G alpha (s) signaling events (Homo sapiens)

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253, 4, 6, 20293, 4, 6, 209, 17, 233, 4, 6, 20257, 2215262, 10, 12, 16, 181, 8, 14, 27, 28, 30...1, 8, 14, 27, 28, 30...135, 11, 24endoplasmic reticulum lumencytosolADCY5 OR2V1 OR51B5 OR4D9 P2RY11 DRD5 OR6B3 OR1S1 OR4A8P PGI2 OR10W1 OR2B8P OR5B2 Melanocortin receptors OR2AG2 OR52N5 OR10G4 GDP OR9A4 OR4K17 GNGT1 PEA OR6C6 OR51V1 OR10K2 GNG13 ADCY2 OR5AL1 RLN3(119-142) OR4F3 CALCA(83-119) TAAR5 OR8D1 OR2F1 RLN2(25-53) OR9I1 NPSR1 OR7G2 OR5H1 GNGT1OR51B2 OR8B12 OR2B6 GNGT1 GRK2 OR14J1 ADCY1 PTHLH OR4C6 ADCY7 OR51I1 OR2A14 FSHR OR1A2 OR1Q1 OR2G6 OR5AK2 Ligand:GPCRcomplexes thatactivate GsOR2W5 PTH1R OR6X1 OR2W3 OR2T4 PGD2 CGA OR8K5 OR10K2 OR2AG1 OR7G2 GDPPTGIR OR4A16 OR10X1 Mg2+ IAPP(34-70) OR2V2 TSHB OR4C12 ATP OR51Q1 CCA OR6N1 ARRBGNB1 pS-ADRB2 GLP1R ADORA2B OR11H7 Zn2+ OR6N2 OR51B4 OR5AS1 OR5J2 OR52E8 GNG7 OR4C11 OR1D4 ADCY4 OR10H4 OR4N2 OR6C74 ADPOR51B2 OR2L13 AMY1-3 OR3A3 OR2AT4 Adrenomedullin receptor OR10T2 ADCY1 OR4M2 MC3R(1-360) ADORA2A ATP SCT CALCA(83-119) GHRHR PTGER4 ADRB1 AVPR2 HTR4,6,7 OR5B12 ADR, NAd NAd OR4K13 POMC(138-176) OR4X2 OR13J1 GNGT2 ADCY4 GRK2, GRK3, GRK5,GRK6OR2M5 OR1S1 OR52A1 ADCY2 AVPR2 LHB POMC(217-234) GNAS1 GPR39 OR14A16 OR5AK3P GNB1 DRD1 GNAS2 MC4R OR2A12 OR1J2 Constitutively active orphan GPCRs OR2D3 VIPR1 ADCY8 GNGT1 OR51A4 MC2R OR2F2 LHCGR POMC(138-150) MC3R(1-360) DA OR10AD1 GNAS2 Constitutively active orphan GPCRs OR6K6 OR2F1 OR2A1 OR6A2 ADCY4 OR4F15 ADR GIPR OR8B8 OR2I1P REEPsOR10P1 OR5B17 OR2F2 LHCGR OR10C1 TAAR8 GNG2 pS-ADRB2 OR8G2 ADCY6 OR52D1 OR4S2 GNB2 PGI2 OR5AS1 OR4K14 OR2A25 OR5T2 OR1D4 GNAS1 MC2R OR52E5 GPHB5 OR2M7 OR7C2 OR2A4 OR4F5 OR2A12 LHB OR4X1 OR2T11 GNALOR6T1 OR4C15 Olfactory receptorsOR51B4 GNG3 GNG8 TSHR OR10Q1 GCG(146-178) POMC(217-234) OR4K17 OR2T3 ADR OR52I2 RTP3 OR1A2 Olfactory receptor:Gprotein trimerCRH NAd PTGIR OR6C4 OR2B2 GTPHTR4 OR51J1 G alpha (s):GTPOR7G1 GIP(52-93) OR8K1 OR2C1 PTGER4 OR1D2 NAd PEA OR3A1 AVP(20-28) GHRH GPHA2 RAMP3 OR5G3 OR2A2 OR4F5 OR5M10 OR7D2 GHRHR OR5I1 OR4F6 ADCY9 OR5AU1 OR11H2 OR52N4 PTH1R OR6P1 OR10J3 NPS RXFP2 ligands OR51A7 OR2T35 GNB1 ADCYAP1(132-169) OR1K1 GNAT3 OR52J3 TAAR6 OR4C3 SCT MC1R OR10AG1 OR4D2 OR12D3 ADCY3 OR4L1 CRH OR2AK2 OR2T12 GNG11 OR2G2 OR6K2 GNB5 GNG12 PTH SCT VIP(125-152) Constitutively active orphan GPCRs OR51F2 OR14A2 OR4D6 ADRB3 OR12D2 PGI2 OR2M5 RXFP2 GPHA2 OR4K5 ADCY9 OR6V1 HTR7 POMC(138-150) OR8H2 RXFP1 OR2J3 OR52A5 AVP(20-28) CRHR1 OR9G9 CALCRL OR10K1 OR5H14 OR7A10 GCG(53-81) OR9G1 GNG10 ADM(95-146) OR14A16 OR13C4 GNG11 OR1I1 OR9Q2 OR52E5 OR6Q1 OR2L5 HTR4 OR2T29 OR10J1 OR5P2 OR56A3 TAAR8 Phosphodiesterases, cyclic AMP-selective G alpha (s):GDPADCY6 OR4F15 OR6X1 OR52A1 OR52D1 OR51S1 GNB2 CGA MC4R OR52L2P OR5B3 OR2S2 OR7A2P OR4X2 OR5AL1 RTP4 OR4D2 OR10D4P PTH2R OR14C36 OR4C16 OR9Q1 AVPR2 CDCA PTGER2 OR10G8 OR10J1 ADCY1 MC1R OR51A7 RAMP1 OR10J4 OR5D13 OR56B4 OR7G3 POMC(217-234) OR2W3 HTR6 PTGIR ADM2(19-153) ADCY6 OR6C65 OR11L1 OR1N2 OR4A47 CALCA(83-119) OR4Q3 OR52W1 OR1L3 OR8K3 OR2AJ1 OR2AK2 OR4K2 GNGT2 OR4K14 GCG(146-178) OR56B2P OR13H1 OR1S2 ADCY8 OR1J2 ADRB2 AMPOR5V1 OR5A1 ADCY6 OR2T5 NAd OR8J2 OR2L2 GNG8 OR2AJ1 OR8U8 OR10Z1 OR11H1 OR11H4 ADM2(19-153) RXFP1 OR2B3 ADRB1 PTGER2,PTGER4 RAMP2 OR13F1 ADCYAP1(132-158) PGE2 OR6K2 OR52A4 GNG7 OR8I2 5HT GPHB5 PTGER2 pS-ADRB2:Catecholamine:ARRB1,ARRB2OR51A2 OR5AP2 OR5AK2 OR10G7 OR13C9 Mg2+ OR5P3 OR2B2 OR2M2 OR8K5 OR2L8 OR1L6 OR6Y1 MC1R OR2AG1 OR6P1 OR1J4 OR1E2 OR5M9 TSHR OR5H1 OR52I2 OR2AE1 OR1D5 5HT OR4Q2 OR8D4 REEP3 GNG12 OR52B2 RXFP2 OR6C65 OR10J5 GPBAR1 OR6C76 GRK5 OR51E2 TAAR2 GNB3 OR1E1 OR51Q1 CRHR2 ADCY9 OR9A2 PGE2 CCA OR1M1 Ade-Rib OR2B11 5HT OR7D2 ADCY7 ADM(95-146) OR1G1 PEA OR6C1 G alpha(s):GTP:AdenylatecyclaseHTR7 OR10H1 OR8K3 INSL3(106-131) OR11G2 ATPOR52P1P PTGER2 OR11H2 OR2Z1 OR4C12 OR10A3 OR13H1 OR7C1 ADCYAP1(132-169) OR4S1 GNB1 OR1E3 OR51L1 OR52B6 POMC(77-87) OR52N1 LHCGR GNGT1 REEP2 OR6C2 PTH1R OR2D3 GNG3 OR1L6 OR1J1 OR1N1 OR5H2 PTH2R OR6C75 OR2V1 ADR OR5R1 POMC(138-176) OR52M1 RLN3(119-142) OR52E1 NAd OR8B2 VIPR1 OR52P1P ADORA2A,B OR51I2 OR2T35 CALCA(83-119) OR8G1 PPiOR2K2 ADCY7 OR56A3 OR10S1 RLN3(119-142) OR7A17 CALCRL OR51E2 OR2T5 OR2J2 OR8J3 OR3A2 OR51I1 OR4C6 FSHR GTP OR8D1 OR52H1 OR2AP1 OR7E24 OR1F2P OR4D5 NAd MSH OR8D2 OR5AP2 PGD2 GNG11 PiOR4A4P OR51E1 HTR6 OR56B2P OR1S2 OR4D11 OR1L4 OR10J4 MC5R ADRB2:Catecholamine:GRKOR14I1 OR2I1P OR2T1 ADR NPSR1 ADCYAP1R1 GNAS2 OR4F3 OR4M1 OR8B12 OR51F1 H2OHist OR8G5 GPHB5 GPCR:ligandcomplexes that actonGs:HeterotrimericG-protein Gs(active)GNAL:GNB1:GNGT1mature GLP-1 ADRB2 OR2K2 CCA OR1A1 ATPOR8G1 Hist OR4D10 ArgN-GCG(98-127) OR10G6 OR51G2 OR1L1 OR2V2 Ade-Rib OR5AC2 OR6J1 OR52E6 GIP(52-93) GNG4 OR2S2 OR52L1 CALCB(82-118) LCHA OR5H15 OR5D14 OR2H2 ADRB1 OR2G6 OR52E6 OR10J6P GHRH OR4S1 OR2L3 OR13A1 OR2T2 TAAR8 OR4K5 GNG12 ADCYAP1R1 OR6C75 GNB1OR4F4 OR4C16 GNG13 Phosphodiesterases, dual (cAMP, cGMP) activity OR10V1 GCGR GCGR GPHA2 SCTR OR6C70 OR4D10 OR2T29 OR6C70 HRH2 DA OR6C3 P2RY11 OR5L2 TAAR6 NPS OR2B3 OR10A4 OR51V1 RTP2 OR8B3 OR4Q3 OR7E24 OR51D1 OR10A7 GNB3 ADRB3 GNG2 PTH1R,PTH2R ligands OR51T1 OR4A5 PTGDR OR4E2 OR5K3 CALCA(83-119) OR51J1 IAPP(34-70) TSHB OR5M3 GNB2 OR9K2 GNG12 OR5AC1 OR5H15 OR52N2 OR52I1 GNAZ OR6C68 POMC(138-150) TAAR2 OR5H6 OR51B5 OR8B4 OR8S1 OR2Y1 OR1M1 OR1F12 OR52B6 GPHA2 HTR4 OR4A8P Zn2+ MC2R OR1B1 OR2H1 LCHA OR52N2 OR2J2 RLN3(26-52) OR5K1 OR2L2 OR6Y1 PTH ADR ADR PTH2(62-100) OR5K3 HRH2 DRD1,5 OR4K3 OR2G3 OR2J3 OR10H3 OR2M4 OR52Z1 OR51G2 Relaxin-2, Relaxin-3 OR10A7 OR10H5 GNG10 OR7C2 OR10A4 OR5L1 TAAR2 OR4A47 TAAR3 OR1I1 OR4F21 OR4Q2 OR5AN1 OR9G1 CRHR1 OR11H6 GLP1R OR2T6 GNB5 OR4C13 TAAR9 OR10A3 OR51L1 ADCY2 GNG3 TAAR6 OR6F1 OR8H1 OR2T27 CALCR RXFP1 OR5B21 ADRB2 OR4P4 OR5F1 CDCA PTH PTGDR OR1E1 OR52N4 GIPR OR2H2 GNB5 GTP POMC(77-87) OR2M7 GPR39 OR6C74 OR5M9 ADM2(19-153) OR5A2 pS-ADRB2:Catecholamine:GRKOR6S1 ADCY8 OR4N5 PTHLH DCA OR52M1 OR5R1 GDP OR51A2 OR6B1 VIPR2 GRK6 OR2T8 GPBAR1 OR2A7 OR4N2 OR2T34 OR2T12 PGE2 OR51E1 OR4M2 GIPR OR3A2 GRK2 DCA G-protein beta:gammasignallingOR2L5 GNG3 OR10W1 OR2M3 OR5AC1 OR51H1P OR51A4 REEP1 CALCRL OR56A1 OR10V1 GDP ATP OR4X1 OR6B1 OR5W2 OR13C9 Adenylate cyclase(Mg2+ cofactor)OR2M2 DRD5 RAMP2 OR4M1 ADM,ADM2 OR5M10 OR5L2 OR6A2 RLN2(25-53) RTP5 OR11H1 FSHB NPSR1 RXFP2 OR10D4P ADRB3 OR10G3 OR1L8 OR5T1 OR8U9 OR5AR1 OR52E1 NAd CRHR2 OR13G1 OR4C13 OR4K1 OR5T1 OR4E1 OR4D5 OR51S1 OR2T2 GNGT2 OR51B6 Constitutively active orphan GPCRs OR13C8 PTGER4 ADR OR1L3 OR10AC1P OR4N4 PTGDR OR10R2 OR14K1 OR10D3 RAMP3 GPHB5 OR2Y1 Ligand:GPCRcomplexes thatactivateGs:HeterotrimericG-protein Gs(inactive)OR1E2 OR1L1 OR14L1P OR9K2 OR2T3 HTR6 OR8H3 GIPR OR9Q2 OR1K1 OR14L1P OR9G4 OR51F2 OR8U9 OR2AG2 OR4C3 GNB2 OR8J1 OR51T1 ATP AVP(20-28) GNG5 GHRH GCG(53-81) GNGT1 OR52A5 OR5A1 CALCR OR5G3 TSHB OR5AU1 OR10G3 OR1J4 OR4F6 TSHB Mg2+ RLN2(25-53) REEP4 OR13C3 OR5K1 FSHB OR56A5 OR5B21 ADCY3 OR6K3 OR7A5 OR6Q1 Zn2+ OR2L8 OR5AN1 OR8J1 OR4C46 ADCYAP1(132-169) GLP2R OR11H6 OR52W1 VIPR1 OR1D2 HRH2 GRK5 TAAR1 FSHR OR4K2 OR11H4 GLP-1 (7-37) GNB1 VIPR2 Hist OR5P2 OR10G4 OR8J2 GNAS1 OR12D2 GNAL ADCYAP1(132-158) OR1F2P OR5C1 LHB OR5D14 NAd OR3A3 OR14I1 OR13C5 OR4N4 OR2G2 OR2C1 OR8S1 CGA GCG(53-81) OR5W2 OR52R1 OR1P1 ADRB3 GNGT2 OR10AC1P OR8J3 SCTR OR10G2 OR6N1 GLP1R OR7G1 Trace amine-associated receptor OR4D11 GCG(53-81) OR10H5 OR4E2 OR4K1 OR8H2 GNG10 OR10Z1 OR2T4 OR52H1 cAMPOR5K2 OR13C5 OR1Q1 OR52N1 OR5F1 TAAR9 GNAI2 DRD5 OR5D16 ADCYAP1 peptides OR8I2 LHB OR7A17 OR2W6P OR5C1 OR1P1 OR2AT4 OR4L1 GLP1R OR2T34 INSL3(21-55) GNB4 OR2W6P RXFP2 OR10G2 OR2AP1 LHCGR OR10AD1 OR2J1 ADCY5 OR2T10 POMC(138-176) OR2A2 OR10C1 OR4A15 OR5M1 G-protein alpha(i):GTP:AdenylatecyclaseOR52L1 OR6C3 OR5H14 PTH2R GNG4 ADORA2B OR10G9 OR56A1 OR5B12 PTGIR OR8U1 TAAR3 ADCY4 ADORA2A OR6C2 ARRB2 GNAS2 OR4P4 CALCR CALCA(83-119) GRK6 OR2B6 OR1F12 OR9G9 OR8A1 OR5H6 OR52K1 RLN3(26-52) OR6T1 OR2T1 OR4A5 Mg2+ OR10A6 OR10A6 OR2J1 OR5B2 OR2B8P OR14K1 OR2G3 OR4B1 GNAS2 OR10H2 GPCRs that activateGsOR2W1 GNG5 OR8U8 OR52E4 REEP5 OR51B6 GNG10 OR6K6 GCGR OR4K15 CGA OR4C15 GLP2R GNAI1 OR4K13 GNG2 ADCYAP1R1 GCGR CRH OR2T7 MC3R(1-360) ARRB1 OR2A25 GIP(52-93) OR5K2 ADRB2 OR5M11 OR13A1 Bile acids GTP OR1F1 OR13C4 RAMP3 OR6K3 Ade-Rib OR5AK3P OR5M1 INSL3(21-55) REEP6 OR9A2 OR6B3 OR52K2 PEA OR5D13 OR10J3 SCTR OR52J3 ADCYAP1(82-129) GHRHR OR4F4 P2RY11 OR4E1 OR2AE1 OR10A2 OR1L4 OR10A2 OR6C4 OR13J1 GCG(146-178) OR5J2 OR11H7 ADCYAP1(82-129) OR2T10 OR2W5 OR10J5 ADORA2A RTP1 OR7C1 LCHA OR4A16 OR51G1 CALCB(82-118) TAAR3 OR5P3 OR56A5 ADCY5 ArgN-GCG(98-127) OR8G2 OR3A4P RLN2(162-185) GLP2R 5HT RLN3(26-52) OR6M1 PTH2(62-100) OR1D5 PTGDR OR6S1 OR4C45 CRH OR8G5 GNB4 OR13C3 CALCB(82-118) AVP(20-28) OR2T27 DA OR6M1 OR13C2 GPR39 RAMP2 TSHR OR2T6 GNG2 OR1N2 OR13D1 OR1F1 OR13F1 OR4C45 Ligands of GPCRsthat activate GsOR10G7 CRHR1 OR2A5 OR8B4 OR5L1 OR5H2 OR6V1 OR51D1 OR4B1 OR10G8 GNG4 GTP HRH2 SCTR OR5B3 FSHR OR13C2 OR51H1P ADCY1 OR52R1 OR8B8 OR4C11 OR1B1 OR1C1 OR2M4 AVPR2 GNG5 OR8K1 OR4D1 ADRBK2 NPS OR4D6 OR52E4 OR4D1 OR10A5 OR5I1 OR2A4 OR7A5 OR13D1 OR7D4 OR2A5 OR56A4 DRD1 OR14C36 NPSR1 GRK6 HTR7 OR7A10 TAAR5 RAMP1 GNG7 OR5AC2 OR52E2 TSHR GNAL ADCY7 GNAS1 OR9I1 GLP-1 (7-37) ADCY9 Ade-Rib CALCRL OR6C6 OR2Z1 OR5K4 OR10P1 pS-ADRB2 OR7G3 RLN2(162-185) SCT OR10H2 OR2A1 OR51M1 RAMP1 TAAR9 GNAS1 GNB4 OR8D2 PGI2 CGRP ligands PTH1R,PTH2R OR6F1 OR9A1P FSHB ADCY8 ADCYAP1R1 OR14J1 OR2D2 OR2D2 CRHR1, CRHR2 GLP-1 (7-37) OR8H3 ADR MC5R OR56B4 OR10X1 P2RY11 OR6N2 OR11L1 OR1L8 OR2T33 OR13C8 OR9A4 OR1J1 OR5AR1 GNG4 OR10S1 OR52E8 OR2C3 OR52I1 DA OR1A1 OR2A14 ADCY5 PGE2 OR52A4 OR9A1P OR4F17 OR12D3 OR10G9 OR4S2 OR5K4 GRK2 OR2T8 OR52K2 OR52N5 GNB4 OR3A4P OR5D18 OR4A15 OR1E3 GPR39 OR2B11 OR10H4 GNG5 OR2T11 G-protein alpha(z):GTP:AdenylatecyclaseVIPR1,VIPR2 OR4C46 GNG11 OR2M3 OR5V1 OR5T2 OR9G4 GPBAR1 NPS GNG8 GPBAR1 OR6C76 OR1C1 OR10D3 OR11A1 IAPP(34-70) GRK5 TAAR1 OR10T2 OR14A2 RAMP1 OR4K15 IAPP(34-70) INSL3(21-55) OR10Q1 OR8D4 OR10H3 TAAR1 OR6B2 OR52B2 ARRB1 ADORA2B GNB5 OR4C5 PTH2(62-100) OR10AG1 ADRB1 POMC(138-176) GTP OR11G2 PTHLH OR2W1 OR2L3 OR10R2 GCG(146-178) ADRBK2 OR5D16 OR52K1 GNG13 OR51G1 OR51M1 MC5R ADCYAP1(132-158) OR5A2 OR51I2 GNAS1 FSHB OR4C5 pS-ADRB2:CatecholamineOR52L2P VIPR2 GNAS2 CALCA(83-119) ADRB2 OR10K1 OR10G6 OR5B17 OR4A4P GNG8 ADCY3 OR1G1 OR5M3 GNB1 OR6J1 G-protein beta-gammacomplexRXFP1 OR5M8 OR10A5 OR2T33 PGD2 OR5M8 ADCYAP1(82-129) OR3A1 OR9Q1 GHRHR OR5M11 OR52E2 GNB3 OR10H1 GNGT1 OR52Z1 ArgN-GCG(98-127) OR13G1 INSL3(106-131) ADRB2:ADR,NAdOR8U1 OR7D4 RLN2(162-185) PGD2 OR56A4 GLP2R OR2L13 OR56B1 OR4N5 MC2R RTPsOR4K3 ADCY3 GNG13 GHRH Zn2+ OR1N1 OR10J6P OR2T7 OR4F17 DCA INSL3(106-131) POMC(77-87) OR6C68 TAAR5 CDCA MC4R OR2A7 HeterotrimericG-protein Gs(inactive)OR7A2P ADM(95-146) OR11A1 Hist OR51F1 OR8B3 cAMPphosphodiesterasesOR8A1 OR6B2 OR5T3 OR2C3 OR5T3 OR56B1 ADRBK2 OR5D18 VIP(125-152) GNAI3 GNB3 OR4D9 DRD1 GIP(52-93) CRHR2 OR4F21 VIP(125-152) ARRB2 OR6C1 ADRB2 ADCY2 OR8H1 GNG7 VIP(125-152) OR2H1 OR8B2 CALCR 1919191921


