Methionine de novo and salvage pathway (Homo sapiens)

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1, 2FADmagnesiumMethylatedMetaboliteMTRRDimethylglycinepotassiumMethyltranferasesMetaboliteS-AdenosylmethionineL-MethionineMAT2AMAT2BS-AdenosylhomocysteineDNA, RNA & Protein MethylationHomocysteineAHCYNADCobalaminMTRZincZincBHMTCholineMethionine De Novo PathwayBetaineCHDHAdenosineWaterWaterATPDiphosphatePhosphate5-Methyltetrahydrofolic acidTetrahydrofolic acidFolic Acid CycleProtein-bound methionineMethionine sulfoxideFree/Protein Methionine EquilibriumL-MethionineProtein-bound Methionine sulfoxideProtein-bound MethionineMSRAMSRB2MSRB3ThioredoxinWaterThioredoxin disulfideThioredoxin disulfideWaterThioredoxinThioredoxin disulfideWaterThioredoxinROSROSMethionine Salvage PathwayS-Adenosylmethioninamine2-Oxo-4-methylthiobutanoic acidpyruvateAMD1Carbon dioxideTATPyridoxal 5'-phosphateOxoglutaric acidL-Glutamic acidFADAmmoniaIL4I1Hydrogen peroxideOxygenWater1,2-Dihydroxy-3-keto-5-methylthiopentene5-(methylthio)-2,3-Dioxopentyl phosphate5-Methylthioribulose 1-phosphate5'-Methylthioadenosine5-Methylthioribose 1-phosphateODC1OrnithineCarbon dioxidePutrescineSRMSpermidineSpermidineSpermineSMSCellular ProliferationMTAPAdeninePhosphateMRI1ZincAPIPWaterIronADI1Formic acidOxygenENOPH1MagnesiumPhosphoric acidWaterOxygenFormic acid3-Methylthiopropionic acidCarbon monoxideNickelADI1Polyamine BiosynthesisProtein synthesisMAT1APotassiumWaterATPDiphosphatePhosphatecobalt(2+) ionmagnesiumcobalt(2+) ion


Description

Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway

Pathway adapted from KEGG.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. Alvarez L, Corrales F, Martin-Duce A, Mato JM; ''Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.''; Biochem J, 1993 PubMed Europe PMC Scholia
  2. ''Cysteine and methionine metabolism''; https://www.kegg.jp/dbget-bin/www_bget?pathway+map00270,

