Vitamin A and carotenoid metabolism (Homo sapiens)
From WikiPathways
Description
This pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some additional entities (see Waagmeester et al. 2009).
Quality Tags
Ontology Terms
Bibliography
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- Waagmeester A, Pezik P, Coort S, Tourniaire F, Evelo C, Rebholz-Schuhmann D; ''Pathway enrichment based on text mining and its validation on carotenoid and vitamin A metabolism.''; OMICS, 2009 PubMed Europe PMC Scholia
- Bendich A, Olson JA; ''Biological actions of carotenoids.''; FASEB J, 1989 PubMed Europe PMC Scholia
- Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL; ''Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis.''; Eur J Pediatr, 1997 PubMed Europe PMC Scholia
- Boosalis MG, Snowdon DA, Tully CL, Gross MD; ''Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study.''; Nutrition, 1996 PubMed Europe PMC Scholia
- VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, Stacewicz-Sapuntzakis M, Mares-Perlman JA; ''Influence of using different sources of carotenoid data in epidemiologic studies.''; J Am Diet Assoc, 1996 PubMed Europe PMC Scholia
- Sies H, Stahl W, Sundquist AR; ''Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.''; Ann N Y Acad Sci, 1992 PubMed Europe PMC Scholia
- Ruhl CE, Everhart JE; ''Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States.''; Gastroenterology, 2003 PubMed Europe PMC Scholia
- Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, Beecher GR, Smith JC Jr; ''Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men.''; Am J Clin Nutr, 1992 PubMed Europe PMC Scholia
- Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr; ''Separation and identification of carotenoids and their oxidation products in the extracts of human plasma.''; Anal Chem, 1992 PubMed Europe PMC Scholia
- Sun Y, Ng L, Lam W, Lo CK, Chan PT, Yuen YL, Wong PF, Tsang DS, Cheung WT, Lee SS; ''Identification and characterization of a novel mouse peroxisome proliferator-activated receptor alpha-regulated and starvation-induced gene, Ppsig.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia
- Balmer JE, Blomhoff R; ''Gene expression regulation by retinoic acid.''; J Lipid Res, 2002 PubMed Europe PMC Scholia
- Czeczuga-Semeniuk E, Wolczynski S, Markiewicz W; ''Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue.''; Neoplasma, 2003 PubMed Europe PMC Scholia
- Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, Levy J, Sharoni Y; ''Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.''; Nutr Cancer, 1999 PubMed Europe PMC Scholia
- Johansson S, Melhus H; ''Vitamin A antagonizes calcium response to vitamin D in man.''; J Bone Miner Res, 2001 PubMed Europe PMC Scholia
- Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E; ''Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol.''; Am J Clin Nutr, 1994 PubMed Europe PMC Scholia
- Handelman GJ, Dratz EA, Reay CC, van Kuijk JG; ''Carotenoids in the human macula and whole retina.''; Invest Ophthalmol Vis Sci, 1988 PubMed Europe PMC Scholia
- Hidiroglou M, Williams CJ; ''Interrelationships among liposoluble vitamins in ruminants.''; Am J Vet Res, 1986 PubMed Europe PMC Scholia
- Torma H, Rollman O, Binderup L, Michaelsson G; ''Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture.''; J Investig Dermatol Symp Proc, 1996 PubMed Europe PMC Scholia
