Enterohepatic circulation of bile acids (Homo sapiens)

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COLONOCYTEILEOCYTEHEPATOCYTERENAL PROXIMALTUBULE CELLHEPATOCYTE1ILEUMSYSTEMIC CIRCULATIONLIVERNa+NTCPOATP1B1ILBPBile Acid SynthesisBile Acidstaurine (T) conjugated bile acids (BA) : T-BAglycine (G) conjugated bile acids (BA) : G-BAT-BANa+G-BABILECanalicular effluxOATP1B3BASulfate (S) conjugatedbile acids (BA) : S-BAGlucocuronide (U) conjugatedbile acids (BA) : U-BAS-BAU-BAMRP2hydroxylation (H) conjugatedbile acids (BA) : H-BAH-BAMDR1Sulfate (S) conjugatedbile acids (BA) : S-BAGlucocuronide (U) conjugatedbile acids (BA) : U-BAS-BAU-BAMRP3taurine (T) conjugated bile acids (BA) : T-BAglycine (G) conjugated bile acids (BA) : G-BAT-BAG-BABSEPMRP4T-BAG-BAT-BAG-BAOSTαOSTβOSTαOSTβCOLONOSTαOSTβKIDNEY,URINARYOUTPUTFECAL OUTPUTPORTAL VEINASBTASBTASBTOSTαOSTβMRP2MRP3MRP4taurine (T) conjugated bile acids (BA) : T-BANa+glycine (G) conjugated bile acids (BA) : G-BAT-BANa+G-BASulfate (S) conjugatedbile acids (BA) : S-BAGlucocuronide (U) conjugatedbile acids (BA) : U-BAS-BAU-BAS-BAU-BASulfate (S) conjugatedbile acids (BA) : S-BAGlucocuronide (U) conjugatedbile acids (BA) : U-BAT-BAG-BAtaurine (T) conjugated bile acids (BA) : T-BAglycine (G) conjugated bile acids (BA) : G-BAtaurine (T) conjugated bile acids (BA) : T-BAglycine (G) conjugated bile acids (BA) : G-BAT-BAG-BAtaurine (T) conjugated bile acids (BA) : T-BANa+glycine (G) conjugated bile acids (BA) : G-BAT-BANa+G-BAtaurine (T) conjugated bile acids (BA) : T-BAglycine (G) conjugated bile acids (BA) : G-BAS-BAU-BASulfate (S) conjugatedbile acids (BA) : S-BAGlucocuronide (U) conjugatedbile acids (BA) : U-BAMRP2Sulfate (S) conjugatedbile acids (BA) : S-BAGlucocuronide (U) conjugatedbile acids (BA) : U-BAMRP3BABile AcidsS-BASulfate (S) conjugatedbile acids (BA) : S-BAGlucocuronide (U) conjugatedbile acids (BA) : U-BASulfate (S) conjugatedbile acids (BA) : S-BAGlucocuronide (U) conjugatedbile acids (BA) : U-BAMRP2MRP3U-BABile AcidsNa+


Description

Enterohepatic circulation of bile acids showing the individual transport proteins in hepatocytes, ileocytes (ileal enterocytes), and renal proximal tubule cells

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Quality Tags

Ontology Terms

 

