Direct reversal repair (Homo sapiens)

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Description

Direct reversal repair is a mechanism of repair where the damaged area or lesion is repaired directly by specialized proteins. It does not involve breakage of the phosphodiester backbone and doesn't require a reference template unlike the other single-strand repair mechanism. Methylation of guanine bases is directly reversed by the protein methyl guanine methyl transferase (MGMT). This is an expensive process because each MGMT molecule can be used only once. Methylation of the bases cytosine and adenine is repaired by ALKBH2 and ALKBH3. This pathway is based on information from REPAIRtoire and Wikipedia.

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Ontology Terms

 

Bibliography

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  1. ''Direct reversal repair''; REPAIRtoire,
  2. Fang Q; ''The Versatile Attributes of MGMT: Its Repair Mechanism, Crosstalk with Other DNA Repair Pathways, and Its Role in Cancer.''; Cancers (Basel), 2024 PubMed Europe PMC Scholia
  3. Kanazhevskaya LY, Smyshliaev DA, Timofeyeva NA, Ishchenko AA, Saparbaev M, Kuznetsov NA, Fedorova OS; ''Conformational Dynamics of Human ALKBH2 Dioxygenase in the Course of DNA Repair as Revealed by Stopped-Flow Fluorescence Spectroscopy.''; Molecules, 2022 PubMed Europe PMC Scholia
  4. Gutierrez R, O'Connor TR; ''DNA direct reversal repair and alkylating agent drug resistance.''; Cancer Drug Resist, 2021 PubMed Europe PMC Scholia
  5. Gutierrez R, Chan AYS, Lai SWT, Itoh S, Lee DH, Sun K, Battad A, Chen S, O'Connor TR, Shuck SC; ''Lack of mismatch repair enhances resistance to methylating agents for cells deficient in oxidative demethylation.''; J Biol Chem, 2024 PubMed Europe PMC Scholia
  6. You C, Wang P, Nay SL, Wang J, Dai X, O'Connor TR, Wang Y; ''Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated and Ethylated Thymidine Lesions.''; ACS Chem Biol, 2016 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
141432view11:53, 14 November 2025DeSlAdded refs for drie proteins individually, and two describing all three in relationship to PW title
141351view03:08, 11 November 2025EweitzClear cached dimensions
141350view03:08, 11 November 2025EweitzEconomize layout
136381view01:24, 1 February 2025KhanspersModified description
136380view01:23, 1 February 2025Khanspersupdated reference
136379view01:22, 1 February 2025KhanspersOntology Term : 'regulatory pathway' added !
136378view01:21, 1 February 2025Khanspersupdated color on object
136377view01:20, 1 February 2025Khanspersadded reference, added labels to groups
117699view12:21, 22 May 2021EweitzModified title
110595view06:09, 20 May 2020KhanspersOntology Term : 'DNA repair pathway' added !
110594view05:55, 20 May 2020KhanspersModified description
110593view05:39, 20 May 2020Khanspersdecreased board height
110592view05:39, 20 May 2020Khanspersdecreased board height
110591view05:38, 20 May 2020KhanspersNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
ALKBH2GeneProductENSG00000189046 (Ensembl)
ALKBH3GeneProductENSG00000166199 (Ensembl)
MGMTGeneProductENSG00000170430 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4931"