Retinol metabolism (Homo sapiens)

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3, 411-cis-retinolall-trans-retinoate9-cis-retinoateRDH1318-hydroxy RA9-cis-retinalIodopsinall-trans-retinolRPE6511-cis retinalAldehyde oxidaseVitamins A and D - action mechanisms (Homo Sapiens)CP3A7PNPL4all-trans-retinyl esters4-hydroxy RA11-cis-retinyl tetradecanoate4-oxo RACP26ADHRS911-cis-retinyl palmitateADH1ARDH12Aldehyde oxidaseAWAT2beta-CaroteneCP2W1SDR16C5Retinal dehydrogenase 19-cis-retinolVitamin A and carotenoid metabolism (Homo sapiens)DHRS4CP1A1BCDO1all-trans-retinalAWAT2CP2A611-cis-retinyl-palmitate hydrolaseLRAT1, 25Retinal dehydrogenase 1RDH13CP1A1CP26ACP2A6CP3A7CP1A1CP26ACP2A6CP3A7


Description

This pathway describes the metabolism of retinol. Retinol, more common known as vitamin A, is involved in various physiological processes in the human body.

Vitamin A must acquired from the diet. When taken up, retinol metabolism is important to create all the different retinoid forms, such as retinoic acid and retinyl esters. All these types have their own function.

There are many carries proteins and enzymes specific to retinoid metabolism involved in the processes.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Blaner WS, Prystowsky JH, Smith JE, Goodman DS; ''Rat liver retinyl palmitate hydrolase activity. Relationship to cholesteryl oleate and triolein hydrolase activities.''; Biochim Biophys Acta, 1984 PubMed Europe PMC Scholia
  2. Blaner WS, Das SR, Gouras P, Flood MT; ''Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells.''; J Biol Chem, 1987 PubMed Europe PMC Scholia
  3. Travis GH, Golczak M, Moise AR, Palczewski K; ''Retinol Metabolism''; Kegg,
  4. Li Y, Wongsiriroj N, Blaner WS; ''The multifaceted nature of retinoid transport and metabolism.''; Hepatobiliary Surg Nutr, 2014 PubMed Europe PMC Scholia
  5. Arne JM, Widjaja-Adhi MAK, Hughes T, Huynh KW, Silvaroli JA, Chelstowska S, Moiseenkova-Bell VY, Golczak M; ''Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2.''; J Lipid Res, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
122585view10:03, 18 April 2022EweitzModified description
122547view01:42, 15 April 2022EweitzModified title
122215view07:00, 16 March 2022RvanrosmeulenAdded more info in the description
122167view14:27, 14 March 2022RvanrosmeulenAdded pathway datanodes
122160view13:55, 14 March 2022RvanrosmeulenUpdated the layout of the pathway
122159view12:52, 14 March 2022DeSlOntology Term : 'classic metabolic pathway' added !
122142view11:06, 14 March 2022RvanrosmeulenOntology Term : 'signaling pathway' added !
122141view11:05, 14 March 2022RvanrosmeulenOntology Term : 'compound eye retinal cell' added !
122140view11:05, 14 March 2022RvanrosmeulenOntology Term : 'Pathway Ontology' added !
122139view11:04, 14 March 2022RvanrosmeulenModified title
122138view10:44, 14 March 2022Rvanrosmeulenadded specification on 11-cis-retinol conversion
122137view09:59, 14 March 2022RvanrosmeulenUpdated HMDB ID structures
122130view12:43, 12 March 2022RvanrosmeulenUpdates description, added literature, changed geneproduct annotations in protein annotations, added correct annotations for three proteins
122109view00:44, 11 March 2022DeSlSmall layout changes
122020view10:11, 9 March 2022RvanrosmeulenAdded literature and another description
121609view08:33, 22 February 2022RvanrosmeulenAdded extra end product conversion all-trans-retinoate
121600view18:10, 21 February 2022AndraOntology Term : 'retinol metabolic pathway' added !
121486view10:09, 18 February 2022RvanrosmeulenAdded abbreviations
121330view10:06, 15 February 2022RvanrosmeulenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-cis retinalMetaboliteQ17002962 (Wikidata)
11-cis-retinolMetaboliteCHEBI:16302 (ChEBI)
11-cis-retinyl palmitateMetaboliteCHEBI:16254 (ChEBI)
11-cis-retinyl tetradecanoateMetaboliteCHEBI:138676 (ChEBI)
11-cis-retinyl-palmitate hydrolaseProtein3.1.1.63 (BRENDA)
18-hydroxy RAMetaboliteHMDB0012452 (HMDB)
4-hydroxy RAMetaboliteQ27132808 (Wikidata)
4-oxo RAMetaboliteCHEBI:80656 (ChEBI)
9-cis-retinalMetaboliteCHEBI:78273 (ChEBI)
9-cis-retinoateMetaboliteCHEBI:78630 (ChEBI)
9-cis-retinolMetaboliteCHEBI:78272 (ChEBI)
ADH1AProteinP07327 (Uniprot-TrEMBL)
AWAT2ProteinQ6E213 (Uniprot-TrEMBL)
Aldehyde oxidaseProteinQ06278 (Uniprot-TrEMBL)
BCDO1ProteinQ9HAY6 (Uniprot-TrEMBL)
CP1A1ProteinP04798 (Uniprot-TrEMBL)
CP26AProtein043174 (Uniprot-TrEMBL)
CP2A6ProteinP11509 (Uniprot-TrEMBL)
CP2W1ProteinQ8TAV3 (Uniprot-TrEMBL)
CP3A7ProteinP24462 (Uniprot-TrEMBL)
DHRS4 ProteinQ9BTZ2 (Uniprot-TrEMBL)
DHRS9ProteinQ9BPW9 (Uniprot-TrEMBL)
IodopsinMetaboliteCHEBI:5949 (ChEBI)
LRATProteinO95237 (Uniprot-TrEMBL)
PNPL4ProteinP41247 (Uniprot-TrEMBL)
RDH12ProteinQ96NR8 (Uniprot-TrEMBL)
RDH13 ProteinQ8NBN7 (Uniprot-TrEMBL)
RDH13ProteinQ8NBN7 (Uniprot-TrEMBL)
RPE65 ProteinQ16518 (Uniprot-TrEMBL)
Retinal dehydrogenase 1ProteinP00352 (Uniprot-TrEMBL)
SDR16C5ProteinQ8N3Y7 (Uniprot-TrEMBL)
Vitamin A and carotenoid metabolism (Homo sapiens)PathwayWP716 (WikiPathways)
Vitamins A and D - action mechanisms (Homo Sapiens)PathwayWP4342 (WikiPathways)
all-trans-retinalMetaboliteCHEBI:17898 (ChEBI)
all-trans-retinoateMetaboliteCHEBI:35291 (ChEBI)
all-trans-retinolMetaboliteCHEBI:17336 (ChEBI)
all-trans-retinyl estersMetaboliteCHEBI:63410 (ChEBI)
beta-CaroteneMetaboliteHMDB0000561 (HMDB)

Annotated Interactions

No annotated interactions

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