Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists (Homo sapiens)

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1 Liver IntestineVKACoumarins (4-hydroxycoumarins)Most commonly used VKAsVitamin K absorptionPXRmenaquinoneWarfarinLithocholic acidphylloquinoneVDR1-butyratePPAR alphaNPC1L1CYP2C91CD361SR-BImenaquinone1PPAR betaCoumatetralylPhenprocoumonAcenocoumarolApaxibandicoumarolTioclomarolBrodifacoumPindoneChlorophacinoneDiphacinoneAnisindioneFluindionePhenindioneIndandionesLeft: rodenticides, 'first-generation' anticoagulants.Right: anticoagulants more toxic than warfarin, rarely used.VKA metabolites


Description

A hypothetical pathway showing the interactions of metabolites produced by the intestinal microbiome, which can affects the anticoagulant response of vitamin K antagonists (VKAs)

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Bibliography

  1. Han Yan, Yi Chen, Hong Zhu, Wei-Hua Huang, Xin-He Cai, Dan Li, Ya-Juan Lv, Si-Zhao, Hong-Hao Zhou, Fan-Yan Luo, Wei Zhang, Xi Li; ''The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism''; Front Med (Lausanne), 2022 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
123985view10:51, 9 September 2022EweitzModified title
123592view13:38, 4 August 2022DeSlUpdate HGNC IDs to UniProt
123591view13:36, 4 August 2022DeSlUpdated description
123590view13:35, 4 August 2022DeSlOntology Term : 'hepatocyte' added !
123589view13:35, 4 August 2022DeSlOntology Term : 'gut absorptive cell' added !
123588view13:34, 4 August 2022DeSlOntology Term : 'vitamin and vitamin metabolites signaling pathway' added !
123587view13:34, 4 August 2022DeSlOntology Term : 'vitamin K deficiency bleeding' added !
123586view13:34, 4 August 2022DeSlOntology Term : 'vitamin K antagonist drug pathway' added !
123585view13:33, 4 August 2022DeSlAdded more comments for datanodes
123584view13:25, 4 August 2022DeSlNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
1-butyrateMetaboliteCHEBI:17968 (ChEBI)
AcenocoumarolMetaboliteCHEBI:53766 (ChEBI)
AnisindioneMetaboliteCHEBI:133809 (ChEBI)
ApaxibanMetaboliteCHEBI:72296 (ChEBI) AKA Eliquis, alternative to warfarin
BrodifacoumMetaboliteQ421203 (Wikidata)
CD36GeneProductCD36 (HGNC)
CYP2C9GeneProductCYP2C9 (HGNC)
ChlorophacinoneMetaboliteQ413488 (Wikidata)
CoumatetralylMetaboliteQ415772 (Wikidata)
DiphacinoneMetaboliteCHEBI:81896 (ChEBI)
FluindioneMetaboliteQ3074488 (Wikidata)
Lithocholic acidMetaboliteCHEBI:16325 (ChEBI) secondary bile acid produced by intestinal bacteria
NPC1L1GeneProductNPC1L1 (HGNC)
PPAR alphaProteinQ07869 (Uniprot-TrEMBL) AKA PPARA, PPARα, the peroxisome proliferator-activated receptor α
PPAR betaProteinQ03181 (Uniprot-TrEMBL) AKA PPARB, PPARβ, the peroxisome proliferator-activated receptor β; PPARbeta (formerly PPARdelta)
PXRProteinO75469 (Uniprot-TrEMBL) AKA regnane X receptor, NR1I2
PhenindioneMetaboliteCHEBI:8066 (ChEBI)
PhenprocoumonMetaboliteCHEBI:50438 (ChEBI)
PindoneMetaboliteHMDB0256560 (HMDB)
SR-BIProteinQ8WTV0 (Uniprot-TrEMBL) AKA Scavenger receptor class B member 1
TioclomarolMetaboliteCHEBI:135730 (ChEBI)
VDRGeneProductVDR (HGNC) AKA vitamin D receptor
Vitamin K absorptionPathway
WarfarinMetaboliteCHEBI:10033 (ChEBI) AKA Coumadin
dicoumarolMetaboliteCHEBI:4513 (ChEBI)
menaquinoneMetaboliteCHEBI:16374 (ChEBI) Figure in paper describes menaquinone, text mentiones: "MK-4 has been found as the most common menaquinone in humans, as well as the only menaquinone converted by phylloquinone. The other menaquinone is synthesized by some obligate and facultative anaerobic bacteria. Except for MK-4, the other menaquinone in humans is mostly synthesized by intestinal bacteria. [PMID:35510250]. Therefore, annotated with overarching Vit.K2 ID from chebi (which should constitute all subforms)
phylloquinoneMetaboliteCHEBI:28433 (ChEBI) AKA VK1

Annotated Interactions

No annotated interactions

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