Description

The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase (Tesmer et al. 1997), which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. Another downstream effector of G alpha (s) is the protein tyrosine kinase c-Src (Ma et al. 2000). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 418555
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Jupe, Steve

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Bibliography

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  1. Siderovski DP, Willard FS.; ''The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits.''; PubMed Europe PMC Scholia
  2. Richardson RM, Kim C, Benovic JL, Hosey MM.; ''Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase.''; PubMed Europe PMC Scholia
  3. Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR.; ''Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.''; PubMed Europe PMC Scholia
  4. Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ.; ''beta-Arrestin: a protein that regulates beta-adrenergic receptor function.''; PubMed Europe PMC Scholia
  5. Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H.; ''Genetic variation in a human odorant receptor alters odour perception.''; PubMed Europe PMC Scholia
  6. Kozasa T, Itoh H, Tsukamoto T, Kaziro Y.; ''Isolation and characterization of the human Gs alpha gene.''; PubMed Europe PMC Scholia
  7. Wenzel-Seifert K, Liu HY, Seifert R.; ''Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants.''; PubMed Europe PMC Scholia
  8. Baker LP, Nielsen MD, Impey S, Metcalf MA, Poser SW, Chan G, Obrietan K, Hamblin MW, Storm DR.; ''Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor.''; PubMed Europe PMC Scholia
  9. Martin AL, Steurer MA, Aronstam RS.; ''Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.''; PubMed Europe PMC Scholia
  10. Oldham WM, Hamm HE.; ''Structural basis of function in heterotrimeric G proteins.''; PubMed Europe PMC Scholia
  11. Ma YC, Huang J, Ali S, Lowry W, Huang XY.; ''Src tyrosine kinase is a novel direct effector of G proteins.''; PubMed Europe PMC Scholia
  12. Malnic B, Godfrey PA, Buck LB.; ''The human olfactory receptor gene family.''; PubMed Europe PMC Scholia
  13. Graziano MP, Freissmuth M, Gilman AG.; ''Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein.''; PubMed Europe PMC Scholia
  14. Sterne-Marr R, Gurevich VV, Goldsmith P, Bodine RC, Sanders C, Donoso LA, Benovic JL.; ''Polypeptide variants of beta-arrestin and arrestin3.''; PubMed Europe PMC Scholia
  15. SUTHERLAND EW, RALL TW.; ''Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles.''; PubMed Europe PMC Scholia
  16. Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ.; ''Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.''; PubMed Europe PMC Scholia
  17. Feldman DS, Zamah AM, Pierce KL, Miller WE, Kelly F, Rapacciuolo A, Rockman HA, Koch WJ, Luttrell LM.; ''Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.''; PubMed Europe PMC Scholia
  18. Zhang X, De la Cruz O, Pinto JM, Nicolae D, Firestein S, Gilad Y.; ''Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray.''; PubMed Europe PMC Scholia
  19. Lambert NA.; ''Dissociation of heterotrimeric g proteins in cells.''; PubMed Europe PMC Scholia
  20. Maurice DH.; ''Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system.''; PubMed Europe PMC Scholia
  21. Belluscio L, Gold GH, Nemes A, Axel R.; ''Mice deficient in G(olf) are anosmic.''; PubMed Europe PMC Scholia
  22. Violin JD, Ren XR, Lefkowitz RJ.; ''G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.''; PubMed Europe PMC Scholia
  23. Dupré DJ, Robitaille M, Rebois RV, Hébert TE.; ''The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes.''; PubMed Europe PMC Scholia
  24. Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, Kwatra MM, Snyder SH, Caron MG, Lefkowitz RJ.; ''Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.''; PubMed Europe PMC Scholia
  25. Mitsuhashi M, Mitsuhashi T, Payan DG.; ''Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells.''; PubMed Europe PMC Scholia
  26. Ménard L, Ferguson SS, Barak LS, Bertrand L, Premont RT, Colapietro AM, Lefkowitz RJ, Caron MG.; ''Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.''; PubMed Europe PMC Scholia
  27. Cabrera-Vera TM, Vanhauwe J, Thomas TO, Medkova M, Preininger A, Mazzoni MR, Hamm HE.; ''Insights into G protein structure, function, and regulation.''; PubMed Europe PMC Scholia
  28. Dessauer CW, Chen-Goodspeed M, Chen J.; ''Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase.''; PubMed Europe PMC Scholia
  29. Zhang JY, Nawoschik S, Kowal D, Smith D, Spangler T, Ochalski R, Schechter L, Dunlop J.; ''Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein.''; PubMed Europe PMC Scholia
  30. Oldham WM, Hamm HE.; ''Heterotrimeric G protein activation by G-protein-coupled receptors.''; PubMed Europe PMC Scholia
  31. Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D.; ''Genetic elucidation of human hyperosmia to isovaleric acid.''; PubMed Europe PMC Scholia
  32. Buck L, Axel R.; ''A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116411view09:06, 7 May 2021EweitzModified title
113271view11:34, 2 November 2020ReactomeTeamReactome version 74
101710view14:50, 1 November 2018DeSlOntology Term : 'PW:0000230' removed !
101709view14:50, 1 November 2018DeSlOntology Term : 'G protein mediated signaling pathway via Galphas family' added !
101708view14:49, 1 November 2018DeSlOntology Term : 'G protein mediated signaling pathway via Galpha12/Galpha13 family' added !
101395view11:28, 1 November 2018ReactomeTeamreactome version 66
100933view21:04, 31 October 2018ReactomeTeamreactome version 65
100471view19:38, 31 October 2018ReactomeTeamreactome version 64
100276view16:57, 31 October 2018ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
5HT MetaboliteCHEBI:28790 (ChEBI)
ADCY1 ProteinQ08828 (Uniprot-TrEMBL)
ADCY2 ProteinQ08462 (Uniprot-TrEMBL)
ADCY3 ProteinO60266 (Uniprot-TrEMBL)
ADCY4 ProteinQ8NFM4 (Uniprot-TrEMBL)
ADCY5 ProteinO95622 (Uniprot-TrEMBL)
ADCY6 ProteinO43306 (Uniprot-TrEMBL)
ADCY7 ProteinP51828 (Uniprot-TrEMBL)
ADCY8 ProteinP40145 (Uniprot-TrEMBL)
ADCY9 ProteinO60503 (Uniprot-TrEMBL)
ADCYAP1 peptides R-HSA-420080 (Reactome)
ADCYAP1(132-158) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1(132-169) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1(82-129) ProteinP18509 (Uniprot-TrEMBL)
ADCYAP1R1 ProteinP41586 (Uniprot-TrEMBL)
ADM(95-146) ProteinP35318 (Uniprot-TrEMBL)
ADM,ADM2 R-HSA-420061 (Reactome)
ADM2(19-153) ProteinQ7Z4H4 (Uniprot-TrEMBL)
ADORA2A ProteinP29274 (Uniprot-TrEMBL)
ADORA2A,B R-HSA-418907 (Reactome)
ADORA2B ProteinP29275 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
ADR MetaboliteCHEBI:28918 (ChEBI)
ADR, NAd R-ALL-390627 (Reactome)
ADRB1 ProteinP08588 (Uniprot-TrEMBL)
ADRB2 ProteinP07550 (Uniprot-TrEMBL)
ADRB2:ADR,NAdComplexR-HSA-8852028 (Reactome)
ADRB2:Catecholamine:GRKComplexR-HSA-8982633 (Reactome)
ADRB3 ProteinP13945 (Uniprot-TrEMBL)
ADRBK2 ProteinP35626 (Uniprot-TrEMBL)
AMPMetaboliteCHEBI:16027 (ChEBI)
AMY1-3 R-HSA-420237 (Reactome)
ARRB1 ProteinP49407 (Uniprot-TrEMBL)
ARRB2 ProteinP32121 (Uniprot-TrEMBL)
ARRBComplexR-HSA-1911410 (Reactome)
ATP MetaboliteCHEBI:15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
AVP(20-28) ProteinP01185 (Uniprot-TrEMBL)
AVPR2 ProteinP30518 (Uniprot-TrEMBL)
Ade-Rib MetaboliteCHEBI:16335 (ChEBI)
Adenylate cyclase (Mg2+ cofactor)ComplexR-HSA-170665 (Reactome)
Adrenomedullin receptor R-HSA-420118 (Reactome)
ArgN-GCG(98-127) ProteinP01275 (Uniprot-TrEMBL) The amide group at the C-terminus is not necessary for biological activity.
Bile acids R-ALL-444840 (Reactome)
CALCA(83-119) ProteinP01258 (Uniprot-TrEMBL)
CALCA(83-119) ProteinP06881 (Uniprot-TrEMBL)
CALCB(82-118) ProteinP10092 (Uniprot-TrEMBL)
CALCR ProteinP30988 (Uniprot-TrEMBL)
CALCRL ProteinQ16602 (Uniprot-TrEMBL)
CCA MetaboliteCHEBI:16359 (ChEBI)
CDCA MetaboliteCHEBI:16755 (ChEBI)
CGA ProteinP01215 (Uniprot-TrEMBL)
CGRP ligands R-HSA-419795 (Reactome)
CRH ProteinP06850 (Uniprot-TrEMBL)
CRHR1 ProteinP34998 (Uniprot-TrEMBL)
CRHR1, CRHR2 R-HSA-420140 (Reactome)
CRHR2 ProteinQ13324 (Uniprot-TrEMBL)
Constitutively active orphan GPCRs R-HSA-6805225 (Reactome)
DA MetaboliteCHEBI:18243 (ChEBI)
DCA MetaboliteCHEBI:28834 (ChEBI)
DRD1 ProteinP21728 (Uniprot-TrEMBL)
DRD1,5 R-HSA-390836 (Reactome)
DRD5 ProteinP21918 (Uniprot-TrEMBL)
FSHB ProteinP01225 (Uniprot-TrEMBL)
FSHR ProteinP23945 (Uniprot-TrEMBL)
G alpha

(s):GTP:Adenylate

cyclase
ComplexR-HSA-163622 (Reactome)
G alpha (s):GDPComplexR-HSA-164333 (Reactome)
G alpha (s):GTPComplexR-HSA-164358 (Reactome)
G-protein alpha

