Sphingolipid metabolism (integrated pathway) (Mus musculus)

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416High fat dietATP3-keto-sphinganinePpap2a5CerkSgpp1Asah1Palmitoyl-CoA5Sgms1Sphk2Sgpl1UgcgSerine5HexadecanalSptlc1Sphk1Degs1KdsrSptlc2Ethanolamine-phosphateH2OSphingosineSphinganineSphinganine-1-phosphate5CerS4CerS5CerS62, 3, 6C16 CerP3C16DH CerPC16 SMC16 Glc-erC16DH SMC16DH GlcCerC16 GalCerC16DH GalCerSmpd1Degs2Sgms2Sphingosine-1-phosphate1-HexadecenalPpap2bPpap2cUgt8aCoA(16:0)CoA(18:0)CoA(20:0)CoA(22:0)CoA(24:0)CoA(24:1)C16DH-CerCerS13CerS4Cers23CoA(26:0)CoA(26:1)Cers3ADPSgpp2Sphk2Sphk1Sgpl1CerS4Cers23CerS43CoA(14:0)C14DH-CeramideCerS5CerS633C16 CerCerk5UgcgSmpd1Sgms1Sgms2Ugt8aC18 CerPC18DH CerPC18 SMC18 GlcCerC18DH SMC18DH GlcCerC18 GalCerC18DH GalCerC18DH-CerC18 CerC20 CerPC20DH CerPC20 SMC20 GlcCerC20DH SMC20DH GlcCerC20 GalCerC20DH GalCerC20DH-CerC20 CerC22 CerPC22DH CerPC22 SMC22 GlcCerC22DH SMC22DH GlcCerC22 GalCerC22DH GalCerC22DH-CerC22 CerC24 CerPC24DH CerPC24 SMC24 GlcCerC24DH SMC24DH GlcCerC24 GalCerC24DH GalCerC24DH-CerC24 CerC24:1 CerPC24:1DH CerPC24:1 SMC24:1 GlcCerC24:1DH SMC24:1DH GlcCerC24:1 GalCerC24:1DH GalCerC24:1DH-CerC24:1 CerCers3C26:1 CerPC26:1DH CerPC26:1 SMC26:1 GlcCerC26:1DH SMC26:1DH GlcCerC26:1 GalCerC26:1DH GalCerC26:1DH-CerC26:1 CerC26 CerPC26DH CerPC26 SMC26 GlcCerC26DH SMC26DH GlcCerC26 GalCerC26DH GalCerC26DH-CerC26 Cer


Description

This pathway is inspired by the Lipidmaps>Sphingolipids pathway (all chain lengths) [1].

Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules.

