Eicosanoid metabolism via lipoxygenases (LOX) (Mus musculus)

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41Cyp4a10Lta4hEXA4Non-enzymatic5-HEDHMgst2Gpx4LTA4Cyp4f35,6-Ep-15S-HETE20-oxo-leukotriene B4 Arachidonic acidGpx1Alox5Mgst315S-HpETE15S-HETE8-HpETE8S-HETE15-oxoETEAlox15LXA4Hpgd12S-HpETE12S-HETE12-oxoETEHXB3HXA3Trioxilin A3Trioxilin B3Ephx212-HEDHLXB4LTB412-epi-LTB46-trans-12-epi-delta-LTB46-trans-delta-LTB4LTC4LTD4LTE4EXC4EXD4EXE420-hydroxy-LTB420-carboxy-LTB418-carboxy-dinor-LTB411-trans-LTC411-trans-LTD411-trans-LTE45S-HpETE5S-HETE5-oxoETE15-oxo-LXA413,14-dihydro-15-oxo-LXA412-oxo-LTB4Ltc4sCyp4a12aCyp4a12bCyp4f14Cyp4f18Acox1Acox2Acox3EhhadhAcaa1aGgt1Ggt5Dpep1Dpep2Ptgr1Ptgr2Alox12Alox5Ptgr1Ptgr2HpgdAlox55S-HpETEAlox151Alox15


Description

This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [1].

Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[2], lipooxygenases(LOX)[3], or cytochrome P450 monooxygenases (CYP)[4]. This pathway visualises the second route, via LOX.

Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed Europe PMC Scholia
  2. Lee TH, Menica-Huerta JM, Shih C, Corey EJ, Lewis RA, Austen KF; ''Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.''; J Biol Chem, 1984 PubMed Europe PMC Scholia
  3. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  4. Buczynski MW, Dumlao DS, Dennis EA; ''Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.''; J Lipid Res, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
126096view09:06, 5 April 2023Conroy lipids
126094view08:36, 5 April 2023Conroy lipidsfix non-conneced conversions
126093view08:33, 5 April 2023Conroy lipidscorrect gene IDs
126089view09:03, 4 April 2023Conroy lipidsModified description
126088view09:01, 4 April 2023Conroy lipidsReverted to remove erroneous interpretation of Dennis and Norris (2015) corrected wrong lipids, moved arrow to mim-conversion, added Rhea
125977view15:59, 23 March 2023DeSlTrying to resolve clickability issues by moving all DataNodes to front
124744view08:50, 8 December 2022DeSlUpdated link to LIPID MAPS PWs.
124604view19:28, 15 November 2022EgonwReplaced an old LIPID MAPS identifier
117877view10:20, 23 May 2021EweitzModified title
106329view08:41, 21 August 2019DeSlAdded general LipidMaps publication.
106273view14:31, 19 August 2019DeSlModified description
106272view14:31, 19 August 2019DeSlModified description
102924view12:46, 29 January 2019DeSlConnected interactions differently for readability
102923view12:43, 29 January 2019DeSlLast layout changes
102921view12:38, 29 January 2019DeSlAdded info from second lit. ref
102917view14:53, 28 January 2019DeSlAdded info from lit ref
102916view12:35, 28 January 2019DeSlChanged layout, checked all reactions according to LipidMaps drawing
102894view16:14, 26 January 2019EgonwModified description
102889view15:48, 25 January 2019DeSlModified title
102887view15:46, 25 January 2019DeSlOntology Term : 'eicosanoid metabolic pathway' added !
102886view15:46, 25 January 2019DeSlOntology Term : 'PW:0000002' removed !
102885view15:46, 25 January 2019DeSlOntology Term : 'lipoxygenase mediated pathway of arachidonic acid metabolism' added !
102880view15:45, 25 January 2019DeSlModified description
102878view15:44, 25 January 2019DeSlModified description
98608view12:41, 21 September 2018RyanmillerOntology Term : 'classic metabolic pathway' added !
98578view15:54, 17 September 2018EoinfahyNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-trans-LTC4MetaboliteLMFA03020020 (LIPID MAPS)
11-trans-LTD4MetaboliteLMFA03020021 (LIPID MAPS)
11-trans-LTE4MetaboliteLMFA03020022 (LIPID MAPS)
12-HEDHGeneProduct
12-epi-LTB4MetaboliteLMFA03020015 (LIPID MAPS)
12-oxo-LTB4MetaboliteLMFA03020024 (LIPID MAPS)
12-oxoETEMetaboliteLMFA03060019 (LIPID MAPS)
12S-HETEMetaboliteLMFA03060007 (LIPID MAPS)
12S-HpETEMetaboliteLMFA03060013 (LIPID MAPS)
13,14-dihydro- 15-oxo-LXA4MetaboliteLMFA03040008 (LIPID MAPS)
15-oxo-LXA4MetaboliteLMFA03040009 (LIPID MAPS)
15-oxoETEMetaboliteLMFA03060051 (LIPID MAPS)
15S-HETEMetaboliteLMFA03060001 (LIPID MAPS)
15S-HpETEMetaboliteLMFA03060014 (LIPID MAPS)
18-carboxy- dinor-LTB4MetaboliteLMFA01170145 (LIPID MAPS)
20-carboxy-LTB4MetaboliteLMFA03020016 (LIPID MAPS)
20-hydroxy-LTB4MetaboliteLMFA03020018 (LIPID MAPS)
20-oxo-leukotriene B4 MetaboliteLMFA03020064 (LIPID MAPS)
5,6-Ep-15S-HETEMetaboliteLMFA03060075 (LIPID MAPS)
5-HEDHGeneProduct
5-oxoETEMetaboliteLMFA03060011 (LIPID MAPS)
5S-HETEMetaboliteLMFA03060084 (LIPID MAPS)
5S-HpETEMetaboliteLMFA03060012 (LIPID MAPS)
6-trans-12-epi-delta-LTB4MetaboliteLMFA03020014 (LIPID MAPS)
6-trans-delta-LTB4MetaboliteLMFA03020013 (LIPID MAPS)
8-HpETEMetaboliteLMFA03060073 (LIPID MAPS)
8S-HETEMetaboliteLMFA03060006 (LIPID MAPS)
Acaa1aGeneProduct113868 (Entrez Gene)
Acox1GeneProduct11430 (Entrez Gene)
Acox2GeneProduct93732 (Entrez Gene)
Acox3GeneProduct80911 (Entrez Gene)
Alox12GeneProduct11684 (Entrez Gene)
Alox15GeneProduct11687 (Entrez Gene)
Alox5GeneProductP48999 (Uniprot-TrEMBL)
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
Cyp4a10GeneProduct13117 (Entrez Gene)
Cyp4a12aGeneProduct277753 (Entrez Gene)
Cyp4a12bGeneProduct13118 (Entrez Gene)
Cyp4f14GeneProduct64385 (Entrez Gene)
Cyp4f18GeneProduct72054 (Entrez Gene)
Cyp4f3GeneProductQ99N16 (Uniprot-TrEMBL)
Dpep1GeneProductP31428 (Uniprot-TrEMBL)
Dpep2GeneProductQ8C255 (Uniprot-TrEMBL)
EXA4MetaboliteLMFA03020037 (LIPID MAPS)
EXC4MetaboliteLMFA03020031 (LIPID MAPS)
EXD4MetaboliteLMFA03020032 (LIPID MAPS)
EXE4MetaboliteLMFA03020033 (LIPID MAPS)
EhhadhGeneProduct74147 (Entrez Gene)
Ephx2GeneProductP34914 (Uniprot-TrEMBL)
Ggt1GeneProductQ60928 (Uniprot-TrEMBL)
Ggt5GeneProductQ9Z2A9 (Uniprot-TrEMBL)
Gpx1GeneProductP11352 (Uniprot-TrEMBL)
Gpx4GeneProductO70325 (Uniprot-TrEMBL)
HXA3MetaboliteLMFA03090005 (LIPID MAPS)
HXB3MetaboliteLMFA03090003 (LIPID MAPS)
HpgdGeneProductQ8VCC1 (Uniprot-TrEMBL)
LTA4MetaboliteLMFA03020023 (LIPID MAPS)
LTB4MetaboliteLMFA03020001 (LIPID MAPS)
LTC4MetaboliteLMFA03020003 (LIPID MAPS)
LTD4MetaboliteLMFA03020006 (LIPID MAPS)
LTE4MetaboliteLMFA03020002 (LIPID MAPS)
LXA4MetaboliteLMFA03040001 (LIPID MAPS)
LXB4MetaboliteLMFA03040002 (LIPID MAPS)
Lta4hGeneProductP24527 (Uniprot-TrEMBL)
Ltc4sGeneProductQ60860 (Uniprot-TrEMBL)
Mgst2GeneProductA2RST1 (Uniprot-SwissProt)
Mgst3GeneProductQ9CPU4 (Uniprot-TrEMBL)
Non-enzymaticMetabolite
Ptgr1GeneProduct67103 (Entrez Gene) AKA Ltb4dh
Ptgr2GeneProduct77219 (Entrez Gene) AKA Zadh1
Trioxilin A3MetaboliteLMFA03090002 (LIPID MAPS)
Trioxilin B3MetaboliteLMFA03090004 (LIPID MAPS)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
12S-HpETE12S-HETEmim-conversion50709 (Rhea) EC:1.11.1.9
12S-HpETEHXA3mim-conversion50217 (Rhea)
15-oxo-LXA413,14-dihydro- 15-oxo-LXA4mim-conversion41593 (Rhea)
15S-HETE15-oxoETEmim-conversion23261 (Rhea) EC:1.1.1.232
15S-HpETE15S-HETEmim-conversion48857 (Rhea)
20-hydroxy-LTB420-oxo-leukotriene B4 mim-conversion48669 (Rhea)
20-oxo-leukotriene B4 20-carboxy-LTB4mim-conversion48673 (Rhea)
5S-HpETE5S-HETEmim-conversion48621 (Rhea)
5S-HpETELTA4mim-conversion17962 (Rhea)
5S-HpETEmim-conversion17486 (Rhea)
Arachidonic acid12S-HpETEmim-conversion10429 (Rhea)
Arachidonic acid15S-HpETEmim-conversion16870 (Rhea) EC:1.13.11.33
Arachidonic acid5S-HpETEmim-conversion17486 (Rhea)
Arachidonic acidLTA4mim-conversion32308 (Rhea) EC:1.13.11.34
Arachidonic acidmim-conversion38676 (Rhea)
EXA4mim-conversion50141 (Rhea) EC:1.13.11.33
HXA3Trioxilin A3mim-conversion50897 (Rhea)
HXB3Trioxilin B3mim-conversion50901 (Rhea)
LTA4LTC4mim-conversion17619 (Rhea)
LTA4LXB4mim-catalysis22325 (Rhea) EC:3.3.2.6
LTA4mim-conversion22325 (Rhea) EC:3.3.2.6
LTB412-oxo-LTB4mim-conversion50609 (Rhea) EC:1.3.1.48
LTB420-hydroxy-LTB4mim-conversion22177 (Rhea) EC:1.14.14.94
LTC4LTD4mim-conversion31564 (Rhea) EC:3.4.19.14
LTD4LTE4mim-conversion48617 (Rhea)
LXA415-oxo-LXA4mim-conversion41573 (Rhea)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4348"
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