot-TrEMBL)
OR4D11 ProteinQ8NGI4 (Uniprot-TrEMBL)
OR4D2 ProteinP58180 (Uniprot-TrEMBL)
OR4D5 ProteinQ8NGN0 (Uniprot-TrEMBL)
OR4D6 ProteinQ8NGJ1 (Uniprot-TrEMBL)
OR4D9 ProteinQ8NGE8 (Uniprot-TrEMBL)
OR4E1 ProteinP0C645 (Uniprot-TrEMBL)
OR4E2 ProteinQ8NGC2 (Uniprot-TrEMBL)
OR4F15 ProteinQ8NGB8 (Uniprot-TrEMBL)
OR4F17 ProteinQ8NGA8 (Uniprot-TrEMBL)
OR4F21 ProteinO95013 (Uniprot-TrEMBL)
OR4F3 ProteinQ6IEY1 (Uniprot-TrEMBL)
OR4F4 ProteinQ96R69 (Uniprot-TrEMBL)
OR4F5 ProteinQ8NH21 (Uniprot-TrEMBL)
OR4F6 ProteinQ8NGB9 (Uniprot-TrEMBL)
OR4K1 ProteinQ8NGD4 (Uniprot-TrEMBL)
OR4K13 ProteinQ8NH42 (Uniprot-TrEMBL)
OR4K14 ProteinQ8NGD5 (Uniprot-TrEMBL)
OR4K15 ProteinQ8NH41 (Uniprot-TrEMBL)
OR4K17 ProteinQ8NGC6 (Uniprot-TrEMBL)
OR4K2 ProteinQ8NGD2 (Uniprot-TrEMBL)
OR4K3 ProteinQ96R72 (Uniprot-TrEMBL)
OR4K5 ProteinQ8NGD3 (Uniprot-TrEMBL)
OR4L1 ProteinQ8NH43 (Uniprot-TrEMBL)
OR4M1 ProteinQ8NGD0 (Uniprot-TrEMBL)
OR4M2 ProteinQ8NGB6 (Uniprot-TrEMBL)
OR4N2 ProteinQ8NGD1 (Uniprot-TrEMBL)
OR4N4 ProteinQ8N0Y3 (Uniprot-TrEMBL)
OR4N5 ProteinQ8IXE1 (Uniprot-TrEMBL)
OR4P4 ProteinQ8NGL7 (Uniprot-TrEMBL)
OR4Q2 ProteinP0C623 (Uniprot-TrEMBL)
OR4Q3 ProteinQ8NH05 (Uniprot-TrEMBL)
OR4S1 ProteinQ8NGB4 (Uniprot-TrEMBL)
OR4S2 ProteinQ8NH73 (Uniprot-TrEMBL)
OR4X1 ProteinQ8NH49 (Uniprot-TrEMBL)
OR4X2 ProteinQ8NGF9 (Uniprot-TrEMBL)
OR51A2 ProteinQ8NGJ7 (Uniprot-TrEMBL)
OR51A4 ProteinQ8NGJ6 (Uniprot-TrEMBL)
OR51A7 ProteinQ8NH64 (Uniprot-TrEMBL)
OR51B2 ProteinQ9Y5P1 (Uniprot-TrEMBL)
OR51B4 ProteinQ9Y5P0 (Uniprot-TrEMBL)
OR51B5 ProteinQ9H339 (Uniprot-TrEMBL)
OR51B6 ProteinQ9H340 (Uniprot-TrEMBL)
OR51D1 ProteinQ8NGF3 (Uniprot-TrEMBL)
OR51E1 ProteinQ8TCB6 (Uniprot-TrEMBL)
OR51E2 ProteinQ9H255 (Uniprot-TrEMBL)
OR51F1 ProteinA6NGY5 (Uniprot-TrEMBL)
OR51F2 ProteinQ8NH61 (Uniprot-TrEMBL)
OR51G1 ProteinQ8NGK1 (Uniprot-TrEMBL)
OR51G2 ProteinQ8NGK0 (Uniprot-TrEMBL)
OR51H1P ProteinQ8NH63 (Uniprot-TrEMBL)
OR51I1 ProteinQ9H343 (Uniprot-TrEMBL)
OR51I2 ProteinQ9H344 (Uniprot-TrEMBL)
OR51J1 ProteinQ9H342 (Uniprot-TrEMBL)
OR51L1 ProteinQ8NGJ5 (Uniprot-TrEMBL)
OR51M1 ProteinQ9H341 (Uniprot-TrEMBL)
OR51Q1 ProteinQ8NH59 (Uniprot-TrEMBL)
OR51S1 ProteinQ8NGJ8 (Uniprot-TrEMBL)
OR51T1 ProteinQ8NGJ9 (Uniprot-TrEMBL)
OR51V1 ProteinQ9H2C8 (Uniprot-TrEMBL)
OR52A1 ProteinQ9UKL2 (Uniprot-TrEMBL)
OR52A4 ProteinA6NMU1 (Uniprot-TrEMBL)
OR52A5 ProteinQ9H2C5 (Uniprot-TrEMBL)