This pathway shows all different tail lengths and their conversions into specific products. All products will be annotated with lipid-specific identifiers.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  2. Lahiri S, Futerman AH; ''LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  3. Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH; ''Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.''; FEBS Lett, 2007 PubMed Europe PMC Scholia
  4. Mizutani Y, Kihara A, Igarashi Y; ''Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.''; Biochem J, 2005 PubMed Europe PMC Scholia
  5. Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M, Degen J, Dörmann P, Hoch M; ''Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity.''; J Biol Chem, 2016 PubMed Europe PMC Scholia
  6. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S; ''Characterization of murine sphingosine-1-phosphate phosphohydrolase.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  7. Merrill AH Jr; ''De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.''; J Biol Chem, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124752view08:56, 8 December 2022DeSlUpdated link to LIPID MAPS PWs.
123514view11:24, 29 July 2022Conroy lipidsupdate COA IDs to lipidmaps, add missing ID
117946view10:46, 23 May 2021EweitzModified title
107209view14:30, 17 September 2019MaintBotChEBI identifier normalization
106335view08:54, 21 August 2019DeSlAdded general LipidMaps publication.
106334view08:53, 21 August 2019DeSlModified description
106269view14:17, 19 August 2019DeSlModified description
106268view14:17, 19 August 2019DeSlAnnotated specific lipids if part of tabular Data file of LipidMaps.
106267view14:05, 19 August 2019DeSlCompleted bottom part of PW.
106266view14:00, 19 August 2019DeSlAdd C26 length products.
106265view13:52, 19 August 2019DeSlAdded C22-C24 specific metabolite nodes.
106263view13:33, 19 August 2019DeSlOntology Term : 'sphingolipid biosynthetic pathway' added !
106262view13:32, 19 August 2019DeSlOntology Term : 'sphingomyelin metabolic pathway' added !
106255view13:27, 19 August 2019DeSlModified description
106252view13:25, 19 August 2019DeSlUpdated title
106251view13:24, 19 August 2019DeSlAdded specific metabolites for several chain lengths.
106249view12:55, 19 August 2019DeSlNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
1-HexadecenalMetaboliteLMFA06000088 (LIPID MAPS)
3-keto-sphinganineMetaboliteLMSP01020002 (LIPID MAPS)
ADPMetabolite456216 (ChEBI)
ATPMetabolite30616 (ChEBI)
Asah1ProteinQ9WV54 (Uniprot-TrEMBL)
C14DH-CeramideMetabolite
C16 CerMetabolite
C16 CerPMetabolite
C16 GalCerMetabolite
C16 Glc-erMetabolite
C16 SMMetaboliteSM = sphingomyelin
C16DH CerPMetabolite
C16DH GalCerMetabolite
C16DH GlcCerMetabolite
C16DH SMMetaboliteSM = sphingomyelin
C16DH-CerMetabolite
C18 CerMetabolite
C18 CerPMetabolite
C18 GalCerMetabolite
C18 GlcCerMetabolite
C18 SMMetaboliteSM = sphingomyelin
C18DH CerPMetabolite
C18DH GalCerMetabolite
C18DH GlcCerMetabolite
C18DH SMMetaboliteSM = sphingomyelin
C18DH-CerMetabolite
C20 CerMetabolite
C20 CerPMetabolite
C20 GalCerMetabolite
C20 GlcCerMetabolite
C20 SMMetaboliteSM = sphingomyelin
C20DH CerPMetabolite
C20DH GalCerMetabolite
C20DH GlcCerMetabolite
C20DH SMMetaboliteSM = sphingomyelin
C20DH-CerMetabolite
C22 CerMetabolite
C22 CerPMetabolite
C22 GalCerMetabolite
C22 GlcCerMetabolite
C22 SMMetaboliteSM = sphingomyelin
C22DH CerPMetabolite
C22DH GalCerMetabolite
C22DH GlcCerMetabolite
