Sphingolipid metabolism (integrated pathway) (Mus musculus)

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234High fat dietSerineSphingosine3-keto-sphinganineAsah1Sptlc1CerkPalmitoyl-CoAHexadecanalSgpl1Sptlc2Degs1UgcgSgms1KdsrEthanolamine-phosphateSphk2H2OSgpp1ATPSphk1Ppap2a1Sphinganine11Sphinganine-1-phosphate1DH-CeramideCerS41CerS54-6CerS66Ceramide1Cer-1-PDH-Cer-1-PSMGlc-CerDH-SMDH-Glc-CerGal-CerDH-Gal-CerSmpd1Degs2Sgms2Sphingosine-1-phosphate1-HexadecenalPpap2bPpap2cUgt8aCoA(16:0)CoA(18:0)CoA(20:0)CoA(22:0)CoA(24:0)CoA(24:1)C16DH-CerDH-CeramideDH-CeramideDH-CeramideCerS16CerS4Cers26CoA(26:0)CoA(26:1)DH-CeramideCers3ADPSgpp2Sphk2Sphk1Sgpl1DH-CeramideCerS46Cers2DH-CeramideCerS46CoA(14:0)C14DH-CeramideCerS5CerS666


Description

This pathway is inspired by the Lipidmaps>Sphingolipids pathway [1].

Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules.

