Fatty acid beta-oxidation (Homo sapiens)

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Trans-Tetradex-2-enoyl-CoACronoyl-CoA(S)-3-Hydroxydodexanonyl-CoALipasesTrans-Hexadecanoyl-CoAFatty AcidGlutarate(S)-Hydrocyhexanoyl4-cis-dexeboyl-CoASaturated fatty acidsOctaoyl-CoA3-Oxododexanoyl-CoADxotetradecanoyl-CoAUnsaturated fatty acidstrans,cis-Lauro-2,6-dienoyl-CoA3-Oxocanoyl-CoATCA cycleHADHAHADHB2-trans-dodecenoyl-CoATrans-Dec-2-enoyl-CoAAcetyl-CoAButanoyl-CoACHKBcis,cis-3,6-Dodecadienoyl-CoAHexanoyl-CoA(S)-3-Hydroxydecanoyl-CoAACADSECHS1Acetyl-CoAHADHA3-Oxohexanoyl-CoA(S)-3-Hydroxytetradecanoyl-CoAHADHSC3-Oxopalmitoyl-CoAACSL5LPLECHS1HADHBHADHAGPD2HADHBACADSTriacylglycerolAcetyl-CoAACSL3HADHA3-Oxo-octanoyl-CoAHADHASLC25A203-trans-decenoyl-CoAHADHBHADHBACADLPNPLA2ACADLAcetyl-CoAHADHBAcetoacetyl-CoAHADHBDecanoyl-CoAMyristoyl-CoAL-Glycerol-3-PhosphateACADM2-trans-4-cis-decadienoyl-CoAHADHAAcetyl-CoAHADHBHADHBLIPFECHS1CRATACADLAcetyl-CoAPalmitoyl-CoAHADHBACSL4ECHS1Glyceraldehyde-3-PhosphateHADHAHADHBHADHAHADHAAcetyl-CoAGlutaryl-CoACPT1AHADHSCHADHATPI1CPT2ACADMLauroyl-CoADCIDECR1Acyl-CoA(S)-3-Hydroxyhexadecanoyl-CoADihydroxyacetone PhosphateGlycerolHADHAGCDHHADHBGK2Trans-Hex-2-enoyl-CoAACADLACSL6ECHS1ACSL1ACADVLLIPEHADHACPT1BHADHBDCIACAT1ACADMLinoleoyl-CoA(S)-3-Hydroxybutanoyl-CoATrans-Oct-2-enoyl-CoAACAS2HADHSCHADHSCGKAcetyl-CoAHADHSCHADHAAcetyl-CoA(S)-3-Hydroxyoctanoyl-CoADLDLIPCTCA cycleTCA cycleTCA cycleTCA cycleTCA cycleTCA cycleTCA cycle


Description

Complete fatty acid beta-oxidation pathway for saturated and unsaturated fatty acids, developed and curated internally by BiGCaT Bioinformatics.

