Serotonin HTR1 group and FOS pathway (Homo sapiens)

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139, 146, 258873381019, 43, 48, 79, 187...18, 64, 90, 119, 144...3, 28, 71, 95, 134...121, 131, 138, 179, 191...24, 39, 41, 52, 184...36, 92, 14545, 47, 300, 33142, 116, 226, 301, 34254, 99, 198, 199, 208...74, 168, 177, 180, 190...243113, 223, 33812, 989883, 130, 160, 178, 1812, 8, 20, 60, 66...26, 29, 88, 136, 158...14, 23, 118, 176, 195...989, 125, 141, 202, 221...50, 1016, 55, 56, 84, 100...140, 153, 162, 163, 24685, 29416, 76, 111, 203, 3109840, 67, 106, 114, 129...24315, 34, 62, 153, 156...6824370, 10822, 267, 303, 32269, 115, 117, 171, 172, 214...5, 35, 77, 120, 148...8937, 72, 94, 188, 192...103, 2205361, 78, 135, 164, 194...8938, 82, 291, 344, 348104, 152, 161, 32333, 123236, 2852229830, 105, 142, 150, 175...1, 57, 58, 63, 102...109, 122, 124, 133, 143...2009817, 97, 127, 183, 218...34732, 132, 207, 240, 328988731, 74, 137, 186, 244...11, 27, 46, 86, 151...7, 25, 65, 110, 209...2439844, 51, 81, 182, 215...242, 244, 280, 3261749812815513, 59, 80, 2162979149149, 206, 311, 321, 343Promoter BindingLEGENDSynthesis ReceptorIndirect RegulationFunctional Protein ClassBindingDirect RegulationProteinProtein ModificationSmall MoleculeHTR1BMAP3K1PtdIns3PCREB1MAP2K1RPS6KGNAI2GNAI1HTR1FMAP2K2MAP2K6ELK4MAPKAPK2ITPR1MAPK1PI3KSerotoninMAP2K31,2-DiacetinMAPKAPK3HTR1DGb/gMAPK3RASGRF1PKCRHOAELK1BRAFGNAO1GNAI3SRFPDPK1RAP1AFOSCALCIUMPLCMAPK14RasHTR1ARPS6KA5RASGRP1HTR1E1,4,5-Insp3


Description

This pathway depicts the downstream signaling of serotonin via the receptors 1 group, resulting in the production of FOS via ELK-SRF and CREB1.

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History

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CompareRevisionActionTimeUserComment
125764view14:31, 9 March 2023DeSlAdded rhea ID and ref. for PI3K interaction
125763view14:27, 9 March 2023DeSlFixed PI3K enzyme conversion
125656view15:59, 6 March 2023DeSlIntegrated description from WP733
125655view15:58, 6 March 2023DeSlIntegrated WP733
125651view15:51, 6 March 2023DeSlAdded two annotations
125650view15:47, 6 March 2023DeSlConverted (in)direct regulation to MIM-stimulation
125649view15:43, 6 March 2023DeSlVretical layout, converted arrow to MIM-conversion
125648view15:41, 6 March 2023DeSlChanged layout
125647view15:40, 6 March 2023DeSlConverted some arrows to specific MIM-types
125646view15:35, 6 March 2023DeSlUpdating to current color scheme
125633view02:01, 6 March 2023AlexanderPicoModified description
125272view15:34, 31 January 2023EgonwFixed two more references
125271view15:22, 31 January 2023EgonwFixed a reference
120570view01:00, 17 December 2021Khanspersupdated lit refs
120569view00:58, 17 December 2021Khanspersupdated lit refs
120568view00:45, 17 December 2021Khanspersfixed literature references to remove weird characters
117823view15:06, 22 May 2021EweitzModified title
106177view12:07, 16 August 2019MaintBotHMDB identifier normalization
102357view19:43, 20 December 2018Fehrhartfixed unconnected lines
102125view17:03, 1 December 2018EgonwRemoved whitespace in PubMed identifiers.
74511view05:59, 27 April 2014EgonwLast batch of PubMed ID fixes.
74501view17:12, 26 April 2014EgonwMore PubMed ID fixes.
74499view16:58, 26 April 2014EgonwFixed PubMed IDs.
73767view00:49, 22 February 2014MaintBotupdating schema
49735view09:04, 25 July 2012AndraRDF Tidy
49638view10:31, 23 July 2012AndraRDF Tidy
49633view09:57, 23 July 2012AndraRDF Tidy
49625view09:24, 23 July 2012AndraRDF Tidy
49624view09:22, 23 July 2012AndraRDF Tidy
49621view08:51, 23 July 2012AndraRDF Tidy
49580view07:14, 21 July 2012AndraRDF Tidy
49556view19:33, 20 July 2012AndraRDF tidy
49540view09:59, 20 July 2012AndraCorrected references
49539view09:48, 20 July 2012AndraCorrected a erroneous pubmed reference
49534view09:06, 20 July 2012AndraCorrected a pubmed error
46093view03:28, 15 December 2011AlexanderPicoconverted more hugo to hgnc
45025view18:43, 6 October 2011ThomasOntology Term : 'serotonin signaling pathway' added !
41105view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
39767view07:54, 17 January 2011AlexanderPico
34469view18:32, 10 December 2009MaintBotAutomatic update of empty xrefs
33424view14:53, 30 November 2009MaintBotRemoved group label
33185view17:56, 5 November 2009KhanspersModified categories
31150view04:01, 5 August 2009ArukeModified description
30189view21:58, 8 July 2009ArukePeriodical save, work in progress
30183view04:17, 8 July 2009ArukePeriodical save, work in progress
30177view18:15, 7 July 2009ArukeAdded legend
30176view18:05, 7 July 2009ArukePeriodical save, work in progress
30071view18:39, 30 June 2009ArukeSpecify description
30070view18:37, 30 June 2009ArukePeriodical save, work in progress
30069view18:34, 30 June 2009ArukeSpecify description

