Markers of kidney cell lineage (Homo sapiens)

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5, 12281543progenitorsNon cell-autonomous pathways in the stromaGround stateNPCEPOproducingcellsseparate pathway:cell autonomos - stromal progenitor within kidneyNephronacting on neprhogenic precursorsconnecting tubulejuxtaglomerular locationintegration into kidneyTIMECell-autonomous pathways in the stromaNPCPrimedNPCPretubularaggregateproximalproximalproximaldistal segmentHenle's loopproximal segmentvisceral epithelial cells(podocytes)parietalepithelial cells(Bowman's capsule)visceral epithelial cells(podocytes)parietalepithelial cells(Bowman's capsule)CITED1KCTD1SMAD1PBX1OSR1NOTCH2?SFRP1SALL1HNF1BNPHS2FGF8FOXD1ACTA2BMP4EMX2RSPO1FOXD1AP2B1HNF1ANT5ETNCFGF7DESWNT?WNT4GDNF/RET signaling axisLHX1PECAM1SIX2GDNFNOTCH1KITEPOWT1LIV2?FOXD1SFRP1KDRPBX1VSX2PDGFRBTBX18AXIN2RENNPHS1OSR1PAX2TCF21BMP7SIX1EYA1TBX18Development of ureteric collection systemRSPO3JAG1EGLN1FOXD1WNT5AHNF4ASMAD5714181349, 161046612engaged progenitorsrenalvesiclecomma-shapedS-shapedelongatedS-shapedmature nephrondistal tubuleHenle's loopProximal tubuleGlomerulusHNF1BHNF1BHNF1BHNF1BWT1distaldistalintermediatedistalWT1WT1WT1ppPAX2PAX2PAX2PAX2PAX2NOTCH1JAG1Development stagestromalprogenitorsdifferentiated stromal cellsmesangial cellspericytescapsule cellsinterstitial fibroblastsALDH1A2intermediatemesodermPeriWolffianmesenchymeUretermesenchymeUretersmooth muscleTBX1866MetanephricmesenchymeSIX27FOXD1CITED1716OSR1VSX27TLX111VSX211stromalprogenitorswithin kidney11EGLN28EGLN3Peripheral stroma8Renal capsuleCortical stromaMedullary stromaBMP4TNCFOXD1paraxialmesoderm13VSX2TLX111lateralmesoderm11mesenchymearound aortaVascular progenitorswithin kidney4Blood vesselsAngioblastsStromaBlood vesselsFAT4ALDH1A2NTN1PBX1DCNPDGFRBFAT4WT1CTNNB1RARATGFB1FAT4ALDH1A2acting on UBTCF21TCF21DCNTGFB1RARBRenin positive cellCTALMTALATLDTL2DTL1DCTCNTS3S2S1


