Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids (Homo sapiens)

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1Stimulation or inhibition depending on the animal model used InflammationStress responseAgingAgingNeuro degenerationNeuro degenerationSphingosine 1-phosphate receptor 1Phospholipase D1Ceramide kinaseRas homolog enriched in the brainInsulin-like growth factor 1 receptorSphingosine 1-phosphate receptor 3ceramide 1-phosphatesarginineSphingosineCeramide synthase 1Hypoxia-inducible factor-1 alphaNeutral ceramidasemTORC1Amino acidsceramideRNSTuberous sclerosis proteinSphingosine 1-phosphatePI3KNF-kBInhibitor of NF-kB kinaseSphingosine kinase 2ROSProtein associated with MycglucoseROSAKT1ROSRNSceramideStimulation or inhibition depending on the animal model used Stimulation or inhibition depending on the animal model used


Description

Modulation of the PI3K-Akt-mTOR signaling by bioactive sphinoglipids

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Quality Tags

Ontology Terms

 

Bibliography

  1. Jęśko H, Stępień A, Lukiw WJ, Strosznajder RP; ''The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration.''; Mol Neurobiol, 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135482view05:20, 16 September 2024EgonwIt seems to me the ChEBI ID was wrong, and for a different kinase
134496view05:30, 22 July 2024EgonwRemoved a template comment
128742view04:54, 21 February 2024EweitzStandardize case
122557view02:15, 16 April 2022EweitzModified title
122178view10:06, 15 March 2022Jespervisual changes
122177view09:56, 15 March 2022JesperOntology Term : 'senile degeneration of brain' added !
122176view09:52, 15 March 2022JesperChanged databases
122175view09:45, 15 March 2022JesperAdded and changed identifiers and added text labels
121872view22:32, 7 March 2022DeSlMore layout and condensation of pathway
121871view22:02, 7 March 2022DeSlMore layout changes for readability
121870view21:58, 7 March 2022DeSlLayout top of page
121869view21:56, 7 March 2022DeSlConnected last unconnected line
121596view18:04, 21 February 2022AnnaVanWerschAdded pathway reference
121594view17:58, 21 February 2022AnnaVanWerschchanged some interactions, hoping to fix the unconnected interactions
121593view17:49, 21 February 2022AnnaVanWerschChanged activation arrow to inhibition interaction
121588view17:39, 21 February 2022AnnaVanWerschFixed some interactions and aligned some boxes
121434view12:55, 17 February 2022JesperTitle change
121432view12:53, 17 February 2022JesperAddition of new data nodes
121351view09:47, 16 February 2022JesperNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
Amino acidsMetaboliteCHEBI:33704 (ChEBI)
Ceramide kinaseProteinQ8TCT0 (Uniprot-TrEMBL)
Ceramide synthase 1ProteinENSG00000223802 (Ensembl Human)
Hypoxia-inducible factor-1 alphaGeneProductENSG00000100644 (Ensembl)
Inhibitor of NF-kB kinaseMetaboliteCHEBI:77113 (Other)
Insulin-like growth factor 1 receptorProteinENSG00000140443 (Ensembl Human)
NF-kBGeneProductENSG00000109320 (Ensembl)
Neutral ceramidaseProteinQ9NR71 (Uniprot-TrEMBL)
PI3KProteinENSG00000121879 (Ensembl)
Phospholipase D1ProteinENSG00000075651 (Ensembl Human)
Protein associated with MycProtein
RNSMetabolite62764 (ChEBI)
ROSMetabolite26523 (ChEBI)
Ras homolog enriched in the brainProtein
Sphingosine kinase 2ProteinENSG00000063176 (Ensembl Human)
Sphingosine 1-phosphate receptor 1ProteinENSG00000170989 (Ensembl Human)
Sphingosine 1-phosphate receptor 3ProteinQ99500 (Uniprot-TrEMBL)
Sphingosine 1-phosphateMetaboliteHMDB0000277 (HMDB)
SphingosineMetaboliteCHEBI:45719 (ChEBI)
Tuberous sclerosis proteinProteinQ92574 (Uniprot-TrEMBL)
arginineMetaboliteCHEBI:29016 (ChEBI)
ceramide 1-phosphatesMetaboliteCHEBI:16197 (ChEBI)
ceramideMetaboliteCHEBI:52639 (ChEBI)
glucoseMetaboliteCHEBI:17234 (ChEBI)
mTORC1ProteinENSG00000198793 (Ensembl)

Annotated Interactions

No annotated interactions

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