(i):GTP:Adenylate

cyclase
ComplexR-HSA-396910 (Reactome)
G-protein alpha

(z):GTP:Adenylate

cyclase
ComplexR-HSA-392049 (Reactome)
G-protein beta-gamma complexComplexR-HSA-167434 (Reactome)
G-protein beta:gamma signallingPathwayR-HSA-397795 (Reactome) The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.
GCG(146-178) ProteinP01275 (Uniprot-TrEMBL)
GCG(53-81) ProteinP01275 (Uniprot-TrEMBL)
GCGR ProteinP47871 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GHRH ProteinP01286 (Uniprot-TrEMBL)
GHRHR ProteinQ02643 (Uniprot-TrEMBL)
GIP(52-93) ProteinP09681 (Uniprot-TrEMBL)
GIPR ProteinP48546 (Uniprot-TrEMBL)
GLP-1 (7-37) ProteinP01275 (Uniprot-TrEMBL)
GLP1R ProteinP43220 (Uniprot-TrEMBL)
GLP2R ProteinO95838 (Uniprot-TrEMBL)
GNAI1 ProteinP63096 (Uniprot-TrEMBL)
GNAI2 ProteinP04899 (Uniprot-TrEMBL)
GNAI3 ProteinP08754 (Uniprot-TrEMBL)
GNAL ProteinP38405 (Uniprot-TrEMBL)
GNAL:GNB1:GNGT1ComplexR-HSA-380924 (Reactome) The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of intracellular second messengers. GPCRs activate the G-proteins, which consist of an alpha-subunit that binds and hydrolyses guanosine triphosphate (GTP), a beta and a gamma subunit.
GNALProteinP38405 (Uniprot-TrEMBL)
GNAS1 ProteinQ5JWF2 (Uniprot-TrEMBL)
GNAS2 ProteinP63092 (Uniprot-TrEMBL)
GNAT3 ProteinA8MTJ3 (Uniprot-TrEMBL)
GNAZ ProteinP19086 (Uniprot-TrEMBL)
GNB1 ProteinP62873 (Uniprot-TrEMBL)
GNB1ProteinP62873 (Uniprot-TrEMBL)
GNB2 ProteinP62879 (Uniprot-TrEMBL)
GNB3 ProteinP16520 (Uniprot-TrEMBL)
GNB4 ProteinQ9HAV0 (Uniprot-TrEMBL)
GNB5 ProteinO14775 (Uniprot-TrEMBL)
GNG10 ProteinP50151 (Uniprot-TrEMBL)
GNG11 ProteinP61952 (Uniprot-TrEMBL)
GNG12 ProteinQ9UBI6 (Uniprot-TrEMBL)
GNG13 ProteinQ9P2W3 (Uniprot-TrEMBL)
GNG2 ProteinP59768 (Uniprot-TrEMBL)
GNG3 ProteinP63215 (Uniprot-TrEMBL)
GNG4 ProteinP50150 (Uniprot-TrEMBL)
GNG5 ProteinP63218 (Uniprot-TrEMBL)
GNG7 ProteinO60262 (Uniprot-TrEMBL)
GNG8 ProteinQ9UK08 (Uniprot-TrEMBL)
GNGT1 ProteinP63211 (Uniprot-TrEMBL)
GNGT1ProteinP63211 (Uniprot-TrEMBL)
GNGT2 ProteinO14610 (Uniprot-TrEMBL)
GPBAR1 ProteinQ8TDU6 (Uniprot-TrEMBL)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
ComplexR-HSA-744890 (Reactome)
GPCRs that activate GsComplexR-HSA-790204 (Reactome)
GPHA2 ProteinQ96T91 (Uniprot-TrEMBL)
GPHB5 ProteinQ86YW7 (Uniprot-TrEMBL)
GPR39 ProteinO43194 (Uniprot-TrEMBL)
GRK2 ProteinP25098 (Uniprot-TrEMBL)
GRK2, GRK3, GRK5, GRK6ComplexR-HSA-8852026 (Reactome)
GRK5 ProteinP34947 (Uniprot-TrEMBL)
GRK6 ProteinP43250 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HRH2 ProteinP25021 (Uniprot-TrEMBL)
HTR4 ProteinQ13639 (Uniprot-TrEMBL)
HTR4,6,7 R-HSA-390942 (Reactome)
HTR6 ProteinP50406 (Uniprot-TrEMBL)
HTR7 ProteinP34969 (Uniprot-TrEMBL)
Heterotrimeric

G-protein Gs

(inactive)
ComplexR-HSA-391179 (Reactome)
Hist MetaboliteCHEBI:18295 (ChEBI)
IAPP(34-70) ProteinP10997 (Uniprot-TrEMBL)
INSL3(106-131) ProteinP51460 (Uniprot-TrEMBL)
INSL3(21-55) ProteinP51460 (Uniprot-TrEMBL)
LCHA MetaboliteCHEBI:16325 (ChEBI)
LHB ProteinP01229 (Uniprot-TrEMBL)
LHCGR ProteinP22888 (Uniprot-TrEMBL)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
ComplexR-HSA-744885 (Reactome)
Ligand:GPCR