This pathway was previously split into three parts plus a meta file for statistics. If you still have these you can replace all four with this single pathway.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
124923view22:50, 31 December 2022EgonwFixed the AcylCoA identifier
116506view10:42, 7 May 2021EweitzModified title
113903view06:46, 8 December 2020EgonwMade more pathway nodes clickable
108064view13:29, 27 November 2019DeSlChanged textlabels to Metabolites; converted MIM-stimulation to Catalysis for enzyme linked to M1->M2 conversion.
107936view07:59, 12 November 2019MkutmonModified description
107778view02:31, 3 November 2019LicongModified title
107117view14:19, 17 September 2019MaintBotChEBI identifier normalization
106415view21:58, 28 August 2019KhanspersModified description
105498view05:52, 8 August 2019KhanspersModified description
98914view15:37, 15 October 2018DeSlRemoved license info
98913view15:37, 15 October 2018DeSlReverted to version '16:32, 23 June 2018' by DeSl
98815view21:42, 9 October 2018Priyanka KModified title
97915view16:32, 23 June 2018EgonwAdded a few more metabolite IDs.
97914view16:26, 23 June 2018EgonwReplaced a salt with a parent ID (from ChEBI)
94768view18:29, 5 October 2017EgonwMore mim annotation.
94765view16:01, 5 October 2017EgonwConverted labels to metabolite DataNode and added mim-type annotation to conversions, and converted stimulation to catalysis.
93218view13:52, 4 August 2017DeSlChanged 3-Oxododexanoyl-CoA ID to more stereospecific one.
79783view15:41, 16 April 2015MkutmonFixed unconnected lines
71172view11:13, 11 October 2013Mkutmonfix unconnected lines
70676view19:04, 26 August 2013Mkutmonconnected lines
68951view17:37, 8 July 2013MaintBotUpdated to 2013 gpml schema
59762view15:10, 7 March 2013EgonwConverted Labels into DataNode's.
56441view21:35, 7 January 2013EgonwAdded missing data source info for three data nodes.
45258view18:42, 7 October 2011AlexanderPicoOntology Term : 'fatty acid metabolism' added !
45257view18:42, 7 October 2011AlexanderPicoOntology Term : 'fatty acid metabolic pathway' added !
45256view18:42, 7 October 2011AlexanderPicoOntology Term : 'fatty acid degradation pathway' added !
45255view18:41, 7 October 2011AlexanderPicoOntology Term : 'fatty acid beta degradation pathway' added !
43430view15:34, 21 June 2011AdrienDefayChange all the TCA text label to a Pathway node with the gene ID and the correct database.
41108view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
39785view15:47, 18 January 2011FerryJagersPeriodical save, work in progress
39784view15:37, 18 January 2011FerryJagersPeriodical save, work in progress
39783view15:27, 18 January 2011FerryJagersPeriodical save, work in progress
39782view14:55, 18 January 2011FerryJagersPeriodical save, work in progress
32874view22:19, 16 September 2009MaintBotChanged type for metabolites
31971view13:08, 14 August 2009MaintBotFixed group labels
20983view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Fatty Acid Beta-oxidation BiGCaT]] moved to [[Pathway:WP143]]: Moved to stable identifier
14286view08:56, 22 May 2008Pahlesgrouping and connections ready, metabolites need to be checked
14155view15:38, 21 May 2008PahlesGrouping genes, connecting to reactions
14153view15:35, 21 May 2008PahlesPeriodical save, work in progress
14151view15:25, 21 May 2008PahlesPeriodical save, work in progress
14123view14:20, 21 May 2008Pahlespartly curated
14091view12:03, 21 May 2008SusanSmall adaption
13066view11:12, 17 May 2008MaintBotautomated metabolite conversion
11784view09:24, 29 April 2008MichielResized to make GenMAPP compatible
11777view18:52, 28 April 2008EveloModified description
10773view09:54, 22 February 2008MichielPosition correction
10772view09:48, 22 February 2008MichielModified description
10771view09:47, 22 February 2008MichielSpecify description
10770view09:43, 22 February 2008MichielCorrected unsaturated path
10769view09:38, 22 February 2008MichielAdded unsaturated fatty acid metabolism

