DNA replication (Caenorhabditis elegans)

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Ubiquitinp180Mcm7Orc3Mcm5p58RFC Heteropentamer:RNA primer-DNA primer:OriginMcm6Ubiquitinated Orc1PrimaseATPMcm5Orc5Mcm6Cdc6Cdc6PCNA homotrimerADPMcm2Orc2DNA polymerase alpha: primase: origin complexATPRNA PrimerRNA primer-DNA primer:origin duplex:PCNAProcessive complexOrc34. Switching of origins to post-replicative state2. Activation of the pre-replicative complexDegraded by proteasome in cytosoldATPdGTPOrc complexATPCdt1Mcm4UTPOrc ComplexCdc6RFC36RFC37Ubiquitinated Cdc6ATPOrc2Orc2GTPwith the replication forkPhosphorylated Cdc6RFC Heteropentamer:RNA primer-DNA primerMcm3Mcm 4,6,7 trimer forms and associatesOrc4p49aOrc complexRNA primer-DNA primerCTPdUTPRFC38Orc complexOrc5Phosphorylation of Mcm 2-7 complexOrc4Cdt1Orc complex5. Leading/lagging strand synthesis3. DNA replication initiationMcm41. Assembly of the pre-replicative complexADPMcm10RNA primer-DNA primerOrc5Orc2Cdt1Mcm2UbiquitinGemininMcm3Degraded by proteasome in cytosolDNA polymerase alpha: primase: origin complexDNA PolymeraseCdc6Pre-replicative complexRFC140dCTPRFC40p70Cdt1Pre-replicative complexOrc3Phosphorylated Orc1Mcm7Orc3Cdt1Orc1RPA4Y47D3A.28POLD4Y47D3A.29mcm-6Y39A1A.12F10C2.4CDC7ubq-1ORC3LASKCDK2pri-1ORC5Lubq-2orc-2rfc-2rfc-1POLD3ORC6LRPA1RPA2mcm-2mcm-3ARPAdiv-1CDC46CDT1mcm-7rfc-3mcm-4pri-2RPA3F33H2.5POLD2ORC4LPCNAF08B4.5GMNNRFC4cdc-6F34D10.2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Brauchle M, Baumer K, Gönczy P; ''Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  2. Rose A.; ''Replication and repair''; WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook, 2014 DOI Scholia

History

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CompareRevisionActionTimeUserComment
125278view16:10, 31 January 2023LarsgwAdd DOI to publication
118534view11:08, 28 May 2021DeSlAdded 2 lit. refs
118433view14:37, 27 May 2021UlasBabayigitConnected all lines to their nodes/labels
118149view10:40, 25 May 2021EweitzModified title
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct (Entrez Gene)
ATPMetaboliteCHEBI:15422 (ChEBI)
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct (Entrez Gene)
CDK2GeneProduct (Entrez Gene)
CDT1GeneProduct (Entrez Gene)
CTPMetaboliteCHEBI:17677 (ChEBI)
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct (Entrez Gene)
GTPMetaboliteCHEBI:15996 (ChEBI)
ORC3LGeneProduct (Entrez Gene)
ORC4LGeneProduct (Entrez Gene)
ORC5LGeneProduct (Entrez Gene)
ORC6LGeneProduct (Entrez Gene)
PCNAGeneProduct (Entrez Gene)
POLD2GeneProduct (Entrez Gene)
POLD3GeneProduct (Entrez Gene)
POLD4GeneProduct (Entrez Gene)
RFC4GeneProduct (Entrez Gene)
RPA1GeneProduct (Entrez Gene)
RPA2GeneProduct (Entrez Gene)
RPA3GeneProduct (Entrez Gene)
RPA4GeneProduct (Entrez Gene)
UTPMetaboliteCHEBI:15713 (ChEBI)
UbiquitinProtein
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
dATPMetaboliteCHEBI:16284 (ChEBI)
dCTPMetaboliteCHEBI:16311 (ChEBI)
dGTPMetaboliteCHEBI:16497 (ChEBI)
dUTPMetaboliteCHEBI:17625 (ChEBI)
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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