complexes that

activate Gs
ComplexR-HSA-391181 (Reactome)
Ligands of GPCRs that activate GsComplexR-HSA-790205 (Reactome)
MC1R ProteinQ01726 (Uniprot-TrEMBL)
MC2R ProteinQ01718 (Uniprot-TrEMBL)
MC3R(1-360) ProteinP41968 (Uniprot-TrEMBL)
MC4R ProteinP32245 (Uniprot-TrEMBL)
MC5R ProteinP33032 (Uniprot-TrEMBL)
MSH R-HSA-388597 (Reactome)
Melanocortin receptors R-HSA-388601 (Reactome)
Mg2+ MetaboliteCHEBI:18420 (ChEBI)
NAd MetaboliteCHEBI:18357 (ChEBI)
NPS ProteinP0C0P6 (Uniprot-TrEMBL)
NPSR1 ProteinQ6W5P4 (Uniprot-TrEMBL)
OR10A2 ProteinQ9H208 (Uniprot-TrEMBL)
OR10A3 ProteinP58181 (Uniprot-TrEMBL)
OR10A4 ProteinQ9H209 (Uniprot-TrEMBL)
OR10A5 ProteinQ9H207 (Uniprot-TrEMBL)
OR10A6 ProteinQ8NH74 (Uniprot-TrEMBL)
OR10A7 ProteinQ8NGE5 (Uniprot-TrEMBL)
OR10AC1P ProteinQ8NH08 (Uniprot-TrEMBL)
OR10AD1 ProteinQ8NGE0 (Uniprot-TrEMBL)
OR10AG1 ProteinQ8NH19 (Uniprot-TrEMBL)
OR10C1 ProteinQ96KK4 (Uniprot-TrEMBL)
OR10D3 ProteinQ8NH80 (Uniprot-TrEMBL)
OR10D4P ProteinQ8NGN7 (Uniprot-TrEMBL)
OR10G2 ProteinQ8NGC3 (Uniprot-TrEMBL)
OR10G3 ProteinQ8NGC4 (Uniprot-TrEMBL)
OR10G4 ProteinQ8NGN3 (Uniprot-TrEMBL)
OR10G6 ProteinQ8NH81 (Uniprot-TrEMBL)
OR10G7 ProteinQ8NGN6 (Uniprot-TrEMBL)
OR10G8 ProteinQ8NGN5 (Uniprot-TrEMBL)
OR10G9 ProteinQ8NGN4 (Uniprot-TrEMBL)
OR10H1 ProteinQ9Y4A9 (Uniprot-TrEMBL)
OR10H2 ProteinO60403 (Uniprot-TrEMBL)
OR10H3 ProteinO60404 (Uniprot-TrEMBL)
OR10H4 ProteinQ8NGA5 (Uniprot-TrEMBL)
OR10H5 ProteinQ8NGA6 (Uniprot-TrEMBL)
OR10J1 ProteinP30954 (Uniprot-TrEMBL)
OR10J3 ProteinQ5JRS4 (Uniprot-TrEMBL)
OR10J4 ProteinP0C629 (Uniprot-TrEMBL)
OR10J5 ProteinQ8NHC4 (Uniprot-TrEMBL)
OR10J6P ProteinQ8NGY7 (Uniprot-TrEMBL)
OR10K1 ProteinQ8NGX5 (Uniprot-TrEMBL)
OR10K2 ProteinQ6IF99 (Uniprot-TrEMBL)
OR10P1 ProteinQ8NGE3 (Uniprot-TrEMBL)
OR10Q1 ProteinQ8NGQ4 (Uniprot-TrEMBL)
OR10R2 ProteinQ8NGX6 (Uniprot-TrEMBL)
OR10S1 ProteinQ8NGN2 (Uniprot-TrEMBL)
OR10T2 ProteinQ8NGX3 (Uniprot-TrEMBL)
OR10V1 ProteinQ8NGI7 (Uniprot-TrEMBL)
OR10W1 ProteinQ8NGF6 (Uniprot-TrEMBL)
OR10X1 ProteinQ8NGY0 (Uniprot-TrEMBL)
OR10Z1 ProteinQ8NGY1 (Uniprot-TrEMBL)
OR11A1 ProteinQ9GZK7 (Uniprot-TrEMBL)
OR11G2 ProteinQ8NGC1 (Uniprot-TrEMBL)
OR11H1 ProteinQ8NG94 (Uniprot-TrEMBL)
OR11H2 ProteinQ8NH07 (Uniprot-TrEMBL)
OR11H4 ProteinQ8NGC9 (Uniprot-TrEMBL)
OR11H6 ProteinQ8NGC7 (Uniprot-TrEMBL)
OR11H7 ProteinQ8NGC8 (Uniprot-TrEMBL)
OR11L1 ProteinQ8NGX0 (Uniprot-TrEMBL)
OR12D2 ProteinP58182 (Uniprot-TrEMBL)
OR12D3 ProteinQ9UGF7 (Uniprot-TrEMBL)
OR13A1 ProteinQ8NGR1 (Uniprot-TrEMBL)
OR13C2 ProteinQ8NGS9 (Uniprot-TrEMBL)
OR13C3 ProteinQ8NGS6 (Uniprot-TrEMBL)
OR13C4 ProteinQ8NGS5 (Uniprot-TrEMBL)
OR13C5 ProteinQ8NGS8 (Uniprot-TrEMBL)
OR13C8 ProteinQ8NGS7 (Uniprot-TrEMBL)
OR13C9 ProteinQ8NGT0 (Uniprot-TrEMBL)
OR13D1 ProteinQ8NGV5 (Uniprot-TrEMBL)
OR13F1 ProteinQ8NGS4 (Uniprot-TrEMBL)
OR13G1 ProteinQ8NGZ3 (Uniprot-TrEMBL)
OR13H1 ProteinQ8NG92 (Uniprot-TrEMBL)
OR13J1 ProteinQ8NGT2 (Uniprot-TrEMBL)
OR14A16 ProteinQ8NHC5 (Uniprot-TrEMBL)
OR14A2 ProteinQ96R54 (Uniprot-TrEMBL)
OR14C36 ProteinQ8NHC7 (Uniprot-TrEMBL)
OR14I1 ProteinA6ND48 (Uniprot-TrEMBL)
OR14J1 ProteinQ9UGF5 (Uniprot-TrEMBL)
OR14K1 ProteinQ8NGZ2 (Uniprot-TrEMBL)
OR14L1P ProteinQ8NHC6 (Uniprot-TrEMBL)
OR1A1 ProteinQ9P1Q5 (Uniprot-TrEMBL)
OR1A2 ProteinQ9Y585 (Uniprot-TrEMBL)
OR1B1 ProteinQ8NGR6 (Uniprot-TrEMBL)
OR1C1 ProteinQ15619 (Uniprot-TrEMBL)
OR1D2 ProteinP34982 (Uniprot-TrEMBL)
OR1D4 ProteinP47884 (Uniprot-TrEMBL)
OR1D5 ProteinP58170 (Uniprot-TrEMBL)
OR1E1 ProteinP30953 (Uniprot-TrEMBL)
OR1E2 ProteinP47887 (Uniprot-TrEMBL)
OR1E3 ProteinQ8WZA6 (Uniprot-TrEMBL)
OR1F1 ProteinO43749 (Uniprot-TrEMBL)
OR1F12 ProteinQ8NHA8 (Uniprot-TrEMBL)
OR1F2P ProteinQ96R84 (Uniprot-TrEMBL)
OR1G1 ProteinP47890 (Uniprot-TrEMBL)
OR1I1 ProteinO60431 (Uniprot-TrEMBL)
OR1J1 ProteinQ8NGS3 (Uniprot-TrEMBL)
OR1J2 ProteinQ8NGS2 (Uniprot-TrEMBL)
OR1J4 ProteinQ8NGS1 (Uniprot-TrEMBL)
OR1K1 ProteinQ8NGR3 (Uniprot-TrEMBL)
OR1L1 ProteinQ8NH94 (Uniprot-TrEMBL)
OR1L3 ProteinQ8NH93 (Uniprot-TrEMBL)
OR1L4 ProteinQ8NGR5 (Uniprot-TrEMBL)
OR1L6 ProteinQ8NGR2 (Uniprot-TrEMBL)
OR1L8 ProteinQ8NGR8 (Uniprot-TrEMBL)
OR1M1 ProteinQ8NGA1 (Uniprot-TrEMBL)
OR1N1 ProteinQ8NGS0 (Uniprot-TrEMBL)
OR1N2 ProteinQ8NGR9 (Uniprot-TrEMBL)
OR1P1 ProteinQ8NH06 (Uniprot-TrEMBL)
OR1Q1 ProteinQ15612 (Uniprot-TrEMBL)
OR1S1 ProteinQ8NH92 (Uniprot-TrEMBL)
OR1S2 ProteinQ8NGQ3 (Uniprot-TrEMBL)
OR2A1 ProteinQ8NGT9 (Uniprot-TrEMBL)
OR2A12 ProteinQ8NGT7 (Uniprot-TrEMBL)
OR2A14 ProteinQ96R47 (Uniprot-TrEMBL)
OR2A2 ProteinQ6IF42 (Uniprot-TrEMBL)
OR2A25 ProteinA4D2G3 (Uniprot-TrEMBL)
OR2A4 ProteinO95047 (Uniprot-TrEMBL)
OR2A5 ProteinQ96R48 (Uniprot-TrEMBL)
OR2A7 ProteinQ96R45 (Uniprot-TrEMBL)
OR2AE1 ProteinQ8NHA4 (Uniprot-TrEMBL)
OR2AG1 ProteinQ9H205 (Uniprot-TrEMBL)
OR2AG2 ProteinA6NM03 (Uniprot-TrEMBL)
OR2AJ1 ProteinQ8NGZ0 (Uniprot-TrEMBL)
OR2AK2 ProteinQ8NG84 (Uniprot-TrEMBL)
OR2AP1 ProteinQ8NGE2 (Uniprot-TrEMBL)
OR2AT4 ProteinA6NND4 (Uniprot-TrEMBL)
OR2B11 ProteinQ5JQS5 (Uniprot-TrEMBL)
OR2B2 ProteinQ9GZK3 (Uniprot-TrEMBL)
OR2B3 ProteinO76000 (Uniprot-TrEMBL)
OR2B6 ProteinP58173 (Uniprot-TrEMBL)
OR2B8P ProteinP59922 (Uniprot-TrEMBL)
OR2C1 ProteinO95371 (Uniprot-TrEMBL)
OR2C3 ProteinQ8N628 (Uniprot-TrEMBL)
OR2D2 ProteinQ9H210 (Uniprot-TrEMBL)
OR2D3 ProteinQ8NGH3 (Uniprot-TrEMBL)
OR2F1 ProteinQ13607 (Uniprot-TrEMBL)
OR2F2 ProteinO95006 (Uniprot-TrEMBL)
OR2G2 ProteinQ8NGZ5 (Uniprot-TrEMBL)
OR2G3 ProteinQ8NGZ4 (Uniprot-TrEMBL)
OR2G6 ProteinQ5TZ20 (Uniprot-TrEMBL)
OR2H1 ProteinQ9GZK4 (Uniprot-TrEMBL)
OR2H2 ProteinO95918 (Uniprot-TrEMBL)
OR2I1P ProteinQ8NGU4 (Uniprot-TrEMBL)
OR2J1 ProteinQ9GZK6 (Uniprot-TrEMBL)
OR2J2 ProteinO76002 (Uniprot-TrEMBL)
OR2J3 ProteinO76001 (Uniprot-TrEMBL)
OR2K2 ProteinQ8NGT1 (Uniprot-TrEMBL)
OR2L13 ProteinQ8N349 (Uniprot-TrEMBL)
OR2L2 ProteinQ8NH16 (Uniprot-TrEMBL)
