Aryl hydrocarbon receptor pathway (Homo sapiens)

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153116, 281945, 56224434514484, 30, 53503649, 5442STAT114CyNuHSP9029ActivationTCDD16CyNuNEDD8SUMO7CyNuCyNuNucleusProteinProteinCYP1A1ARNTPAHp27Kip1EBNA-3EGFRproliferation and tumorigenesis CCL1Hsp90Nrf2XRETCDDp300Calcium ChannelAIPNqo1ZAC1pRbVEGFKLF6RETERDRE region15, 18, 255724, 3536, 38L12, 41AIP52465016, 28, 3210, 47, 53833425527PAHRP233, 29AHRAHRHSP901611, 40HSP9026C-myc13TATAEGFR PathwayTNF-α4CDC37c-srcRAF1P54PMAP2K1ERK1/2PCOX-222SRC-1Rel Ap50Rel Ap50p300SRC-19AngiogenesisERAP140RIP140CYP1A1CD36Lpl6Nrf2Fgf21GstsGclcOxidative StressRIP140NF-1NCOA7SMRT243CYP1A237CYP1B11, 23Estrogen MetabolismEnzyme ComplexProteinReceptorLigandmRNASmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMoleculep21cip117, 21CDK2RbE2F1Cell cycle inhibitionDetoxification of Xenobiotics and metabolism of xenobioticsCell SurvivalAHRRp30039FAS/ FAS-L (Apoptosis)NRASHRASKRASTCDDPAH15, 18, 2524, 357Cell Survivalmodulation of Estrogen receptor signalling


Description

The Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or polycyclic aromatic hydrocarbons which are widespread environmental pollutant causing a variety of severe health effects, e.g. immunosuppression, carcinogenesis and hepatotoxicity.

AhR is a member of basic helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. In the absence of ligand, the AhR can be found in the cytosol, bound to a dimer of the heat shock protein of 90 kDa (Hsp90) and the immunophilin-like protein, AIP (also known as XAP2 and ARA9). Upon ligand binding, the AHR translocates to the nucleus and binds with ARNT. The AHR/ARNT heterodimer binds to xenobiotic response elements and regulates a diverse set of genes.

This pathway is part the CPTAC Assay Portal.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
126477view20:59, 5 May 2023EgonwAdded an identifier for the calcium channel
121728view01:30, 27 February 2022EweitzUse gene symbols
121727view20:09, 26 February 2022EweitzReplace text node with gene node in complex, and replace its references
121726view19:56, 26 February 2022EweitzCopy BiopaxRef to new node
121725view19:52, 26 February 2022EweitzDraft change
121724view19:35, 26 February 2022EweitzRefine case and copyediting
120796view20:59, 8 January 2022AlexanderPicoReverted to version '04:12, 17 December 2021' by AlexanderPico
120574view11:14, 17 December 2021EweitzModified description
120573view11:12, 17 December 2021EweitzModified title
117654view11:46, 22 May 2021EweitzModified title
115347view10:30, 15 February 2021EgonwMade six more pathways clickable
107439view07:01, 8 October 2019DeSlModified title
107135view14:21, 17 September 2019MaintBotChEBI identifier normalization
106305view17:45, 20 August 2019KhanspersModified description
105536view06:04, 9 August 2019KhanspersModified description
91687view13:42, 29 March 2017DeSlAnnotation update for several datanodes
91671view13:20, 29 March 2017DeSlAnnotation update for angiogenesis
89793view10:53, 6 October 2016Mkutmonfixed special character in datanode label
88982view09:41, 18 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
88981view09:40, 18 August 2016MirellaKalafatiReverted to version '08:09, 17 August 2016' by MirellaKalafati
88901view08:13, 17 August 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
88900view08:09, 17 August 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
88899view08:09, 17 August 2016MirellaKalafatiOntology Term : 'DOID:5395' removed !
85335view16:12, 7 May 2016EgonwReplaced a mim-conversion with Arrow.
79995view21:04, 29 April 2015ZariAnnotated EBNA-3,COX-2,ERK1/2 , CYP1A1 and Gsts
78547view10:30, 7 January 2015MaintBotadded missing graphIds
76318view06:58, 2 July 2014Mkutmonfixed datasource for pRb datanode
73592view16:10, 3 February 2014Prakamya1986Modified description
73591view16:06, 3 February 2014Prakamya1986Modified description
73590view15:53, 3 February 2014Prakamya1986Specify description
73436view16:30, 28 January 2014Prakamya1986Specify description
73435view16:20, 28 January 2014Prakamya1986Specify description
73434view16:16, 28 January 2014Prakamya1986Periodical save, work in progress
73433view16:09, 28 January 2014Prakamya1986Specify description
73432view16:05, 28 January 2014Prakamya1986Periodical save, work in progress
73431view15:54, 28 January 2014Prakamya1986Specify description
73430view15:52, 28 January 2014Prakamya1986Specify description
73429view14:44, 28 January 2014Prakamya1986Specify description
73385view12:14, 25 January 2014Prakamya1986Specify description
73384view12:13, 25 January 2014Prakamya1986Specify description
73383view12:12, 25 January 2014Prakamya1986Specify description
73340view17:01, 21 January 2014Prakamya1986Specify description
73339view16:54, 21 January 2014Prakamya1986Specify description
73338view16:50, 21 January 2014Prakamya1986Specify description
73337view16:39, 21 January 2014Prakamya1986Specify description
73336view16:27, 21 January 2014Prakamya1986Specify description
73335view16:18, 21 January 2014Prakamya1986Specify description
73334view16:03, 21 January 2014Prakamya1986Specify description
73333view15:59, 21 January 2014Prakamya1986Periodical save, work in progress
73332view15:31, 21 January 2014Prakamya1986Specify description