C22DH SMMetaboliteSM = sphingomyelin
C22DH-CerMetabolite
C24 CerMetabolite
C24 CerPMetabolite
C24 GalCerMetabolite
C24 GlcCerMetabolite
C24 SMMetaboliteSM = sphingomyelin
C24:1 CerMetabolite
C24:1 CerPMetabolite
C24:1 GalCerMetabolite
C24:1 GlcCerMetabolite
C24:1 SMMetaboliteSM = sphingomyelin
C24:1DH CerPMetabolite
C24:1DH GalCerMetabolite
C24:1DH GlcCerMetabolite
C24:1DH SMMetaboliteSM = sphingomyelin
C24:1DH-CerMetabolite
C24DH CerPMetabolite
C24DH GalCerMetabolite
C24DH GlcCerMetabolite
C24DH SMMetaboliteSM = sphingomyelin
C24DH-CerMetabolite
C26 CerMetabolite
C26 CerPMetabolite
C26 GalCerMetabolite
C26 GlcCerMetabolite
C26 SMMetaboliteSM = sphingomyelin
C26:1 CerMetabolite
C26:1 CerPMetabolite
C26:1 GalCerMetabolite
C26:1 GlcCerMetabolite
C26:1 SMMetaboliteSM = sphingomyelin
C26:1DH CerPMetabolite
C26:1DH GalCerMetabolite
C26:1DH GlcCerMetabolite
C26:1DH SMMetaboliteSM = sphingomyelin
C26:1DH-CerMetabolite
C26DH CerPMetabolite
C26DH GalCerMetabolite
C26DH GlcCerMetabolite
C26DH SMMetaboliteSM = sphingomyelin
C26DH-CerMetabolite
CerS1ProteinP27545 (Uniprot-TrEMBL)
CerS4Protein67260 (Entrez Gene) Protein found in literature (not in original LipidMapsPW)
CerS5ProteinQ9D6K9 (Uniprot-TrEMBL) AKA Lass5
CerS6ProteinQ8C172 (Uniprot-TrEMBL) AKA Lass6
CerkProtein223753 (Entrez Gene)
Cers2Protein76893 (Entrez Gene)
Cers3ProteinQ1A3B0 (Uniprot-TrEMBL)
CoA(14:0)Metabolite
CoA(16:0)MetaboliteLMFA07050360 (LIPID MAPS)
CoA(18:0)Metabolite15541 (ChEBI)
CoA(20:0)Metabolite15527 (ChEBI)
CoA(22:0)Metabolite24330-89-0 (CAS) AKA "Coenzyme A, S-​docosanoate"
CoA(24:0)Metabolite24305-30-4 (CAS) AKA "Coenzyme A, S-​(tetracosanoate)​"
CoA(24:1)Metabolite88362-35-0 (CAS) AKA "Coenzyme A, S-​(15Z)​-​15-​tetracosenoate"
CoA(26:0)Metabolite99313-57-2 (CAS) AKA "Coenzyme A, S-​hexacosanoate"
CoA(26:1)Metabolite
Degs1Protein13244 (Entrez Gene)
Degs2Protein70059 (Entrez Gene)
Ethanolamine-phosphateMetabolite1015 (PubChem-compound)
H2OMetabolite15377 (ChEBI)
HexadecanalMetaboliteLMFA06000088 (LIPID MAPS)
KdsrProteinQ6GV12 (Uniprot-TrEMBL) AKA Fvt1
Palmitoyl-CoAMetaboliteLMFA07050360 (LIPID MAPS) aka CoA(16:0)
Ppap2aProtein19012 (Entrez Gene)
Ppap2bProtein67916 (Entrez Gene)
Ppap2cProtein50784 (NCBI Protein)
SerineMetabolite5951 (PubChem-compound)
Sgms1Protein208449 (Entrez Gene)
Sgms2Protein74442 (Entrez Gene)
Sgpl1Protein20397 (Entrez Gene)
Sgpp1ProteinQ9JI99 (Uniprot-TrEMBL)
Sgpp2ProteinQ810K3 (Uniprot-TrEMBL)
Smpd1Protein20597 (Entrez Gene)
Sphinganine-1-phosphateMetaboliteLMSP01050002 (LIPID MAPS)
SphinganineMetaboliteLMSP01020001 (LIPID MAPS)
Sphingosine-1-phosphateMetaboliteLMSP01050001 (LIPID MAPS)
SphingosineMetaboliteLMSP01010001 (LIPID MAPS)
Sphk1ProteinQ8CI15 (Uniprot-TrEMBL)
Sphk2ProteinQ9JIA7 (Uniprot-TrEMBL)
Sptlc1Protein268656 (Entrez Gene)
Sptlc2ProteinP97363 (Uniprot-TrEMBL)
UgcgProtein22234 (Entrez Gene)
Ugt8aProtein22239 (Entrez Gene)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
3-keto-sphinganineSphinganinemim-conversion22642 (Rhea)
ADPmim-conversion15466 (Rhea)
ATPmim-conversion15466 (Rhea)
CoA(16:0)mim-conversion36540 (Rhea)
H2Omim-conversion27515 (Rhea)
Palmitoyl-CoA3-keto-sphinganinemim-conversion14762 (Rhea)
Sphinganine-1-phosphateSphinganinemim-conversion27515 (Rhea)
SphinganineSphinganine-1-phosphatemim-conversion15466 (Rhea)
Sphinganinemim-conversion36540 (Rhea) Kinetic info: [PMID:17977534]
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4690"
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