OR2L3 ProteinQ8NG85 (Uniprot-TrEMBL)
OR2L5 ProteinQ8NG80 (Uniprot-TrEMBL)
OR2L8 ProteinQ8NGY9 (Uniprot-TrEMBL)
OR2M2 ProteinQ96R28 (Uniprot-TrEMBL)
OR2M3 ProteinQ8NG83 (Uniprot-TrEMBL)
OR2M4 ProteinQ96R27 (Uniprot-TrEMBL)
OR2M5 ProteinA3KFT3 (Uniprot-TrEMBL)
OR2M7 ProteinQ8NG81 (Uniprot-TrEMBL)
OR2S2 ProteinQ9NQN1 (Uniprot-TrEMBL)
OR2T1 ProteinO43869 (Uniprot-TrEMBL)
OR2T10 ProteinQ8NGZ9 (Uniprot-TrEMBL)
OR2T11 ProteinQ8NH01 (Uniprot-TrEMBL)
OR2T12 ProteinQ8NG77 (Uniprot-TrEMBL)
OR2T2 ProteinQ6IF00 (Uniprot-TrEMBL)
OR2T27 ProteinQ8NH04 (Uniprot-TrEMBL)
OR2T29 ProteinQ8NH02 (Uniprot-TrEMBL)
OR2T3 ProteinQ8NH03 (Uniprot-TrEMBL)
OR2T33 ProteinQ8NG76 (Uniprot-TrEMBL)
OR2T34 ProteinQ8NGX1 (Uniprot-TrEMBL)
OR2T35 ProteinQ8NGX2 (Uniprot-TrEMBL)
OR2T4 ProteinQ8NH00 (Uniprot-TrEMBL)
OR2T5 ProteinQ6IEZ7 (Uniprot-TrEMBL)
OR2T6 ProteinQ8NHC8 (Uniprot-TrEMBL)
OR2T7 ProteinP0C7T2 (Uniprot-TrEMBL)
OR2T8 ProteinA6NH00 (Uniprot-TrEMBL)
OR2V1 ProteinQ8NHB1 (Uniprot-TrEMBL)
OR2V2 ProteinQ96R30 (Uniprot-TrEMBL)
OR2W1 ProteinQ9Y3N9 (Uniprot-TrEMBL)
OR2W3 ProteinQ7Z3T1 (Uniprot-TrEMBL)
OR2W5 ProteinA6NFC9 (Uniprot-TrEMBL)
OR2W6P ProteinQ8NHA6 (Uniprot-TrEMBL)
OR2Y1 ProteinQ8NGV0 (Uniprot-TrEMBL)
OR2Z1 ProteinQ8NG97 (Uniprot-TrEMBL)
OR3A1 ProteinP47881 (Uniprot-TrEMBL)
OR3A2 ProteinP47893 (Uniprot-TrEMBL)
OR3A3 ProteinP47888 (Uniprot-TrEMBL)
OR3A4P ProteinP47883 (Uniprot-TrEMBL)
OR4A15 ProteinQ8NGL6 (Uniprot-TrEMBL)
OR4A16 ProteinQ8NH70 (Uniprot-TrEMBL)
OR4A47 ProteinQ6IF82 (Uniprot-TrEMBL)
OR4A4P ProteinQ8NGN8 (Uniprot-TrEMBL)
OR4A5 ProteinQ8NH83 (Uniprot-TrEMBL)
OR4A8P ProteinP0C604 (Uniprot-TrEMBL)
OR4B1 ProteinQ8NGF8 (Uniprot-TrEMBL)
OR4C11 ProteinQ6IEV9 (Uniprot-TrEMBL)
OR4C12 ProteinQ96R67 (Uniprot-TrEMBL)
OR4C13 ProteinQ8NGP0 (Uniprot-TrEMBL)
OR4C15 ProteinQ8NGM1 (Uniprot-TrEMBL)
OR4C16 ProteinQ8NGL9 (Uniprot-TrEMBL)
OR4C3 ProteinQ8NH37 (Uniprot-TrEMBL)
OR4C45 ProteinA6NMZ5 (Uniprot-TrEMBL)
OR4C46 ProteinA6NHA9 (Uniprot-TrEMBL)
OR4C5 ProteinQ8NGB2 (Uniprot-TrEMBL)
OR4C6 ProteinQ8NH72 (Uniprot-TrEMBL)
OR4D1 ProteinQ15615 (Uniprot-TrEMBL)
OR4D10 ProteinQ8NGI6 (Uniprot-TrEMBL)
OR4D11 ProteinQ8NGI4 (Uniprot-TrEMBL)
OR4D2 ProteinP58180 (Uniprot-TrEMBL)
OR4D5 ProteinQ8NGN0 (Uniprot-TrEMBL)
OR4D6 ProteinQ8NGJ1 (Uniprot-TrEMBL)
OR4D9 ProteinQ8NGE8 (Uniprot-TrEMBL)
OR4E1 ProteinP0C645 (Uniprot-TrEMBL)
OR4E2 ProteinQ8NGC2 (Uniprot-TrEMBL)
OR4F15 ProteinQ8NGB8 (Uniprot-TrEMBL)
OR4F17 ProteinQ8NGA8 (Uniprot-TrEMBL)
OR4F21 ProteinO95013 (Uniprot-TrEMBL)
OR4F3 ProteinQ6IEY1 (Uniprot-TrEMBL)
OR4F4 ProteinQ96R69 (Uniprot-TrEMBL)
OR4F5 ProteinQ8NH21 (Uniprot-TrEMBL)
OR4F6 ProteinQ8NGB9 (Uniprot-TrEMBL)
OR4K1 ProteinQ8NGD4 (Uniprot-TrEMBL)
OR4K13 ProteinQ8NH42 (Uniprot-TrEMBL)
OR4K14 ProteinQ8NGD5 (Uniprot-TrEMBL)
OR4K15 ProteinQ8NH41 (Uniprot-TrEMBL)
OR4K17 ProteinQ8NGC6 (Uniprot-TrEMBL)
OR4K2 ProteinQ8NGD2 (Uniprot-TrEMBL)
OR4K3 ProteinQ96R72 (Uniprot-TrEMBL)
OR4K5 ProteinQ8NGD3 (Uniprot-TrEMBL)
OR4L1 ProteinQ8NH43 (Uniprot-TrEMBL)
OR4M1 ProteinQ8NGD0 (Uniprot-TrEMBL)
OR4M2 ProteinQ8NGB6 (Uniprot-TrEMBL)
OR4N2 ProteinQ8NGD1 (Uniprot-TrEMBL)
OR4N4 ProteinQ8N0Y3 (Uniprot-TrEMBL)
OR4N5 ProteinQ8IXE1 (Uniprot-TrEMBL)
OR4P4 ProteinQ8NGL7 (Uniprot-TrEMBL)
OR4Q2 ProteinP0C623 (Uniprot-TrEMBL)
OR4Q3 ProteinQ8NH05 (Uniprot-TrEMBL)
OR4S1 ProteinQ8NGB4 (Uniprot-TrEMBL)
OR4S2 ProteinQ8NH73 (Uniprot-TrEMBL)
OR4X1 ProteinQ8NH49 (Uniprot-TrEMBL)
OR4X2 ProteinQ8NGF9 (Uniprot-TrEMBL)
OR51A2 ProteinQ8NGJ7 (Uniprot-TrEMBL)
OR51A4 ProteinQ8NGJ6 (Uniprot-TrEMBL)
OR51A7 ProteinQ8NH64 (Uniprot-TrEMBL)
OR51B2 ProteinQ9Y5P1 (Uniprot-TrEMBL)
OR51B4 ProteinQ9Y5P0 (Uniprot-TrEMBL)
OR51B5 ProteinQ9H339 (Uniprot-TrEMBL)
OR51B6 ProteinQ9H340 (Uniprot-TrEMBL)
OR51D1 ProteinQ8NGF3 (Uniprot-TrEMBL)
OR51E1 ProteinQ8TCB6 (Uniprot-TrEMBL)
OR51E2 ProteinQ9H255 (Uniprot-TrEMBL)
OR51F1 ProteinA6NGY5 (Uniprot-TrEMBL)
OR51F2 ProteinQ8NH61 (Uniprot-TrEMBL)
OR51G1 ProteinQ8NGK1 (Uniprot-TrEMBL)
OR51G2 ProteinQ8NGK0 (Uniprot-TrEMBL)
OR51H1P ProteinQ8NH63 (Uniprot-TrEMBL)
OR51I1 ProteinQ9H343 (Uniprot-TrEMBL)
OR51I2 ProteinQ9H344 (Uniprot-TrEMBL)
OR51J1 ProteinQ9H342 (Uniprot-TrEMBL)
OR51L1 ProteinQ8NGJ5 (Uniprot-TrEMBL)
OR51M1 ProteinQ9H341 (Uniprot-TrEMBL)
OR51Q1 ProteinQ8NH59 (Uniprot-TrEMBL)
OR51S1 ProteinQ8NGJ8 (Uniprot-TrEMBL)
OR51T1 ProteinQ8NGJ9 (Uniprot-TrEMBL)
OR51V1 ProteinQ9H2C8 (Uniprot-TrEMBL)
OR52A1 ProteinQ9UKL2 (Uniprot-TrEMBL)
OR52A4 ProteinA6NMU1 (Uniprot-TrEMBL)
OR52A5 ProteinQ9H2C5 (Uniprot-TrEMBL)
OR52B2 ProteinQ96RD2 (Uniprot-TrEMBL)
OR52B6 ProteinQ8NGF0 (Uniprot-TrEMBL)
OR52D1 ProteinQ9H346 (Uniprot-TrEMBL)
OR52E1 ProteinQ8NGJ3 (Uniprot-TrEMBL)
OR52E2 ProteinQ8NGJ4 (Uniprot-TrEMBL)
OR52E4 ProteinQ8NGH9 (Uniprot-TrEMBL)
OR52E5 ProteinQ8NH55 (Uniprot-TrEMBL)
OR52E6 ProteinQ96RD3 (Uniprot-TrEMBL)
OR52E8 ProteinQ6IFG1 (Uniprot-TrEMBL)
OR52H1 ProteinQ8NGJ2 (Uniprot-TrEMBL)
OR52I1 ProteinQ8NGK6 (Uniprot-TrEMBL)
OR52I2 ProteinQ8NH67 (Uniprot-TrEMBL)
OR52J3 ProteinQ8NH60 (Uniprot-TrEMBL)
OR52K1 ProteinQ8NGK4 (Uniprot-TrEMBL)
OR52K2 ProteinQ8NGK3 (Uniprot-TrEMBL)
OR52L1 ProteinQ8NGH7 (Uniprot-TrEMBL)
OR52L2P ProteinQ8NGH6 (Uniprot-TrEMBL)
OR52M1 ProteinQ8NGK5 (Uniprot-TrEMBL)
OR52N1 ProteinQ8NH53 (Uniprot-TrEMBL)
OR52N2 ProteinQ8NGI0 (Uniprot-TrEMBL)
OR52N4 ProteinQ8NGI2 (Uniprot-TrEMBL)
OR52N5 ProteinQ8NH56 (Uniprot-TrEMBL)
OR52P1P ProteinQ8NH57 (Uniprot-TrEMBL)
OR52R1 ProteinQ8NGF1 (Uniprot-TrEMBL)
OR52W1 ProteinQ6IF63 (Uniprot-TrEMBL)
OR52Z1 ProteinP0C646 (Uniprot-TrEMBL)
OR56A1 ProteinQ8NGH5 (Uniprot-TrEMBL)
OR56A3 ProteinQ8NH54 (Uniprot-TrEMBL)
OR56A4 ProteinQ8NGH8 (Uniprot-TrEMBL)
OR56A5 ProteinP0C7T3 (Uniprot-TrEMBL)
OR56B1 ProteinQ8NGI3 (Uniprot-TrEMBL)
OR56B2P ProteinQ8NGI1 (Uniprot-TrEMBL)
OR56B4 ProteinQ8NH76 (Uniprot-TrEMBL)
OR5A1 ProteinQ8NGJ0 (Uniprot-TrEMBL)
OR5A2 ProteinQ8NGI9 (Uniprot-TrEMBL)
