Glycolysis and gluconeogenesis (Homo sapiens)
From WikiPathways
Description
Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH.
Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids. Description adapted from Wikipedia.
This pathway is part the CPTAC Assay Portal.Quality Tags
Ontology Terms
Pathway Ontology : disease pathway
Disease : congenital heart disease oculocerebrorenal syndrome male infertility juvenile myoclonic epilepsy Senior-Loken syndrome Pallister-Hall syndrome Bardet-Biedl syndrome sensorineural hearing loss Carpenter syndrome hydrolethalus syndrome cone-rod dystrophy asphyxiating thoracic dystrophy holoprosencephaly nephronophthisis orofaciodigital syndrome infertility ciliopathy retinitis pigmentosa Leber congenital amaurosis Greig cephalopolysyndactyly syndrome primary ciliary dyskinesia Meckel syndrome Ellis-Van Creveld syndrome medulloblastoma lethal congenital contracture syndrome Birt-Hogg-Dube syndrome polycystic kidney disease Joubert syndrome
Bibliography
- Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J; ''A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.''; Science, 2012 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
1,3BP-Glycerate | Metabolite | HMDB01270 (HMDB) ![]() | |
2P-Glycerate | Metabolite | HMDB00362 (HMDB) ![]() | |
3P-Glycerate | Metabolite | HMDB00807 (HMDB) ![]() | |
ALDOA | GeneProduct | 226 (Entrez Gene) ![]() | |
ALDOB | GeneProduct | 229 (Entrez Gene) ![]() | |
ALDOC | GeneProduct | 230 (Entrez Gene) ![]() | |
Acetyl-CoA | Metabolite | HMDB01206 (HMDB) ![]() | |
Aspartate | Metabolite | HMDB00191 (HMDB) ![]() | |
DLAT | GeneProduct | 1737 (Entrez Gene) ![]() | |
DLD | GeneProduct | 1738 (Entrez Gene) ![]() | |
Dihydroxyacetone-P | Metabolite | HMDB01473 (HMDB) ![]() | |
ENO1 | GeneProduct | 2023 (Entrez Gene) ![]() | |
ENO2 | GeneProduct | 2026 (Entrez Gene) ![]() | |
ENO3 | GeneProduct | 2027 (Entrez Gene) ![]() | |
FBP1 | GeneProduct | 2203 (Entrez Gene) ![]() | |
FBP2 | GeneProduct | 8789 (Entrez Gene) ![]() | |
Fructose 6P (open) | Metabolite | CHEBI:57579 (ChEBI) ![]() | fructose-6-phosphate (2-) open form |
Fructose 6P | Metabolite | 61527 (ChEBI) ![]() | |
Fructose-1,6BP | Metabolite | HMDB01058 (HMDB) ![]() | |
G6PC | GeneProduct | 2538 (Entrez Gene) ![]() | Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway |
GAPDH | GeneProduct | ENSG00000111640 (Ensembl) ![]() | |
GCK | GeneProduct | 2645 (Entrez Gene) ![]() | Gck is mainly active in liver |
GOT1 | GeneProduct | 2805 (Entrez Gene) ![]() | |
GOT2 | GeneProduct | 2806 (Entrez Gene) ![]() | |
GPI | GeneProduct | 2821 (Entrez Gene) ![]() | glucose-6-phosphate isomerase |
Glucose-6P (open) | Metabolite | CHEBI:57584 (ChEBI) ![]() | D-Glucose-6-Phosphate (2-) open form |
Glucose-6P | Metabolite | CHEBI:75052 (ChEBI) ![]() | Glucose-6-Phosphate (2-) |
Glucose | Metabolite | HMDB00122 (HMDB) ![]() | |
Glyceraldehyde 3P | Metabolite | HMDB01112 (HMDB) ![]() | |
Glycogen metabolism | Pathway | WP500 (WikiPathways) ![]() | |
HK1 | GeneProduct | 3098 (Entrez Gene) ![]() | |
HK2 | GeneProduct | 3099 (Entrez Gene) ![]() | |
HK3 | GeneProduct | 3101 (Entrez Gene) ![]() | |
LDHA | GeneProduct | 3939 (Entrez Gene) ![]() | |
LDHAL6B | GeneProduct | 92483 (Entrez Gene) ![]() | |
LDHB | GeneProduct | 3945 (Entrez Gene) ![]() | |
LDHC | GeneProduct | 3948 (Entrez Gene) ![]() | |
Lactate | Metabolite | HMDB00190 (HMDB) ![]() | |
MDH1 | GeneProduct | 4190 (Entrez Gene) ![]() | |
MDH2 | GeneProduct | 4191 (Entrez Gene) ![]() | |
MPC1 | GeneProduct | 51660 (Entrez Gene) ![]() | |
MPC2 | GeneProduct | 25874 (Entrez Gene) ![]() | |
Malate | Metabolite | HMDB00744 (HMDB) ![]() | |
Oxaloacetate | Metabolite | HMDB00223 (HMDB) ![]() | |
P-enolpyruvate | Metabolite | HMDB00263 (HMDB) ![]() | |
PC | GeneProduct | 5091 (Entrez Gene) ![]() | |
PCK1 | GeneProduct | 5105 (Entrez Gene) ![]() | |
PDHA1 | GeneProduct | 5160 (Entrez Gene) ![]() | |
PFKL | GeneProduct | 5211 (Entrez Gene) ![]() | |
PFKM | GeneProduct | 5213 (Entrez Gene) ![]() | |
PFKP | GeneProduct | 5214 (Entrez Gene) ![]() | |
PGAM1 | GeneProduct | 5223 (Entrez Gene) ![]() | |
PGAM2 | GeneProduct | 5224 (Entrez Gene) ![]() | |
PGI | GeneProduct | 5.3.1.9 (Enzyme Nomenclature) ![]() | phosphoglucose isomerase (PGI) |
PGK1 | GeneProduct | 5230 (Entrez Gene) ![]() | |
PGK2 | GeneProduct | 5232 (Entrez Gene) ![]() | |
PKLR | GeneProduct | 5313 (Entrez Gene) ![]() | |
PKM1 | GeneProduct | 5315 (Entrez Gene) ![]() | |
PKM2 | GeneProduct | 5315 (Entrez Gene) ![]() | |
Pentose Phosphate Pathway | Pathway | WP134 (WikiPathways) ![]() | |
Pyruvate | Metabolite | HMDB00243 (HMDB) ![]() | |
SLC2A1 | GeneProduct | 6513 (Entrez Gene) ![]() | |
SLC2A2 | GeneProduct | 6514 (Entrez Gene) ![]() | |
SLC2A3 | GeneProduct | 6515 (Entrez Gene) ![]() | |
SLC2A4 | GeneProduct | 6517 (Entrez Gene) ![]() | |
SLC2A5 | GeneProduct | 6518 (Entrez Gene) ![]() | |
TCA Cycle | Pathway | WP78 (WikiPathways) ![]() | |
TPI1 | GeneProduct | 7167 (Entrez Gene) ![]() | |
Triglyceride synthesis | Pathway | WP325 (WikiPathways) ![]() |
Annotated Interactions
No annotated interactions