COVID-19 and endothelial cell senescence (Homo sapiens)

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4SARS-CoV 2blood monocytesEndothelial cells senescencemitonchondrial dysfunctionWP4961IL17RAIL17AANO6virus proteinTLR4ORF3aORF8IL17RCNSP44cytokines


Description

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Bibliography

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  1. Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY; ''Evasion of Type I Interferon by SARS-CoV-2.''; Cell Rep, 2020 PubMed Europe PMC Scholia
  2. Xia H, Shi PY; ''Antagonism of Type I Interferon by Severe Acute Respiratory Syndrome Coronavirus 2.''; J Interferon Cytokine Res, 2020 PubMed Europe PMC Scholia
  3. Yamauchi K, Shibata Y, Kimura T, Abe S, Inoue S, Osaka D, Sato M, Igarashi A, Kubota I; ''Azithromycin suppresses interleukin-12p40 expression in lipopolysaccharideand interferon-gamma stimulated macrophages.''; Int J Biol Sci, 2009 PubMed Europe PMC Scholia
  4. Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD; ''A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.''; Proc Natl Acad Sci U S A, 2008 PubMed Europe PMC Scholia
  5. Aghai ZH, Kode A, Saslow JG, Nakhla T, Farhath S, Stahl GE, Eydelman R, Strande L, Leone P, Rahman I; ''Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants.''; Pediatr Res, 2007 PubMed Europe PMC Scholia
  6. Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF 3rd, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK; ''The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.''; Nat Immunol, 2015 PubMed Europe PMC Scholia
  7. Sa Ribero M, Jouvenet N, Dreux M, Nisole S; ''''; , PubMed Europe PMC Scholia
  8. Baines KJ, Wright TK, Gibson PG, Powell H, Hansbro PM, Simpson JL; ''Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD.''; ERJ Open Res, 2018 PubMed Europe PMC Scholia
  9. Baines KJ, Wright TK, Gibson PG, Powell H, Hansbro PM, Simpson JL; ''Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD.''; ERJ Open Res, 2018 PubMed Europe PMC Scholia
  10. Khanmohammadi S, Rezaei N; ''Role of Toll-like receptors in the pathogenesis of COVID-19.''; J Med Virol, 2021 PubMed Europe PMC Scholia
  11. Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z, Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z, Xiang Z, Wang J; ''Activation and evasion of type I interferon responses by SARS-CoV-2.''; Nat Commun, 2020 PubMed Europe PMC Scholia
  12. Edelmann MJ, Nicholson B, Kessler BM; ''Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.''; Expert Rev Mol Med, 2011 PubMed Europe PMC Scholia
  13. Wu X, Xia T, Shin WJ, Yu KM, Jung W, Herrmann A, Foo SS, Chen W, Zhang P, Lee JS, Poo H, Comhair SAA, Jehi L, Choi YK, Ensser A, Jung JU; ''Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8.''; mBio, 2022 PubMed Europe PMC Scholia
  14. Carter-Timofte ME, Jørgensen SE, Freytag MR, Thomsen MM, Brinck Andersen NS, Al-Mousawi A, Hait AS, Mogensen TH; ''Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19.''; Front Immunol, 2020 PubMed Europe PMC Scholia
  15. Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, Doudier B, Courjon J, Giordanengo V, Vieira VE, Dupont HT, Honoré S, Colson P, Chabrière E, La Scola B, Rolain JM, Brouqui P, Raoult D; ''Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.''; Int J Antimicrob Agents, 2020 PubMed Europe PMC Scholia
  16. Yamauchi K, Shibata Y, Kimura T, Abe S, Inoue S, Osaka D, Sato M, Igarashi A, Kubota I; ''Azithromycin suppresses interleukin-12p40 expression in lipopolysaccharide and interferon-gamma stimulated macrophages.''; Int J Biol Sci, 2009 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
124640view12:48, 18 November 2022Jfigueirahasbunupdated viral protein labels, shapes and identifiers
124554view12:38, 8 November 2022EweitzReduce negative space at top and left of pathway graphic
124553view12:32, 8 November 2022EweitzUse name instead of ID as pathway label, fix typos, refine virus dimensions
124552view12:25, 8 November 2022EweitzModified title
124041view15:07, 14 September 2022DeSlUpdate ID for NSP4
124040view15:05, 14 September 2022DeSlChnaged MIM-conversion to Arrows
124039view15:04, 14 September 2022DeSlConverted SARS-COV2 drawing to graphical lines
123978view10:43, 9 September 2022EweitzModified title
123678view09:52, 9 August 2022EgonwNot a mim-conversion
123532view06:33, 2 August 2022EgonwMade a pathway clickable
123236view14:51, 5 July 2022LaureAlix
123235view14:48, 5 July 2022LaureAlix
123222view14:21, 5 July 2022LaureAlixModified description
123221view14:20, 5 July 2022LaureAlix
123220view14:10, 5 July 2022LaureAlix
123217view14:06, 5 July 2022LaureAlix
123215view14:03, 5 July 2022LaureAlixchanges
123209view13:39, 5 July 2022LaureAlix
123208view13:38, 5 July 2022LaureAlixNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ANO6GeneProductENSG00000177119 (Ensembl)
IL17AGeneProductENSG00000112115 (Ensembl)
IL17RAGeneProductENSG00000177663 (Ensembl)
IL17RCGeneProductENSG00000163702 (Ensembl)
NSP4GeneProductP0DTD1-PRO_0000449622 (Uniprot-TrEMBL) PDB structure for SARS-CoV strain: 6JYT
ORF3aProteinP0DTC3 (Uniprot-TrEMBL) PDB structure for SARS-CoV strain: 6JYT
ORF8GeneProduct43740577 (Entrez Gene) PDB structure for SARS-CoV strain: 6JYT
TLR4ProteinO00206 (Uniprot-TrEMBL)
WP4961PathwayWP4961 (WikiPathways)

Annotated Interactions

No annotated interactions

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