OR52B2 ProteinQ96RD2 (Uniprot-TrEMBL)
OR52B6 ProteinQ8NGF0 (Uniprot-TrEMBL)
OR52D1 ProteinQ9H346 (Uniprot-TrEMBL)
OR52E1 ProteinQ8NGJ3 (Uniprot-TrEMBL)
OR52E2 ProteinQ8NGJ4 (Uniprot-TrEMBL)
OR52E4 ProteinQ8NGH9 (Uniprot-TrEMBL)
OR52E5 ProteinQ8NH55 (Uniprot-TrEMBL)
OR52E6 ProteinQ96RD3 (Uniprot-TrEMBL)
OR52E8 ProteinQ6IFG1 (Uniprot-TrEMBL)
OR52H1 ProteinQ8NGJ2 (Uniprot-TrEMBL)
OR52I1 ProteinQ8NGK6 (Uniprot-TrEMBL)
OR52I2 ProteinQ8NH67 (Uniprot-TrEMBL)
OR52J3 ProteinQ8NH60 (Uniprot-TrEMBL)
OR52K1 ProteinQ8NGK4 (Uniprot-TrEMBL)
OR52K2 ProteinQ8NGK3 (Uniprot-TrEMBL)
OR52L1 ProteinQ8NGH7 (Uniprot-TrEMBL)
OR52L2P ProteinQ8NGH6 (Uniprot-TrEMBL)
OR52M1 ProteinQ8NGK5 (Uniprot-TrEMBL)
OR52N1 ProteinQ8NH53 (Uniprot-TrEMBL)
OR52N2 ProteinQ8NGI0 (Uniprot-TrEMBL)
OR52N4 ProteinQ8NGI2 (Uniprot-TrEMBL)
OR52N5 ProteinQ8NH56 (Uniprot-TrEMBL)
OR52P1P ProteinQ8NH57 (Uniprot-TrEMBL)
OR52R1 ProteinQ8NGF1 (Uniprot-TrEMBL)
OR52W1 ProteinQ6IF63 (Uniprot-TrEMBL)
OR52Z1 ProteinP0C646 (Uniprot-TrEMBL)
OR56A1 ProteinQ8NGH5 (Uniprot-TrEMBL)
OR56A3 ProteinQ8NH54 (Uniprot-TrEMBL)
OR56A4 ProteinQ8NGH8 (Uniprot-TrEMBL)
OR56A5 ProteinP0C7T3 (Uniprot-TrEMBL)
OR56B1 ProteinQ8NGI3 (Uniprot-TrEMBL)
OR56B2P ProteinQ8NGI1 (Uniprot-TrEMBL)
OR56B4 ProteinQ8NH76 (Uniprot-TrEMBL)
OR5A1 ProteinQ8NGJ0 (Uniprot-TrEMBL)
OR5A2 ProteinQ8NGI9 (Uniprot-TrEMBL)
OR5AC1 ProteinP0C628 (Uniprot-TrEMBL)
OR5AC2 ProteinQ9NZP5 (Uniprot-TrEMBL)
OR5AK2 ProteinQ8NH90 (Uniprot-TrEMBL)
OR5AK3P ProteinQ8NH89 (Uniprot-TrEMBL)
OR5AL1 ProteinP0C617 (Uniprot-TrEMBL)
OR5AN1 ProteinQ8NGI8 (Uniprot-TrEMBL)
OR5AP2 ProteinQ8NGF4 (Uniprot-TrEMBL)
OR5AR1 ProteinQ8NGP9 (Uniprot-TrEMBL)
OR5AS1 ProteinQ8N127 (Uniprot-TrEMBL)
OR5AU1 ProteinQ8NGC0 (Uniprot-TrEMBL)
OR5B12 ProteinQ96R08 (Uniprot-TrEMBL)
OR5B17 ProteinQ8NGF7 (Uniprot-TrEMBL)
OR5B2 ProteinQ96R09 (Uniprot-TrEMBL)
OR5B21 ProteinA6NL26 (Uniprot-TrEMBL)
OR5B3 ProteinQ8NH48 (Uniprot-TrEMBL)
OR5C1 ProteinQ8NGR4 (Uniprot-TrEMBL)
OR5D13 ProteinQ8NGL4 (Uniprot-TrEMBL)
OR5D14 ProteinQ8NGL3 (Uniprot-TrEMBL)
OR5D16 ProteinQ8NGK9 (Uniprot-TrEMBL)
OR5D18 ProteinQ8NGL1 (Uniprot-TrEMBL)
OR5F1 ProteinO95221 (Uniprot-TrEMBL)
OR5G3 ProteinP0C626 (Uniprot-TrEMBL)
OR5H1 ProteinA6NKK0 (Uniprot-TrEMBL)
OR5H14 ProteinA6NHG9 (Uniprot-TrEMBL)
OR5H15 ProteinA6NDH6 (Uniprot-TrEMBL)
OR5H2 ProteinQ8NGV7 (Uniprot-TrEMBL)
OR5H6 ProteinQ8NGV6 (Uniprot-TrEMBL)
