Diclofenac metabolic pathway (Homo sapiens)

Revision as of 13:12, 19 November 2020 by DeSl (Talk | contribs)

Description

CYP metabolism of the diclofenac drug.

View approved pathways at the new wikipathways.org.

Bort R, Macé K, Boobis A, Gómez-Lechón MJ, Pfeifer A, Castell J; ''Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.''; Biochem Pharmacol, 1999 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
117698	view	12:20, 22 May 2021	Eweitz	Modified title
113831	view	08:41, 30 November 2020	Fehrhart	Ontology Term : 'Disease' added !
113747	view	13:12, 19 November 2020	DeSl	Updated description.
92287	view	12:39, 19 May 2017	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
73891	view	09:56, 2 March 2014	Egonw	Modified description
71432	view	19:03, 17 October 2013	MaintBot	updated data sources
70516	view	12:45, 9 August 2013	Egonw	Added a missing metabolite identifier.
70515	view	12:43, 9 August 2013	Egonw	Ontology Term : 'phase I biotransformation pathway via cytochrome P450' added !
62552	view	23:34, 29 April 2013	AlexanderPico	Modified representation of group
62341	view	22:23, 27 April 2013	MaintBot	Modified categories
62324	view	15:10, 27 April 2013	Egonw	Added Uniprot IDs
62323	view	15:02, 27 April 2013	Egonw	Readded the lit ref that was removed by the previous applet edit.
62320	view	14:36, 27 April 2013	Egonw	Completed all reactions from the paper.
62317	view	14:04, 27 April 2013	Egonw	Added a name for the CYP product.
62316	view	13:42, 27 April 2013	Egonw	New pathway

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Name	Type	Database reference
3'-Hydroxydiclofenac	Metabolite	112230 (PubChem-compound)
4',5-Dihydroxydiclofenac	Metabolite	3052567 (PubChem-compound)
4'-hydroxydiclofenac	Metabolite	116545 (PubChem-compound)
5-hydroxydiclofenac	Metabolite	3052566 (PubChem-compound)
CYP2B6	Protein	P20813 (Uniprot-TrEMBL)
CYP2C18	Protein	P33260 (Uniprot-TrEMBL)
CYP2C19	Protein	P33261 (Uniprot-TrEMBL)
CYP2C8	Protein	P10632 (Uniprot-TrEMBL)
CYP2C9	Protein	Q6IRV8 (Uniprot-TrEMBL)
Metabolite	Metabolite	10065052 (PubChem-compound)
diclofenac	Metabolite	3033 (PubChem-compound)

No annotated interactions