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,2-DiacetinMetabolite102-62-5 (CAS) diacylglycerol
1,4,5-Insp3Metabolite85166-31-0 (CAS)
BRAFGeneProduct673 (Entrez Gene) v-raf murine sarcoma viral oncogene homolog B1
CALCIUMMetabolite7440-70-2 (CAS)
CREB1GeneProduct1385 (Entrez Gene) cAMP response element-binding protein 1
ELK1GeneProduct2002 (Entrez Gene) ELK1, member of ETS oncogene family
ELK4GeneProduct2005 (Entrez Gene) ETS domain-containing protein Elk-4 (SRF accessory protein 1)
FOSGeneProduct2353 (Entrez Gene) proto-oncogene protein c-fos
GNAI1Protein2770 (Entrez Gene)
GNAI2Protein2771 (Entrez Gene)
GNAI3Protein2773 (Entrez Gene)
GNAO1Protein2775 (Entrez Gene)
Gb/gComplex
HTR1AProtein3350 (Entrez Gene)
HTR1BProtein3351 (Entrez Gene)
HTR1DProtein3352 (Entrez Gene)
HTR1EProtein3354 (Entrez Gene)
HTR1FProtein3355 (Entrez Gene)
ITPR1GeneProduct3708 (Entrez Gene) inositol 1,4,5-triphosphate receptor 1
MAP2K1GeneProduct5604 (Entrez Gene) mitogen activated protein kinase kinase 1
MAP2K2GeneProduct5605 (Entrez Gene) mitogen activated protein kinase kinase 2
MAP2K3GeneProduct5606 (Entrez Gene) mitogen activated protein kinase kinase 3
MAP2K6GeneProduct5608 (Entrez Gene) mitogen activated protein kinase kinase 6
MAP3K1GeneProduct4214 (Entrez Gene) mitogen activated protein kinase kinase kinase 1
MAPK14GeneProduct1432 (Entrez Gene) mitogen activated protein kinase 14
MAPK1GeneProductMAPK1 (HGNC) mitogen activated protein kinase 1
MAPK3GeneProduct5595 (Entrez Gene) mitogen activated protein kinase 3
MAPKAPK2GeneProduct9261 (Entrez Gene) mitogen activated protein kinase 3
MAPKAPK3GeneProduct7867 (Entrez Gene) mitogen-activated protein kinase-activated protein kinase 3
PDPK1GeneProduct5170 (Entrez Gene) 3-phosphoinositide dependent protein kinase-1
PI3KGeneProduct5290 (Entrez Gene) phosphatidylinositol 3-kinase
PKCGeneProduct50818 (Entrez Gene) protein kinase C
PLCGeneProductphospholipase C
PtdIns3PGeneProductphosphatidylinositol 3,4,5-triphosphate
RAP1AGeneProduct5906 (Entrez Gene) RAS-related protein-1a
RASGRF1GeneProduct5923 (Entrez Gene) RAS protein-specific guanine nucleotide-releasing factor 1
RASGRP1GeneProduct10125 (Entrez Gene) RAS guanyl releasing protein 1
RHOAGeneProduct387 (Entrez Gene) ras homolog gene family, member A
RPS6KGeneProductFunctional Class RPS6K (ribosomal protein S6 kinase)
RPS6KA5GeneProduct9252 (Entrez Gene) ribosomal protein S6 kinase, polypeptide 5
RasGeneProductRAS oncogene homolog
SRFGeneProduct6722 (Entrez Gene) serum response factor
SerotoninMetaboliteHMDB0000259 (HMDB)

Annotated Interactions

No annotated interactions

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