OR5I1 ProteinQ13606 (Uniprot-TrEMBL)
OR5J2 ProteinQ8NH18 (Uniprot-TrEMBL)
OR5K1 ProteinQ8NHB7 (Uniprot-TrEMBL)
OR5K2 ProteinQ8NHB8 (Uniprot-TrEMBL)
OR5K3 ProteinA6NET4 (Uniprot-TrEMBL)
OR5K4 ProteinA6NMS3 (Uniprot-TrEMBL)
OR5L1 ProteinQ8NGL2 (Uniprot-TrEMBL)
OR5L2 ProteinQ8NGL0 (Uniprot-TrEMBL)
OR5M1 ProteinQ8NGP8 (Uniprot-TrEMBL)
OR5M10 ProteinQ6IEU7 (Uniprot-TrEMBL)
OR5M11 ProteinQ96RB7 (Uniprot-TrEMBL)
OR5M3 ProteinQ8NGP4 (Uniprot-TrEMBL)
OR5M8 ProteinQ8NGP6 (Uniprot-TrEMBL)
OR5M9 ProteinQ8NGP3 (Uniprot-TrEMBL)
OR5P2 ProteinQ8WZ92 (Uniprot-TrEMBL)
OR5P3 ProteinQ8WZ94 (Uniprot-TrEMBL)
OR5R1 ProteinQ8NH85 (Uniprot-TrEMBL)
OR5T1 ProteinQ8NG75 (Uniprot-TrEMBL)
OR5T2 ProteinQ8NGG2 (Uniprot-TrEMBL)
OR5T3 ProteinQ8NGG3 (Uniprot-TrEMBL)
OR5V1 ProteinQ9UGF6 (Uniprot-TrEMBL)
OR5W2 ProteinQ8NH69 (Uniprot-TrEMBL)
OR6A2 ProteinO95222 (Uniprot-TrEMBL)
OR6B1 ProteinO95007 (Uniprot-TrEMBL)
OR6B2 ProteinQ6IFH4 (Uniprot-TrEMBL)
OR6B3 ProteinQ8NGW1 (Uniprot-TrEMBL)
OR6C1 ProteinQ96RD1 (Uniprot-TrEMBL)
OR6C2 ProteinQ9NZP2 (Uniprot-TrEMBL)
OR6C3 ProteinQ9NZP0 (Uniprot-TrEMBL)
OR6C4 ProteinQ8NGE1 (Uniprot-TrEMBL)
OR6C6 ProteinA6NF89 (Uniprot-TrEMBL)
OR6C65 ProteinA6NJZ3 (Uniprot-TrEMBL)
OR6C68 ProteinA6NDL8 (Uniprot-TrEMBL)
OR6C70 ProteinA6NIJ9 (Uniprot-TrEMBL)
OR6C74 ProteinA6NCV1 (Uniprot-TrEMBL)
OR6C75 ProteinA6NL08 (Uniprot-TrEMBL)
OR6C76 ProteinA6NM76 (Uniprot-TrEMBL)
OR6F1 ProteinQ8NGZ6 (Uniprot-TrEMBL)
OR6J1 ProteinQ8NGC5 (Uniprot-TrEMBL)
OR6K2 ProteinQ8NGY2 (Uniprot-TrEMBL)
OR6K3 ProteinQ8NGY3 (Uniprot-TrEMBL)
OR6K6 ProteinQ8NGW6 (Uniprot-TrEMBL)
OR6M1 ProteinQ8NGM8 (Uniprot-TrEMBL)
OR6N1 ProteinQ8NGY5 (Uniprot-TrEMBL)
OR6N2 ProteinQ8NGY6 (Uniprot-TrEMBL)
OR6P1 ProteinQ8NGX9 (Uniprot-TrEMBL)
OR6Q1 ProteinQ8NGQ2 (Uniprot-TrEMBL)
OR6S1 ProteinQ8NH40 (Uniprot-TrEMBL)
OR6T1 ProteinQ8NGN1 (Uniprot-TrEMBL)
OR6V1 ProteinQ8N148 (Uniprot-TrEMBL)
OR6X1 ProteinQ8NH79 (Uniprot-TrEMBL)
OR6Y1 ProteinQ8NGX8 (Uniprot-TrEMBL)
OR7A10 ProteinO76100 (Uniprot-TrEMBL)
OR7A17 ProteinO14581 (Uniprot-TrEMBL)
OR7A2P ProteinQ8NGA2 (Uniprot-TrEMBL)
OR7A5 ProteinQ15622 (Uniprot-TrEMBL)
OR7C1 ProteinO76099 (Uniprot-TrEMBL)
OR7C2 ProteinO60412 (Uniprot-TrEMBL)
OR7D2 ProteinQ96RA2 (Uniprot-TrEMBL)
OR7D4 ProteinQ8NG98 (Uniprot-TrEMBL)
OR7E24 ProteinQ6IFN5 (Uniprot-TrEMBL)
OR7G1 ProteinQ8NGA0 (Uniprot-TrEMBL)
OR7G2 ProteinQ8NG99 (Uniprot-TrEMBL)
