Nanoparticle triggered regulated necrosis (Homo sapiens)
From WikiPathways
Description
No description
Quality Tags
Ontology Terms
Bibliography
- Andón FT, Fadeel B; ''Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials.''; Acc Chem Res, 2012 PubMed Europe PMC Scholia
- Ma YH, Huang CP, Tsai JS, Shen MY, Li YK, Lin LY; ''Water-soluble germanium nanoparticles cause necrotic cell death and the damage can be attenuated by blocking the transduction of necrotic signaling pathway.''; Toxicol Lett, 2011 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ATP ↓ | Metabolite | ||
Arachidonic acid | Metabolite | HMDB01043 (HMDB) | |
CASP8 | GeneProduct | ENSG00000064012 (Ensembl) | |
Calcium | Metabolite | HMDB00464 (HMDB) | |
Calpains | |||
Ceramide | Ceramide (Wikipedia) | ||
FADD | GeneProduct | ENSG00000168040 (Ensembl) | |
Ferritin | Protein | P02792 (Uniprot-TrEMBL) | |
Ge NP | |||
Glutaminolysis | Glutaminolysis (Wikipedia) | ||
Glycogenolysis | Glycogenolysis (Wikipedia) | ||
Glycolysis | Glycolysis (Wikipedia) | ||
Iron | Metabolite | HMDB00692 (HMDB) | |
JNK | GeneProduct | ENSG00000107643 (Ensembl) | |
Labile iron pool | |||
Nec-1 | Metabolite | 2828334 (PubChem-compound) | |
Necroptosis | Pathway | ||
PAMPs | |||
PARP1 | GeneProduct | ENSG00000143799 (Ensembl) | |
RIPK1 | GeneProduct | ENSG00000137275 (Ensembl) | |
RIPK3 | GeneProduct | ENSG00000129465 (Ensembl) | |
ROS | Metabolite | CHEBI:26523 (ChEBI) | |
SMases | Sphingomyelinase (Wikipedia) | ||
TLRs | Protein | Toll-like_receptor (Wikipedia) | |
TNFR1 | GeneProduct | ENSG00000067182 (Ensembl) | |
TNF | Protein | TNF (Uniprot-TrEMBL) | |
TRADD | GeneProduct | ENSG00000102871 (Ensembl) | |
TRIF | GeneProduct | ENSG00000127666 (Ensembl) | |
cPLA₂ | |||
lipoxygenase | |||
pH ↓ |
Annotated Interactions
No annotated interactions