Estrogen metabolism (Homo sapiens)

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AKR1C3CYP2C19HSD17B4CYP3A44-MethoxyestradiolAndrostenedioneHSD17B24-MethoxyestroneCYP1A22-hydroxyestroneHSD17B1CYP1B1COMTHSD17B1CYP19A1HSD17B2CYP2C9SULT1E1HSD17B14HSD17B10EstroneHSD17B8CYP1A1HSD17B7HSD17B32-MethoxyestradiolEstriolTestosteroneCYP2C8Estrone sulfate2-Methoxyestrone16alpha-hydroxyestrone4-HydroxyestroneCYP3A74-HydroxyestradiolHSD17B4STSCYP3A5Estradiol2-HydroxyestradiolAKR1C3COMTCYP1B1CYP3A5CYP2C9CYP3A4CYP1A2CYP1A1CYP2C19CYP1B1CYP3A5CYP2C9CYP3A4CYP1A2CYP1A1


Description

Estrogen synthesis and metabolism. Data from W. Griffiths

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kallionpää RA, Järvinen E, Finel M; ''Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.''; J Steroid Biochem Mol Biol, 2015 PubMed Europe PMC Scholia
  2. Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, Shackleton CHL, Storbeck KH; ''Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.''; J Steroid Biochem Mol Biol, 2019 PubMed Europe PMC Scholia
  3. Sneitz N, Vahermo M, Mosorin J, Laakkonen L, Poirier D, Finel M; ''Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.''; Drug Metab Dispos, 2013 PubMed Europe PMC Scholia
  4. Lépine J, Bernard O, Plante M, Têtu B, Pelletier G, Labrie F, Bélanger A, Guillemette C; ''Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.''; J Clin Endocrinol Metab, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134703view12:05, 26 July 2024EweitzStandardize case, refine node padding
134702view11:59, 26 July 2024EweitzStandardize case
134701view11:57, 26 July 2024EweitzEconomize layout, align anchors
134700view11:49, 26 July 2024EweitzEconomize layout
134699view11:41, 26 July 2024EweitzFix truncated text in nodes
134694view00:54, 26 July 2024EweitzOntology Term : 'C18-steroid hormone biosynthetic pathway' added !
126877view14:56, 29 June 2023DeSlAdded info on Rhea IDs in description
126876view14:51, 29 June 2023WilliamJGriffiths
126875view14:45, 29 June 2023DeSlConnected unconnected line
125492view10:21, 20 February 2023LinaSchifferModified description
125451view14:35, 14 February 2023Conroy lipidsfix typos, box sizes
125449view14:14, 14 February 2023Conroy lipidsexpert corrections
124302view11:29, 12 October 2022Conroy lipidsadded a couple of missing rhea IDs
123930view09:06, 2 September 2022Conroy lipids
123929view08:26, 2 September 2022Conroy lipids
123928view06:50, 2 September 2022Conroy lipidsadd glucuronides, refs, rhea
123923view16:04, 31 August 2022Conroy lipidsadded refs, new glucuronid metabolites
123922view12:32, 31 August 2022Conroy lipidsadd glucuroniate, rheas, refs
123921view12:18, 31 August 2022Conroy lipidsadd overall ref and some Rhea IDs
123723view14:44, 11 August 2022Conroy lipids
123721view14:35, 11 August 2022Conroy lipidsmssing anchor
123719view14:29, 11 August 2022Conroy lipidsmissing anchor fixed
123712view13:46, 11 August 2022Conroy lipidsadd anchors to conversions
123708view09:29, 11 August 2022Conroy lipidsOntology Term : 'steroid biosynthetic pathway' added !
123707view09:28, 11 August 2022Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
123706view09:28, 11 August 2022Conroy lipidsOntology Term : 'classic metabolic pathway' added !
123683view14:14, 9 August 2022EgonwFixed a datasource
123681view11:34, 9 August 2022Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
16alpha-hydroxyestroneMetaboliteLMST02010041 (LIPID MAPS)
2-HydroxyestradiolMetaboliteLMST02010027 (LIPID MAPS)
2-MethoxyestradiolMetaboliteLMST02010035 (LIPID MAPS)
2-MethoxyestroneMetaboliteLMST02010033 (LIPID MAPS)
2-hydroxyestroneMetaboliteLMST02010032 (LIPID MAPS)
4-HydroxyestradiolMetaboliteLMST02010028 (LIPID MAPS)
4-HydroxyestroneMetaboliteLMST02010056 (LIPID MAPS)
4-MethoxyestradiolMetaboliteLMST02010055 (LIPID MAPS)
4-MethoxyestroneMetaboliteLMST02010057 (LIPID MAPS)
AKR1C3GeneProductP42330 (Uniprot-TrEMBL)
AndrostenedioneMetaboliteLMST02020007 (LIPID MAPS)
COMTGeneProductP21964 (Uniprot-TrEMBL)
CYP19A1GeneProductP11511 (Uniprot-TrEMBL)
CYP1A1GeneProductQ0VHD5 (Uniprot-TrEMBL)
CYP1A2GeneProductP05177 (Uniprot-TrEMBL)
CYP1B1GeneProductQ16678 (Uniprot-TrEMBL)
CYP2C19GeneProductP33261 (Uniprot-TrEMBL)
CYP2C8GeneProductP10632 (Uniprot-TrEMBL)
CYP2C9GeneProductP11712 (Uniprot-TrEMBL)
CYP3A4GeneProductP08684 (Uniprot-TrEMBL)
CYP3A5GeneProductP20815 (Uniprot-TrEMBL)
CYP3A7GeneProductP24462 (Uniprot-TrEMBL)
EstradiolMetaboliteLMST02010001 (LIPID MAPS)
EstriolMetaboliteLMST02010003 (LIPID MAPS)
Estrone sulfateMetaboliteLMST02010043 (LIPID MAPS)
EstroneMetaboliteLMST02010004 (LIPID MAPS)
HSD17B10GeneProductQ99714 (Uniprot-TrEMBL)
HSD17B14GeneProductQ9BPX1 (Uniprot-TrEMBL)
HSD17B1GeneProductP14061 (Uniprot-TrEMBL)
HSD17B2GeneProductP37059 (Uniprot-TrEMBL)
HSD17B3GeneProductP37058 (Uniprot-TrEMBL)
HSD17B4GeneProductP51659 (Uniprot-TrEMBL)
HSD17B7GeneProductP56937 (Uniprot-TrEMBL)
HSD17B8GeneProductQ92506 (Uniprot-TrEMBL)
STSGeneProductP08842 (Uniprot-TrEMBL)
SULT1E1GeneProductP49888 (Uniprot-TrEMBL)
TestosteroneMetaboliteLMST02020002 (LIPID MAPS)

Annotated Interactions

No annotated interactions

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