OR7G3 ProteinQ8NG95 (Uniprot-TrEMBL)
OR8A1 ProteinQ8NGG7 (Uniprot-TrEMBL)
OR8B12 ProteinQ8NGG6 (Uniprot-TrEMBL)
OR8B2 ProteinQ96RD0 (Uniprot-TrEMBL)
OR8B3 ProteinQ8NGG8 (Uniprot-TrEMBL)
OR8B4 ProteinQ96RC9 (Uniprot-TrEMBL)
OR8B8 ProteinQ15620 (Uniprot-TrEMBL)
OR8D1 ProteinQ8WZ84 (Uniprot-TrEMBL)
OR8D2 ProteinQ9GZM6 (Uniprot-TrEMBL)
OR8D4 ProteinQ8NGM9 (Uniprot-TrEMBL)
OR8G1 ProteinQ15617 (Uniprot-TrEMBL)
OR8G2 ProteinQ6IF36 (Uniprot-TrEMBL)
OR8G5 ProteinQ8NG78 (Uniprot-TrEMBL)
OR8H1 ProteinQ8NGG4 (Uniprot-TrEMBL)
OR8H2 ProteinQ8N162 (Uniprot-TrEMBL)
OR8H3 ProteinQ8N146 (Uniprot-TrEMBL)
OR8I2 ProteinQ8N0Y5 (Uniprot-TrEMBL)
OR8J1 ProteinQ8NGP2 (Uniprot-TrEMBL)
OR8J2 ProteinQ8NGG1 (Uniprot-TrEMBL)
OR8J3 ProteinQ8NGG0 (Uniprot-TrEMBL)
OR8K1 ProteinQ8NGG5 (Uniprot-TrEMBL)
OR8K3 ProteinQ8NH51 (Uniprot-TrEMBL)
OR8K5 ProteinQ8NH50 (Uniprot-TrEMBL)
OR8S1 ProteinQ8NH09 (Uniprot-TrEMBL)
OR8U1 ProteinQ8NH10 (Uniprot-TrEMBL)
OR8U8 ProteinP0C7N1 (Uniprot-TrEMBL)
OR8U9 ProteinP0C7N5 (Uniprot-TrEMBL)
OR9A1P ProteinQ8NGU1 (Uniprot-TrEMBL)
OR9A2 ProteinQ8NGT5 (Uniprot-TrEMBL)
OR9A4 ProteinQ8NGU2 (Uniprot-TrEMBL)
OR9G1 ProteinQ8NH87 (Uniprot-TrEMBL)
OR9G4 ProteinQ8NGQ1 (Uniprot-TrEMBL)
OR9G9 ProteinP0C7N8 (Uniprot-TrEMBL)
OR9I1 ProteinQ8NGQ6 (Uniprot-TrEMBL)
OR9K2 ProteinQ8NGE7 (Uniprot-TrEMBL)
OR9Q1 ProteinQ8NGQ5 (Uniprot-TrEMBL)
OR9Q2 ProteinQ8NGE9 (Uniprot-TrEMBL)
Olfactory receptor:G protein trimerComplexR-HSA-381747 (Reactome) Olfactory receptors (ORs) have diverse protein sequences but can be assigned to subfamilies on the basis of sequence relationships. Odorants and pheromones bind to these seven transmembrane domain G-protein-coupled receptors that permit signal transduction. These receptors are encoded by large multigene families that evolved in mammal species in function of specific olfactory needs. Members of the same subfamily have related sequences and are likely to recognize structurally related odorants.
Of the 960 human OR genes and pseudogenes, there is experimental evidence which indicates that at least 437 actually are expressed in human olfactory epithelium; this includes 357 OR genes, and 80 OR pseudogenes (Zhang, 2007). These 357 olfactory-expressed OR genes are therefore expected to be functional in the Olfactory Signaling Pathway, and to interact directly with human G alpha olf in human olfactory cells.