This pathway provides an overview of the different tail lengths (on the right), which are used to convert sphinganine to DH-ceramide.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  2. Lahiri S, Futerman AH; ''LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  3. Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH; ''Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.''; FEBS Lett, 2007 PubMed Europe PMC Scholia
  4. Mizutani Y, Kihara A, Igarashi Y; ''Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.''; Biochem J, 2005 PubMed Europe PMC Scholia
  5. Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M, Degen J, Dörmann P, Hoch M; ''Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity.''; J Biol Chem, 2016 PubMed Europe PMC Scholia
  6. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S; ''Characterization of murine sphingosine-1-phosphate phosphohydrolase.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  7. Merrill AH Jr; ''De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.''; J Biol Chem, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
124752view08:56, 8 December 2022DeSlUpdated link to LIPID MAPS PWs.
123514view11:24, 29 July 2022Conroy lipidsupdate COA IDs to lipidmaps, add missing ID
117946view10:46, 23 May 2021EweitzModified title
107209view14:30, 17 September 2019MaintBotChEBI identifier normalization
106335view08:54, 21 August 2019DeSlAdded general LipidMaps publication.
106334view08:53, 21 August 2019DeSlModified description
106269view14:17, 19 August 2019DeSlModified description
106268view14:17, 19 August 2019DeSlAnnotated specific lipids if part of tabular Data file of LipidMaps.
106267view14:05, 19 August 2019DeSlCompleted bottom part of PW.
106266view14:00, 19 August 2019DeSlAdd C26 length products.
106265view13:52, 19 August 2019DeSlAdded C22-C24 specific metabolite nodes.
106263view13:33, 19 August 2019DeSlOntology Term : 'sphingolipid biosynthetic pathway' added !
106262view13:32, 19 August 2019DeSlOntology Term : 'sphingomyelin metabolic pathway' added !
106255view13:27, 19 August 2019DeSlModified description
106252view13:25, 19 August 2019DeSlUpdated title
106251view13:24, 19 August 2019DeSlAdded specific metabolites for several chain lengths.
106249view12:55, 19 August 2019DeSlNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
1-HexadecenalMetaboliteLMFA06000088 (LIPID MAPS)
3-keto-sphinganineMetaboliteLMSP01020002 (LIPID MAPS)
ADPMetabolite456216 (ChEBI)
ATPMetabolite30616 (ChEBI)
Asah1ProteinQ9WV54 (Uniprot-TrEMBL)
C14DH-CeramideMetabolite
C16DH-CerMetabolite
Cer-1-PMetaboliteLMSP02050000 (LIPID MAPS)
CerS1ProteinP27545 (Uniprot-TrEMBL)
CerS4Protein67260 (Entrez Gene)
CerS5ProteinQ9D6K9 (Uniprot-TrEMBL) AKA Lass5
CerS6ProteinQ8C172 (Uniprot-TrEMBL) AKA Lass6
CeramideMetaboliteLMSP02010000 (LIPID MAPS)
CerkProtein223753 (Entrez Gene)
Cers2Protein76893 (Entrez Gene)
Cers3ProteinQ1A3B0 (Uniprot-TrEMBL)
CoA(14:0)Metabolite
CoA(16:0)MetaboliteLMFA07050360 (LIPID MAPS)
CoA(18:0)Metabolite15541 (ChEBI)
CoA(20:0)Metabolite15527 (ChEBI)
CoA(22:0)Metabolite24330-89-0 (CAS) AKA "Coenzyme A, S-​docosanoate"
CoA(24:0)Metabolite24305-30-4 (CAS) AKA "Coenzyme A, S-​(tetracosanoate)​"
CoA(24:1)Metabolite88362-35-0 (CAS) AKA "Coenzyme A, S-​(15Z)​-​15-​tetracosenoate"
CoA(26:0)Metabolite99313-57-2 (CAS) AKA "Coenzyme A, S-​hexacosanoate"
CoA(26:1)Metabolite
DH-Cer-1-PMetaboliteLMSP020500A0 (LIPID MAPS)
DH-CeramideMetaboliteLMSP02020000 (LIPID MAPS)
DH-Gal-CerMetabolite
DH-Glc-CerMetabolite
DH-SMMetaboliteLMSP030100A0 (LIPID MAPS)
Degs1Protein13244 (Entrez Gene)
Degs2Protein70059 (Entrez Gene)
Ethanolamine-phosphateMetabolite1015 (PubChem-compound)
Gal-CerMetaboliteLMSP0501AC00 (LIPID MAPS)
Glc-CerMetaboliteLMSP0501AA00 (LIPID MAPS)
H2OMetabolite15377 (ChEBI)
HexadecanalMetaboliteLMFA06000088 (LIPID MAPS)
KdsrProteinQ6GV12 (Uniprot-TrEMBL) AKA Fvt1
Palmitoyl-CoAMetaboliteLMFA07050360 (LIPID MAPS) aka CoA(16:0)
Ppap2aProtein19012 (Entrez Gene)
Ppap2bProtein67916 (Entrez Gene)
Ppap2cProtein50784 (NCBI Protein)
SMMetaboliteLMSP0301 (LIPID MAPS)
SerineMetabolite5951 (PubChem-compound)
Sgms1Protein208449 (Entrez Gene)
Sgms2Protein74442 (Entrez Gene)
Sgpl1Protein20397 (Entrez Gene)
Sgpp1ProteinQ9JI99 (Uniprot-TrEMBL)
Sgpp2ProteinQ810K3 (Uniprot-TrEMBL)
Smpd1Protein20597 (Entrez Gene)
Sphinganine-1-phosphateMetaboliteLMSP01050002 (LIPID MAPS)
SphinganineMetaboliteLMSP01020001 (LIPID MAPS)
Sphingosine-1-phosphateMetaboliteLMSP01050001 (LIPID MAPS)
SphingosineMetaboliteLMSP01010001 (LIPID MAPS)
Sphk1ProteinQ8CI15 (Uniprot-TrEMBL)
Sphk2ProteinQ9JIA7 (Uniprot-TrEMBL)
Sptlc1Protein268656 (Entrez Gene)
Sptlc2ProteinP97363 (Uniprot-TrEMBL)
UgcgProtein22234 (Entrez Gene)
Ugt8aProtein22239 (Entrez Gene)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
3-keto-sphinganineSphinganinemim-conversion22642 (Rhea)
ADPmim-conversion15466 (Rhea)
ATPmim-conversion15466 (Rhea)
CoA(16:0)mim-conversion36540 (Rhea)
H2Omim-conversion27515 (Rhea)
Palmitoyl-CoA3-keto-sphinganinemim-conversion14762 (Rhea)
Sphinganine-1-phosphateSphinganinemim-conversion27515 (Rhea)
SphinganineSphinganine-1-phosphatemim-conversion15466 (Rhea)
Sphinganinemim-conversion36540 (Rhea) Kinetic info: [PMID:17977534]
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