External references

DataNodes

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NameTypeDatabase referenceComment
AHRGeneProduct196 (Entrez Gene)
AHRRGeneProduct57491 (Entrez Gene)
AIPGeneProductENSG00000110711 (Ensembl)
ARNTGeneProduct405 (Entrez Gene)
AngiogenesisPathwayWP1539 (WikiPathways)
C-mycProtein4609 (Entrez Gene)
CCL1GeneProduct6346 (Entrez Gene) PMID: 16679317 PAHs induce expression of the chemokine CCL1 in an AhR- and calcium-dependent manner.
CD36GeneProduct948 (Entrez Gene)
CDC37GeneProduct11140 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
COX-2GeneProduct5743 (Entrez Gene)
CYP1A1Protein1543 (Entrez Gene)
CYP1A2GeneProduct1544 (Entrez Gene)
CYP1B1GeneProduct1545 (Entrez Gene)
Calcium Channel
Cell SurvivalPathway
Cell Survival Pathway
Cell cycle inhibitionPathway
DRE regionComplex
Detoxification of Xenobiotics and metabolism of xenobiotics Pathway
E2F1GeneProduct1869 (Entrez Gene)
EBNA-3Protein17494212 (Entrez Gene)
EGFR PathwayPathwayWP1910 (WikiPathways)
EGFRGeneProduct1956 (Entrez Gene)
ERProtein2099 (Entrez Gene) Estrogen Receptor
ERAP140Protein135112 (Entrez Gene) Official Symbol= NCOA7
ERK1/2 Protein5594 (Entrez Gene)
Estrogen MetabolismPathwayWP697 (WikiPathways)
FAS/ FAS-L (Apoptosis)PathwayWP254 (WikiPathways)
Fgf21Protein26291 (Entrez Gene)
GclcProtein2729 (Entrez Gene)
GstsProtein27306 (Entrez Gene)
HRASGeneProductENSG00000174775 (Ensembl)
HSP90GeneProduct3320 (Entrez Gene)
Hsp90Protein3320 (Entrez Gene)
KLF6GeneProduct1316 (Entrez Gene)
KRASGeneProductENSG00000133703 (Ensembl)
LplProtein4023 (Entrez Gene) lipoprotein lipase
MAP2K1GeneProductENSG00000169032 (Ensembl)
NCOA7Protein135112 (Entrez Gene)
NF-1Protein4763 (Entrez Gene)
NRASGeneProductENSG00000213281 (Ensembl)
Nqo1Protein1728 (Entrez Gene)
Nrf2GeneProduct4780 (Entrez Gene)
Oxidative Stress PathwayWP408 (WikiPathways)
P23GeneProductENSG00000110711 (Ensembl)
PAHMetabolite33848 (ChEBI)
RAF1GeneProductENSG00000132155 (Ensembl)
RETProtein5979 (Entrez Gene)
RIP140Protein8204 (Entrez Gene)
RbGeneProduct5925 (Entrez Gene)
Rel AGeneProduct5970 (Entrez Gene)
SMRTProtein9612 (Entrez Gene)
SRC-1GeneProduct84722 (Entrez Gene)
TATAComplex
TCDDMetabolite28119 (ChEBI)
TNF-αGeneProduct7124 (Entrez Gene)
VEGFGeneProduct7422 (Entrez Gene)
XRExenobiotic responsive element
ZAC1Protein5325 (Entrez Gene)
c-srcProtein6714 (Entrez Gene)
modulation of Estrogen receptor signallingPathwayWP712 (WikiPathways)
p21cip1GeneProduct1026 (Entrez Gene)
p27Kip1GeneProduct1027 (Entrez Gene)
p300Protein2033 (Entrez Gene)
p50GeneProduct4790 (Entrez Gene)
pRbProteinP06400 (Uniprot-TrEMBL)
proliferation and tumorigenesis Pathway

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2586"
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