OR5AC1 ProteinP0C628 (Uniprot-TrEMBL)
OR5AC2 ProteinQ9NZP5 (Uniprot-TrEMBL)
OR5AK2 ProteinQ8NH90 (Uniprot-TrEMBL)
OR5AK3P ProteinQ8NH89 (Uniprot-TrEMBL)
OR5AL1 ProteinP0C617 (Uniprot-TrEMBL)
OR5AN1 ProteinQ8NGI8 (Uniprot-TrEMBL)
OR5AP2 ProteinQ8NGF4 (Uniprot-TrEMBL)
OR5AR1 ProteinQ8NGP9 (Uniprot-TrEMBL)
OR5AS1 ProteinQ8N127 (Uniprot-TrEMBL)
OR5AU1 ProteinQ8NGC0 (Uniprot-TrEMBL)
OR5B12 ProteinQ96R08 (Uniprot-TrEMBL)
OR5B17 ProteinQ8NGF7 (Uniprot-TrEMBL)
OR5B2 ProteinQ96R09 (Uniprot-TrEMBL)
OR5B21 ProteinA6NL26 (Uniprot-TrEMBL)
OR5B3 ProteinQ8NH48 (Uniprot-TrEMBL)
OR5C1 ProteinQ8NGR4 (Uniprot-TrEMBL)
OR5D13 ProteinQ8NGL4 (Uniprot-TrEMBL)
OR5D14 ProteinQ8NGL3 (Uniprot-TrEMBL)
OR5D16 ProteinQ8NGK9 (Uniprot-TrEMBL)
OR5D18 ProteinQ8NGL1 (Uniprot-TrEMBL)
OR5F1 ProteinO95221 (Uniprot-TrEMBL)
OR5G3 ProteinP0C626 (Uniprot-TrEMBL)
OR5H1 ProteinA6NKK0 (Uniprot-TrEMBL)
OR5H14 ProteinA6NHG9 (Uniprot-TrEMBL)
OR5H15 ProteinA6NDH6 (Uniprot-TrEMBL)
OR5H2 ProteinQ8NGV7 (Uniprot-TrEMBL)
OR5H6 ProteinQ8NGV6 (Uniprot-TrEMBL)
OR5I1 ProteinQ13606 (Uniprot-TrEMBL)
OR5J2 ProteinQ8NH18 (Uniprot-TrEMBL)
OR5K1 ProteinQ8NHB7 (Uniprot-TrEMBL)
OR5K2 ProteinQ8NHB8 (Uniprot-TrEMBL)
OR5K3 ProteinA6NET4 (Uniprot-TrEMBL)
OR5K4 ProteinA6NMS3 (Uniprot-TrEMBL)
OR5L1 ProteinQ8NGL2 (Uniprot-TrEMBL)
OR5L2 ProteinQ8NGL0 (Uniprot-TrEMBL)
OR5M1 ProteinQ8NGP8 (Uniprot-TrEMBL)
OR5M10 ProteinQ6IEU7 (Uniprot-TrEMBL)
OR5M11 ProteinQ96RB7 (Uniprot-TrEMBL)
OR5M3 ProteinQ8NGP4 (Uniprot-TrEMBL)
OR5M8 ProteinQ8NGP6 (Uniprot-TrEMBL)
OR5M9 ProteinQ8NGP3 (Uniprot-TrEMBL)
OR5P2 ProteinQ8WZ92 (Uniprot-TrEMBL)
OR5P3 ProteinQ8WZ94 (Uniprot-TrEMBL)
OR5R1 ProteinQ8NH85 (Uniprot-TrEMBL)
OR5T1 ProteinQ8NG75 (Uniprot-TrEMBL)
OR5T2 ProteinQ8NGG2 (Uniprot-TrEMBL)
OR5T3 ProteinQ8NGG3 (Uniprot-TrEMBL)
OR5V1 ProteinQ9UGF6 (Uniprot-TrEMBL)
OR5W2 ProteinQ8NH69 (Uniprot-TrEMBL)
OR6A2 ProteinO95222 (Uniprot-TrEMBL)
OR6B1 ProteinO95007 (Uniprot-TrEMBL)
OR6B2 ProteinQ6IFH4 (Uniprot-TrEMBL)
OR6B3 ProteinQ8NGW1 (Uniprot-TrEMBL)
OR6C1 ProteinQ96RD1 (Uniprot-TrEMBL)
OR6C2 ProteinQ9NZP2 (Uniprot-TrEMBL)
OR6C3 ProteinQ9NZP0 (Uniprot-TrEMBL)
OR6C4 ProteinQ8NGE1 (Uniprot-TrEMBL)
OR6C6 ProteinA6NF89 (Uniprot-TrEMBL)
OR6C65 ProteinA6NJZ3 (Uniprot-TrEMBL)
OR6C68 ProteinA6NDL8 (Uniprot-TrEMBL)
OR6C70 ProteinA6NIJ9 (Uniprot-TrEMBL)
OR6C74 ProteinA6NCV1 (Uniprot-TrEMBL)
OR6C75 ProteinA6NL08 (Uniprot-TrEMBL)
OR6C76 ProteinA6NM76 (Uniprot-TrEMBL)
OR6F1 ProteinQ8NGZ6 (Uniprot-TrEMBL)
OR6J1 ProteinQ8NGC5 (Uniprot-TrEMBL)
OR6K2 ProteinQ8NGY2 (Uniprot-TrEMBL)
OR6K3 ProteinQ8NGY3 (Uniprot-TrEMBL)
OR6K6 ProteinQ8NGW6 (Uniprot-TrEMBL)
OR6M1 ProteinQ8NGM8 (Uniprot-TrEMBL)
OR6N1 ProteinQ8NGY5 (Uniprot-TrEMBL)
OR6N2 ProteinQ8NGY6 (Uniprot-TrEMBL)
OR6P1 ProteinQ8NGX9 (Uniprot-TrEMBL)
OR6Q1 ProteinQ8NGQ2 (Uniprot-TrEMBL)
OR6S1 ProteinQ8NH40 (Uniprot-TrEMBL)
OR6T1 ProteinQ8NGN1 (Uniprot-TrEMBL)
OR6V1 ProteinQ8N148 (Uniprot-TrEMBL)
OR6X1 ProteinQ8NH79 (Uniprot-TrEMBL)
OR6Y1 ProteinQ8NGX8 (Uniprot-TrEMBL)
OR7A10 ProteinO76100 (Uniprot-TrEMBL)
OR7A17 ProteinO14581 (Uniprot-TrEMBL)
OR7A2P ProteinQ8NGA2 (Uniprot-TrEMBL)
OR7A5 ProteinQ15622 (Uniprot-TrEMBL)
OR7C1 ProteinO76099 (Uniprot-TrEMBL)
OR7C2 ProteinO60412 (Uniprot-TrEMBL)
OR7D2 ProteinQ96RA2 (Uniprot-TrEMBL)
OR7D4 ProteinQ8NG98 (Uniprot-TrEMBL)
OR7E24 ProteinQ6IFN5 (Uniprot-TrEMBL)
OR7G1 ProteinQ8NGA0 (Uniprot-TrEMBL)
OR7G2 ProteinQ8NG99 (Uniprot-TrEMBL)
OR7G3 ProteinQ8NG95 (Uniprot-TrEMBL)
OR8A1 ProteinQ8NGG7 (Uniprot-TrEMBL)
OR8B12 ProteinQ8NGG6 (Uniprot-TrEMBL)
OR8B2 ProteinQ96RD0 (Uniprot-TrEMBL)
OR8B3 ProteinQ8NGG8 (Uniprot-TrEMBL)
OR8B4 ProteinQ96RC9 (Uniprot-TrEMBL)
OR8B8 ProteinQ15620 (Uniprot-TrEMBL)
OR8D1 ProteinQ8WZ84 (Uniprot-TrEMBL)
OR8D2 ProteinQ9GZM6 (Uniprot-TrEMBL)
OR8D4 ProteinQ8NGM9 (Uniprot-TrEMBL)
OR8G1 ProteinQ15617 (Uniprot-TrEMBL)
OR8G2 ProteinQ6IF36 (Uniprot-TrEMBL)
OR8G5 ProteinQ8NG78 (Uniprot-TrEMBL)
OR8H1 ProteinQ8NGG4 (Uniprot-TrEMBL)
OR8H2 ProteinQ8N162 (Uniprot-TrEMBL)
OR8H3 ProteinQ8N146 (Uniprot-TrEMBL)
OR8I2 ProteinQ8N0Y5 (Uniprot-TrEMBL)
OR8J1 ProteinQ8NGP2 (Uniprot-TrEMBL)
OR8J2 ProteinQ8NGG1 (Uniprot-TrEMBL)
OR8J3 ProteinQ8NGG0 (Uniprot-TrEMBL)
OR8K1 ProteinQ8NGG5 (Uniprot-TrEMBL)
OR8K3 ProteinQ8NH51 (Uniprot-TrEMBL)
OR8K5 ProteinQ8NH50 (Uniprot-TrEMBL)
OR8S1 ProteinQ8NH09 (Uniprot-TrEMBL)
OR8U1 ProteinQ8NH10 (Uniprot-TrEMBL)
OR8U8 ProteinP0C7N1 (Uniprot-TrEMBL)
OR8U9 ProteinP0C7N5 (Uniprot-TrEMBL)
OR9A1P ProteinQ8NGU1 (Uniprot-TrEMBL)
OR9A2 ProteinQ8NGT5 (Uniprot-TrEMBL)
OR9A4 ProteinQ8NGU2 (Uniprot-TrEMBL)
OR9G1 ProteinQ8NH87 (Uniprot-TrEMBL)
OR9G4 ProteinQ8NGQ1 (Uniprot-TrEMBL)
OR9G9 ProteinP0C7N8 (Uniprot-TrEMBL)
OR9I1 ProteinQ8NGQ6 (Uniprot-TrEMBL)
OR9K2 ProteinQ8NGE7 (Uniprot-TrEMBL)
OR9Q1 ProteinQ8NGQ5 (Uniprot-TrEMBL)
OR9Q2 ProteinQ8NGE9 (Uniprot-TrEMBL)
Olfactory receptor:G protein trimerComplexR-HSA-381747 (Reactome) Olfactory receptors (ORs) have diverse protein sequences but can be assigned to subfamilies on the basis of sequence relationships. Odorants and pheromones bind to these seven transmembrane domain G-protein-coupled receptors that permit signal transduction. These receptors are encoded by large multigene families that evolved in mammal species in function of specific olfactory needs. Members of the same subfamily have related sequences and are likely to recognize structurally related odorants.
Of the 960 human OR genes and pseudogenes, there is experimental evidence which indicates that at least 437 actually are expressed in human olfactory epithelium; this includes 357 OR genes, and 80 OR pseudogenes (Zhang, 2007). These 357 olfactory-expressed OR genes are therefore expected to be functional in the Olfactory Signaling Pathway, and to interact directly with human G alpha olf in human olfactory cells.

