Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids (Homo sapiens)

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1AgingNeuro degenerationNeuro degenerationAgingStimulation or inhibition depending on the animal model used InflammationStress responseHypoxia-inducible factor-1 alphaProtein associated with MycSphingosineROSmTORC1glucoseInsulin-like growth factor 1 receptorceramideRNSROSSphingosine 1-phosphateNeutral ceramidaseAKT1Sphingosine kinase 2Phospholipase D1NF-kBCeramide kinaseAmino acidsarginineInhibitor of NF-kB kinaseceramide 1-phosphatesPI3KSphingosine 1-phosphate receptor 3Ceramide synthase 1Sphingosine 1-phosphate receptor 1Tuberous sclerosis proteinRas homolog enriched in the brainROSRNSceramideStimulation or inhibition depending on the animal model used Stimulation or inhibition depending on the animal model used


Description

Modulation of the PI3K-Akt-mTOR signaling by bioactive sphinoglipids

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Quality Tags

Ontology Terms

 

Bibliography

  1. Jęśko H, Stępień A, Lukiw WJ, Strosznajder RP; ''The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration.''; Mol Neurobiol, 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135482view05:20, 16 September 2024EgonwIt seems to me the ChEBI ID was wrong, and for a different kinase
134496view05:30, 22 July 2024EgonwRemoved a template comment
128742view04:54, 21 February 2024EweitzStandardize case
122557view02:15, 16 April 2022EweitzModified title
122178view10:06, 15 March 2022Jespervisual changes
122177view09:56, 15 March 2022JesperOntology Term : 'senile degeneration of brain' added !
122176view09:52, 15 March 2022JesperChanged databases
122175view09:45, 15 March 2022JesperAdded and changed identifiers and added text labels
121872view22:32, 7 March 2022DeSlMore layout and condensation of pathway
121871view22:02, 7 March 2022DeSlMore layout changes for readability
121870view21:58, 7 March 2022DeSlLayout top of page
121869view21:56, 7 March 2022DeSlConnected last unconnected line
121596view18:04, 21 February 2022AnnaVanWerschAdded pathway reference
121594view17:58, 21 February 2022AnnaVanWerschchanged some interactions, hoping to fix the unconnected interactions
121593view17:49, 21 February 2022AnnaVanWerschChanged activation arrow to inhibition interaction
121588view17:39, 21 February 2022AnnaVanWerschFixed some interactions and aligned some boxes
121434view12:55, 17 February 2022JesperTitle change
121432view12:53, 17 February 2022JesperAddition of new data nodes
121351view09:47, 16 February 2022JesperNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
Amino acidsMetaboliteCHEBI:33704 (ChEBI)
Ceramide kinaseProteinQ8TCT0 (Uniprot-TrEMBL)
Ceramide synthase 1ProteinENSG00000223802 (Ensembl)
Hypoxia-inducible factor-1 alphaGeneProductENSG00000100644 (Ensembl)
Inhibitor of NF-kB kinaseMetaboliteCHEBI:77113 (ChEBI)
Insulin-like growth factor 1 receptorProteinENSG00000140443 (Ensembl)
NF-kBGeneProductENSG00000109320 (Ensembl)
Neutral ceramidaseProteinQ9NR71 (Uniprot-TrEMBL)
PI3KProteinENSG00000121879 (Ensembl)
Phospholipase D1ProteinENSG00000075651 (Ensembl)
Protein associated with MycProtein
RNSMetabolite62764 (ChEBI)
ROSMetabolite26523 (ChEBI)
Ras homolog enriched in the brainProtein
Sphingosine kinase 2ProteinENSG00000063176 (Ensembl)
Sphingosine 1-phosphate receptor 1ProteinENSG00000170989 (Ensembl)
Sphingosine 1-phosphate receptor 3ProteinQ99500 (Uniprot-TrEMBL)
Sphingosine 1-phosphateMetaboliteHMDB0000277 (HMDB)
SphingosineMetaboliteCHEBI:45719 (ChEBI)
Tuberous sclerosis proteinProteinQ92574 (Uniprot-TrEMBL)
arginineMetaboliteCHEBI:29016 (ChEBI)
ceramide 1-phosphatesMetaboliteCHEBI:16197 (ChEBI)
ceramideMetaboliteCHEBI:52639 (ChEBI)
glucoseMetaboliteCHEBI:17234 (ChEBI)
mTORC1ProteinENSG00000198793 (Ensembl)

Annotated Interactions

No annotated interactions

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