Portal:CPTAC
From WikiPathways
CPTAC Pathways
Welcome to the CPTAC Pathway PortalThis portal highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC). The National Cancer Institute, part of the National Institutes of Health, announced the launch of a Clinical Proteomic Tumor Analysis Consortium in August 2011. CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The overarching goal of CPTAC is to improve our ability to diagnose, treat and prevent cancer. To achieve this goal in a scientifically rigorous manner, the NCI launched CPTAC to systematically identify proteins that derive from alterations in cancer genomes and related biological processes, and provide this data with accompanying assays and protocols to the public. The pathways included in this portal have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors. To read more, see Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011. | 
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Cancer Hallmark Categories
| Sustaining proliferative signaling
Translation inhibitors in chronically activated PDGFRA cells (Homo sapiens) Image does not exist Translation inhibitors in chronically activated PDGFRA cells | Evading growth suppressors
Retinoblastoma gene in cancer (Homo sapiens) Image does not exist Retinoblastoma gene in cancer | Activating invasion and metastasis
H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer (Homo sapiens) Image does not exist H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer |
| Enabling replicative immortality
Wnt signaling (Homo sapiens) Image does not exist Wnt signaling | Inducing angiogenesis
Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors (Homo sapiens) Image does not exist Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors | Resisting cell death
PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer (Homo sapiens) Image does not exist PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer |
| Deregulating cellular energetics
TCA cycle nutrient use and invasiveness of ovarian cancer (Homo sapiens) Image does not exist TCA cycle nutrient use and invasiveness of ovarian cancer | Genome instability and mutation
DNA damage response (Homo sapiens) Image does not exist DNA damage response | Tumor promoting inflammation
Chemokine signaling (Homo sapiens) Image does not exist Chemokine signaling |
| Avoiding immune destruction
Altered glycosylation of MUC1 in tumor microenvironment (Homo sapiens) Image does not exist Altered glycosylation of MUC1 in tumor microenvironment | Therapeutics
lncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens) Image does not exist lncRNA-mediated mechanisms of therapeutic resistance |
Featured Pathways
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Image does not exist PDGFR-beta pathway Zhang, et al. Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer |
| View featured pathways |
| List of all pathways for this portal |
Assay Portal
CPTAC also includes an Assay Portal to widely disseminate highly characterized proteomic assays to the global research community, with access to SOPs, reagents, and assay characterization/validation data
Resources
- Over 2400 protein and peptide assays: Browse assays
- Over 750 antibodies and antigen targets: Browse antibodies
- Hundreds of terabytes of data sets: Browse data
Learn how they incorpated WikiPathways images with custom links on their site.
Pathway Curation
On this page you see rotating displays of hallmark and featured pathways. Where did these pathways come from? They came from people like you! The CPTAC set of pathways can be edited, fixed and added to using the pathway drawing and annotation tools here at WikiPathways.
Getting Started
- Introduction to WikiPathways (slides)
- WikiPathways Overview or New Contributor Quickstart
- General help pages
- CPTAC Workshop Exercises
Resources
- Learn more about CPTAC
- Pathway analysis
- Cytoscape and the WikiPathways app
- PathVisio and the WikiPathways plugin
Curation projects
- Curating Hallmark Pathways -- How to
- Example: construction of Pathways in Renal Cancer
- Contact Alex Pico if interested in curating, adding or using CPTAC pathways, [email protected]