- Moise AR, Kuksa V, Imanishi Y, Palczewski K; ''Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
- Moise AR, Kuksa V, Blaner WS, Baehr W, Palczewski K; ''Metabolism and transactivation activity of 13,14-dihydroretinoic acid.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
11-cis-Retinal | Metabolite | HMDB02152 (HMDB) | |
11-cis-Retinol | Metabolite | HMDB06216 (HMDB) | |
13,14 dehydro RA | Metabolite | ||
13,14 dehydroretinal | Metabolite | ||
4-oxo-Retinoic acid | Metabolite | HMDB06285 (HMDB) | |
9-cis-Retinal | Metabolite | HMDB06218 (HMDB) | |
9-cis-Retinoic acid | Metabolite | HMDB02369 (HMDB) | |
9-cis-Retinol | Metabolite | HMDB06217 (HMDB) | |
ARAT | GeneProduct | ||
Abcg5 | 64240 (Entrez Gene) | ||
Abcg8 | 64241 (Entrez Gene) | ||
Adh1 | GeneProduct | 124 (Entrez Gene) | |
Adh4 | GeneProduct | 127 (Entrez Gene) | |
Aldh1a1 | GeneProduct | 216 (Entrez Gene) | |
Aldh1a2 | GeneProduct | 8854 (Entrez Gene) | |
Aldh1a3 | 220 (Entrez Gene) | ||
All-trans-13,14-dihydroretinol | Metabolite | HMDB11618 (HMDB) | |
Alpha-Carotene | Metabolite | HMDB03993 (HMDB) | |
Astaxanthin | Metabolite | HMDB02204 (HMDB) | |
Bcdo2 | GeneProduct | 83875 (Entrez Gene) | |
Bcmo1 | GeneProduct | 53630 (Entrez Gene) | |
Beta-Cryptoxanthin | Metabolite | HMDB02268 (HMDB) | |
Betacarotene | Metabolite | HMDB00561 (HMDB) | |
Canthaxanthin | Metabolite | HMDB03154 (HMDB) | |
Cd36 | 948 (Entrez Gene) | ||
Crabp1 | GeneProduct | 1381 (Entrez Gene) | |
Crabp2 | GeneProduct | 1382 (Entrez Gene) | |
Cyp26a1 | 1592 (Entrez Gene) | ||
Cyp26b1 | 56603 (Entrez Gene) | ||
Cyp2e1 | 1571 (Entrez Gene) | ||
Dhrs3 | GeneProduct | 9249 (Entrez Gene) | |
Lpl | 4023 (Entrez Gene) | ||
Lrat | GeneProduct | 6685 (HUGO) | |
Lutein | Metabolite | HMDB03233 (HMDB) | |
Lycopene | Metabolite | HMDB03000 (HMDB) | |
MAPK | GeneProduct | 2.7.11.24 (enzyme) | |
Npc1l1 | 29881 (Entrez Gene) | ||
RARa | 5914 (Entrez Gene) | ||
RARb | 5915 (Entrez Gene) | ||
RARg | 5916 (Entrez Gene) | ||
RPE65 | 6121 (Entrez Gene) | ||
RXRa | 6256 (Entrez Gene) | ||
RXRb | 6257 (Entrez Gene) | ||
RXRg | 6258 (Entrez Gene) | ||
Rbp1 | GeneProduct | 5947 (Entrez Gene) | |
Rbp2 | GeneProduct | 5948 (Entrez Gene) | |
Rbp4 | GeneProduct | 5950 (Entrez Gene) | |
Rbp7 | GeneProduct | 116362 (Entrez Gene) | |
Rdh10 | 157506 (Entrez Gene) | ||
Rdh12 | 145226 (Entrez Gene) | ||
Rdh5 | GeneProduct | 5959 (Entrez Gene) | |
Rdh8 | 50700 (Entrez Gene) | ||
Retinal Vitamin A aldehyde | Metabolite | HMDB01358 (HMDB) | |
Retinol Vitamin A | Metabolite | HMDB00305 (HMDB) | |
Retinol dehydrogenases | GeneProduct | 1.1.1.105 (enzyme) | |
Retinyl ester | Metabolite | HMDB03598 (HMDB) | |
Retsat | GeneProduct | 54884 (Entrez Gene) | |
Rlbp1 | 6017 (Entrez Gene) | ||
Scarb1 | 949 (Entrez Gene) | ||
Sult1a1 | 6817 (Entrez Gene) | ||
Sult2b1 | 6820 (Entrez Gene) | ||
Violaxanthin | Metabolite | HMDB03101 (HMDB) | |
Vitamin D3 | Metabolite | HMDB00876 (HMDB) | |
Zeaxanthin | Metabolite | HMDB02789 (HMDB) | |
all-trans Retinal | Metabolite | HMDB01358 (HMDB) | |
all-trans Retinoic acid Vitamin A acid | Metabolite | HMDB01852 (HMDB) | |
all-trans Retinol Vitamin A | Metabolite | HMDB00305 (HMDB) | |
all-transe 4-oxo RA | Metabolite | ||
beta 10' apocorotenal | Metabolite |
Annotated Interactions
No annotated interactions