Mineralocorticoid biosynthesis (Homo sapiens)

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1Allotetrahydrocorticosterone5beta-dihydrodeoxycorticosteroneCorticosteroneCYP21A2AlfadoloneHSD11B2CYP11B111-DehydrocorticosteroneHSD11B15alpha-pregnan-21-ol-3,11,20-trioneAldosterone 18-glucuronideAldosterone18-Hydroxy-11-dehydrotetrahydrocorticosteroneUGT2B7Tetrahydrocorticosterone5beta-dihydrodeoxycorticosteroneAKR1D15beta-pregnan-21-ol-3,11,20-trioneCYP11B2UGT1A10Tetrahydroaldosterone3alpha,21-dihydroxy-5beta-pregnane-11,20-dione5beta-DihydrocorticosteroneSRD5A118-Hydroxycorticosterone5beta-DihydroaldosteroneSRD5A2AKR1D15alpha-Dihydrocorticosterone3alpha,11beta,18,21-tetrahydroxy-5beta-pregnan-20-oneSteroid hormone precursor biosynthesis11β,18,21-trihydroxy-5β-pregnan-3,20-dioneHSD11B211-deoxycorticosteroneProgesteroneAKR1D1AKR1D1AKR1D1AKR1C2CYP11B2CYP11B2SRD5A2SRD5A1AKR1C2AKR1C2AKR1C2