Bibliography

  1. Paul A. Dawson; ''Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition''; Handb Exp Pharmacol., 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128532view17:57, 11 February 2024EweitzOntology Term : 'hepatocyte' added !
127770view13:18, 3 December 2023EgonwChEBI id for Na+ instead of the "Na" atom
126992view15:03, 12 July 2023DeSlAdded ATP dependant reactions
126989view14:49, 12 July 2023DeSlAdded a more detailed description
126986view14:27, 12 July 2023DeSlConnected enzymes to interactions, added Na involvement
126984view14:14, 12 July 2023DeSlAdded specific hydroxylation conjugate IDs
126983view14:12, 12 July 2023DeSlAdded specific glucuronide conjugate IDs
126982view14:06, 12 July 2023DeSlAdded specific sulfate conjugate IDs
126961view16:08, 7 July 2023DeSlAdded all transport reaction (still need to be connected to enzymes)
126960view15:54, 7 July 2023DeSlAdded transport for renal cells
126959view15:42, 7 July 2023DeSlAdded more visual descriptors from pathway
126958view15:33, 7 July 2023DeSlAdded more transport reactions
126956view15:17, 7 July 2023DeSlAdded first transport reactions to Bile
126954view13:55, 7 July 2023DeSlAnnotated metabolite with group IDs
126953view13:52, 7 July 2023DeSlAdded pathway link
126949view13:38, 7 July 2023DeSlOntology Term : 'bile acid transport pathway' added !
126947view13:36, 7 July 2023DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASBTProteinQ12908 (Uniprot-TrEMBL) AKA SLC10A2
BAMetaboliteCHEBI:36078 (ChEBI) Annotated with ChEBI group ID for cholanoids
BSEPProteinO95342 (Uniprot-TrEMBL) AKA ABCB11
Bile Acid SynthesisPathwayWP5176 (WikiPathways)
Bile AcidsMetaboliteCHEBI:36078 (ChEBI) Annotated with ChEBI group ID for cholanoids
G-BAMetaboliteCHEBI:36255 (ChEBI) Annotated with ChEBI group ID for bile acid glycine conjugates
Glucocuronide (U) conjugated bile acids (BA) : U-BAMetaboliteCHEBI:36249 (ChEBI) Annotated with ChEBI group ID for bile acid conjugates; nothing more specific available at this time
H-BAMetaboliteCHEBI:36249 (ChEBI) Annotated with ChEBI group ID for bile acid conjugates; nothing more specific available at this time
ILBPProteinP51161 (Uniprot-TrEMBL) AKA FABP6
MDR1ProteinP08183 (Uniprot-TrEMBL) AKA ABCB1A (PMID:21103970), UniProt: ABCB1 (ABCB1A is used for mouse). MDR1A in Figure (PMID:21103970)
MRP2ProteinQ92887 (Uniprot-TrEMBL) AKA ABCC2
MRP3ProteinO15438 (Uniprot-TrEMBL) AKA ABCC3
MRP4ProteinO15439 (Uniprot-TrEMBL) AKA ABBC4 (PMID:21103970); according to UniProt ABCC4 is the correct gene name.
NTCPProteinQ14973 (Uniprot-TrEMBL) AKA SLC10A1
Na+MetaboliteCHEBI:26708 (ChEBI)
OATP1B1ProteinQ9Y6L6 (Uniprot-TrEMBL) AKA SLCO1B1
OATP1B3ProteinQ9NPD5 (Uniprot-TrEMBL) AKA SLCO1B3
OSTαProteinQ86UW1 (Uniprot-TrEMBL) heteromeric transporter OSTα-OSTβ , assumed to be gene SLC51A based on UniProt entry (gene name not mentioned in publication)
OSTβProteinQ86UW2 (Uniprot-TrEMBL) heteromeric transporter OSTα-OSTβ , assumed to be gene SLC51B based on UniProt entry (gene name not mentioned in publication)
S-BAMetaboliteCHEBI:195349 (ChEBI) Annotated with ChEBI group ID for bile acid sulfate conjugates
Sulfate (S) conjugated bile acids (BA) : S-BAMetaboliteCHEBI:195349 (ChEBI) Annotated with ChEBI group ID for bile acid sulfate conjugates
T-BAMetaboliteCHEBI:23219 (ChEBI) Annotated with ChEBI group ID for bile acid taurine conjugates
U-BAMetaboliteCHEBI:36249 (ChEBI) Annotated with ChEBI group ID for bile acid conjugates; nothing more specific available at this time
glycine (G) conjugated bile acids (BA) : G-BAMetaboliteCHEBI:36255 (ChEBI) Annotated with ChEBI group ID for bile acid glycine conjugates
hydroxylation (H) conjugated bile acids (BA) : H-BAMetaboliteCHEBI:36249 (ChEBI) Annotated with ChEBI group ID for bile acid conjugates; nothing more specific available at this time
taurine (T) conjugated bile acids (BA) : T-BAMetaboliteCHEBI:23219 (ChEBI) Annotated with ChEBI group ID for bile acid taurine conjugates

Annotated Interactions

No annotated interactions

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