(Note: A subset of 200 of these 357 OR genes are shown as components of OR-G Protein reaction. The others will be added to Reactome later.)

Olfactory receptorsComplexR-HSA-381741 (Reactome)
P2RY11 ProteinQ96G91 (Uniprot-TrEMBL)
PEA MetaboliteCHEBI:18397 (ChEBI)
PGD2 MetaboliteCHEBI:15555 (ChEBI)
PGE2 MetaboliteCHEBI:15551 (ChEBI)
PGI2 MetaboliteCHEBI:15552 (ChEBI)
POMC(138-150) ProteinP01189 (Uniprot-TrEMBL)
POMC(138-176) ProteinP01189 (Uniprot-TrEMBL)
POMC(217-234) ProteinP01189 (Uniprot-TrEMBL)
POMC(77-87) ProteinP01189 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PTGDR ProteinQ13258 (Uniprot-TrEMBL)
PTGER2 ProteinP43116 (Uniprot-TrEMBL)
PTGER2,PTGER4 R-HSA-391921 (Reactome)
PTGER4 ProteinP35408 (Uniprot-TrEMBL)
PTGIR ProteinP43119 (Uniprot-TrEMBL)
PTH ProteinP01270 (Uniprot-TrEMBL)
PTH1R ProteinQ03431 (Uniprot-TrEMBL)
PTH1R,PTH2R R-HSA-420554 (Reactome)
PTH1R,PTH2R ligands R-HSA-420569 (Reactome)
PTH2(62-100) ProteinQ96A98 (Uniprot-TrEMBL)
PTH2R ProteinP49190 (Uniprot-TrEMBL)
PTHLH ProteinP12272 (Uniprot-TrEMBL)
Phosphodiesterases, cyclic AMP-selective R-HSA-418543 (Reactome)
Phosphodiesterases, dual (cAMP, cGMP) activity R-HSA-418547 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RAMP1 ProteinO60894 (Uniprot-TrEMBL)
RAMP2 ProteinO60895 (Uniprot-TrEMBL)
RAMP3 ProteinO60896 (Uniprot-TrEMBL)
REEP1 ProteinQ9H902 (Uniprot-TrEMBL)
REEP2 ProteinQ9BRK0 (Uniprot-TrEMBL)
REEP3 ProteinQ6NUK4 (Uniprot-TrEMBL)
REEP4 ProteinQ9H6H4 (Uniprot-TrEMBL)
REEP5 ProteinQ00765 (Uniprot-TrEMBL)
REEP6 ProteinQ96HR9 (Uniprot-TrEMBL)
REEPsComplexR-HSA-8939723 (Reactome)
RLN2(162-185) ProteinP04090 (Uniprot-TrEMBL)
RLN2(25-53) ProteinP04090 (Uniprot-TrEMBL)
RLN3(119-142) ProteinQ8WXF3 (Uniprot-TrEMBL)
RLN3(26-52) ProteinQ8WXF3 (Uniprot-TrEMBL)
RTP1 ProteinP59025 (Uniprot-TrEMBL)
RTP2 ProteinQ5QGT7 (Uniprot-TrEMBL)