(Note: A subset of 200 of these 357 OR genes are shown as components of OR-G Protein reaction. The others will be added to Reactome later.)

Olfactory receptorsComplexR-HSA-381741 (Reactome)
P2RY11 ProteinQ96G91 (Uniprot-TrEMBL)
PEA MetaboliteCHEBI:18397 (ChEBI)
PGD2 MetaboliteCHEBI:15555 (ChEBI)
PGE2 MetaboliteCHEBI:15551 (ChEBI)
PGI2 MetaboliteCHEBI:15552 (ChEBI)
POMC(138-150) ProteinP01189 (Uniprot-TrEMBL)
POMC(138-176) ProteinP01189 (Uniprot-TrEMBL)
POMC(217-234) ProteinP01189 (Uniprot-TrEMBL)
POMC(77-87) ProteinP01189 (Uniprot-TrEMBL)
PPiMetaboliteCHEBI:29888 (ChEBI)
PTGDR ProteinQ13258 (Uniprot-TrEMBL)
PTGER2 ProteinP43116 (Uniprot-TrEMBL)
PTGER2,PTGER4 R-HSA-391921 (Reactome)
PTGER4 ProteinP35408 (Uniprot-TrEMBL)
PTGIR ProteinP43119 (Uniprot-TrEMBL)
PTH ProteinP01270 (Uniprot-TrEMBL)
PTH1R ProteinQ03431 (Uniprot-TrEMBL)
PTH1R,PTH2R R-HSA-420554 (Reactome)
PTH1R,PTH2R ligands R-HSA-420569 (Reactome)
PTH2(62-100) ProteinQ96A98 (Uniprot-TrEMBL)
PTH2R ProteinP49190 (Uniprot-TrEMBL)
PTHLH ProteinP12272 (Uniprot-TrEMBL)
Phosphodiesterases, cyclic AMP-selective R-HSA-418543 (Reactome)
Phosphodiesterases, dual (cAMP, cGMP) activity R-HSA-418547 (Reactome)
PiMetaboliteCHEBI:18367 (ChEBI)
RAMP1 ProteinO60894 (Uniprot-TrEMBL)
RAMP2 ProteinO60895 (Uniprot-TrEMBL)
RAMP3 ProteinO60896 (Uniprot-TrEMBL)
REEP1 ProteinQ9H902 (Uniprot-TrEMBL)
REEP2 ProteinQ9BRK0 (Uniprot-TrEMBL)
REEP3 ProteinQ6NUK4 (Uniprot-TrEMBL)
REEP4 ProteinQ9H6H4 (Uniprot-TrEMBL)
REEP5 ProteinQ00765 (Uniprot-TrEMBL)
REEP6 ProteinQ96HR9 (Uniprot-TrEMBL)
REEPsComplexR-HSA-8939723 (Reactome)
RLN2(162-185) ProteinP04090 (Uniprot-TrEMBL)
RLN2(25-53) ProteinP04090 (Uniprot-TrEMBL)
RLN3(119-142) ProteinQ8WXF3 (Uniprot-TrEMBL)
RLN3(26-52) ProteinQ8WXF3 (Uniprot-TrEMBL)
RTP1 ProteinP59025 (Uniprot-TrEMBL)
RTP2 ProteinQ5QGT7 (Uniprot-TrEMBL)
RTP3 ProteinQ9BQQ7 (Uniprot-TrEMBL)
RTP4 ProteinQ96DX8 (Uniprot-TrEMBL)
RTP5 ProteinQ14D33 (Uniprot-TrEMBL)
RTPsComplexR-HSA-8939445 (Reactome)
RXFP1 ProteinQ9HBX9 (Uniprot-TrEMBL)
RXFP2 ProteinQ8WXD0 (Uniprot-TrEMBL)
RXFP2 ligands R-HSA-444902 (Reactome)
Relaxin-2, Relaxin-3 R-HSA-444858 (Reactome)
SCT ProteinP09683 (Uniprot-TrEMBL)
SCTR ProteinP47872 (Uniprot-TrEMBL)
TAAR1 ProteinQ96RJ0 (Uniprot-TrEMBL)
TAAR2 ProteinQ9P1P5 (Uniprot-TrEMBL)
TAAR3 ProteinQ9P1P4 (Uniprot-TrEMBL)
TAAR5 ProteinO14804 (Uniprot-TrEMBL)
TAAR6 ProteinQ96RI8 (Uniprot-TrEMBL)
TAAR8 ProteinQ969N4 (Uniprot-TrEMBL)
TAAR9 ProteinQ96RI9 (Uniprot-TrEMBL)
TSHB ProteinP01222 (Uniprot-TrEMBL)
TSHR ProteinP16473 (Uniprot-TrEMBL)
Trace amine-associated receptor R-HSA-391201 (Reactome)
VIP(125-152) ProteinP01282 (Uniprot-TrEMBL)
VIPR1 ProteinP32241 (Uniprot-TrEMBL)
VIPR1,VIPR2 R-HSA-420267 (Reactome)
VIPR2 ProteinP41587 (Uniprot-TrEMBL)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)
cAMP phosphodiesterasesComplexR-HSA-418562 (Reactome)
cAMPMetaboliteCHEBI:17489 (ChEBI)
mature GLP-1 R-HSA-381662 (Reactome)
pS-ADRB2 ProteinP07550 (Uniprot-TrEMBL)
pS-ADRB2:Catecholamine:ARRB1,ARRB2ComplexR-HSA-8852170 (Reactome)
pS-ADRB2:Catecholamine:GRKComplexR-HSA-8982648 (Reactome)
pS-ADRB2:CatecholamineComplexR-HSA-8852152 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADPArrowR-HSA-8851797 (Reactome)
ADRB2:ADR,NAdR-HSA-8982645 (Reactome)
ADRB2:Catecholamine:GRKArrowR-HSA-8982645 (Reactome)
ADRB2:Catecholamine:GRKR-HSA-8851797 (Reactome)
ADRB2:Catecholamine:GRKmim-catalysisR-HSA-8851797 (Reactome)
AMPArrowR-HSA-418553 (Reactome)
ARRBR-HSA-8852167 (Reactome)
ATPR-HSA-392129 (Reactome)
ATPR-HSA-8851797 (Reactome)
Adenylate cyclase (Mg2+ cofactor)R-HSA-163617 (Reactome)
Adenylate cyclase (Mg2+ cofactor)mim-catalysisR-HSA-392129 (Reactome)
G alpha

