Methionine de novo and salvage pathway (Homo sapiens)
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Carbon monoxide
AMD1
ATP
IL4I1
Diphosphate
Methionine Salvage Pathway
L-Methionine
Formic acid
CHDH
Cellular Proliferation
Methionine sulfoxide
S-Adenosylhomocysteine
Cobalamin
Tetrahydrofolic acid
Homocysteine
5-(methylthio)-2,3-dioxopentyl phosphate ???
Carbon dioxide
SMS
Ornithine
S-Adenosylmethionine
Carbon dioxide
Iron
5-Methylthioribose 1-phosphate
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one ???
Glycine
Oxygen
ROS
Zinc
SRM
DNA & Protein Methylation
NAD
Water
MAT2A
ENOPH1
Water
AHCY
Phosphate
Pyruvate
Sarcosine
MRI1
GNMT
S-Adenosylmethioninamine
Adenine
ALDH7A1
Phosphate
MAT2B
2-Oxo-4-methylthiobutanoic acid
APIP
ADI1
MAT1A
3-Methylthiopropionic acid
ODC1
Water
TAT
5-Methylthioribulose 1-phosphate
Methionine De Novo Pathway
Dimethylglycine
Adenosine
Spermine
Protein-bound Methionine
5-Methyltetrahydrofolic acid
MTR
DNA containing 5-methylcytosine
MTAP
DNA
Nickel
Putrescine
Choline
Folic Acid Cycle
5'-Methylthioadenosine
Spermidine
Betaine
ADI1
MSRA
MSRB2
MSRB3
DNMT1
BHMT
Phosphate
Free/Protein
Methionine Equilibrium
ROS
Polyamine Biosynthesis
Zinc
Description
No description
Comments
Methionine Salvage Pathway KEGG
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Quality Tags
Ontology Terms
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Bibliography
Alvarez L, Corrales F, Martin-Duce A, Mato JM; ''Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: tissue-specific gene expression and mRNA levels in hepatopathies.''; Biochem J, 1993
PubMed
Europe PMC
Scholia
''Cysteine and methionine metabolism''; https://www.kegg.jp/dbget-bin/www_bget?pathway+map00270,
History
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Compare
Revision
Action
Time
User
Comment
127752
view
11:27, 2 December 2023
Egonw
ChEBI id for K+ instead of the "K" atom
120915
view
06:19, 31 January 2022
Egonw
Replaced an old HMDB identifier with the current one
119246
view
19:25, 22 June 2021
Finterly
added KEGG pathway info to publicationXref
118456
view
15:00, 27 May 2021
Marvin M2
added title to kegg ref
118413
view
14:17, 27 May 2021
Mkutmon
fix publication refs
117788
view
14:04, 22 May 2021
Eweitz
Modified title
107143
view
14:22, 17 September 2019
MaintBot
ChEBI identifier normalization
106740
view
13:22, 17 September 2019
MaintBot
HMDB identifier normalization
106510
view
20:52, 5 September 2019
Khanspers
added reference
106509
view
20:51, 5 September 2019
Khanspers
Modified description
105648
view
05:11, 10 August 2019
Khanspers
Modified description
96434
view
07:27, 15 March 2018
Egonw
Replaced secondary ChEBI identifiers with primary identifiers.
94518
view
19:44, 16 September 2017
AlexanderPico
Ontology Term : 'classic metabolic pathway' added !
94517
view
19:43, 16 September 2017
AlexanderPico
Ontology Term : 'methionine biosynthetic pathway' added !
94304
view
11:25, 1 September 2017
Marvin M2
Connected the last unconnected line
94226
view
23:04, 25 August 2017
DeSl
Annoatated metabolites with missing IDs.
94225
view
22:44, 25 August 2017
DeSl
Modified description
88173
view
13:37, 29 July 2016
Mkutmon
work in progress
83805
view
03:55, 11 December 2015
Mkutmon
update Polyamine Biosynthesis part
83804
view
02:49, 11 December 2015
Mkutmon
updated version of the pathway
83678
view
03:17, 2 December 2015
Mkutmon
layout
83677
view
03:06, 2 December 2015
Mkutmon
layotu
83676
view
03:00, 2 December 2015
Mkutmon
connected lines
83522
view
03:08, 20 November 2015
Paul Cavuoto
Specify description
83521
view
02:59, 20 November 2015
Paul Cavuoto
Periodical save, work in progress
83520
view
02:49, 20 November 2015
Paul Cavuoto
Periodical save, work in progress
83519
view
02:39, 20 November 2015
Paul Cavuoto
Periodical save, work in progress
83499
view
06:06, 19 November 2015
Mkutmon
layout update
83498
view
05:46, 19 November 2015
Mkutmon
using mim conversion instead of arrow to add more semantic meaning to the interactions
83497
view
05:33, 19 November 2015
Paul Cavuoto
Specify description
83496
view
05:16, 19 November 2015
Paul Cavuoto
Update pathway
83495
view
04:52, 19 November 2015
Paul Cavuoto
Periodical save, work in progress
83494
view
04:12, 19 November 2015
Mkutmon
layout
83493
view
04:11, 19 November 2015
Mkutmon
layout
83492
view
04:04, 19 November 2015
Mkutmon
Modified description
83491
view
04:03, 19 November 2015
Mkutmon
83490
view
03:49, 19 November 2015
Mkutmon
layout update
83489
view
03:48, 19 November 2015
Mkutmon
testing curved lines
83488
view
03:47, 19 November 2015
Mkutmon
using labels instead of pathway nodes
83487
view
03:40, 19 November 2015
Mkutmon
changed Ensembl Human to Ensembl
83486
view
03:38, 19 November 2015
Mkutmon
layout work in progress
83485
view
03:15, 19 November 2015
Mkutmon
layout update in progress
83484
view
03:04, 19 November 2015
Mkutmon
updating layout
83483
view
02:40, 19 November 2015
Paul Cavuoto
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one ???