RTP3 ProteinQ9BQQ7 (Uniprot-TrEMBL)
RTP4 ProteinQ96DX8 (Uniprot-TrEMBL)
RTP5 ProteinQ14D33 (Uniprot-TrEMBL)
RTPsComplexR-HSA-8939445 (Reactome)
RXFP1 ProteinQ9HBX9 (Uniprot-TrEMBL)
RXFP2 ProteinQ8WXD0 (Uniprot-TrEMBL)
RXFP2 ligands R-HSA-444902 (Reactome)
Relaxin-2, Relaxin-3 R-HSA-444858 (Reactome)
SCT ProteinP09683 (Uniprot-TrEMBL)
SCTR ProteinP47872 (Uniprot-TrEMBL)
TAAR1 ProteinQ96RJ0 (Uniprot-TrEMBL)
TAAR2 ProteinQ9P1P5 (Uniprot-TrEMBL)
TAAR3 ProteinQ9P1P4 (Uniprot-TrEMBL)
TAAR5 ProteinO14804 (Uniprot-TrEMBL)
TAAR6 ProteinQ96RI8 (Uniprot-TrEMBL)
TAAR8 ProteinQ969N4 (Uniprot-TrEMBL)
TAAR9 ProteinQ96RI9 (Uniprot-TrEMBL)
TSHB ProteinP01222 (Uniprot-TrEMBL)
TSHR ProteinP16473 (Uniprot-TrEMBL)
Trace amine-associated receptor R-HSA-391201 (Reactome)
VIP(125-152) ProteinP01282 (Uniprot-TrEMBL)
VIPR1 ProteinP32241 (Uniprot-TrEMBL)
VIPR1,VIPR2 R-HSA-420267 (Reactome)
VIPR2 ProteinP41587 (Uniprot-TrEMBL)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)
adenosine 5'-monophosphateMetaboliteCHEBI:16027 (ChEBI)
cAMP phosphodiesterasesComplexR-HSA-418562 (Reactome)
cAMPMetaboliteCHEBI:17489 (ChEBI)
mature GLP-1 R-HSA-381662 (Reactome)
pS-ADRB2 ProteinP07550 (Uniprot-TrEMBL)
pS-ADRB2:Catecholamine:ARRB1,ARRB2ComplexR-HSA-8852170 (Reactome)
pS-ADRB2:Catecholamine:GRKComplexR-HSA-8982648 (Reactome)
pS-ADRB2:CatecholamineComplexR-HSA-8852152 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADPArrowR-HSA-8851797 (Reactome)
ADRB2:Catecholamine:GRKArrowR-HSA-8982645 (Reactome)
ADRB2:Catecholamine:GRKR-HSA-8851797 (Reactome)
ADRB2:Catecholamine:GRKmim-catalysisR-HSA-8851797 (Reactome)
ADRB2:CatecholamineR-HSA-8982645 (Reactome)
ARRBR-HSA-8852167 (Reactome)
ATPR-HSA-392129 (Reactome)
ATPR-HSA-8851797 (Reactome)
Adenylate cyclase (Mg2+ cofactor)R-HSA-163617 (Reactome)
Adenylate cyclase (Mg2+ cofactor)mim-catalysisR-HSA-392129 (Reactome)
G alpha