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(S)-3-Hydroxybutanoyl-CoAMetaboliteCHEBI:15453 (ChEBI)
(S)-3-Hydroxydecanoyl-CoAMetaboliteCHEBI:28325 (ChEBI)
(S)-3-Hydroxydodexanonyl-CoAMetabolite
(S)-3-Hydroxyhexadecanoyl-CoAMetaboliteCHEBI:27402 (ChEBI)
(S)-3-Hydroxyoctanoyl-CoAMetaboliteCHEBI:28632 (ChEBI)
(S)-3-Hydroxytetradecanoyl-CoAMetaboliteCHEBI:27466 (ChEBI)
2-trans-4-cis-decadienoyl-CoAMetaboliteCHEBI:29119 (ChEBI)
2-trans-dodecenoyl-CoAMetaboliteCHEBI:15471 (ChEBI)
3-Oxo-octanoyl-CoAMetaboliteCHEBI:28264 (ChEBI)
3-Oxocanoyl-CoAMetabolite
3-Oxododexanoyl-CoAMetabolite11966169 (PubChem-compound)
3-Oxohexanoyl-CoAMetaboliteCHEBI:27648 (ChEBI)
3-Oxopalmitoyl-CoAMetaboliteCHEBI:15491 (ChEBI)
3-trans-decenoyl-CoAMetaboliteCHEBI:29126 (ChEBI)
4-cis-dexeboyl-CoAMetabolite
ACADLGeneProduct33 (Entrez Gene)
ACADMGeneProduct34 (Entrez Gene)
ACADSGeneProduct35 (Entrez Gene)
ACADVLGeneProduct37 (Entrez Gene)
ACAS2GeneProduct55902 (Entrez Gene)
ACAT1GeneProduct38 (Entrez Gene)
ACSL1GeneProduct2180 (Entrez Gene)
ACSL3GeneProduct2181 (Entrez Gene)
ACSL4GeneProduct2182 (Entrez Gene)
ACSL5GeneProduct51703 (Entrez Gene)
ACSL6GeneProduct23305 (Entrez Gene)
Acetoacetyl-CoAMetabolite1420-36-6 (CAS)
Acetyl-CoAMetabolite72-89-9 (CAS)
Acyl-CoAMetabolite9029-97-4 (CAS)
Butanoyl-CoAMetaboliteCHEBI:15517 (ChEBI)
CHKBGeneProduct1120 (Entrez Gene)
CPT1AGeneProduct1374 (Entrez Gene)
CPT1BGeneProduct1375 (Entrez Gene)
CPT2GeneProduct1376 (Entrez Gene)
CRATGeneProduct1384 (Entrez Gene)
DCIGeneProduct1632 (Entrez Gene)
DECR1GeneProduct1666 (Entrez Gene)
DLDGeneProduct1738 (Entrez Gene)
Decanoyl-CoAMetaboliteCHEBI:28493 (ChEBI)
Dihydroxyacetone PhosphateMetabolite57-04-5 (CAS)
Dxotetradecanoyl-CoAMetabolite
ECHS1GeneProduct1892 (Entrez Gene)
Fatty AcidMetaboliteCHEBI:35366 (ChEBI)
GCDHGeneProduct2639 (Entrez Gene)
GK2GeneProduct2712 (Entrez Gene)
GKGeneProduct2710 (Entrez Gene)
GPD2GeneProduct2820 (Entrez Gene)
GlutarateMetabolite743 (PubChem-compound)
Glutaryl-CoAMetabolite15524 (ChEBI)
Glyceraldehyde-3-PhosphateMetabolite591-57-1 (CAS)
GlycerolMetabolite56-81-5 (CAS)
HADHAGeneProduct3030 (Entrez Gene)
HADHBGeneProduct3032 (Entrez Gene)
HADHSCGeneProduct3033 (Entrez Gene)
Hexanoyl-CoAMetaboliteCHEBI:27540 (ChEBI)
L-Glycerol-3-PhosphateMetaboliteCHEBI:15978 (ChEBI)
LIPCGeneProduct3990 (Entrez Gene)
LIPEGeneProduct3991 (Entrez Gene)
LIPFGeneProduct8513 (Entrez Gene)
LPLGeneProduct4023 (Entrez Gene)
Lauroyl-CoAMetabolite6244-92-4 (CAS)
Linoleoyl-CoAMetabolite40757-80-0 (CAS)
Myristoyl-CoAMetaboliteCHEBI:15532 (ChEBI)
Octaoyl-CoAMetabolite
PNPLA2GeneProduct57104 (Entrez Gene)
Palmitoyl-CoAMetaboliteCHEBI:15525 (ChEBI)
SLC25A20GeneProduct788 (Entrez Gene)
TCA cyclePathwayWP78 (WikiPathways)
TPI1GeneProduct7167 (Entrez Gene)
Trans-Dec-2-enoyl-CoAMetaboliteCHEBI:10723 (ChEBI)
Trans-Hex-2-enoyl-CoAMetaboliteCHEBI:28706 (ChEBI)
Trans-Hexadecanoyl-CoAMetabolite
Trans-Oct-2-enoyl-CoAMetaboliteCHEBI:27537 (ChEBI)
Trans-Tetradex-2-enoyl-CoAMetabolite
TriacylglycerolMetaboliteCHEBI:17855 (ChEBI)
cis,cis-3,6-Dodecadienoyl-CoAMetaboliteCHEBI:28002 (ChEBI)
trans,cis-Lauro-2,6-dienoyl-CoAMetaboliteCHEBI:28387 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP143"
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