Description

Mineralocorticoid synthesis and metabolism. The pathway knowledge depicted in this model stems from William Griffths.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, Shackleton CHL, Storbeck KH; ''Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.''; J Steroid Biochem Mol Biol, 2019 PubMed Europe PMC Scholia
  2. C Fardella, W Miller; ''Molecular biology of mineralocorticoid metabolism''; Annu Rev Nutr ., 1996 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134507view11:40, 22 July 2024EweitzModified description
134505view11:38, 22 July 2024EweitzModified description
126878view15:01, 29 June 2023DeSlAdded Rhea info in introduction
125494view10:29, 20 February 2023LinaSchifferModified description
125454view20:54, 14 February 2023EgonwAll TrEMBL
125448view13:44, 14 February 2023Conroy lipidsadd more enzymes
124378view09:41, 20 October 2022DeSlFound a more general Rhea ID for reaction catalyzed by SRD5A1 and A2
124377view09:19, 20 October 2022DeSlAdded a more elaborate description
124373view09:04, 20 October 2022DeSlChanged width for interactions missing a Rhea ID
124372view09:01, 20 October 2022DeSlUpdated layout of nodes for readability
124370view08:52, 20 October 2022DeSlOntology Term : 'classic metabolic pathway' added !
124368view08:51, 20 October 2022DeSlOntology Term : 'aldosterone biosynthetic pathway' added !
124362view08:45, 20 October 2022DeSlUpdated description
124309view08:00, 13 October 2022Conroy lipidscorrect typo in name
124049view09:36, 15 September 2022DeSlReplace UniProt ID for UGT2B7 to reviewed version.
124048view09:34, 15 September 2022DeSlOntology Term : 'mineralocorticoid biosynthetic pathway' added !
123924view05:17, 2 September 2022EgonwReplace SwissProt with TrEMBL
123906view08:28, 26 August 2022Conroy lipids
123905view08:25, 26 August 2022Conroy lipids
123904view08:19, 26 August 2022Conroy lipids
123903view08:10, 26 August 2022Conroy lipids
123902view07:59, 26 August 2022Conroy lipidsmove rhea annotation from catalysis to conversin
123891view07:58, 25 August 2022Conroy lipidscorrect typo in title
123884view07:49, 24 August 2022Conroy lipids
123883view11:21, 23 August 2022Conroy lipids
123882view11:04, 23 August 2022Conroy lipids
123881view10:52, 23 August 2022Conroy lipids
123878view10:22, 23 August 2022Conroy lipidsanchors
123877view10:11, 23 August 2022Conroy lipids
123870view10:38, 22 August 2022Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
123869view10:37, 22 August 2022Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-DehydrocorticosteroneMetaboliteLMST02030284 (LIPID MAPS)
11-deoxycorticosteroneMetaboliteLMST02030087 (LIPID MAPS)
11β,18,21-trihydroxy-5β-pregnan-3,20-dioneMetaboliteLMST02030277 (LIPID MAPS)
18-Hydroxy-11-dehydrotetrahydrocorticosteroneMetaboliteLMST02030279 (LIPID MAPS)
18-HydroxycorticosteroneMetaboliteLMST02030091 (LIPID MAPS)
3alpha,11beta,18,21-tetrahydroxy-5beta-pregnan-20-oneMetaboliteLMST02030278 (LIPID MAPS)
3alpha,21-dihydroxy-5beta-pregnane-11,20-dioneMetaboliteLMST02030288 (LIPID MAPS)
5alpha-DihydrocorticosteroneMetaboliteLMST02030281 (LIPID MAPS)
5alpha-pregnan-21-ol-3,11,20-trioneMetaboliteLMST02030286 (LIPID MAPS)
5beta-DihydroaldosteroneMetaboliteLMST02030276 (LIPID MAPS)
5beta-DihydrocorticosteroneMetaboliteLMST02030280 (LIPID MAPS)
5beta-dihydrodeoxycorticosteroneMetaboliteLMST02030282 (LIPID MAPS)
5beta-dihydrodeoxycorticosteroneMetaboliteLMST02030283 (LIPID MAPS)
5beta-pregnan-21-ol-3,11,20-trioneMetaboliteLMST02030285 (LIPID MAPS)
AKR1C2GeneProductP52895 (Uniprot-TrEMBL)
AKR1D1GeneProductP51857 (Uniprot-TrEMBL)
Aldosterone 18-glucuronideMetaboliteLMST05010062 (LIPID MAPS)
AldosteroneMetaboliteLMST02030026 (LIPID MAPS)
AlfadoloneMetaboliteLMST02030287 (LIPID MAPS)
AllotetrahydrocorticosteroneMetaboliteLMST02030142 (LIPID MAPS)
CYP11B1GeneProductP15538 (Uniprot-TrEMBL)
CYP11B2GeneProductP19099 (Uniprot-TrEMBL)
CYP21A2GeneProductP08686 (Uniprot-TrEMBL)
CorticosteroneMetaboliteLMST02030186 (LIPID MAPS)
HSD11B1GeneProductP28845 (Uniprot-TrEMBL)
HSD11B2GeneProductP80365 (Uniprot-TrEMBL)
ProgesteroneMetaboliteLMST02030159 (LIPID MAPS)
SRD5A1GeneProductP18405 (Uniprot-TrEMBL)
SRD5A2GeneProductP31213 (Uniprot-TrEMBL)
Steroid hormone precursor biosynthesisPathwayWP5277 (WikiPathways)
TetrahydroaldosteroneMetaboliteLMST02030275 (LIPID MAPS)
TetrahydrocorticosteroneMetaboliteLMST02030100 (LIPID MAPS)
UGT1A10GeneProductQ9HAW8 (Uniprot-TrEMBL)
UGT2B7GeneProductP16662 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
11-DehydrocorticosteroneCorticosteronemim-conversion42202 (Rhea) EC:1.1.1.146
11-deoxycorticosterone5beta-dihydrodeoxycorticosteronemim-conversion46669 (Rhea) EC:1.3.1.3
11-deoxycorticosteroneCorticosteronemim-conversion46105 (Rhea)
18-HydroxycorticosteroneAldosteronemim-conversion50793 (Rhea)
Aldosterone5beta-Dihydroaldosteronemim-conversion46673 (Rhea) EC:1.3.1.3
Corticosterone11-Dehydrocorticosteronemim-conversion42205 (Rhea)
Corticosterone18-Hydroxycorticosteronemim-conversion11873 (Rhea) EC:1.14.15.4
Corticosterone5beta-Dihydrocorticosteronemim-conversion46665 (Rhea) EC:1.3.1.3
Progesterone11-deoxycorticosteronemim-conversion50305 (Rhea) EC:1.14.14.16
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