(s):GTP:Adenylate

cyclase
ArrowR-HSA-163617 (Reactome)
G alpha

(s):GTP:Adenylate

cyclase
ArrowR-HSA-392129 (Reactome)
G alpha (s):GDPArrowR-HSA-164381 (Reactome)
G alpha (s):GDPR-HSA-751013 (Reactome)
G alpha (s):GTPArrowR-HSA-744886 (Reactome)
G alpha (s):GTPR-HSA-163617 (Reactome)
G alpha (s):GTPR-HSA-164381 (Reactome)
G alpha (s):GTPmim-catalysisR-HSA-164381 (Reactome)
G-protein alpha

(i):GTP:Adenylate

cyclase
TBarR-HSA-392129 (Reactome)
G-protein alpha

(z):GTP:Adenylate

cyclase
TBarR-HSA-392129 (Reactome)
G-protein beta-gamma complexArrowR-HSA-744886 (Reactome)
G-protein beta-gamma complexR-HSA-751013 (Reactome)
GDPArrowR-HSA-379044 (Reactome)
GNAL:GNB1:GNGT1ArrowR-HSA-381749 (Reactome)
GNAL:GNB1:GNGT1R-HSA-381750 (Reactome)
GNALR-HSA-381749 (Reactome)
GNB1R-HSA-381749 (Reactome)
GNGT1R-HSA-381749 (Reactome)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
ArrowR-HSA-379044 (Reactome)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
R-HSA-744886 (Reactome)
GPCRs that activate GsArrowR-HSA-744886 (Reactome)
GRK2, GRK3, GRK5, GRK6ArrowR-HSA-8982641 (Reactome)
GRK2, GRK3, GRK5, GRK6R-HSA-8982645 (Reactome)
GTPR-HSA-379044 (Reactome)
H2OR-HSA-418553 (Reactome)
Heterotrimeric

G-protein Gs

(inactive)
ArrowR-HSA-751013 (Reactome)
Heterotrimeric

G-protein Gs

(inactive)
R-HSA-744887 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
ArrowR-HSA-744887 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
R-HSA-379044 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
mim-catalysisR-HSA-379044 (Reactome)
Ligand:GPCR

complexes that

activate Gs
R-HSA-744887 (Reactome)
Ligands of GPCRs that activate GsArrowR-HSA-744886 (Reactome)
Olfactory receptor:G protein trimerArrowR-HSA-381750 (Reactome)
Olfactory receptorsR-HSA-381750 (Reactome)
PPiArrowR-HSA-392129 (Reactome)
PiArrowR-HSA-164381 (Reactome)
R-HSA-163617 (Reactome) G(s)-alpha:GTP binds to inactive adenylate cyclase, causing a conformational transition in adenylate cyclase exposing the catalytic site and activating it.
R-HSA-164381 (Reactome) When a ligand activates a G protein-coupled receptor, it induces a conformational change in the receptor (a change in shape) that allows the receptor to function as a guanine nucleotide exchange factor (GEF), stimulating the exchange of GDP for GTP on the G alpha subunit. In the traditional view of heterotrimeric protein activation, this exchange triggers the dissociation of the now active G alpha subunit from the beta:gamma dimer, initiating downstream signalling events. The G alpha subunit has intrinsic GTPase activity and will eventually hydrolyze the attached GTP to GDP, allowing reassociation with G beta:gamma. Additional GTPase-activating proteins (GAPs) stimulate the GTPase activity of G alpha, leading to more rapid termination of the transduced signal. In some cases the downstream effector may have GAP activity, helping to deactivate the pathway. This is the case for phospholipase C beta, which possesses GAP activity within its C-terminal region (Kleuss et al. 1994).
R-HSA-379044 (Reactome) The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein. This event is negatively regulated by some Activators of G protein signaling (AGS) proteins, a class of proteins identified in yeast functional screens for proteins able to activate G protein signaling in the absence of a G protein–coupled receptor (GPCR) (Cismowski et al. 1999, Takesono et al. 1999). AGS proteins contain G protein regulatory (GPR) motifs (also referred to as the GoLoco motif) that bind and stabilize the Galpha subunit in its GDP-bound conformation (Mochizuki et al. 1996, Peterson et al. 2000, Cao et al. 2004, Blumer & Lanier 2014). Some RGS proteins similarly bind to Galpha preventing the exchange of GDP for GTP (Soundararajan et al. 2008).
R-HSA-381749 (Reactome) The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of intracellular second messengers. GPCRs activate the G-proteins, which consist of an alpha-subunit that binds and hydrolyses guanosine triphosphate (GTP), a beta and a gamma subunit.
R-HSA-381750 (Reactome) Olfactory receptors (ORs) have diverse protein sequences but can be assigned to subfamilies on the basis of sequence relationships. Odorants and pheromones bind to these seven transmembrane domain G-protein-coupled receptors that permit signal transduction. These receptors are encoded by large multigene families that evolved in mammal species in function of specific olfactory needs. Members of the same subfamily have related sequences and are likely to recognize structurally related odorants.
Of the 960 human OR genes and pseudogenes, there is experimental evidence which indicates that at least 437 actually are expressed in human olfactory epithelium; this includes 357 OR genes, and 80 OR pseudogenes (Zhang, 2007). These 357 olfactory-expressed OR genes are therefore expected to be functional in the Olfactory Signaling Pathway, and to interact directly with human G alpha olf in human olfactory cells.

