Eicosanoid metabolism via lipoxygenases (LOX) (Mus musculus)

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311BLT1GGTLXA4Lta4hCyp4a108/15-LOXLTA412(R)-HpETE5-HEDHAlox5Arachidonic acid5,12 DiHETEMBD1115-HpETE11115-HETE18-HpETE8-HETE115-oxoETEAlox15LXA4Hpgd12-HpETE12-HETE12-oxoETE2Alox12HXB3HXA3TXA3TXB3HXEH12-HEDHLXB4LTB4112-epi-LTB416-trans-12-epi-delta-LTB46-trans-delta-LTB4LTC41LTD4LTE41EXC41EXD4EXE420-hydroxy-LTB420-carboxy-LTB418-carboxy-dinor-LTB411-trans-LTC411-trans-LTD411-trans-LTE45-HpETE5-HETE25-oxoETE15-oxo-LXA413,14-dihydro-15-oxo-LXA412-oxo-LTB4Ltc4sCyp4a12aCyp4a12bCyp4f14Cyp4f18Acox1Acox2Acox3EhhadhAcaa1aGgt1Ggt5Dpep1Dpep2Ptgr1Ptgr2Alox12Alox5Ptgr1Ptgr2HpgdAlox5Lta4h11BLT21PPAR alpha11Ltc4s1111CYSLT11CYSLT21111115-epi-LXA4115-epi-LXB411LXB4ALX111118/15-LOX112/15-LOX12/15-LOX11112-LOX1, 2112(R)-LOX1111111PPAR alpha1PPAR beta11111TRPA11TRPV111115-LOX222225-LOX222215-HETE215-LOX2212-LOX5,12-diHETE1, 222215-LOX228/15-LOX112/15-LOX12-LOX112(R)-LOX11


Description

This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [1].

Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[2], lipooxygenases(LOX)[3], or cytochrome P450 monooxygenases (CYP)[4]. This pathway visualises the second route, via LOX.

Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed Europe PMC Scholia
  2. Lee TH, Menica-Huerta JM, Shih C, Corey EJ, Lewis RA, Austen KF; ''Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.''; J Biol Chem, 1984 PubMed Europe PMC Scholia
  3. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  4. Buczynski MW, Dumlao DS, Dennis EA; ''Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.''; J Lipid Res, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126096view09:06, 5 April 2023Conroy lipids
126094view08:36, 5 April 2023Conroy lipidsfix non-conneced conversions
126093view08:33, 5 April 2023Conroy lipidscorrect gene IDs
126089view09:03, 4 April 2023Conroy lipidsModified description
126088view09:01, 4 April 2023Conroy lipidsReverted to remove erroneous interpretation of Dennis and Norris (2015) corrected wrong lipids, moved arrow to mim-conversion, added Rhea
125977view15:59, 23 March 2023DeSlTrying to resolve clickability issues by moving all DataNodes to front
124744view08:50, 8 December 2022DeSlUpdated link to LIPID MAPS PWs.
124604view19:28, 15 November 2022EgonwReplaced an old LIPID MAPS identifier
117877view10:20, 23 May 2021EweitzModified title
106329view08:41, 21 August 2019DeSlAdded general LipidMaps publication.
106273view14:31, 19 August 2019DeSlModified description
106272view14:31, 19 August 2019DeSlModified description
102924view12:46, 29 January 2019DeSlConnected interactions differently for readability
102923view12:43, 29 January 2019DeSlLast layout changes
102921view12:38, 29 January 2019DeSlAdded info from second lit. ref
102917view14:53, 28 January 2019DeSlAdded info from lit ref
102916view12:35, 28 January 2019DeSlChanged layout, checked all reactions according to LipidMaps drawing
102894view16:14, 26 January 2019EgonwModified description
102889view15:48, 25 January 2019DeSlModified title
102887view15:46, 25 January 2019DeSlOntology Term : 'eicosanoid metabolic pathway' added !
102886view15:46, 25 January 2019DeSlOntology Term : 'PW:0000002' removed !
102885view15:46, 25 January 2019DeSlOntology Term : 'lipoxygenase mediated pathway of arachidonic acid metabolism' added !
102880view15:45, 25 January 2019DeSlModified description
102878view15:44, 25 January 2019DeSlModified description
98608view12:41, 21 September 2018RyanmillerOntology Term : 'classic metabolic pathway' added !
98578view15:54, 17 September 2018EoinfahyNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-trans-LTC4MetaboliteLMFA03020020 (LIPID MAPS)
11-trans-LTD4MetaboliteLMFA03020021 (LIPID MAPS)
11-trans-LTE4MetaboliteLMFA03020022 (LIPID MAPS)
12(R)-HpETE MetaboliteLMFA03060070 (LIPID MAPS)
12(R)-LOXProteinP39655 (Uniprot-TrEMBL)
12-HEDHGeneProduct
12-HETEMetaboliteLMFA03060088 (LIPID MAPS)
12-HpETEMetaboliteLMFA03060013 (LIPID MAPS) AKA 12S-HpETE
12-LOXProteinP39655 (Uniprot-TrEMBL)
12-epi-LTB4MetaboliteLMFA03020015 (LIPID MAPS)
12-oxo-LTB4MetaboliteLMFA03020024 (LIPID MAPS)
12-oxoETEMetaboliteLMFA03060019 (LIPID MAPS)
12/15-LOXProteinP39654 (Uniprot-TrEMBL) Alox15 (also termed leukocyte-type 12-Lox, 12-Lox-l, and 12/15-Lox) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
13,14-dihydro- 15-oxo-LXA4MetaboliteLMFA03040008 (LIPID MAPS)
15-HETEMetaboliteLMFA03060087 (LIPID MAPS) "Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE." [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid]
15-HpETEMetaboliteLMFA03060014 (LIPID MAPS) "Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HpETE). This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE." [https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid]
15-LOXProteinP39654 (Uniprot-TrEMBL) AKA ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) [https://en.wikipedia.org/wiki/ALOX15]
15-epi-LXA4Metabolite
15-epi-LXB4Metabolite
15-oxo-LXA4MetaboliteLMFA03040009 (LIPID MAPS)
15-oxoETEMetaboliteLMFA03060051 (LIPID MAPS)
18-carboxy- dinor-LTB4MetaboliteLMFA03020056 (LIPID MAPS)
