DNA replication (Caenorhabditis elegans)

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Mcm2DNA polymerase alpha: primase: origin complexPhosphorylated Cdc6dATPPre-replicative complex4. Switching of origins to post-replicative stateADPOrc5Orc1RNA primer-DNA primer:origin duplex:PCNAOrc complexp49Orc3Orc2RFC140UbiquitinMcm7Ubiquitinated Orc1RFC Heteropentamer:RNA primer-DNA primerATPOrc55. Leading/lagging strand synthesisDegraded by proteasome in cytosolCdc6Orc complexDNA PolymeraseGTPMcm 4,6,7 trimer forms and associatesCdc6Orc4Originp180Mcm3Cdt1Cdt1Mcm4Orc2PrimaseATPMcm3CTPDegraded by proteasome in cytosolMcm2RFC Heteropentamer:RNA primer-DNA primer:Orc3Orc5Phosphorylation of Mcm 2-7 complexMcm6dCTPCdc6RNA primer-DNA primer3. DNA replication initiationOrc complexOrc2Pre-replicative complexMcm6ATPUbiquitinated Cdc6Cdc6Orc2p58with the replication forkMcm5DNA polymerase alpha: primase: origin complexMcm10RNA PrimerdGTPCdt1Phosphorylated Orc1Orc3Ubiquitin2. Activation of the pre-replicative complexdUTPGemininRNA primer-DNA primerp70Cdt1RFC40aOrc3Processive complexRFC36Orc complexOrc ComplexUTPMcm7Orc41. Assembly of the pre-replicative complexRFC37Mcm5ADPPCNA homotrimerCdt1Mcm4RFC38ATPdiv-1ARPAcdc-6pri-2F34D10.2orc-2F33H2.5mcm-6PCNAmcm-4ORC5LRFC4CDC7F10C2.4mcm-2RPA3ASKRPA4GMNNORC4LPOLD2mcm-3ORC3LY39A1A.12mcm-7F08B4.5ubq-1POLD4ORC6LCDT1RPA2rfc-3Y47D3A.28CDK2ubq-2rfc-1RPA1rfc-2pri-1CDC46POLD3Y47D3A.29


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms

 

Bibliography

  1. Brauchle M, Baumer K, Gönczy P; ''Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  2. Rose A.; ''Replication and repair''; WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook, 2014 DOI Scholia

History

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CompareRevisionActionTimeUserComment
125278view16:10, 31 January 2023LarsgwAdd DOI to publication
118534view11:08, 28 May 2021DeSlAdded 2 lit. refs
118433view14:37, 27 May 2021UlasBabayigitConnected all lines to their nodes/labels
118149view10:40, 25 May 2021EweitzModified title
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct (Entrez Gene)
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct (Entrez Gene)
CDK2GeneProduct (Entrez Gene)
CDT1GeneProduct (Entrez Gene)
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct (Entrez Gene)
ORC3LGeneProduct (Entrez Gene)
ORC4LGeneProduct (Entrez Gene)
ORC5LGeneProduct (Entrez Gene)
ORC6LGeneProduct (Entrez Gene)
PCNAGeneProduct (Entrez Gene)
POLD2GeneProduct (Entrez Gene)
POLD3GeneProduct (Entrez Gene)
POLD4GeneProduct (Entrez Gene)
RFC4GeneProduct (Entrez Gene)
RPA1GeneProduct (Entrez Gene)
RPA2GeneProduct (Entrez Gene)
RPA3GeneProduct (Entrez Gene)
RPA4GeneProduct (Entrez Gene)
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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