(Note: A subset of 200 of these 357 OR genes are shown as components of OR-G Protein reaction. The others will be added to Reactome later.)

R-HSA-392129 (Reactome) The activation of adenylyl (adenylate) cyclase (AC) results in the production of adenosine-3',5'-monophosphate i.e. cyclic AMP. Humans have 9 genes encoding membrane-associated AC and one encoding a soluble AC. Two of the classes of heterotrimeric G-proteins are named according to their effect on AC; Gs stimulates all membrane-bound ACs (the s in Gs denotes AC stimulatory); the Gi class inhibits some AC isoforms, particularly 5 and 6. Beta-gamma subunits of heterotrimeric G-proteins can also regulate AC. Ca2+/Calmodulin activates some AC isoforms (1, 8 and 3) but is inhibitory to others (5 and 6).
R-HSA-418553 (Reactome) Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.
R-HSA-744886 (Reactome) The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
R-HSA-744887 (Reactome) The role of the guanine nucleotide-binding protein G alpha-s subunit (G alpha-s) (Kozasa T et al, 1988) is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn, activates cAMP-dependent protein kinase.
R-HSA-751013 (Reactome) The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active alpha subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (s):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates into the inactive heterotrimeric G-protein.
R-HSA-8851797 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 phosphorylate the beta-2 adrenergic receptor (ADRB2) in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011). GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
R-HSA-8852167 (Reactome) Two ubiquitously expressed forms of arrestin, arrestin-2 (ARRB1) and arrestin-3 (ARRB2), can bind and desensitize B2AR (Lohse et al. 1990, Attramadal et al. 1992, Sterne-Marr et al. 1993). Unlike visual arrestin, which has 10-fold greater affinity for phosphorylated rather than unphosphorylated rhodopsin, ARRB1 and ARRB2 show only a 2-fold difference in binding levels and are much less selective in their receptor preferences (Gurevich & Gurevich 2006). GRK-mediated receptor phosphorylation followed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs. included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region.
R-HSA-8982641 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 can bind and phosphorylate the beta-2 adrenergic receptor (ADRB2) in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). Following this, phosphorylated ADRB2 dissociates from the ADRB2:GRK complex. GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011).

GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
R-HSA-8982645 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 can bind to beta-2 adrenergic receptor (ADRB2) and subsequently phosphorylate them in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011).

GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
REEPsArrowR-HSA-381750 (Reactome)
RTPsArrowR-HSA-381750 (Reactome)
adenosine 5'-monophosphateArrowR-HSA-418553 (Reactome)
cAMP phosphodiesterasesmim-catalysisR-HSA-418553 (Reactome)
cAMPArrowR-HSA-392129 (Reactome)
cAMPR-HSA-418553 (Reactome)
pS-ADRB2:Catecholamine:ARRB1,ARRB2ArrowR-HSA-8852167 (Reactome)
pS-ADRB2:Catecholamine:GRKArrowR-HSA-8851797 (Reactome)
pS-ADRB2:Catecholamine:GRKR-HSA-8982641 (Reactome)
pS-ADRB2:CatecholamineArrowR-HSA-8982641 (Reactome)
pS-ADRB2:CatecholamineR-HSA-8852167 (Reactome)
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