Eicosanoid metabolism via lipoxygenases (LOX) (Mus musculus)

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Lta4hCyp4a10LTA4Alox5Arachidonic acid5-HEDH15-HpETE15-HETE8-HpETE8-HETE15-oxoETEAlox15LXA4Hpgd12-HpETE12-HETE12-oxoETEAlox12HXB3HXA3TXA3TXB3HXEH12-HEDHLXB4LTB412-epi-LTB46-trans-12-epi-delta-LTB46-trans-delta-LTB4LTC4LTD4LTE4EXC4EXD4EXE420-hydroxy-LTB420-carboxy-LTB418-carboxy-dinor-LTB411-trans-LTC411-trans-LTD411-trans-LTE45-HpETE5-HETE5-oxoETE15-oxo-LXA413,14-dihydro-15-oxo-LXA412-oxo-LTB4Ltc4sCyp4a12aCyp4a12bCyp4f14Cyp4f18Acox1Acox2Acox3EhhadhAcaa1aGgt1Ggt5Dpep1Dpep2Ptgr1Ptgr2


Description

This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [1].

Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX), lipooxygenases(LOX), or cytochrome P450 monooxygenases.

This pathway visualises the second route, via LOX.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed Europe PMC Scholia
  2. Lee TH, Menica-Huerta JM, Shih C, Corey EJ, Lewis RA, Austen KF; ''Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.''; J Biol Chem, 1984 PubMed Europe PMC Scholia
  3. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  4. Buczynski MW, Dumlao DS, Dennis EA; ''Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.''; J Lipid Res, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126096view09:06, 5 April 2023Conroy lipids
126094view08:36, 5 April 2023Conroy lipidsfix non-conneced conversions
126093view08:33, 5 April 2023Conroy lipidscorrect gene IDs
126089view09:03, 4 April 2023Conroy lipidsModified description
126088view09:01, 4 April 2023Conroy lipidsReverted to remove erroneous interpretation of Dennis and Norris (2015) corrected wrong lipids, moved arrow to mim-conversion, added Rhea
125977view15:59, 23 March 2023DeSlTrying to resolve clickability issues by moving all DataNodes to front
124744view08:50, 8 December 2022DeSlUpdated link to LIPID MAPS PWs.
124604view19:28, 15 November 2022EgonwReplaced an old LIPID MAPS identifier
117877view10:20, 23 May 2021EweitzModified title
106329view08:41, 21 August 2019DeSlAdded general LipidMaps publication.
106273view14:31, 19 August 2019DeSlModified description
106272view14:31, 19 August 2019DeSlModified description
102924view12:46, 29 January 2019DeSlConnected interactions differently for readability
102923view12:43, 29 January 2019DeSlLast layout changes
102921view12:38, 29 January 2019DeSlAdded info from second lit. ref
102917view14:53, 28 January 2019DeSlAdded info from lit ref
102916view12:35, 28 January 2019DeSlChanged layout, checked all reactions according to LipidMaps drawing
102894view16:14, 26 January 2019EgonwModified description
102889view15:48, 25 January 2019DeSlModified title
102887view15:46, 25 January 2019DeSlOntology Term : 'eicosanoid metabolic pathway' added !
102886view15:46, 25 January 2019DeSlOntology Term : 'PW:0000002' removed !
102885view15:46, 25 January 2019DeSlOntology Term : 'lipoxygenase mediated pathway of arachidonic acid metabolism' added !