Metabolite
HMDB12134 (HMDB)
2-Oxo-4-methylthiobutanoic acid
Metabolite
HMDB01553 (HMDB)
3-Methylthiopropionic acid
Metabolite
HMDB01527 (HMDB)
5'-Methylthioadenosine
Metabolite
HMDB01173 (HMDB)
5-(methylthio)-2,3-dioxopentyl phosphate ???
Metabolite
5-Methyltetrahydrofolic acid
Metabolite
HMDB01396 (HMDB)
5-Methylthioribose 1-phosphate
Metabolite
HMDB00963 (HMDB)
5-Methylthioribulose 1-phosphate
Metabolite
HMDB01299 (HMDB)
ADI1
GeneProduct
ENSG00000182551 (Ensembl Human)
AHCY
GeneProduct
ENSG00000101444 (Ensembl)
ALDH7A1
GeneProduct
ENSG00000164904 (Ensembl)
AMD1
GeneProduct
ENSG00000123505 (Ensembl Human)
APIP
GeneProduct
ENSG00000149089 (Ensembl)
ATP
Metabolite
HMDB00538 (HMDB)
Adenine
Metabolite
HMDB00034 (HMDB)
Adenosine
Metabolite
HMDB00050 (HMDB)
BHMT
GeneProduct
ENSG00000145692 (Ensembl Human)
Betaine
Metabolite
HMDB00043 (HMDB)
CHDH
GeneProduct
ENSG00000016391 (Ensembl Human)
Carbon dioxide
Metabolite
HMDB01967 (HMDB)
Carbon monoxide
Metabolite
HMDB01361 (HMDB)
Cellular Proliferation
Pathway
Choline
Metabolite
HMDB00097 (HMDB)
Cobalamin
Metabolite
HMDB02174 (HMDB)
DNA
Metabolite
DNA & Protein Methylation
Pathway
DNA containing 5-methylcytosine
Metabolite
DNMT1
GeneProduct
ENSG00000130816 (Ensembl)
Dimethylglycine
Metabolite
HMDB00092 (HMDB)
Diphosphate
Metabolite
ENOPH1
GeneProduct
ENSG00000145293 (Ensembl Human)
Folic Acid Cycle
Pathway
Formic acid
Metabolite
HMDB00142 (HMDB)
Free/Protein Methionine Equilibrium
Pathway
GNMT
GeneProduct
ENSG00000124713 (Ensembl)
Glycine
Metabolite
HMDB00123 (HMDB)
Homocysteine
Metabolite
HMDB00742 (HMDB)
IL4I1
GeneProduct
ENSG00000104951 (Ensembl Human)
Iron
Metabolite
HMDB00692 (HMDB)
L-Methionine
Metabolite
HMDB00696 (HMDB)
MAT1A
GeneProduct
ENSG00000151224 (Ensembl Human)
MAT2A
GeneProduct
ENSG00000168906 (Ensembl Human)
MAT2B
GeneProduct
ENSG00000038274 (Ensembl Human)
MRI1
GeneProduct
ENSG00000037757 (Ensembl)
MSRA
GeneProduct
ENSG00000175806 (Ensembl Human)
MSRB2
GeneProduct
ENSG00000148450 (Ensembl Human)
MSRB3
GeneProduct
ENSG00000174099 (Ensembl Human)
MTAP
GeneProduct
ENSG00000099810 (Ensembl)
MTR
GeneProduct
ENSG00000116984 (Ensembl Human)
Methionine De Novo Pathway
Pathway
Methionine Salvage Pathway
Pathway
Methionine sulfoxide
Metabolite
HMDB02005 (HMDB)
NAD
Metabolite
HMDB00902 (HMDB)
Nickel
Metabolite
HMDB02457 (HMDB)
ODC1
GeneProduct
ENSG00000115758 (Ensembl)
Ornithine
Metabolite
HMDB00214 (HMDB)
Oxygen
Metabolite
HMDB01377 (HMDB)
Phosphate
Metabolite
Phosphate
Metabolite
HMDB01429 (HMDB)
Polyamine Biosynthesis
Pathway
Protein-bound Methionine
Metabolite
Putrescine
Metabolite
HMDB01414 (HMDB)
Pyruvate
Metabolite
ROS
Pathway
S-Adenosylhomocysteine
Metabolite
HMDB00939 (HMDB)
S-Adenosylmethioninamine
Metabolite
HMDB00988 (HMDB)
S-Adenosylmethionine
Metabolite
HMDB01185 (HMDB)
SMS
GeneProduct
ENSG00000102172 (Ensembl)
SRM
GeneProduct
ENSG00000116649 (Ensembl)
Sarcosine
Metabolite
HMDB00271 (HMDB)
Spermidine
Metabolite
HMDB01257 (HMDB)
Spermine
Metabolite
HMDB01256 (HMDB)
TAT
GeneProduct
ENSG00000198650 (Ensembl Human)
Tetrahydrofolic acid
Metabolite
HMDB01846 (HMDB)
Water
Metabolite
HMDB02111 (HMDB)
Zinc
Metabolite
HMDB01303 (HMDB)
Annotated Interactions
No annotated interactions
Views
Pathway
Discussion
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View approved pathways at the new wikipathways.org.Quality Tags
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DataNodes
Annotated Interactions
No annotated interactions