Description

This pathway contains a timely and spatially differentiated map of cell markers for kidney development. These are relevant to study the congenital anomalies of kidney and urinary tract (CAKUT) disorders.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Yoshino K, Rubin JS, Higinbotham KG, Uren A, Anest V, Plisov SY, Perantoni AO; ''Secreted Frizzled-related proteins can regulate metanephric development.''; Mech Dev, 2001 PubMed Europe PMC Scholia
  2. Guillaume R, Bressan M, Herzlinger D; ''Paraxial mesoderm contributes stromal cells to the developing kidney.''; Dev Biol, 2009 PubMed Europe PMC Scholia
  3. Brunskill EW, Sequeira-Lopez ML, Pentz ES, Lin E, Yu J, Aronow BJ, Potter SS, Gomez RA; ''Genes that confer the identity of the renin cell.''; J Am Soc Nephrol, 2011 PubMed Europe PMC Scholia
  4. Schmidt-Ott KM, Chen X, Paragas N, Levinson RS, Mendelsohn CL, Barasch J; ''c-kit delineates a distinct domain of progenitors in the developing kidney.''; Dev Biol, 2006 PubMed Europe PMC Scholia
  5. Munro DAD, Hohenstein P, Davies JA; ''Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney.''; Sci Rep, 2017 PubMed Europe PMC Scholia
  6. Bohnenpoll T, Bettenhausen E, Weiss AC, Foik AB, Trowe MO, Blank P, Airik R, Kispert A; ''Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate.''; Dev Biol, 2013 PubMed Europe PMC Scholia
  7. Mugford JW, Sipilä P, McMahon JA, McMahon AP; ''Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney.''; Dev Biol, 2008 PubMed Europe PMC Scholia
  8. Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, Pfaff AS, Olauson H, Wernerson A, Fogo AB, Fong GH, Gross KW, Haase VH; ''Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin.''; J Clin Invest, 2016 PubMed Europe PMC Scholia
  9. Boyle S, Misfeldt A, Chandler KJ, Deal KK, Southard-Smith EM, Mortlock DP, Baldwin HS, de Caestecker M; ''Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia.''; Dev Biol, 2008 PubMed Europe PMC Scholia
  10. Schnabel CA, Godin RE, Cleary ML; ''Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney.''; Dev Biol, 2003 PubMed Europe PMC Scholia
  11. Yallowitz AR, Hrycaj SM, Short KM, Smyth IM, Wellik DM; ''Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma.''; PLoS One, 2011 PubMed Europe PMC Scholia
  12. Munro DAD, Wineberg Y, Tarnick J, Vink CS, Li Z, Pridans C, Dzierzak E, Kalisky T, Hohenstein P, Davies JA; ''Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development.''; Elife, 2019 PubMed Europe PMC Scholia
  13. Hatini V, Huh SO, Herzlinger D, Soares VC, Lai E; ''Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.''; Genes Dev, 1996 PubMed Europe PMC Scholia
  14. Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self M, Oliver G, McMahon AP; ''Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development.''; Cell Stem Cell, 2008 PubMed Europe PMC Scholia
  15. Wilson SB, Little MH; ''The origin and role of the renal stroma.''; Development, 2021 PubMed Europe PMC Scholia
  16. Boyle S, Shioda T, Perantoni AO, de Caestecker M; ''Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis.''; Dev Dyn, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129234view02:27, 16 March 2024EweitzOntology Term : 'progenitor cell' added !
129233view02:25, 16 March 2024EweitzOntology Term : 'mesangial cell' added !
129232view02:25, 16 March 2024EweitzOntology Term : 'pericyte' added !
129231view02:24, 16 March 2024EweitzOntology Term : 'kidney interstitial fibroblast' added !
129230view02:23, 16 March 2024EweitzOntology Term : 'podocyte' added !
129229view02:22, 16 March 2024EweitzOntology Term : 'parietal epithelial cell' added !
125331view22:25, 31 January 2023LarsgwFix reference bp:ID
124473view20:22, 30 October 2022AlexanderPicoconverted non-datanodes to labels; fixed xref
123339view19:30, 16 July 2022AlexanderPicoOntology Term : 'kidney cell' added !
122863view18:29, 25 May 2022MkutmonOntology Term : 'regulatory pathway' added !
122814view15:19, 20 May 2022Fehrhartwork in progress
122813view14:23, 20 May 2022FehrhartModified title
122812view14:17, 20 May 2022Fehrhart
122811view12:03, 20 May 2022FehrhartNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTA2GeneProductENSG00000107796 (Ensembl) α-SMA
ALDH1A2GeneProductENSG00000128918 (Ensembl)
AP2B1GeneProductENSG00000006125 (Ensembl)
AXIN2GeneProductENSG00000168646 (Ensembl)
BMP4GeneProductENSG00000125378 (Ensembl)
BMP7GeneProductENSG00000101144 (Ensembl)
CITED1GeneProductENSG00000125931 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
DCNGeneProductENSG00000011465 (Ensembl)
DESGeneProductENSG00000175084 (Ensembl) desmin
Development of ureteric collection systemPathwayWP5053 (WikiPathways)
EGLN1GeneProductENSG00000135766 (Ensembl) PHD2
EGLN2GeneProductENSG00000269858 (Ensembl) PHD1
EGLN3GeneProductENSG00000129521 (Ensembl) PHD3
EMX2GeneProductENSG00000170370 (Ensembl)
EPOGeneProductENSG00000130427 (Ensembl) Erythropoietin
EYA1GeneProductENSG00000104313 (Ensembl)
FAT4GeneProductENSG00000196159 (Ensembl)
FGF7GeneProductENSG00000140285 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FOXD1GeneProductENSG00000251493 (Ensembl)
GDNF/RET signaling axisPathwayWP4830 (WikiPathways)
GDNFGeneProductENSG00000168621 (Ensembl)
HNF1AGeneProductENSG00000135100 (Ensembl)
HNF1BGeneProductENSG00000275410 (Ensembl)
HNF4AGeneProductENSG00000101076 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
KCTD1GeneProductENSG00000134504 (Ensembl)
KDRGeneProductENSG00000128052 (Ensembl) FLK1
KITGeneProductENSG00000157404 (Ensembl) c-Kit
LHX1GeneProductENSG00000273706 (Ensembl)
LIV2?GeneProduct
NOTCH1GeneProductENSG00000148400 (Ensembl)
NOTCH2?GeneProduct
NPHS1GeneProductENSG00000161270 (Ensembl)
NPHS2GeneProductENSG00000116218 (Ensembl)
NT5EGeneProductENSG00000135318 (Ensembl) membrane-bound enzyme ecto-50-nucleotidase (50NT)
NTN1GeneProductENSG00000065320 (Ensembl) Netrin 1
OSR1GeneProductENSG00000143867 (Ensembl)
PAX2GeneProductENSG00000075891 (Ensembl)
PBX1GeneProductENSG00000185630 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl) Tenascin C
PECAM1GeneProductENSG00000261371 (Ensembl) CD31
RARAGeneProductENSG00000131759 (Ensembl)
RARBGeneProductENSG00000077092 (Ensembl)
RENGeneProductENSG00000143839 (Ensembl) renin
RSPO1GeneProductENSG00000169218 (Ensembl)
RSPO3GeneProductENSG00000146374 (Ensembl)
SALL1GeneProductENSG00000103449 (Ensembl)
SFRP1GeneProductENSG00000104332 (Ensembl)
SIX1GeneProductENSG00000126778 (Ensembl)
SIX2GeneProductENSG00000170577 (Ensembl)
SMAD1GeneProductENSG00000170365 (Ensembl)
SMAD5GeneProductENSG00000113658 (Ensembl)
TBX18GeneProductENSG00000112837 (Ensembl)
TCF21GeneProductENSG00000118526 (Ensembl) POD1
TGFB1GeneProductENSG00000105329 (Ensembl)
TLX1GeneProductENSG00000107807 (Ensembl) alternative name HOX11
TNCGeneProductENSG00000041982 (Ensembl) Tenascin C
VSX2GeneProductENSG00000119614 (Ensembl) alternative name HOX10
WNT4GeneProductENSG00000162552 (Ensembl)
WNT5AGeneProductENSG00000114251 (Ensembl)
WNT?GeneProduct
WT1GeneProductENSG00000184937 (Ensembl)

Annotated Interactions

No annotated interactions

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