102880view15:45, 25 January 2019DeSlModified description
102878view15:44, 25 January 2019DeSlModified description
98608view12:41, 21 September 2018RyanmillerOntology Term : 'classic metabolic pathway' added !
98578view15:54, 17 September 2018EoinfahyNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-trans-LTC4MetaboliteLMFA03020020 (LIPID MAPS)
11-trans-LTD4MetaboliteLMFA03020021 (LIPID MAPS)
11-trans-LTE4MetaboliteLMFA03020022 (LIPID MAPS)
12-HEDHGeneProduct
12-HETEMetaboliteLMFA03060088 (LIPID MAPS)
12-HpETEMetaboliteLMFA03060013 (LIPID MAPS)
12-epi-LTB4MetaboliteLMFA03020015 (LIPID MAPS)
12-oxo-LTB4MetaboliteLMFA03020024 (LIPID MAPS)
12-oxoETEMetaboliteLMFA03060019 (LIPID MAPS)
13,14-dihydro-15-oxo-LXA4MetaboliteLMFA03040008 (LIPID MAPS)
15-HETEMetaboliteLMFA03060087 (LIPID MAPS)
15-HpETEMetaboliteLMFA03060014 (LIPID MAPS)
15-oxo-LXA4MetaboliteLMFA03040009 (LIPID MAPS)
15-oxoETEMetaboliteLMFA03060051 (LIPID MAPS)
18-carboxy-dinor-LTB4MetaboliteLMFA03020057 (LIPID MAPS)
20-carboxy-LTB4MetaboliteLMFA03020016 (LIPID MAPS)
20-hydroxy-LTB4MetaboliteLMFA03020018 (LIPID MAPS)
5-HEDHGeneProduct
5-HETEMetaboliteLMFA03060084 (LIPID MAPS)
5-HpETEMetaboliteLMFA03060108 (LIPID MAPS)
5-oxoETEMetaboliteLMFA03060011 (LIPID MAPS)
6-trans-12-epi-delta-LTB4MetaboliteLMFA03020014 (LIPID MAPS)
6-trans-delta-LTB4MetaboliteLMFA03020013 (LIPID MAPS)
8-HETEMetaboliteLMFA03060086 (LIPID MAPS)
8-HpETEMetaboliteLMFA03060073 (LIPID MAPS)
Acaa1aGeneProduct113868 (Entrez Gene)
Acox1GeneProduct11430 (Entrez Gene)
Acox2GeneProduct93732 (Entrez Gene)
Acox3GeneProduct80911 (Entrez Gene)
Alox12GeneProduct11684 (Entrez Gene)
Alox15GeneProduct11687 (Entrez Gene)
Alox5GeneProduct11689 (Entrez Gene)
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
Cyp4a10GeneProduct13117 (Entrez Gene)
Cyp4a12aGeneProduct277753 (Entrez Gene)
Cyp4a12bGeneProduct13118 (Entrez Gene)
Cyp4f14GeneProduct64385 (Entrez Gene)
Cyp4f18GeneProduct72054 (Entrez Gene)
Dpep1GeneProduct13479 (Entrez Gene)
Dpep2GeneProduct319446 (Entrez Gene)
EXC4MetaboliteLMFA03020031 (LIPID MAPS)
EXD4MetaboliteLMFA03020032 (LIPID MAPS)
EXE4MetaboliteLMFA03020033 (LIPID MAPS)
EhhadhGeneProduct74147 (Entrez Gene)
Ggt1GeneProduct14598 (Entrez Gene)
Ggt5GeneProduct23887 (Entrez Gene)
HXA3MetaboliteLMFA03090005 (LIPID MAPS)
HXB3MetaboliteLMFA03090003 (LIPID MAPS)
HXEHGeneProduct
HpgdGeneProduct15446 (Entrez Gene)
LTA4MetaboliteLMFA03020023 (LIPID MAPS)
LTB4MetaboliteLMFA03020001 (LIPID MAPS)
LTC4MetaboliteLMFA03020003 (LIPID MAPS)
LTD4MetaboliteLMFA03020006 (LIPID MAPS)
LTE4MetaboliteLMFA03020002 (LIPID MAPS)
LXA4MetaboliteLMFA03040001 (LIPID MAPS)
LXB4MetaboliteLMFA03040002 (LIPID MAPS)
Lta4hGeneProduct16993 (Entrez Gene)
Ltc4sGeneProduct17001 (Entrez Gene)
Ptgr1GeneProduct67103 (Entrez Gene)
Ptgr2GeneProduct77219 (Entrez Gene)
TXA3MetaboliteLMFA03030005 (LIPID MAPS)
TXB3MetaboliteLMFA03030006 (LIPID MAPS)

Annotated Interactions

No annotated interactions

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