History

View all...
CompareRevisionActionTimeUserComment
127752view11:27, 2 December 2023EgonwChEBI id for K+ instead of the "K" atom
120915view06:19, 31 January 2022EgonwReplaced an old HMDB identifier with the current one
119246view19:25, 22 June 2021Finterlyadded KEGG pathway info to publicationXref
118456view15:00, 27 May 2021Marvin M2added title to kegg ref
118413view14:17, 27 May 2021Mkutmonfix publication refs
117788view14:04, 22 May 2021EweitzModified title
107143view14:22, 17 September 2019MaintBotChEBI identifier normalization
106740view13:22, 17 September 2019MaintBotHMDB identifier normalization
106510view20:52, 5 September 2019Khanspersadded reference
106509view20:51, 5 September 2019KhanspersModified description
105648view05:11, 10 August 2019KhanspersModified description
96434view07:27, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94518view19:44, 16 September 2017AlexanderPicoOntology Term : 'classic metabolic pathway' added !
94517view19:43, 16 September 2017AlexanderPicoOntology Term : 'methionine biosynthetic pathway' added !
94304view11:25, 1 September 2017Marvin M2Connected the last unconnected line
94226view23:04, 25 August 2017DeSlAnnoatated metabolites with missing IDs.
94225view22:44, 25 August 2017DeSlModified description
88173view13:37, 29 July 2016Mkutmonwork in progress
83805view03:55, 11 December 2015Mkutmonupdate Polyamine Biosynthesis part
83804view02:49, 11 December 2015Mkutmonupdated version of the pathway
83678view03:17, 2 December 2015Mkutmonlayout
83677view03:06, 2 December 2015Mkutmonlayotu
83676view03:00, 2 December 2015Mkutmonconnected lines
83522view03:08, 20 November 2015Paul CavuotoSpecify description
83521view02:59, 20 November 2015Paul CavuotoPeriodical save, work in progress
83520view02:49, 20 November 2015Paul CavuotoPeriodical save, work in progress
83519view02:39, 20 November 2015Paul CavuotoPeriodical save, work in progress
83499view06:06, 19 November 2015Mkutmonlayout update
83498view05:46, 19 November 2015Mkutmonusing mim conversion instead of arrow to add more semantic meaning to the interactions
83497view05:33, 19 November 2015Paul CavuotoSpecify description
83496view05:16, 19 November 2015Paul CavuotoUpdate pathway
83495view04:52, 19 November 2015Paul CavuotoPeriodical save, work in progress
83494view04:12, 19 November 2015Mkutmonlayout
83493view04:11, 19 November 2015Mkutmonlayout
83492view04:04, 19 November 2015MkutmonModified description
83491view04:03, 19 November 2015Mkutmon
83490view03:49, 19 November 2015Mkutmonlayout update
83489view03:48, 19 November 2015Mkutmontesting curved lines
83488view03:47, 19 November 2015Mkutmonusing labels instead of pathway nodes
83487view03:40, 19 November 2015Mkutmonchanged Ensembl Human to Ensembl
83486view03:38, 19 November 2015Mkutmonlayout work in progress
83485view03:15, 19 November 2015Mkutmonlayout update in progress
83484view03:04, 19 November 2015Mkutmonupdating layout
83483view02:40, 19 November 2015Paul CavuotoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,2-Dihydroxy-3-keto- 5-methylthiopenteneMetaboliteHMDB0012134 (HMDB)
2-Oxo-4- methylthiobutanoic acidMetaboliteHMDB0001553 (HMDB)
3-Methylthiopropionic acidMetaboliteHMDB0001527 (HMDB)
5'-MethylthioadenosineMetaboliteHMDB0001173 (HMDB)
5-(methylthio)-2,3- Dioxopentyl phosphateMetaboliteHMDB0059620 (HMDB)
5-Methyltetrahydrofolic acidMetaboliteHMDB0001396 (HMDB)
5-Methylthioribose 1-phosphateMetaboliteHMDB0000963 (HMDB)
5-Methylthioribulose 1-phosphateMetaboliteHMDB0001299 (HMDB)
ADI1GeneProductENSG00000182551 (Ensembl)
AHCYGeneProductENSG00000101444 (Ensembl)
AMD1GeneProductENSG00000123505 (Ensembl)
APIPGeneProductENSG00000149089 (Ensembl)
ATPMetaboliteHMDB0000538 (HMDB)
AdenineMetaboliteHMDB0000034 (HMDB)
AdenosineMetaboliteHMDB0000050 (HMDB)
AmmoniaMetaboliteHMDB0000051 (HMDB)
BHMTGeneProductENSG00000145692 (Ensembl)
BetaineMetaboliteHMDB0000043 (HMDB)
CHDHGeneProductENSG00000016391 (Ensembl)
Carbon dioxideMetaboliteHMDB0001967 (HMDB)
Carbon monoxideMetaboliteHMDB0001361 (HMDB)
Cellular ProliferationPathway
CholineMetaboliteHMDB0000097 (HMDB)
CobalaminMetaboliteHMDB0002174 (HMDB)
DimethylglycineMetaboliteHMDB0000092 (HMDB)
Diphosphate MetaboliteCHEBI:18361 (ChEBI)
ENOPH1GeneProductENSG00000145293 (Ensembl)
FADMetaboliteHMDB0001248 (HMDB)
Formic acidMetaboliteHMDB0000142 (HMDB)
HomocysteineMetaboliteHMDB0000742 (HMDB)
Hydrogen peroxideMetaboliteHMDB0003125 (HMDB)
IL4I1GeneProductENSG00000104951 (Ensembl)
IronMetaboliteHMDB0000692 (HMDB)
L-Glutamic acidMetaboliteHMDB0000148 (HMDB)
L-MethionineMetaboliteHMDB0000696 (HMDB)
MAT1AGeneProductENSG00000151224 (Ensembl)
MAT2AGeneProductENSG00000168906 (Ensembl)
MAT2BGeneProductENSG00000038274 (Ensembl)
MRI1GeneProductENSG00000037757 (Ensembl)
MSRAGeneProductENSG00000175806 (Ensembl)
MSRB2GeneProductENSG00000148450 (Ensembl)
MSRB3GeneProductENSG00000174099 (Ensembl)
MTAPGeneProductENSG00000099810 (Ensembl)
MTRGeneProductENSG00000116984 (Ensembl)
MTRRGeneProduct
MagnesiumMetaboliteHMDB0000547 (HMDB)
MetaboliteMetabolite
Methionine sulfoxideMetaboliteHMDB0002005 (HMDB)
Methylated MetaboliteMetabolite
MethyltranferasesGeneProduct
NADMetaboliteHMDB0000902 (HMDB)
NickelMetaboliteHMDB0002457 (HMDB)
ODC1GeneProductENSG00000115758 (Ensembl)
OrnithineMetaboliteHMDB0000214 (HMDB)
Oxoglutaric acidMetaboliteHMDB0000208 (HMDB)
OxygenMetaboliteHMDB0001377 (HMDB)
PhosphateMetaboliteHMDB0001429 (HMDB)
Phosphoric acidMetaboliteHMDB0002142 (HMDB)
PotassiumMetaboliteCHEBI:26216 (ChEBI)
Protein-bound MethionineMetabolite
Protein-bound Methionine sulfoxideMetabolite
PutrescineMetaboliteHMDB0001414 (HMDB)
Pyridoxal 5'-phosphateMetaboliteHMDB0001491 (HMDB)
S-AdenosylhomocysteineMetaboliteHMDB0000939 (HMDB)
S-AdenosylmethioninamineMetaboliteHMDB0000988 (HMDB)
S-AdenosylmethionineMetaboliteHMDB0001185 (HMDB)
SMSGeneProductENSG00000102172 (Ensembl)
SRMGeneProductENSG00000116649 (Ensembl)
SpermidineMetaboliteHMDB0001257 (HMDB)
SpermineMetaboliteHMDB0001256 (HMDB)
TATGeneProductENSG00000198650 (Ensembl)
Tetrahydrofolic acidMetaboliteHMDB0001846 (HMDB)
Thioredoxin disulfideMetaboliteCHEBI:18191 (ChEBI)
ThioredoxinProteinH9ZYJ2 (Uniprot-TrEMBL)
WaterMetaboliteHMDB0002111 (HMDB)
ZincMetaboliteHMDB0001303 (HMDB)
ZincMetaboliteHMDB0015532 (HMDB)
cobalt(2+) ionMetaboliteCHEBI:48828 (ChEBI)
magnesiumMetaboliteCHEBI:25107 (ChEBI)
potassiumMetaboliteCHEBI:26216 (ChEBI)
pyruvateMetaboliteCHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions

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