STAT5 Activation (Homo sapiens)

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Bibliography

1. Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Zeng L, Richine B, Bowling JD, Fukuda S, Goenka S, Liu Z, Feng GS, Yu M, Sandusky GE, Boswell HS, Zhang ZY, Kapur R, Chan RJ.; ''The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.''; PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
ADP	Metabolite	CHEBI:456216 (ChEBI)
ATP	Metabolite	CHEBI:30616 (ChEBI)
Activators of STAT5:STAT5	Complex	R-HSA-9645118 (Reactome)
Activators of STAT5:p-STAT5	Complex	R-HSA-9645119 (Reactome)
Activators of STAT5		R-HSA-9645129 (Reactome)
Activators of STAT5	Complex	R-HSA-9645129 (Reactome)
Autophosphorylated FLT3	Protein	P36888 (Uniprot-TrEMBL)
FLT3LG	Protein	P49771 (Uniprot-TrEMBL)
GRB2-1	Protein	P62993-1 (Uniprot-TrEMBL)
PTPN11	Protein	Q06124 (Uniprot-TrEMBL)
STAT5A	Protein	P42229 (Uniprot-TrEMBL)
STAT5B	Protein	P51692 (Uniprot-TrEMBL)
STAT5	Complex	R-HSA-1295523 (Reactome)
p-STAT5A, p-STAT5B		R-HSA-507929 (Reactome)
p-STAT5A, p-STAT5B	Complex	R-HSA-507929 (Reactome)
p-Y-GAB2	Protein	Q9UQC2 (Uniprot-TrEMBL)
p-Y694-STAT5A	Protein	P42229 (Uniprot-TrEMBL)
p-Y699-STAT5B	Protein	P51692 (Uniprot-TrEMBL)

Annotated Interactions

Source	Target	Type	Database reference	Comment
	ADP	Arrow	R-HSA-9645137 (Reactome)
ATP			R-HSA-9645137 (Reactome)
	Activators of STAT5:STAT5	Arrow	R-HSA-9645126 (Reactome)
Activators of STAT5:STAT5			R-HSA-9645137 (Reactome)
	Activators of STAT5:p-STAT5	Arrow	R-HSA-9645137 (Reactome)
Activators of STAT5:p-STAT5			R-HSA-9645134 (Reactome)
	Activators of STAT5	Arrow	R-HSA-9645134 (Reactome)
Activators of STAT5			R-HSA-9645126 (Reactome)
			R-HSA-9645126 (Reactome)	Signal transducer and activator of transcription (STAT5A/STAT5B) is a key component in several cell signaling and gene transcription process and regulated cell survival and proliferation. STAT5 is activated by multiple upstream activators including cytokines and growth factors. The process begins when an active upstream regulator binds STAT5 to initiate its phosphorylation (Nabinger et al, 2013).
			R-HSA-9645134 (Reactome)	Signal transducer and activator of transcription (STAT5A/STAT5B) is activated by a range of upstream signals including cytokines and growth factors. Activators bind and phosphorylate STAT5 following which STAT5 is released from the complex and translocates to the nucleus to regulate gene transcription (Nabinger et al, 2013).
			R-HSA-9645137 (Reactome)	Signal transducer and activator of transcription (STAT5A/STAT5B) is regulated by extracellular factors including cytokines and growth factors. Activators bind and phosphorylate STAT5 which results in its activation (Nabinger et al, 2013).
STAT5			R-HSA-9645126 (Reactome)
	p-STAT5A, p-STAT5B	Arrow	R-HSA-9645134 (Reactome)