(s):GTP:Adenylate

cyclase
ArrowR-HSA-163617 (Reactome)
G alpha

(s):GTP:Adenylate

cyclase
ArrowR-HSA-392129 (Reactome)
G alpha (s):GDPArrowR-HSA-164381 (Reactome)
G alpha (s):GDPR-HSA-751013 (Reactome)
G alpha (s):GTPArrowR-HSA-744886 (Reactome)
G alpha (s):GTPR-HSA-163617 (Reactome)
G alpha (s):GTPR-HSA-164381 (Reactome)
G alpha (s):GTPmim-catalysisR-HSA-164381 (Reactome)
G-protein alpha

(i):GTP:Adenylate

cyclase
TBarR-HSA-392129 (Reactome)
G-protein alpha

(z):GTP:Adenylate

cyclase
TBarR-HSA-392129 (Reactome)
G-protein beta-gamma complexArrowR-HSA-744886 (Reactome)
G-protein beta-gamma complexR-HSA-751013 (Reactome)
GDPArrowR-HSA-379044 (Reactome)
GNAL:GNB1:GNGT1ArrowR-HSA-381749 (Reactome)
GNAL:GNB1:GNGT1R-HSA-381750 (Reactome)
GNALR-HSA-381749 (Reactome)
GNB1R-HSA-381749 (Reactome)
GNGT1R-HSA-381749 (Reactome)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
ArrowR-HSA-379044 (Reactome)
GPCR:ligand

complexes that act on Gs:Heterotrimeric G-protein Gs

(active)
R-HSA-744886 (Reactome)
GPCRs that activate GsArrowR-HSA-744886 (Reactome)
GRK2, GRK3, GRK5, GRK6ArrowR-HSA-8982641 (Reactome)
GRK2, GRK3, GRK5, GRK6R-HSA-8982645 (Reactome)
GTPR-HSA-379044 (Reactome)
H2OR-HSA-418553 (Reactome)
Heterotrimeric

G-protein Gs

(inactive)
ArrowR-HSA-751013 (Reactome)
Heterotrimeric

G-protein Gs

(inactive)
R-HSA-744887 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
ArrowR-HSA-744887 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
R-HSA-379044 (Reactome)
Ligand:GPCR

complexes that activate Gs:Heterotrimeric G-protein Gs

(inactive)
mim-catalysisR-HSA-379044 (Reactome)
Ligand:GPCR

complexes that

activate Gs
R-HSA-744887 (Reactome)
Ligands of GPCRs that activate GsArrowR-HSA-744886 (Reactome)
Olfactory receptor:G protein trimerArrowR-HSA-381750 (Reactome)
Olfactory receptorsR-HSA-381750 (Reactome)
PPiArrowR-HSA-392129 (Reactome)
PiArrowR-HSA-164381 (Reactome)
R-HSA-163617 (Reactome) G(s)-alpha:GTP binds to inactive adenylate cyclase, causing a conformational transition in adenylate cyclase exposing the catalytic site and activating it.
R-HSA-164381 (Reactome) When a ligand activates a G protein-coupled receptor, it induces a conformational change in the receptor (a change in shape) that allows the receptor to function as a guanine nucleotide exchange factor (GEF), stimulating the exchange of GDP for GTP on the G alpha subunit. In the traditional view of heterotrimeric protein activation, this exchange triggers the dissociation of the now active G alpha subunit from the beta:gamma dimer, initiating downstream signalling events. The G alpha subunit has intrinsic GTPase activity and will eventually hydrolyze the attached GTP to GDP, allowing reassociation with G beta:gamma. Additional GTPase-activating proteins (GAPs) stimulate the GTPase activity of G alpha, leading to more rapid termination of the transduced signal. In some cases the downstream effector may have GAP activity, helping to deactivate the pathway. This is the case for phospholipase C beta, which possesses GAP activity within its C-terminal region (Kleuss et al. 1994).
R-HSA-379044 (Reactome) The liganded receptor undergoes a conformational change, generating a signal that is propagated in a manner that is not completely understood to the the G-protein. This stimulates the exchange of GDP for GTP in the G-protein alpha subunit, activating the G-protein. This event is negatively regulated by some Activators of G protein signaling (AGS) proteins, a class of proteins identified in yeast functional screens for proteins able to activate G protein signaling in the absence of a G protein–coupled receptor (GPCR) (Cismowski et al. 1999, Takesono et al. 1999). AGS proteins contain G protein regulatory (GPR) motifs (also referred to as the GoLoco motif) that bind and stabilize the Galpha subunit in its GDP-bound conformation (Mochizuki et al. 1996, Peterson et al. 2000, Cao et al. 2004, Blumer & Lanier 2014). Some RGS proteins similarly bind to Galpha preventing the exchange of GDP for GTP (Soundararajan et al. 2008).
R-HSA-381749 (Reactome) The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of intracellular second messengers. GPCRs activate the G-proteins, which consist of an alpha-subunit that binds and hydrolyses guanosine triphosphate (GTP), a beta and a gamma subunit.
R-HSA-381750 (Reactome) Olfactory receptors (ORs) have diverse protein sequences but can be assigned to subfamilies on the basis of sequence relationships. Odorants and pheromones bind to these seven transmembrane domain G-protein-coupled receptors that permit signal transduction. These receptors are encoded by large multigene families that evolved in mammal species in function of specific olfactory needs. Members of the same subfamily have related sequences and are likely to recognize structurally related odorants.
Of the 960 human OR genes and pseudogenes, there is experimental evidence which indicates that at least 437 actually are expressed in human olfactory epithelium; this includes 357 OR genes, and 80 OR pseudogenes (Zhang, 2007). These 357 olfactory-expressed OR genes are therefore expected to be functional in the Olfactory Signaling Pathway, and to interact directly with human G alpha olf in human olfactory cells.

(Note: A subset of 200 of these 357 OR genes are shown as components of OR-G Protein reaction. The others will be added to Reactome later.)

R-HSA-392129 (Reactome) The activation of adenylyl (adenylate) cyclase (AC) results in the production of adenosine-3',5'-monophosphate i.e. cyclic AMP. Humans have 9 genes encoding membrane-associated AC and one encoding a soluble AC. Two of the classes of heterotrimeric G-proteins are named according to their effect on AC; Gs stimulates all membrane-bound ACs (the s in Gs denotes AC stimulatory); the Gi class inhibits some AC isoforms, particularly 5 and 6. Beta-gamma subunits of heterotrimeric G-proteins can also regulate AC. Ca2+/Calmodulin activates some AC isoforms (1, 8 and 3) but is inhibitory to others (5 and 6).
R-HSA-418553 (Reactome) Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.
R-HSA-744886 (Reactome) The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
R-HSA-744887 (Reactome) The role of the guanine nucleotide-binding protein G alpha-s subunit (G alpha-s) (Kozasa T et al, 1988) is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn, activates cAMP-dependent protein kinase.
R-HSA-751013 (Reactome) The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active alpha subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (s):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates into the inactive heterotrimeric G-protein.
R-HSA-8851797 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 phosphorylate the beta-2 adrenergic receptor (ADRB2) in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011). GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
R-HSA-8852167 (Reactome) Two ubiquitously expressed forms of arrestin, arrestin-2 (ARRB1) and arrestin-3 (ARRB2), can bind and desensitize B2AR (Lohse et al. 1990, Attramadal et al. 1992, Sterne-Marr et al. 1993). Unlike visual arrestin, which has 10-fold greater affinity for phosphorylated rather than unphosphorylated rhodopsin, ARRB1 and ARRB2 show only a 2-fold difference in binding levels and are much less selective in their receptor preferences (Gurevich & Gurevich 2006). GRK-mediated receptor phosphorylation followed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs. included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region.
R-HSA-8982641 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 can bind and phosphorylate the beta-2 adrenergic receptor (ADRB2) in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). Following this, phosphorylated ADRB2 dissociates from the ADRB2:GRK complex. GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011).

GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
R-HSA-8982645 (Reactome) G protein-coupled receptor kinase 2 (ADRBK1, GRK2, beta-ARK), ADRBK2 (GRK3, beta-ARK2), GRK5 and GRK6 can phosphorylate activated beta-adrenergic receptors (Benovic et al. 1986a, Richardson et al. 1993, Menard et al. 1996, Violin et al. 2006). GRK2, GRK5 and GRK6 can bind to beta-2 adrenergic receptor (ADRB2) and subsequently phosphorylate them in the carboxy-terminal tail region (Premont et al. 1994, 1995, Violin et al. 2006). GRK2 and GRK6 are thought to be the predominant GRKs that mediate ADRB2 desensitization (Violin et al. 2006), phosphorylating distinct serine residues (Nobles et al. 2011).

GRK phosphorylation follwed by arrestin binding and internalization is the classical model for GPCR desensitization. Many GPCRs have been demonstrated to require phosphorylation before they can bind arrestin, but other receptors do not appear to require phosphorylation in order to bind arrestin (see refs included in Gurevich & Gurevich 2006). In these receptors, spatially close acidic amino acids are thought to provide sites that can bind the arrestin phosphate sensing region. In GPCRs that require phosphorylation, the region most commonly involved in arrestin binding is the C-terminus, but many GPCRs have phosphorylation sites in the 3rd cytoplasmic loop, while in some cases phosphorylation sites are found in the first (i1) or second (i2) cytoplasmic loops (Gurevich & Gurevich 2006).
REEPsArrowR-HSA-381750 (Reactome)
RTPsArrowR-HSA-381750 (Reactome)
cAMP phosphodiesterasesmim-catalysisR-HSA-418553 (Reactome)
cAMPArrowR-HSA-392129 (Reactome)
cAMPR-HSA-418553 (Reactome)
pS-ADRB2:Catecholamine:ARRB1,ARRB2ArrowR-HSA-8852167 (Reactome)
pS-ADRB2:Catecholamine:GRKArrowR-HSA-8851797 (Reactome)
pS-ADRB2:Catecholamine:GRKR-HSA-8982641 (Reactome)
pS-ADRB2:CatecholamineArrowR-HSA-8982641 (Reactome)
pS-ADRB2:CatecholamineR-HSA-8852167 (Reactome)
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