20-carboxy-LTB4MetaboliteLMFA03020016 (LIPID MAPS)
20-hydroxy-LTB4MetaboliteLMFA03020018 (LIPID MAPS)
5,12 DiHETEMetabolite
5,12-diHETEMetaboliteLMFA03060052 (LIPID MAPS)
5-HEDHGeneProduct
5-HETEMetaboliteLMFA03060084 (LIPID MAPS)
5-HpETEMetaboliteLMFA03060108 (LIPID MAPS)
5-LOXProteinP48999 (Uniprot-TrEMBL) AKA Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO [https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase]
5-oxoETEMetaboliteLMFA03060011 (LIPID MAPS)
6-trans-12-epi-delta-LTB4MetaboliteLMFA03020014 (LIPID MAPS)
6-trans-delta-LTB4MetaboliteLMFA03020013 (LIPID MAPS)
8-HETEMetaboliteLMFA03060086 (LIPID MAPS)
8-HpETEMetaboliteLMFA03060073 (LIPID MAPS)
8/15-LOXProteinO35936 (Uniprot-TrEMBL) Alox15b (also termed 8-lipoxygenase, 8-lox, and 15-lipoxygenase type II) [https://en.wikipedia.org/wiki/Lipoxygenase#Mouse_lipoxygenases]
ALXProteinO88536 (Uniprot-TrEMBL) AKA N-formyl peptide receptor 2 (FPR2), because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor. [https://en.wikipedia.org/wiki/Formyl_peptide_receptor_2]
Acaa1aGeneProduct113868 (Entrez Gene)
Acox1GeneProduct11430 (Entrez Gene)
Acox2GeneProduct93732 (Entrez Gene)
Acox3GeneProduct80911 (Entrez Gene)
Alox12GeneProduct11684 (Entrez Gene)
Alox15GeneProduct11687 (Entrez Gene)
Alox5GeneProduct11689 (Entrez Gene)
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
BLT1ProteinO88855 (Uniprot-TrEMBL) AKA Leukotriene B4 receptor 1[https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_1]
BLT2ProteinQ9JJL9 (Uniprot-TrEMBL) AKA Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2 [https://en.wikipedia.org/wiki/Leukotriene_B4_receptor_2]
CYSLT1ProteinQ99JA4 (Uniprot-TrEMBL) AKA Cysteinyl leukotriene receptor 1, also termed CYSLTR1 [https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_1]
CYSLT2ProteinQ920A1 (Uniprot-TrEMBL) AKA Cysteinyl leukotriene receptor 2, also termed CYSLTR [https://en.wikipedia.org/wiki/Cysteinyl_leukotriene_receptor_2]
Cyp4a10GeneProduct13117 (Entrez Gene)
Cyp4a12aGeneProduct277753 (Entrez Gene)
Cyp4a12bGeneProduct13118 (Entrez Gene)
Cyp4f14GeneProduct64385 (Entrez Gene)
Cyp4f18GeneProduct72054 (Entrez Gene)
Dpep1GeneProduct13479 (Entrez Gene)
Dpep2GeneProduct319446 (Entrez Gene)
EXC4MetaboliteLMFA03020031 (LIPID MAPS)
EXD4MetaboliteLMFA03020032 (LIPID MAPS)
EXE4MetaboliteLMFA03020033 (LIPID MAPS)
EhhadhGeneProduct74147 (Entrez Gene)
GGTProtein2.3.2.2 (Enzyme Nomenclature)
Ggt1GeneProduct14598 (Entrez Gene)
Ggt5GeneProduct23887 (Entrez Gene)
HXA3MetaboliteLMFA03090005 (LIPID MAPS)
HXB3MetaboliteLMFA03090003 (LIPID MAPS)
HXEHGeneProduct
HpgdGeneProduct15446 (Entrez Gene)
LTA4MetaboliteLMFA03020023 (LIPID MAPS)
LTB4MetaboliteLMFA03020001 (LIPID MAPS)
LTC4MetaboliteLMFA03020003 (LIPID MAPS)
LTD4MetaboliteLMFA03020006 (LIPID MAPS)
LTE4MetaboliteLMFA03020002 (LIPID MAPS)
LXA4Metabolite
LXA4MetaboliteLMFA03040001 (LIPID MAPS)
LXB4MetaboliteLMFA03040002 (LIPID MAPS)
Lta4hGeneProduct16993 (Entrez Gene)
Ltc4sGeneProduct17001 (Entrez Gene)
MBDProtein3.4.13.19 (Enzyme Nomenclature)
PPAR alphaProteinP23204 (Uniprot-TrEMBL) AKA Peroxisome proliferator-activated receptor alpha
PPAR betaProteinP35396 (Uniprot-TrEMBL) AKA Peroxisome proliferator-activated receptor beta or delta (PPAR-β or PPAR-δ) [https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor_delta]
Ptgr1GeneProduct67103 (Entrez Gene) AKA Ltb4dh
Ptgr2GeneProduct77219 (Entrez Gene) AKA Zadh1
TRPA1ProteinQ8BLA8 (Uniprot-TrEMBL) AKA Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1 or TRPA1 [https://en.wikipedia.org/wiki/TRPA1]
TRPV1ProteinQ704Y3 (Uniprot-TrEMBL) AKA The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1 [https://en.wikipedia.org/wiki/TRPV1]
TXA3MetaboliteLMFA03030005 (LIPID MAPS)
TXB3MetaboliteLMFA03030006 (LIPID MAPS)

Annotated Interactions

No annotated interactions

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